- 基本信息
|
导师姓名：
|
张笑人
|
学科代码：
|
071000
|
|
|
性别：
|
男
|
学科名称：
|
生物学
|
|
培养单位：
|
健康科学研究所
|
三级学科
|
|
|
导师类型：
|
博士生导师
|
专业领域名称：
|
|
|
联系方式：
|
岳阳路320号生命科学实验大楼A座1126室
|
专业领域代码：
|
|
|
邮编：
|
200031
|
邮箱地址：
|
xrzhang@sibs.ac.cn
|
- 研究方向 (点击浏览详细信息)
- 社会任职
- 科研项目
| 31570902 | 组蛋白H3K27去甲基化酶Jmjd3在胸腺髓质上皮细胞发育分化和建立T细胞中枢免疫耐受中的关键作用 | 国家自然基金委面上项目 |
2016-01~2019-12
|
72万元
| 课题负责人 |
| 12222 | 非经典NF-κB信号通路抑制剂的结构优化和 体内抗肿瘤活性研究 | 系统生物医学协同创新中心 |
2015-05~2017-05
|
30万元
| 课题负责人 |
| 31370881 | IkB家族成员Bcl-3调控B细胞命运决定的机制研究 | 国家自然基金委面上项目 |
2014-01~2017-12
|
80万元
| 主要责任人 |
| GJHZ1409 | 临床应用材料的生物反应性研究 | 中国科学院 |
2014-01~2015-12
|
100万元
| 课题负责人 |
| 2014CB541904 | 红斑狼疮免疫发病机理的解析和诊治新策略硏究 | 973项目 |
2014-01~2018-12
|
142.5万元
| 课题参与人 |
| 31270937 | Bcl-3调控边缘区B细胞发育和功能的表观遗传机制 | 国家自然基金委面上项目 |
2013-01~2013-12
|
15万元
| 课题负责人 |
| 2011CB946102 | 胸腺上皮细胞发育及其表观遗传调控 | 973项目 |
2011-01~2014-12
|
625万元
| 课题负责人 |
| 30972695 | 髓质区胸腺上皮细胞发育分化的表观遗传机制 | 国家自然基金委面上项目 |
~
|
38万元
| 主要责任人 |
| 90919017 | 髓质区胸腺上皮细胞发育分化的表观遗传机制 | 国家自然基金委重大研究计划 |
~
|
60万元
| 主要责任人 |
- 学术论文
|
Ma L, Huang C, Wang XJ, Xin DE, Wang LS, Zou QC, Zhang YS, Tan MD, Wang YM, Zhao TC, Chatterjee D, Altura RA, Wang C, Xu YS, Yang JH, Fan YS, Han BH, Si J,, Cheng J, Chang Z, Chin YE.
|
Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation.
|
Mol Cell.
|
2017
|
65(2):296-309.
|
|
Zhan Y, Wei Y, Chen P, Zhang H, Liu D, Zhang J, Liu R, Chen R, Zhang J, Mo W,
|
Expression, purification and biological characterization of the extracellular domain of CD40 from Pichia pastoris
|
BMC Biotechnol.
|
2016
|
16(1):8-15
|
|
Chen X, Cao X, Sun X, Lei R, Chen P, Zhao Y, Jiang Y, Yin J, Chen R, Ye D, Wang Q, Liu Z, Liu S, Cheng C, Mao J, Hou Y, Wang M, Siebenlist U, Eugene Chin Y, Wang Y, Cao L, Hu G,
|
Bcl-3 regulates TGFβ signaling by stabilizing Smad3 during breast cancer pulmonary metastasis.
|
Cell Death Dis.
|
2016
|
7(12):e2508-16
|
|
Ge QL, Liu SH, Ai ZH, Tao MF, Ma L, Wen SY, Dai M, Liu F, Liu HS, Jiang RZ, Xue ZW, Jiang YH, Sun XH, Hu YM, Zhao YX, Chen X, Tao Y, Zhu XL, Ding WJ, Yang BQ, Liu DD, Zhang XR, Teng YC.
|
RelB/NF-κB links cell cycle transition and apoptosis to endometrioid adenocarcinoma tumorigenesis
|
Cell Death Dis.
|
2016
|
7(10):e2402-10
|
|
Sun X, Liu S, Chen P, Fu D, Hou Y, Hu J, Liu Z, Jiang Y, Cao X, Cheng C, Chen X, Tao Y, Li C, Hu Y, Liu Z, Zhan Y, Mao J, Wang Q, Ma Y, Cong X, Sun R, Shi Y, Wang M,
|
miR-449a inhibits colorectal cancer progression by targeting SATB2.
|
Oncotarget
|
2016
|
0（0）：00-00
|
|
Zhi Liu, Wei Cao, Longxia Xu, Xi Chen, Yu Zhan, Qian Yang, Sanhong Liu, Pengfei Chen, Yuhang Jiang, Xiaohua Sun, Yu Tao, Yiming Hu, Cuifeng Li, Qi Wang, Ying Wang, Charlie Degui Chen2, Yufang Shi,
|
The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation
|
Journal of Molecular Cell Biology
|
2015
|
7(6):505-16
|
|
Zhang R, Jin S, Rao W, Song F, Yin Q, Wang Y, Wang L, Xi Y,, Wang M, Ge H
|
OVA12, a novel tumor antigen, promotes cancer cell growth and inhibits 5-fluorouracil-induced apoptosis
|
Cancer Lett
|
2015
|
357(1):141-51
|
|
Sanhong Liu, Xiaohua Sun, Mingliang Wang, Yingyong Hou, Yu Zhan, Yuhang Jiang,
Zhanjie Liu, Xinwei Cao, Pengfei Chen, Zhi Liu, Xi Chen, Yu Tao, Chen Xu, Jie Mao,
Chunyan Cheng, Cuifeng Li, Yiming Hu, Lunshan Wang, Y. Eugene Chin, Yufang Shi,
Ulrich Siebenlist,
|
A microRNA 221– and 222–Mediated Feedback Loop Maintains Constitutive Activation of NFkB and STAT3 in Colorectal Cancer Cells
|
Gastroenterology
|
2014
|
147(4):847–859
|
|
Liu B, Liu YF, Du YR, Mardaryev AN, Yang W, Chen H, Xu ZM, Xu CQ,, Botchkarev VA, Zhang Y, Xu GL
|
Cbx4 regulates the proliferation of thymic epithelial cells and thymus function
|
Development
|
2013
|
140(4):780-8
|
|
Liu Z, Jiang Y, Hou Y, Hu Y, Cao X, Tao Y, Xu C, Liu S, Wang S, Wang L, Shi Y, Siebenlist U,
|
The IκB family member Bcl-3 stabilizes c-Myc in colorectal cancer.
|
J Mol Cell Biol
|
2013
|
5(4):280-2
|
|
Chen P, Zhang J, Zhan Y, Su J, Du Y, Xu G, Shi Y, Siebenlist U,
|
Established Thymic Epithelial Progenitor/Stem Cell-Like Cell Lines Differentiate into Mature Thymic Epithelial Cells and Support T Cell Development.
|
PLoS One
|
2013
|
8(9):e75222
|
|
, Paun A, Claudio E, Wang H, Siebenlist U
|
The tumor promoter and NF-κB modulator Bcl-3 regulates splenic B cell development
|
J Immunol
|
2013
|
191(12):5984-92
|
|
Wang S, Liu Z, Wang L,
|
NF-kappaB signaling pathway, inflammation and colorectal cancer
|
Cell Mol Immunol
|
2009
|
140(4):780-8
|
|
, Wang H, Claudio E, Brown K, Siebenlist U
|
A role for the IkappaB family member Bcl-3 in the control of central immunologic tolerance
|
Immunity
|
2007
|
27(3):438-52
|
|