- 基本信息
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导师姓名：
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张翼飞
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学科代码：
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100201
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性别：
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女
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学科名称：
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内科学
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培养单位：
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附属瑞金医院
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三级学科
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内分泌与代谢病
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导师类型：
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博士生导师
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专业领域名称：
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内科学 专业学位
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联系方式：
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瑞金医院，上海市黄浦区瑞金二路197号，10号楼18楼，内分泌二病区医生办公室
Tel:021-64370045-671803
Email：feifei-a@163.com
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专业领域代码：
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105101
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邮编：
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200025
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邮箱地址：
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feifei-a@163.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
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上海市医学会内分泌分会第十届委员会肝病与代谢学组副组长
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中华医学会糖尿病学分会，第九届委员会，肥胖与糖尿病学组副组长
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上海市医学会糖尿病专科分会，第九届委员会，副主任委员
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中国医师协会循证医学专业委员会，第二届青年委员会，委员
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中国医师协会内分泌代谢科医师分会，第五届委员会，青年委员会副主任委员
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中华医学会内分泌学分会，中西医结合专业学组，委员
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上海市第二届医药卫生青年联合会，常委
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《中华内分泌代谢杂志》第七届编委成员
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- 科研项目
| SJ5603RJ01 | 东方英才领军项目 | 中共上海市委组织部省部级课题 |
2024-01~2026-12
|
120万元
| 课题负责人 |
| 82270896 | 薯蓣皂苷元通过肠道菌群治疗肥胖的作用和机制研究 | 国家自然科学基金面上项目 |
2023-01~2026-12
|
52万元
| 课题负责人 |
| DMRFP_II_01 | 糖尿病视网膜病变筛查与预防—国家标准化代谢性疾病管理中心(MMC)多中心前瞻性研究 | 上海市医药卫生发展基金会糖尿病临床研究项目二期 |
2021-01~2023-12
|
50万元
| 课题负责人 |
| 2019LJ07 | 上海市医学领军人才培养计划 | 上海市卫生健康委员会 |
2019-07~2022-06
|
45万元
| 课题负责人 |
| 81670797 | LGR4调节低密度脂蛋白胆固醇代谢的作用和机制研究 | 国家自然基金委,面上项目 |
2017-01~2020-12
|
58万元
| 课题负责人 |
| 沪交医人【2015】15号 | 小檗碱联合益生菌对初发2型糖尿病患者疗效及肠道共生菌稳态影响的多中心临床研究 | 上海交通大学医学院高峰高原计划—“研究型医师”项目
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2016-07~2019-06
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100万元
| 课题负责人 |
| 2016YFC0901200 | 代谢性疾病专病队列研究 | 国家重点研发计划项目“精准医学研究”重点专项(国家卫计委医药卫生科技发展研究中心)
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2016-06~2020-12
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1833万元
| 课题负责人 |
| 201554 | 肠促胰素及肠道菌群变化参与2型糖尿病发生发展的相关机制研究 | 上海市人才发展基金资助项目 |
2016-01~2018-12
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10万元
| 课题负责人 |
| 14SG17 | 2型糖尿病肠道调控相关机制及生物标志物的研究 | 上海市教委曙光计划项目 |
2015-01~2017-12
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15万元
| 课题负责人 |
| 81471074 | 小檗碱预防肝脏脂肪沉积向脂肪性肝炎和纤维化发展的作用和机制研究 | 国家自然基金面上项目 |
2015-01~2018-12
|
73万元
| 课题负责人 |
| 14411964700 | 2型糖尿病肠道调控相关机制及临床干预研究 | 上海市科学技术委员会 |
2014-08~2017-09
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20万元
| 主要责任人 |
| 2014ZX09101005-008 | 小檗碱治疗糖脂代谢综合征开发研究及药物新适应症研究平台建设 | 国家科技部新药创制科技重大专项 |
2014-01~2016-12
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800万元
| 子课题负责人 |
| 2012-244 | 肠促胰素相关治疗对2型糖尿病患者β细胞功能的影响及其在“肠-胰轴”中的作用及机制探讨 | 上海市卫生局局级课题 |
2013-01~2015-12
|
3万元
| 课题负责人 |
| 81170784 | 小檗碱对机体能量平衡的影响和作用机制研究 | 国家自然科学基金面上项目 |
2012-01~2015-12
|
65万元
| 课题负责人 |
| YG2010MS17 | 小檗碱对肠道菌群的作用及其治疗2型糖尿病的机制探讨 | 上海交通大学“医工交叉研究基金”项目 |
2010-07~2012-06
|
5万元
| 课题负责人 |
| 无 | 基于系统生物学的中药小檗碱治疗代谢综合征机制研究 | 上海交通大学医学院优秀青年教师项目 |
2009-06~2011-06
|
3万元
| 课题负责人 |
| 30700383 | 人参皂苷Re改善胰岛素抵抗机制及作用靶点研究 | 国家自然基金委,面上项目 |
2008-01~2010-12
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17万元
| 课题负责人 |
- 学术论文
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Fang Q, Shi J, Zhang J, Peng Y, Liu C, Wei X, Hu Z, Sun L, Hong J, Gu W, Wang W,
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Visit-to-visit HbA1c variability is associated with aortic stiffness progression in participants with type 2 diabetes.
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Cardiovasc Diabetol
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2023
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6;22(1):167
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Xiang M, Qian X, Han L, Wang H, Wang J, Liu W, Gu Y, Yao S, Yang J,, Peng Y, Zhang Z.
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Aquaporin-8 ameliorates hepatic steatosis through farnesoid X receptor in obese mice.
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iScience
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2023
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26(4):106561.
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Wang S, Ren H, Zhong H, Zhao X, Li C, Ma J, Gu X, Xue Y, Huang S, Yang J, Chen L, Chen G, Qu S, Liang J, Qin L, Huang Q, Peng Y, Li Q, Wang X, Zou Y, Shi Z, Li X, Li T, Yang H, Lai S, Xu G, Li J,, Gu Y, Wang W.
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Combined berberine and probiotic treatment as an effective regimen for improving postprandial hyperlipidemia in type 2 diabetes patients: a double blinded placebo controlled randomized study.
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Gut Microbes
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2022
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14(1):2003176
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, Wang Y, Ning G, He P, Wang W.
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Protecting older people: a high priority during the COVID-19 pandemic.
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Lancet
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2022
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400(10354):729-730
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Shujie Wang, Juan Shi, Ying Peng, Qianhua Fang, Qian Mu, Weiqiong Gu, Jie Hong,, Weiqing Wang
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Stronger association of triglyceride glucose index than the HOMA-IR with arterial stiffness in patients with type 2 diabetes: a real-world single-centre study
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Cardiovasc Diabetol
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2021
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20(1):82
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Qian Mu, Hui Wang, Lei Tong, Qianhua Fang, Minqi Xiang, Luyu Han, Lina Jin, Jian Yang, Zhen Qian, Guang Ning,, Zhiguo Zhang
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Betulinic acid improves nonalcoholic fatty liver disease through YY1/FAS signaling pathway
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FASEB J
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2020
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34(9):13033-13048.
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Xuelin Li, Tianyue Zhang, Shengxian Li, Yuying Deng, Lihua Wang, Tao Tao, Shujie Wang, Yanyun Gu, Weiqiong Gu, Jie Hong, Wei Liu, Weiqing Wang,
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Correlation between glucose metabolism and serum steroid hormones in patients with polycystic ovary syndrome
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Clin Endocrinol (Oxf)
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2020
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92(4):350-357
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, Juan Shi, Ying Peng, Zhiyun Zhao, Qidong Zheng, Zilong Wang, Kun Liu, Shengyin Jiao, Kexin Qiu, Ziheng Zhou, Li Yan, Dong Zhao, Hongwei Jiang, Yuancheng Dai, Benli Su, Pei Gu, Heng Su, Qin Wan, Yongde Peng, Jianjun Liu, Ling Hu, Tingyu Ke, Lei Chen, Fengmei Xu, Qijuan Dong, Demetri Terzopoulos, Guang Ning, Xun Xu, Xiaowei Ding, Weiqing Wang
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Artificial intelligence-enabled screening for diabetic retinopathy: a real-world, multicenter and prospective study
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BMJ Open Diabetes Res Care
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2020
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8(1):e001596.
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Shuangshuang Yao, Yini Yuan, Huizhi Zhang, Xiangjian Meng, Lina Jin, Jian Yang, Weiqing Wang, Guang Ning,, Zhiguo Zhang
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Berberine attenuates the abnormal ectopic lipid deposition in skeletal muscle
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Free Radic Biol Med
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2020
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159:66-75
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Tianyue Zhang, Juan Shi, Ying Peng, Shujie Wang, Qian Mu, Qianhua Fang, Weiqiong Gu, Jie Hong,, Weiqing Wang
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Sex-influenced association between free triiodothyronine levels and poor glycemic control in euthyroid patients with type 2 diabetes mellitus
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J Diabetes Complications
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2020
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34(11):107701
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, Yanyun Gu, Huahui Ren, Shujie Wang, Huanzi Zhong, Xinjie Zhao, Jing Ma, Xuejiang Gu, Yaoming Xue, Shan Huang, Jialin Yang, Li Chen, Gang Chen, Shen Qu, Jun Liang, Li Qin, Qin Huang, Yongde Peng, Qi Li, Xiaolin Wang, Ping Kong, Guixue Hou, Mengyu Gao, Zhun Shi, Xuelin Li, Yixuan Qiu, Yuanqiang Zou, Huanming Yang, Jian Wang, Guowang Xu, Shenghan Lai, Junhua Li, Guang Ning, Weiqing Wang
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Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study)
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Nat Commun
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2020
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11(1):5015
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Ye L, Gu W, Chen Y, Li X, Shi J, Lv A, Hu J, Zhang R, Liu R, Hong J, Wang J,
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The Impact of Shift Work on Glycemic Characteristics Assessed by CGM and its Association with Metabolic Indices in Non-Diabetic Subjects.
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Acta Diabetol.
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2019
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57:53-61
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, Wang W, Ning G.
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Metabolic Management Center: An innovation project for the management of metabolic diseases and complications in China
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J Diabetes
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2019
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11:11–13
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Dandan Zhao,Shaoqian Zhao,Xiao Wang,Mingbo Su,Wen Liu,Qinyun Ma,Jie Hong,Weiqiong Gu,Jingya Li,Ruixin Liu,Guang Ning,Jiqiu Wang,
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Clinical and Physiological Characterization of Elevated Plasma Glucagon-Like Peptide-1 Levels (Hyperglipemia) in a Dipeptidyl Peptidase IV Mutation Carrier.
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Front Endocrinol (Lausanne)
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2018
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9:62. doi: 10.3389/fendo.2018.00062
|
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Wang S, Deng Y, Xie X, Ma J, Xu M, Zhao X, Gu W, Hong J, Wang W, Xu G, Ning G, Gu Y,
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Plasma bile acid changes in type 2 diabetes correlated with insulin secretion in two-step hyperglycemic clamp.
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J Diabetes
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2018
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doi: 10.1111/1753-0407.12771.
|
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, Zhao Z, Wang S, Zhu W, Jiang Y, Sun S, Chen C, Wang K, Mu L, Cao J, Zhou Y, Gu W, Hong J, Wang W, Ning G.
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Intensive insulin therapy combined with metformin is associated with reduction in both glucose variability and nocturnal hypoglycaemia in patients with type 2 diabetes.
|
Diabetes Metab Res Rev.
|
2017
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2017 Jun 13. doi: 10.1002/dmrr.2913
|
|
(1) Yanyun Gu, Xiaokai Wang, Junhua Li,, Huanzi Zhong, Ruixin Liu, Dongya Zhang, Qiang Feng, Xiaoyan Xie, Jie Hong, Huahui Ren, Wei Liu, Jing Ma, Qing Su, Hongmei Zhang, Jialin Yang, Xiaoling Wang, Xinjie Zhao, Weiqiong Gu, Yufang Bi, Yongde Peng, Xiaoqiang Xu, Huihua Xia, Fang Li, Xun Xu, Huanming Yang, Guowang Xu, Lise Madsen, Karsten Kristiansen, Guang Ning & Weiqing Wang.
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Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment.
|
Nat Commun.
|
2017
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8:1785. DOI: 10.1038/s41467-017-01682-2
|
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Zhiguo Zhang, Bo Li, Xiangjian Meng, Shuangshuang Yao, Lina Jin, Jian Yang, Jiqiu Wang, Huizhi Zhang, Zhijian Zhang, Dongsheng Cai,, Guang Ning.
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Berberine prevents progression from hepatic steatosis to steatohepatitis and fibrosis by reducing endoplasmic reticulum stress.
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Sci Rep.
|
2016
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6:20848
|
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Huang Y, Xu M, Xie L, Wang T, Huang X, Lv X, Chen Y, Ding L, Lin L, Wang W, Bi Y, Sun Y,, Ning G
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Obesity and peripheral arterial disease: A Mendelian Randomization analysis.
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Atherosclerosis.
|
2016
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247:218-224
|
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, Weiqing Wang,Guang Ning
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Study on the efficacy and safety of Jinlida in patients with inadequately controlled type-2 diabetes and dyslipidemia under life style intervention (ENJOY LIFE Study)
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J Diabetes
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2015
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7:268-269
|
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, Chi J, Wang W, Hong J, Gu W, Wang B, Ning G.
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Different effects of two dipeptidyl peptidase-4 inhibitors and glimepiride on β-cell function in a newly designed two-step hyperglycemic clamp.
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J Diabetes
|
2015
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7(2):213-21
|
|
, Hu C, Hong J, Zeng J, Lai S, Lv A, Su Q, Dong Y, Zhou Z, Tang W, Zhao J, Cui L, Zou D, Wang D, Li H, Liu C, Wu G, Shen J, Zhu D, Wang W, Shen W, Ning G, Xu G.
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Lipid profiling reveals different therapeutic effects of metformin and glipizide in patients with type 2 diabetes and coronary artery disease.
|
Diabetes Care
|
2014
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2014;37:2804-12
|
|
,Guang Ning
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Diabetes: Young-onset type 2 diabetes mellitus-a challenge for Asia.
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Nat Rev Endocrinol.
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2014
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10:703–704
|
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, Hong J, Chi J, Gu W, Ning G, Wang W.
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Head-to-head comparison of dipeptidyl peptidase-IV inhibitors and sulfonylureas - a meta-analysis from randomized clinical trials.
|
Diabetes Metab Res Rev.
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2014
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30:241-56.
|
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Yuying Deng,, ShengZheng, Jie Hong, Chunling Wang, Ting Liu, Zhehao Sun, Weiqiong Gu, Yanyun Gu, Juan Shi, Shuangshuang Yao, Weiqing Wang, Guang Ning
|
Postprandial glucose, insulin and incretin responses to different carbohydrate tolerance tests.
|
J diabetes
|
2014
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1:1-2
|
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Hong J,, Lai S, Lv A, Su Q, Dong Y, Zhou Z, Tang W, Zhao J, Cui L, Zou D, Wang D, Li H, Liu C, Wu G, Shen J, Zhu D, Wang W, Shen W, Ning G*; on behalf of the SPREAD-DIMCAD Investigators
|
Effects of metformin versus glipizide on cardiovascular outcomes in patients with type 2 diabetes and coronary artery disease.
|
Diabetes Care.
|
2013
|
36:1304-1311
|
|
邓玉颖,,宁光,王卫庆
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二肽基肽酶4及其抑制剂的心血管效应
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诊断学理论与实践
|
2013
|
（2013）06:0635-05
|
|
,洪洁,宁光
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二甲双胍对比格列吡嗪对2型糖尿病合并冠心病
|
中华内分泌杂志
|
2013
|
52（10）:861-861
|
|
Juan Shi,, Gu W, Cui B, Xu M, Yan Q, Wang W, Ning G, Hong J
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Serum liver fatty acid binding protein levels correlate positively with obesity and insulin resistance in Chinese young adults.
|
Plos One
|
2012
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7:e48777
|
|
,顾卫琼,晏群,石娟,翟莹,张豫文,王莉,王卫庆,宁光,洪洁。
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由血清甘油三酯和血糖所得简易指数用于评估胰岛素抵抗的临床研究。
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中华内分泌代谢杂志
|
2012
|
28(5):392-39
|
|
Yan Q,, Hong J, Gu W, Dai M, Shi J, Zhai Y, Wang W, Li X, Ning G.
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The association of serum chemerin level with risk of coronary artery disease in Chinese adults.
|
Endocrine
|
2012
|
41:281-288
|
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, Xi Lu, Jie Hong, Menglei Chao, Weiqiong Gu, Weiqing Wang, Guang Ning
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Positive correlations of liver enzymes with metabolic syndrome including insulin resistance in newly diagnosed type 2 diabetes mellitus.
|
Endocrine
|
2010
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38:181-187
|
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, Lu Qi, Weiqiong Gu, Qun Yan, Meng Dai, Juan Shi, Ying Zhai, Ying Chen, Jianmin Liu, Weiqing Wang, Guang Ning, Jie Hong
|
Relation of Serum Osteocalcin Level to Risk of Coronary Heart Disease in Chinese Adults.
|
Am J Cardiol.
|
2010
|
106:1461-1465
|
|
, Ning Guang, Y Handelsman, and ZT Bloomgarden.
|
Gut hormones and the brain.
|
J Diabetes
|
2010
|
2:138-145
|
|
Yan Gu,,Xianzhe Shi, Xiaoying Li, Jie Hong, Jing Chen, Weiqiong Gu, Xin Lu, Guowang Xu, Guang Ning
|
Effect of traditional Chinese medicine berberine on type 2 diabetes based on comprehensive metabonomics.
|
Talanta.
|
2010
|
81:766-772
|
|
, Jie Hong, Weiqiong, Minghui Gui, Ying Chen, Yu Zhang, Zhenni Chi, Weiqing Wang, Xiaoying Li, Guang Ning
|
Impact of the metabolic syncrome and its individual components on risk and severity of coronary heart disease.
|
Endocrine
|
2009
|
36:233-238.
|
|
, Xiao-ying Li, Dajin Zou, Wei Liu, Jialin Yang, Na Zhu, Li Huo, Miao Wang, Jie Hong, Peihong Wu, Guoguang Ren, Guang Ning
|
Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine.
|
J Clin Endocrinol Metab
|
2008
|
93(7):2559-2565
|
|
, Guang Ning
|
Mecobalamin.
|
Expert Opin Investig Drugs
|
2008
|
17(6):953-964
|
|
,杨义生,洪洁,顾卫琼,沈春芳,徐敏,杜鹏飞,李小英,宁光等。
|
多囊卵巢综合征患者血清白介素18与胰岛素抵抗相关。
|
中华内分泌代谢杂志
|
2008
|
24(3):278-281
|
|
Weiqing Wang,, Dajin Zhou, Zhimin Liu, Xu Hong, Mingcai Qiu, Yangquan Shi, Peijin Xia, Jin Lu, Manjing Xu, Liang An, Wei Feng, Peng Zhang, J.
|
Open-label, randomized, multiple-center, parallel study comparing glycemic responses and safety profiles of Glucerna versus Fresubin in subjects of type 2 diabetes mellitus.
|
Endocrine.
|
2008
|
33(1):45-52.
|
|
Jie Hong,, Weiqiong Gu, Yuwen Zhang, Yuxia Su, Zhenni Chi, Weiqing Wang, Xiaoying Li, Guang Ning
|
Insulin sensitivity and first-phase insulin secretion in obese Chinese with hyperglycemia in 30 and/or 60 min during glucose tolerance tests.
|
Endocrine.
|
2008
|
34:75-80
|
|
, Du Peng-fei, Xu Ming, Zhang Yi, Zhang Lianzhen, Wang Weiqing, Zhao Yongju, Ning Guang.
|
Bioequivalence between rhGH for reconstitution and ready-to-use rhGH in two liquid formulations.
|
English Journal of SSMU
|
2006
|
18(1):10-14
|
|
, Yi-sheng Yang, Jie Hong, Weiqiong Gu, Chunfang Shen, Min Xu, Pengfei Du, Xiaoying Li, Guang Ning
|
Elevated Serum level of interleukin-18 is associated with insulin resistance in women with polycystic ovary syndrome.
|
Endocrine.
|
2006
|
29(3):419-423
|
|
, Hong Jie, Zhuan Weiwei, Li Xiaoying, Gu Weiqiong, Yang Yisheng, Xu Min, Ning Guang.
|
Hyperglycaemia after glucose loading is a major predictor of preclinical atherosclerosis in nondiabetic subjects.
|
Clinical Endocrinology.
|
2006
|
64 (2): 153-157
|
|
,宁 光。
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脂肪细胞因子与多囊卵巢综合征。
|
国外医学妇产科学分册
|
2005
|
32(3):167-170
|
|
,詹唯伟,洪洁,顾卫琼,杨义生,桂明辉,唐金凤,王卫庆,刘建民,赵咏桔,宁光。
|
糖调节受损人群颈动脉内中膜厚度与各代谢指标的关系。
|
中华糖尿病杂志
|
2005
|
13(1):23-26
|
|
,杜鹏飞,徐敏,张毅,张连珍,王卫庆,赵咏桔,宁光。
|
重组人生长激素2种制剂人体生物等效性研究。
|
中国新药与临床杂志
|
2005
|
24(5):373-375
|
|
, Hong Jie, Zhao Yongju, Jiang Ling, Dai Meng, Jin Xiaolong, Chen Jialun, Ning Guang
|
Multiple endocrine neoplasia type 2B caused by a single point mutation in RET proto-oncogene in a Chinese patient.
|
CMJ
|
2004
|
117:1262-1264
|
|
,洪洁,顾卫琼,孙首悦,唐金凤,江凌,戴蒙,赵咏桔,宁光。
|
血清FFA水平在不同体重指数及糖耐量个体中与胰岛素敏感性及血脂水平的关系研究。
|
中华内科杂志
|
2003
|
42:793-796
|
|
,洪洁,赵咏桔,宋怀东,杨秀英,宁光,许曼音,陈家伦。
|
RET原癌基因点突变所致多发性内分泌腺瘤病2B型一例家系研究。
|
中华内科杂志
|
2003
|
42:20-23
|
|
,洪洁,赵咏桔,宋怀东,杨秀英,宁光,许曼音,陈家伦。
|
RET原癌基因点突变所致多发性内分泌腺瘤病2B型一例家系研究。
|
中华内科杂志
|
2003
|
42:20-23
|
|
,戴蒙,江凌,洪洁,顾卫琼,徐飒英,宁光
|
上海地区中国人黑素细胞皮质激素受体－4基因突变与肥胖相关性研究。
|
中华内分泌代谢杂志
|
2003
|
18:197-198
|
|
,宁光。
|
MC4R及其基因突变与肥胖的相关性研究进展。
|
国外医学 遗传学分册
|
2003
|
26(1):39-42
|
|