- 基本信息
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导师姓名：
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裘正军
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学科代码：
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100210
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性别：
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男
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学科名称：
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外科学
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培养单位：
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附属第一人民医院
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三级学科
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普外
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导师类型：
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博士生导师
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专业领域名称：
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外科学 专业学位
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联系方式：
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qiuwryb@126.com
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专业领域代码：
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105111
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邮编：
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200080
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邮箱地址：
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qiuwryb@online.sh.cn
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- 研究方向 (点击浏览详细信息)
- 社会任职
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中国医师协会结直肠肿瘤专业委员会委员
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上海市医师协会普外科专委会委员
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上海市抗癌协会胰腺癌专委会副主委
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中国研究型医院学会微创外科专委会常委
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中华医学会外科学分会外科手术学组委员
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上海市医学会外科学分会微创外科学组组长
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中国临床肿瘤学会胰腺癌专家委员会委员
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上海市医学会普外科专委会委员
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中国抗癌协会胰腺癌专业委员会委员
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中国研究型医院学会胰腺疾病专业委员会委员
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上海市医学会外科学分会胰腺外科学组委员
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中国医师协会外科医师分会委员
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中国成人教育协会医学继续教育专委会消化外科委员会常委
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中国医师协会普外科分会结直肠外科专业委员会委员
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- 科研项目
| 81974372 | 低氧下胰腺癌细胞外泌体来源的LncRNA-LUCAT1调控巨噬细胞M2型极化促进肿瘤转移的机制研究 | 国家自然基金面上项目 |
2020-01~2023-12
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55万元
| 课题负责人 |
| 2019YFC0120403 | 全景复合式数字腹腔镜系统的临床验证与应用研究 | 中华人民共和国科技部，国家重点研发计划 |
2019-12~2021-12
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25万元
| 子课题负责人 |
| 17YF1415700 | HIF-1α介导缺氧微环境下正反馈调控miR-301a-3p引起胰腺癌对吉西他滨耐药性的机制研究 | 上海市青年科技英才扬帆计划 |
2017-05~2020-04
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20万元
| 课题参与人 |
| 14411966800 | FoxM1亚型在胃癌诊断和预后中的临床应用研究 | 上海市科委 |
2014-10~2017-09
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20万元
| 课题参与人 |
| 81372640 | miR-301a在缺氧诱导胰腺癌EMT中的功能机制研究 | 国家自然基金 |
2014-01~2017-12
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70万元
| 课题负责人 |
| w2012FZ092 | 分子诊断技术在结直肠癌个体化治疗中的应用研究 | 卫生部 |
2012-03~2016-05
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30万元
| 课题负责人 |
| 81101844 | Caveolin-1 在胰腺癌转移和EMT 中的作用及其机制研究 | 国家自然基金 |
2012-01~2014-12
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20万元
| 课题参与人 |
| 09QA1404600 | 调控STAT3信号通路对胰腺癌侵袭转移作用及其机制的研究 | 上海市科委人才计划项目 |
2009-07~2011-06
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15万元
| 课题参与人 |
| 06BZ067 | RNAi沉默STAT3对胰腺癌侵袭转移影响及其机制的研究 | 上海市教委,发展基金 |
2007-01~2009-12
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6万元
| 课题负责人 |
- 学术论文
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Yuhan Yang, Zengya Guo,Weiwei Chen, Xiaofeng Wang, Meng Cao, Xuan Han, Kundong Zhang,
Buwei Teng, Jun Cao, Weidong Wu, Peng Cao, Chen Huang,
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M2 Macrophage-Derived Exosomes Promote Angiogenesis and Growth of Pancreatic Ductal Adenocarcinoma by Targeting E2F2
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Molecular Therapy
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2021
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29(3)):1226-1238
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Weiwei Chen, Kundong Zhang, Yuhan Yang, Zengya Guo, Xiaofeng Wang, Buwei Teng, Qian Zhao, Chen Huang,
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MEF2A-mediated lncRNA HCP5 Inhibits Gastric Cancer Progression via MiR-106b-5p/p21 Axis
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Int J Biol Sci
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2021
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17(2): 623–634.
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Bin Wang, Xing Sun, Ke-Jian Huang, Li-Sheng Zhou,
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Long non-coding RNA TP73-AS1 promotes pancreatic cancer growth and metastasis through miRNA-128-3p/GOLM1 axis
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World J Gastroentero
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2021
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27(17): 1993–2014.
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Zhang KD, Hu B, Cen G, Yang YH, Chen WW, Guo ZY, Wang XF, Zhao Q,
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MiR-301a transcriptionally activated by HIF-2α promotes hypoxia-induced epithelial-mesenchymal transition by targeting TP63 in pancreatic cancer.
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World J Gastroenterol.
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2020
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26(19):2349-2373.
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Zhanshan Wang,Guangtao Luo,
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Akt Inhibitor MK-2206 Reduces Pancreatic Cancer
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Oncol Lett
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2020
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19 (3), 1999-2004
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Zengya Guo, Xiaofeng Wang, Yuhan Yang, Weiwei Chen, Kundong Zhang, Buwei Teng, Chen Huang, Qian Zhao,
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Hypoxic Tumor-Derived Exosomal Long Noncoding RNA UCA1 Promotes Angiogenesis via miR-96-5p/AMOTL2 in Pancreatic Cancer
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Mol Ther Nucleic Acids
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2020
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22: 179–195.
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Luo G, Xia X, Wang X, Zhang K, Cao J, Jiang T, Zhao Q,
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miR-301a plays a pivotal role in hypoxia-induced gemcitabine resistance in pancreatic cancer.
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Exp Cell Res
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2018
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369(1):120-128
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Wang X, Luo G, Zhang K, Cao J, Huang C, Jiang T, Liu B, Su L,
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Hypoxic Tumor-Derived Exosomal miR-301a Mediates M2 Macrophage Polarization via PTEN/PI3Kγ to Promote Pancreatic Cancer Metastasis
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Cancer Res
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2018
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78(16):4586-4598
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Xia X, Zhang K, Luo G, Cen G, Cao J, Huang K,
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Downregulation of miR-301a-3p sensitizes pancreatic cancer cells to gemcitabine treatment via PTEN
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Am J Transl Res.
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2017
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9(4):1886-1895
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Cen G, Zhang K, Cao J,
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Downregulation of the N-myc downstream regulated gene 1 is related to enhanced proliferation, invasion and migration of pancreatic cancer.
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Oncol Rep
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2017
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37(2):1189-1195
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Zhang J, Zhang K, Zhou L, Wu W, Jiang T, Cao J, Huang K,, Huang C.
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Expression and potential correlation among Forkhead box protein M1, Caveolin-1 and E-cadherin in colorectal cancer.
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Oncol Lett
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2016
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12(4):2381-2388
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Kundong Zhang, Guang Yang, Weidong Wu, Jing Zhang, Xiang Xia, Tao Jiang, Jun Cao, Kejan Huang,, Chen Huang
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Decreased Expression of Caveolin-1 and E-Cadherin Correlates with the Clinicopathologic Features of Gastric Cancer and the EMT Process
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Recent Pat Anticancer Drug Discov
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2016
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11(2):236-44.
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Xia X, Zhang K, Cen G, Jiang T, Cao J, Huang K, Huang C, Zhao Q,
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MicroRNA-301a-3p promotes pancreatic cancer progression via negative regulation of SMAD4
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Oncotarget
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2015
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6(25):21046-63
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Huang C, Shen JC, Zhang J, Jiang T, Wu WD, Cao J, Huang KJ,
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Clinical comparison of laparoscopy vs open surgery in a radical operation for rectal cancer: A retrospective case-control study
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World J Gastroenterol
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2015
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21(48): 13532-13541
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Xia X, Huang C, Cen G,
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Preoperative diabetes as a protective factor for pancreatic fistula after pancreaticoduodenectomy: a meta-analysis
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Hepatobiliary Pancreat Dis Int.
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2015
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14(2):132-8.
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Huang KJ, Cen G,, Jiang T, Cao J, Fu CY.
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Application of international videoconferences for continuing medical education programs related to laparoscopic surgery
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Telemed J E Health
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2014
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20(2):157-60
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Xia X, Wu W, Zhang K, Cen G, Jiang T, Cao J, Huang K, Huang C,
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Prognostic significance of complications after laparoscopic colectomy for colon cancer.
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PLoS One
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2014
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9(10):e108348
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Xia X, Cen G, Jiang T, Cao J, Huang K, Huang C,
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Risk factor evaluation for postoperative complications in laparoscopic colorectal surgery by a classic severity grading system
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Tumour Biol
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2014
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35(8):8115-23
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Xia X, Huang C, Jiang T, Cen G, Cao J, Huang K,
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Is laparoscopic colorectal cancer surgery associated with an increased risk in obese patients? A retrospective study from China
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World J Surg Oncol
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2014
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12:184
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Pu Y, Cen G, Sun J, Gong J, Zhang Y, Zhang M, Wu X, Zhang J,, Fang F
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Warming with an underbody warming system reduces intraoperative hypothermia in patients undergoing laparoscopic gastrointestinal surgery: a randomized controlled study.
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Int J Nurs Stud
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2014
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51(2):181-9
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Zhu G,Huang C, Feng Z,Lv X,
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Hypoxia-Induced Snail Expression Through Transcriptional Regulation by HIF-1a in Pancreatic Cancer Cells
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Dig Dis Sci
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2013
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58(12):3503–3515
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HUANG C, LI H, WU W, JIANG T,
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Regulation of miR-155 affects pancreatic cancer cell invasiveness and migration by modulating the STAT3 signaling pathway through SOCS1.
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Oncol Rep
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2013
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30（3）: 1223-1230
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Chen Huang,, Liwei Wang, Zhihai Peng, Zhiliang Jia, Craig D. Logsdon,Xiangdong Le, Daoyan Wei, Suyun Huang, and Keping Xie
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A Novel FoxM1-Caveolin Signaling Pathway PromotesPancreatic Cancer Invasion and Metastasis
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Cancer Res
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2012
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72(3); 1–11.
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Huang C, Jiang T, Zhu L, Liu J, Cao J, Huang KJ,
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STAT3-targeting RNA interference inhibits pancreatic cancer angiogenesis in vitro and in vivo
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Int J Oncol
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2011
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38(6):1637-44
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Hai dong Li, Chen Huang, Ke jian Huang, Wei dong Wu ,Tao Jiang, Jun Cao, Zhen zhong Feng,
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STAT3 Knockdown Reduces Pancreatic Cancer Cell Invasiveness and Matrix Metalloproteinase-7 Expression in Nude Mice.
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PLoS ONE
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2011
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6(10):e25941
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Zhu GH, Huang C,, Liu J, Zhang ZH, Zhao N, Feng ZZ, Lv XH
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Expression and prognostic significance of CD151, c-Met, and integrin alpha3/alpha6 in pancreatic ductal adenocarcinoma
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Dig Dis Sci
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2011
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56(4):1090-8
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Sun J, Jiang T,, Cen G, Cao J, Huang K, Pu Y, Liang H, Huang R, Chen S
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Short-term and medium-term clinical outcomes of laparoscopic-assisted and open surgery for colorectal cancer: a single center retrospective case-control study
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BMC Gastroenterol.
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2011
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Huang C, Yang G, Jiang T, Cao J, Huang KJ,
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Down-regulation of STAT3 expression by vector-based small interfering RNA inhibits pancreatic cancer growth
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World J Gastroenterol
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2011
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17(25):2992-3001
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, Sun J, Pu Y, Jiang T, Cao J, Wu W
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Learning curve of transumbilical single incision laparoscopic cholecystectomy (SILS): a preliminary study of 80 selected patients with benign gallbladder diseases
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World J Surg
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2011
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35(9): 2092-101
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Huang C, Yang G, Jiang T, Huang K, Cao J,
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Effects of IL-6 and AG490 on regulation of Stat3 signaling pathway and invasion of human pancreatic cancer cells in vitro
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J Exp Clin Cancer Res
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2010
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Liu X, Li J, Tian Y, Xu P, Chen X, Xie K,, Wang Y, Zhang D, Wolf F, Li C, Huang Q.
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Enhanced pancreatic cancer gene therapy by combination of adenoviral vector expressing c-erb-B2 (Her-2/neu)-targeted immunotoxin with a replication- competent adenovirus or etoposide
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Hum Gene Ther
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2010
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21(2):157-70
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Huang C, Huang R, Jiang T, Huang K, Cao J,
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Laparoscopic and open resection for colorectal cancer: an evaluation of cellular immunity
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BMC Gastroenterol
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2010
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Liu J, Sun HC, Sun J, Huang C, Hu HH, Jin YB,
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Phosph-Akt1 expression is associated with a favourable prognosis in pancreatic cancer
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Ann Acad Med Singapore
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2010
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39(7):548-7
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Yang G, Huang C, Cao J, Huang KJ, Jiang T,
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Lentivirus-mediated shRNA interference targeting STAT3 inhibits human pancreatic cancer cell invasion
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World J Gastroenterol
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2009
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15(30):3757-66
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Sun HC,, Liu J, Sun J, Jiang T, Huang KJ, Yao M, Huang C.
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Expression of hypoxia-inducible factor-1 alpha and associated proteins in pancreatic ductal adenocarcinoma and their impact on prognosis
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Int J Oncol
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2007
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30(6):1359-67
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, Huang C, Sun J, Qiu W, Zhang J, Li H, Jiang T, Huang K, Cao J.
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RNA interference-mediated signal transducers and activators of transcription 3 gene silencing inhibits invasion and metastasis of human pancreatic cancer cells
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Cancer Sci
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2007
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98(7):1099-106
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Huang C, Cao J, Huang KJ, Zhang F, Jiang T, Zhu L,
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Inhibition of STAT3 activity with AG490 decreases the invasion of human pancreatic cancer cells in vitro.
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Cancer Sci
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2006
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97(12):1417-23
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