导师姓名：	刘伟	学科代码：	100210
性别：	男	学科名称：	外科学
培养单位：	附属第九人民医院	三级学科	整形
导师类型：	博士生导师	专业领域名称：	外科学专业学位
联系方式：	liuwei_md@126.com	专业领域代码：	105111
邮编：	200011	邮箱地址：	liuwei_md@yahoo.com.cn


组织工程研究，瘢痕研究和治疗

社会任职

上海市整形外科研究所副所长,中华整形外科杂志编委,中国生物医学工程学会组织工程分会副主任委员,中国生物材料委员会委员，中国解剖学会再生医学分会副主任委员，国际组织工程与再生医学学会(TERMIS) Member at large, Biomaterials 和 Journal of Tissue Engineering and Regenerative Medicine杂志编委, Tissue Engineering”杂志特刊编辑。Scar Club学术委员会委员， Founding Member of Global Scar Society, Fellow of Interntional Union Society of Biomeaterials Science and Technology

科研项目

项目编号	项目名称	课题来源	起止年月	批准经费	承担职责
31870967	模拟肌腱发育时空调控机制促进组织工程肌腱胶原合成与重塑	国家自然基金面上项目	2019-01~2022-12	59万元	课题负责人
2018YFC1105800	生物力学调控组织再生核心技术研发及其临床应用转化	科技部2018年国家重点研发计划	2018-09~2021-07	1173万元	课题负责人
81671921	基于全基因组、转录组和甲基化测序的瘢痕疙瘩易感基因探索研究	2017年国家自然科学基金面上项目	2017-01~2020-12	52万元	课题负责人
20150202828	瘢痕诊断分类及危险评估的临床研究瘢痕诊断分类及危险评估的临床研究瘢痕诊断分类及危险评估的临床研究瘢痕诊断分类及危险评估的临床研究	2015年国家卫计委公益性行业基金	2015-06~2018-12	23万元	课题参与人
31470943	肌腱细胞外基质和拓扑结构诱导人脂肪干细胞成肌腱分化的实验研究	国家自然基金面上项目	2015-01~2018-12	90万元	课题负责人
2012AA020507	结构类组织的组织工程构建技术与产品研发	科技部863	2012-01~2015-12	1200万元	课题负责人
31170937	模拟肌腱细胞形态和力学微环境诱导ASC 成肌腱分化及机制	国家自然科学基金	2012-01~2015-12	60万元	课题负责人
81071590	细胞形态和力学刺激在皮肤成纤维细胞向肌腱细胞转分化中的作用及其分子机制	国家自然科学基金	2011-01~2014-12	35万元	课题负责人
30872694	阻断转化生长因子-beta 效应联合干细胞移植促进伤口皮肤再生	国家自然基金委,面上项目	2009-01~2011-12	34万元	课题负责人
2006AA02A127	组织工程肌腱体外构建及产品研制与开发	科技部863	2006-12~2010-12	450万元	课题负责人
2005CB522703	生物力学调节细胞分化和促进工程化组织形成的机理	科技部973子课题	2005-10~2010-09	450万元	课题负责人

学术论文

作者	论文标题	期刊名	出版年	卷期页码
刘伟（通讯作者）	瘢痕疙瘩发生和发展的整体观机制探讨	组织工程与重建外科	2018	14（4）：181-183
Li Q, Zhang W, Zhou G, Cao Y, Liu W （通讯作者）, Zhang ZY.	Demineralized bone matrix-based microcarrier scaffold favors vascularized large bone regeneration in vivo in a rat model.	J Biomater Appl.	2018	33(2):182-195.
中国整形美容协会瘢痕医学分会常务委员会专家组（通讯作者）	中国瘢痕疙瘩临床治疗推荐指南	中国整形美容外科杂志	2018	29（5）：前插1-5
Deng J, Shi Y, Gao Z, Zhang W, Wu X, Cao W, Liu W. （通讯作者）	Inhibition of Pathological Phenotype of Hypertrophic Scar Fibroblasts Via Coculture with Adipose-Derived Stem Cells.	Tissue Eng Part A.	2018	24(5-6):382-393.
Zhou K, Feng B, Wang W, Jiang Y, Zhang W, Zhou G, Jiang T, Cao Y, Liu W. （通讯作者）	Nanoscaled and microscaled parallel topography promotes tenogenic differentiation of ASC and neotendon formation in vitro.	Int J Nanomedicine.	2018	4;13:3867-3881.
Wang W, Deng D, Wang B, Zhou G, Zhang W, Cao Y, Zhang P, Liu W. （通讯作者）	Comparison of Autologous, Allogeneic, and Cell-Free Scaffold Approaches for Engineered Tendon Repair in a Rabbit Model-A Pilot Study.	Tissue Eng Part A,	2017	2017 DOI: 10.1089/ten.tea.2016.0447
Liu K, Gao Z, Zhou G, Zhang W, Wu X, Liu W. （通讯作者）	Characterization of Smad3 knockout mouse derived skin cells.	In Vitro Cell Dev Biol Anim.	2017	;53(5):458-466
Lin X, Wang W, Zhang W, Zhang Z, Zhou G, Cao Y, Liu W （通讯作者）	Hyaluronic acid coating enhances biocompatibility of non-woven PGA scaffold and cartilage formation.	Tissue Eng Part C,	2017	23(2):86-97.
Shi Y, Zhou K, Zhang W, Zhang Z, Zhou G, Cao Y, Liu W. （通讯作者）	Microgrooved topographical surface directs tenogenic lineage specific differentiation of mouse tendon derived stem cells.	Biomed Mater.	2017	12(1):015013.
Shi Y, Xiong Y, Jiang Y, Zhang Z, Zhou G, Zhang W, Cao Y, He J, Liu W. （通讯作者）	Conditional tenomodulin overexpression favors tenogenic lineage differentiation of transgenic mouse derived cells.	Gene.	2017	598:9-19.
Deng J, Shi Y, Gao Z, Zhang W, Wu X, Cao W, Liu W. （通讯作者）	Inhibition of Pathological Phenotype of Hypertrophic Scar Fibroblasts Via Coculture with Adipose-Derived Stem Cells	Tissue Eng Part A,	2017	2017 DOI: 10.1089/ten.tea.2016.0550
Jiang Y, Shi Y, He J, Zhang Z, Zhou G, Zhang W, Cao Y, Liu W （通讯作者）	Enhanced tenogenic differentiation and tendon-like tissue formation by tenomodulin overexpression in murine mesenchymal stem cells.	J Tissue Eng Regen Med.	2016	2016 Apr 21. doi: 10.1002/term
Wang W, Qu M, Xu L, Wu X, Gao Z, Gu T, Zhang W, Ding X, Liu W （共同第一作者）, Chen YL	Sorafenib exerts an anti-keloid activity by antagonizing TGF-β/Smad and MAPK/ERK signaling pathways.	J Mol Med (Berl).	2016	94(10):1181-1194.
Wang W, Li J, Wang K, Zhang Z, Zhang W, Zhou G, Cao Y, Ye M, Zou H, Liu W （通讯作者）	Induction of predominant tenogenic phenotype in human dermal fibroblasts via synergistic effect of TGF-β and elongated cell shape.	Am J Physiol Cell Physiol.	2016	310(5):C357-72.
Wang W, He J, Feng B, Zhang Z, Zhang W, Zhou G, Cao Y, Fu W, Liu W. （通讯作者）	Aligned nanofibers direct human dermal fibroblasts to tenogenic phenotype in vitro and enhance tendon regeneration in vivo.	Nanomedicine (Lond).	2016	11(9):1055-72.
Lin X, Shi Y, Cao Y, Liu W. （通讯作者）	Recent progress in stem cell differentiation directed by material and mechanical cues.	Biomed Mater.	2016	;11(1):014109.
Huang J, Lin X, Shi Y, Liu W. （通讯作者）	Tissue engineering and regenerative medicine in basic research: a year in review of 2014.	Tissue Eng Part B Rev	2015	21(2):167-76
Lin X, Huang J, Shi Y, Liu W. （通讯作者）	Tissue engineering and regenerative medicine in applied research: a year in review of 2014.	Tissue Eng Part B	2015	;21(2):177-86
Wang W, He A, Zhang Z, Zhang W, Zhou G, Cao Y, Liu W. （通讯作者）	Induction of transient tenogenic phenotype of high-density cultured human dermal fibroblasts.	Connect Tissue Res	2015	56(4):288-99
Xiong Y, He J, Zhang W, Zhou G, Cao Y, Liu W. （通讯作者）	Retention of the stemness of mouse adipose-derived stem cells by their expansion on human bone marrow stromal cell-derived extracellular matrix.	Tissue Eng Part A.	2015	21(11-12):1886-94
Wang X, Gao Z, Wu X, Zhang W, Zhou G, Liu W. （通讯作者）	Inhibitory effect of TGF-β peptide antagonist on the fibrotic phenotype of human hypertrophic scar fibroblasts.	Pharm Biol	2015	2:1-9
Liu W （通讯作者）, Burdick JA, van Osch GJ.	egulation Policy on Tissue Engineering and Regenerative Medicine in Asian-Pacific Region.	Tissue Eng Part A.	2015	21(23-24):2779-80.
Deng D, Wang W, Wang B, Zhang P, Zhou G, Zhang WJ, Cao Y, Liu W. （通讯作者）	Repair of Achilles tendon defect with autologous ASCs engineered tendon in a rabbit model.	Biomaterials	2014	35(31):8801-9
Xiong Y, He J, Zhang W, Zhou G, Cao Y, Liu W. （通讯作者）	Potent Osteogenesis and Chondrogenesis of CD34-Enriched Mouse Adipose-Derived Stem Cells.	J Med Bio Eng	2014	34:230-237
Deng D, Liu W （通讯作者）, Cheema U, Mudera V, Hadjipanayi E, Brown RA.	Less is more: new biomimetic approach to control spatial and temporal cell loading for tissue engineering.	J Biomed Mater Res A.	2014	102(11):4108-17
Liu K, Gao Z, Wu X, Zhou G, Zhang WJ, Yang X, Liu W. （通讯作者）	Knocking out Smad3 favors allogeneic mouse fetal skin development in adult wounds.	Wound Repair Regen.	2014	;22(2):265-71
Qu M, Song N, Chai G, Wu X, Liu W （通讯作者）	Pathological niche environment transforms dermal stem cells to keloid stem cells: A hypothesis of keloid formation and development.	Med Hypotheses.	2013	81(5):807-12
Chen B, Wang B, Zhang WJ, Zhou G, Cao Y, Liu W. （通讯作者）	Macromolecular Crowding Effect on Cartilaginous Matrix Production: A Comparison of Two-Dimensional and Three-Dimensional Models	Tissue Eng Part C	2013	19(8):586-95
Liu W （通讯作者）, Burdick JA, van Osch GJ.	Plant-derived recombinant human collagen: a strategic approach for generating safe human ECM-based scaffold.	Tissue Eng Part A	2013	19(13-14):1489-90
He J, Duan H, Xiong Y, Zhang W, Zhou G, Cao Y, Liu W （通讯作者）	Potent osteogenesis and chondrogenesis of CD34-enriched mouse adipose-derived stem cells	Mol Med Rep	2013	7(4):1111-6
Wang W, Deng D, Li J, Liu W. （通讯作者）	Elongated cell morphology and uniaxial mechanical stretch contribute to physical attributes of niche environment for MSC tenogenic differentiation.	Cell Biol Int	2013	37(7):755-60
Chen B, Wang B, Zhang WJ, Zhou G, Cao Y, Liu W. （通讯作者）	In vivo tendon engineering with skeletal muscle derived cells in a mouse model	Biomaterials	2012	33(26):6086-97
Xia L, Liu Q, Zhang W, Zhou G, Cao Y, Liu W. （通讯作者）	Enhanced proliferation and functions of in vitro expanded human hair follicle outer root sheath cells by low oxygen tension culture	Tissue Eng Part C Methods	2012	18(8):603-13
Zhang Y, Li J, Zhu J, Zhou G, Zhang WJ, Cao Y, Liu W. （通讯作者）	Enhanced cartilage formation by inhibiting cathepsin K expression in chondrocytes expanded in vitro.	Biomaterials	2012	33(30):7394-404
Yuan J, Cao Y, Liu W （通讯作者）	Biomimetic scaffolds: implications for craniofacial regeneration	J Craniofac Surg	2012	23(1):294-7
Song N, Wu X, Gao Z, Zhou G, Zhang WJ, Liu W. （通讯作者）	Enhanced expression of membrane transporter and drug resistance in keloid fibroblasts	Hum Pathol	2012	43(11):2024-32
Jiang Y, Liu H, Li H, Wang F, Cheng K, Zhou G, Zhang W, Ye M, Cao Y, Liu W （通讯作者）, Zou H.	A proteomic analysis of engineered tendon formation under dynamic mechanical loading in vitro.	Biomaterials.	2011	32(17):4085-95.
Xia L, Liu Q, Zhou G, Zhang W, Cao Y, Liu W （通讯作者）	A proteomic analysis of engineered Mouse out root sheath cells cultured on E-cadherin-coated dishes exhibit neuronal cell morphology	Asia-Pacific J Chem Eng ING	2011	6: 816–822
Liu W （通讯作者）, Wu X, Gao Z.	New potential antiscarring approaches.	Wound Repair Regen.	2011	19 Suppl 1:s22-31
Zhu J, Li J, Wang B, Zhang WJ, Zhou G, Cao Y, Liu W. （通讯作者）	Enhanced proliferation capacity of The regulation of phenotype of cultured tenocytes by microgrooved surface structure.	Biomaterials.	2010	31(27):6952-6958
Hu K, Shi H, Zhu J, Deng D, Zhou G, Zhang W, Cao Y, Liu W. （通讯作者）	Compressed collagen gel as the scaffold for skin engineering.	Biomed Microdevices.	2010	12(4):627-35.
Gao Z, Wu X, Song N, Zhang L, Liu W. （通讯作者）	Engineering human neo-tendon tissue in Differential expression of growth differentiation factor-9 in keloids	Burns	2010	36(8):1289-95
Liu W. （通讯作者）	Engineered in vitro models of tumor angiogenesis: introduction to a new special issue format of Tissue Engineering.	Tissue Eng Part A.	2010	16(7):2129-31.
Xu L, Cao D, Liu W （通讯作者）, Zhou G, Zhang WJ, Cao Y.	Engineered in vitro models of tumor angiogenesis: introduction to a new In vivo engineering of a functional tendon sheath in a hen model.	Tissue Eng Part A.	2010	31(14):3894-902.
Zhang Y, Wang B, Zhang WJ, Zhou G, Cao Y, Liu W. （通讯作者）	Enhanced proliferation capacity of porcine tenocytes in low O(2) tension culture.	Biotechnol Lett.	2010	32(2):181-7.
Deng D, Liu W （通讯作者）, Xu F, Yang Y, Zhou G, Zhang WJ, Cui L, Cao Y.	Engineering human neo-tendon tissue in vitro with human dermal fibroblasts under static mechanical strain.	Biomaterials	2009	30(35):6724-30.