• 基本信息
    导师姓名: 张伟滨 学科代码: 100210
    性别: 学科名称: 外科学
    培养单位: 附属瑞金医院 三级学科 骨外
    导师类型: 博士生导师 专业领域名称: 外科学 专业学位
    联系方式: 13501824630 专业领域代码: 105111
    邮编: 200025 邮箱地址: zhangweibin10368@163.com
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    中华医学会骨质疏松与骨矿盐疾病委员会委员
    上海肉瘤专业委员会副主任委员
    中国抗癌协会肉瘤专业委员会常务委员
    中国医师协会骨科医师分会常务委员
    上海骨科专科委员会副主任委员
    上海骨科医师协会副会长
    中华医学会肿瘤学会骨与软组织肿瘤学组委员
    中华医学会骨科学分会基础学组副组长
    中华医学会骨科学会骨肿瘤学组委员
    上海市骨质疏松专科委员会副主任委员
    中华医学会骨科学分会委员
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    14JC1492400表面特殊微纳米羟基磷灰石生物学作用机理研究上海市科委重点科技攻关纳米项目 2014-09~2017-08 40万元  课题负责人
    81172550阻断 PI3K/mTOR 信号通路诱导分化并靶向治疗骨肉瘤干细胞的分子机制研究国家自然科学基金 2012-01~2015-12 55万元  课题负责人
    10431901202重组人MNV-骨形态发生蛋白-2的II期临床研究生物学检测上海市科委科技支撑计划生化重点科技攻关专项 2010-09~2013-09 34万元  课题负责人
    08411950600股骨粗隆间骨质疏松性骨折的生物力学评估评价及指导个体最优化内固定应用上海市科委生化重点科技攻关项目 2008-09~2011-09 25万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Liu Zhuochao, Wen Junxiang, Wu Chuanlong, Hu Chuanzhen, Wang Jun, Bao Qiyuan, Wang Hongyi, Wang Jizhuang, Zhou Qi, Wei Li, Shen Yuhui,  MicroRNA-200a induces immunosuppression by promoting PTEN-mediated PD-L1 upregulation in osteosarcoma  Aging  2020  12(2), 1213-1236 
    Zang S, He Q, Bao Q, Shen Y,  Establishment and validation of a novel survival prediction scoring algorithm for patients with non-small-cell lung cancer spinal metastasis.  Int J Clin Oncol  2019  24(9):1049-1060 
    Fangzhou He,Le Qin, Qiyuan Bao, Shizhao Zang,Qin He,Shijing Qiu, Yuhui Shen,  Pre-Operative Chemotherapy Response Assessed by contrast-enhanced MRI Can Predict the Prognosis of Enneking surgical margins in Patients with Osteosarcoma.   J Orthop Res   2019  37(1) : 258-264 
    Jizhuang Wang; Chuanzhen Hu; Jun Wang; Yuhui Shen; Qiyuan Bao; Fangzhou He; Hongyi Wang; Liangzhi Gong; Zhuochao Liu; Fangqiong Hu; Jing Liang; Qi Zhou; Li Wei; Junxiang Wen; Weibin Zhang  Checkpoint Blockade in Combination With Doxorubicin Augments Tumor Cell Apoptosis in Osteosarcoma. 18.  J Immunother  2019  42(9):321-330 
    Pei Yu, Junxiang Wen, Jun Wang, Jing Liang, Yuhui Shen,  Establishment and characterization of a novel human osteosarcoma cell line for spontaneous pulmonary metastasis research in vivo  Ann Transl Med   2019  7(20):573-580 
    Zhuochao Liu, Zhiyong Zheng, Jin Qi, Jun Wang, Qi Zhou, Fangqiong Hu, Jing Liang,Changwei Li ,,Xingkai Zhang  CD24 identifies nucleus pulposus progenitors/notochordal cells for disc regeneration.   Journal of Biological Engineering   2018  (12):35-50 
    Liangzhi Gong, Qiyuan Bao, Chuanzhen Hu, Jun Wang, Qi Zhou , Li Wei, Lei Tong,, Yuhui Shen  Exosomal miR-675 from metastatic osteosarcoma promotes cell migration and invasion by targeting CALN1.   Biochemical and Biophysical Research Communications   2018  (500):170-176 
    Fangzhou He, Chuanzhen Hua, Yuhui Shena, Qiyuan Bao, Junxiang Wen, Shijing Qiu,Rong Wan,  Patellar height influences knee function in patients withaggressive bone tumors of the proximal tibia after endoprosthetic reconstruction.   Knee  2018  (25): 952–958 
    Qiyuan Bao, Yuhui Shen,  Metastatic Biopsy of Osteosarcoma with Circulating RNA  Ann Surg Oncol   2018  25(Suppl 3):936-937 
    Qiyuan Bao, , Liangzhi Gong, Jizhuang Wang, Junxiang Wen,, Weibin Zhang  Extracellular Vesicle RNA Sequencing Reveals Dramatic Transcriptomic Alterations Between Metastatic and Primary Osteosarcoma in a Liquid Biopsy Approach  Ann Surg Oncol  2018  (25) :2642–2651 
    C. Hu, J. Wen, L. Gong, X. Chen, Y. Shen,, J. Wang, F. Hu, Q. Zhou, J. Liang, L. Wei   Thrombospondin-1 promotes cell migration, invasion and lung metastasis of osteosarcoma through FAK dependent pathway  Oncotarget  2017  8(44): 75881-75892 
    C. Hu, X. Chen, J.X. Wen, L.Z. Gong, Z.C.Liu,J. Wang, J. Liang, F.Q. Hu, Q. Zhou, L. Wei, Y.H. Shen,  Antitumor effect of focal adhesion kinase inhibitor PF562271 against human osteosarcoma in vitro and in vivo  Cancer Sci  2017  108 :1347–1356 
    Zhuochao Liu, Changwei Li, Xiangchao Meng, Yunting Bai, Jin Qi,Jun Wang, Qi Zhou,, Xingkai Zhang.   Hypoxia-inducible factor-la mediates aggrecan and collagen P expression via NOTCH1 signaling in nucleus pulposus cells during intervertebral disc degeneration.  Biochem Biophys Res Commun  2017  488: 554-561  
    Fangzhou He,,Yuhui Shen, Pei Yu, Qiyuan Bao, Junxiang Wen, Chuanzhen Hu, Shijing Qiu   Effects of resection margins on local recurrence of osteosarcoma in extremity and pelvis: Systematic review and meta-analysis  Int J Surg  2016  36 : 283-292 
    Gong Liangzhi,,Shen Yuhui   Magnesium substituted hydroxyapatite whiskers: synthesis, characterization and bioactivity evaluation  RSC Adv  2016  6, 114707–114713 
    Xu Chen, Chuanzhen Hu,, Yuhui Shen, Jun Wang, Fangqiong Hu, Pei Yu  Metformin inhibites the proliferation , metastasis, and cancer stem-like sphere formation in osteosarcoma MG63 cell in vitro  Tumor Biology  2015  2015 Jul 13 
    Wu Zhang, Meng-LeiDing, Jia-Nian Zhang, Jian-ru Qiu, Yu-Hui Shen, Xiao-Yi Ding, Lian-fu Deng, Wei-Bin Zhang,  mTORC1 Maintains Tumoriginity of SSEA4 + High- Grade Osteosarcoma  Scientfic Reports  2015  1-13 
    Y. SUNNASSEE, R. WAN, Y. SHEN, J. XU, E. P. SOUTHERN,  Preliminary results for the use of knee mega-endoprosthesis in the treatment of musculoskeletal complications of haemophilia  Haemophilia  2014  ():1-8 
    Jianqiang Xu, Yaoqi Yang, Rong Wan, Yuhui Shen,  Hydrothermal Preparation and Characterization of tralong Strontium-Substituted ydroxyapatite Whiskers Using Acetamide as Homogeneous Precipitation Reagent  The Scientific World Journal  2014  ():1-6 
    LIU Pei-yi, ZHANG Wei-bin,  Targeting the mammalian target of rapamycin pathway in osteosarcoma using combinative chemotherapy  Chin Med J  2013  126(10):197-8 
    刘沛宜、张伟滨、王君、沈宇辉、魏义勇。,  雷帕霉素对骨肉瘤干细胞和人骨肉瘤细胞中雷帕霉素靶蛋白传导通路的抑制作用及意义  中华肿瘤杂志  2013  35(3):175-180 
    Yuhui Shen, Jinhao Liu, Kaili Lin,  48) Yuhui Shen, Jinhao Liu, Kaili Lin, Weibin Zhang. Synthesis of strontium substituted hydroxyapatite whiskers used as bioactive and mechanical reinforcement material  Materials Letters  2012  70():76-79 
    袁高翔、王蕾、张伟滨、沈宇辉、陈博  动力髋螺钉与股骨近端防旋髓内钉治疗骨质疏松性股骨转子间骨折的有限元比较研究  中华创伤骨科杂志  2012  14(10):876-882 
    Gao-Xiang Yuan, Yu-Hui Shen, Bo Chen,  Biomechanical comparison of internal fixations in osteoporotic intertrochanteric fracture. A finite element analysis  J Saudi medica  2012  7():732-739 
    , Waiching Liu, Weiming Gu,Lei Chen, Yuhui Shen  Strontium modification of biomaterial: the effective approach to enhance the bioactivity and biocompatibility of calcium silicate  Advanced Materials Research  2012  391():195-199 
    Wan R,, Xu J, Hao P, Yang Y, Shen Y, Ding X, Qiu S  The outcome of surgical treatment for recurrent giant cell tumor in the appendicular skeleton. J Orthop Sci  J Orthop Sci  2012  17():464-469 
    陈要林、林开泽、张伟滨(通讯)、王青禾、张武、沈宇辉、方成  人骨肉瘤细胞致瘤性与临床预后关系的实验研究  上海医学  2012  35(2):145-148 
    , Li G, Deng R, Deng L, Qiu S  New bone formation in a true bone ceramic scaffold loaded with desferrioxamine in the treatment of segmental bone defect: a preliminary study  J Orthop Sci  2012  17():289-298 
    王俊青,郝平,万荣,颜凌,  三维重建MRI术前评价骨肉瘤IOR/OS-N4新辅助化疗疗效的临床应用  诊断学理论与实践  2012  11(3):283-289 
    , Pan W, Zhang M, Wei Y  In vivo evaluation of two types of bioactive scaffold used for tendon-bone interface healing in the reconstruction of anterior cruciate ligamen  Biotechnol Lett  2011  33():837-844 
    , Yuhui Shen, Haobo Pan  Effects of strontium in modified biomaterials.  Acta Biomaterialia  2011  7():800-808 
    , Shen Y, Wan R, Zhu Y  Primary clear cell sarcoma of the sacrum: a case report  Skeletal Radiol  2011  40():633-639 
    ,沈宇辉,万荣,周琦,朱亚萍,齐进.  骨折断端血管性血友病因子表达在骨折愈合中的生物学意义  中华创伤杂志  2008   
    代洪宾,杜宁,林开泽,蒋水明,  雄激素对雄性去势大鼠微结构及力学性能的影响  中国骨伤  2008   
    袁石福,,沈宇辉,朱雅萍,王琚魏立  成骨细胞与骨髓间充质干细胞DNA甲基化差异的实验研究  上海医学  2008   
    ,王蕾,沈宇辉,王亚梓,徐建强  锁定钢板治疗桡骨远端不稳定性骨质疏松性骨折  中华创伤杂志  2008   
    代洪宾,李飞跃,罗仕华,张风华,  健骨汤对去睾丸大鼠松质骨的影响  中国中医骨伤科杂志  2008   
    代洪宾,李飞跃,符诗聪,林开泽,蒋水明,  雄激素对男性骨质疏松大鼠模型骨的影响  中国骨质疏松杂志  2008   
    ,庄澄宇,李建民,杨志平,陈晓亮.  盐酸氨基葡萄糖治疗骨性关节炎有效性与安全性评价  中华外科杂志  2007