• 基本信息
    导师姓名： 陆林 学科代码： 100201
    性别： 男 学科名称： 内科学
    培养单位： 附属瑞金医院 三级学科 心血管病
    导师类型： 博士生导师 专业领域名称： 内科学 专业学位
    联系方式： 上海市瑞金二路197号 瑞金医院心内科 专业领域代码： 105101
    邮编： 200025 邮箱地址： rjlulin1965@163.com
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    第八届中华医学会动脉粥样硬化组委员
    中华医师协会转化型医院委员会理事
    中国医师协会心血管分会代谢组组员
    中华医学英文版编委
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    81770430脂肪因子CTRP5促动脉粥样硬化发生和机制研究国家自然科学基金，面上项目 2018-01~2021-12 55万元  课题负责人
    91539117Chromogranin A的关键降解肽段抗动脉粥样硬化机制研究国家自然科学基金委员会,重大专项 2016-01~2018-12 80万元  课题负责人
    2015CB553600中国人代谢综合征的分子营养机制及干预研究科技部973 2015-01~2019-12 125万元  课题参与人
    81370398脂肪因子CTRP1 致动脉粥样硬化及机制研究国家自然基金，面上项目 2014-01~2017-12 70万元  课题负责人
    11140903300建立小鼠动脉不稳定型斑块荧光示踪模型和HMGB2促糖尿病不稳定型斑块形成研究上海市科委 2011-06~2014-06 20万元  课题负责人
    8107010914-3-3蛋白磷酸化修饰RhoGEF和RhoGAP对糖尿病支架术后再狭窄发生的作用研究国家自然基金，面上项目 2011-01~2013-12 35万元  课题负责人
    09JC141000014-3-3蛋白与糖尿病猪冠状动脉雷帕霉素支架术后再狭窄关系的研究上海市科委"创新行动计划"基础研究重点项目 2009-09~2011-08 30万元  课题负责人
    30871027Rho促RKIP磷酸化在糖尿病猪冠状动脉雷帕霉素支架术后再狭窄发生中的作用和机制研究国家自然基金委,面上项目 2009-01~2011-12 33万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Gong DH, Dai Y, Chen S, Wang XQ, Yan XX, Shen Y, Liu J, Yang ZK, Hu J, Yu LJ, Liu LL, Zhang RY, Shen WF, Chen QJ, Ding FH,  Secretory vimentin is associated with coronary artery disease in patients and induces atherogenesis in apoE-/- mice.  Int J Cardiol  2019  283:9-16 
    Li C, Chen JW, Liu ZH, Shen Y, Ding FH, Gu G, Liu J, Qiu JP, Gao J, Zhang RY, Shen WF, Wang XQ,  CTRP5 promotes transcytosis and oxydative modification of low-density lipoprotein and the development of atherosclerosis  Atherosclerosis  2018  278;197-209 
    Liu ZH, Li C, Chen JW, Shen Y, Gao J, Shen WF, Zhang RY, Wang XQ,  C1q/TNF-related protein 1 promotes endothelial barrier dysfunction under disturbed flow.  Biochem Biophys Res Commun  2017  490:580-586 
    Dai Y, Shen Y, Li QR, Ding FH, Wang XQ, Liu HJ, Yan XX, Wang LJ, Yang K, Wang HB, Chen QJ, Shen WF, Zhang RY,  Glycated Apolipoprotein A-IV Induces Atherogenesis in Patients With CAD in Type 2 Diabetes.  J Am Coll Cardiol  2017  70:2006-2019 
    Xiong W, Wang X, Dai D, Zhang B,, Tao R  The anti-inflammatory vasostatin-2 attenuates atherosclerosis in ApoE-/- mice and inhibits monocyte/macrophage recruitment  Thromb Haemost  2017  117:401-414 
    Yan X, Zhang H, Fan Q, Hu J, Tao R, Chen Q, Iwakura Y, Shen W,, Zhang Q, Zhang R.  Dectin-2 Deficiency Modulates Th1 Differentiation and Improves Wound Healing After Myocardial Infarction.  Circ Res  2017  120:1116-1129 
    Wang F, Li C, Ding FH, Shen Y, Gao J, Liu ZH, Chen JW, Zhang RY, Shen WF, Wang XQ,  Increased serum TREM-1 level is associated with in-stent restenosis, and activation of TREM-1 promotes inflammation, proliferation and migration in vascular smooth muscle cells.  Atherosclerosis  2017  267:10-18 
    Liu ZH, Dai DP, Ding FH, Pan WQ, Fang YH, Zhang Q, Li M, Yang P, Wang XQ, Shen Y, Wang LJ, Yan XX, He YH, Yang K, Zhang RY, Shen WF, Chen Y,  ASSOCIATION OF SERUM HMGB2 LEVEL WITH MACE AT 1 MONTH OF MYOCARDIAL INFARCTION: AGGRAVATION OF MYOCARDIAL ISCHEMIC INJURY IN RAT BY HMGB2 VIA ROS.  Am J Physiol Heart Circ Physiol  2017  312:H422-H436 
    He YH, Wang XQ, Zhang J, Liu ZH, Pan WQ, Shen Y, Zhu ZB, Wang LJ, Yan XX, Yang K, Zhang RY, Shen WF, Ding FH,  Association of Serum HMGB2 Levels With In-Stent Restenosis: HMGB2 Promotes Neointimal Hyperplasia in Mice With Femoral Artery Injury and Proliferation and Migration of VSMCs.  Arterioscler Thromb Vasc Biol  2017  37:717-729 
    Shen Y, Li C, Zhang RY, Zhang Q, Shen WF, Ding FH,  Association of increased serum CTRP5 levels with in-stent restenosis after coronary drug-eluting stent implantation: CTRP5 promoting inflammation, migration and proliferation in vascular smooth muscle cells.  Int J Cardiol  2016  228:129-136 
    Pan WQ, He YH, Su Q, Yang J, Fang YH, Ding FH, Yan XX, Liu ZH, Wang XQ, Yang K, Zhang RY, Shen WF, Zhang FR,  Association of decreased serum vasostatin-2 level with ischemic chronic heart failure and with MACE in 3-year follow-up: vasostatin-2 prevents heart failure in myocardial infarction rats  Int J Cardiol  2016  221:1-11 
    Chen K, Chen QJ, Wang LJ, Liu ZH, Zhang Q, Yang K, Wang HB, Yan XX, Zhu ZB, Du R, Zhang RY, Shen WF,  Increment of HFABP level in coronary artery in-stent restenosis segements in diabetic and nondiabetic minipigs: HFABP overexpression promotes multiple pathway-related inflammation, growth and migration in human vascular smooth muscle cells.  J Vasc Res  2016  53:27-38 
    , Zhang RY, Wang XQ, Liu ZH, Shen Y, Ding FH, Meng H, Wang LJ, Yan XX, Yang K, Wang HB, Pu LJ, Zhang Q, Chen QJ, De Caterina R, Shen WF.  C1q/TNF-related protein-1: an adipokine marking and promoting atherosclerosis  Eur Heart J  2015  2015Dec24 
    Shen Y, Ding FH, Sun JT, Pu LJ, Zhang RY, Zhang Q, Chen QJ, Shen WF,  Association of elevated apoA-I glycation and reduced HDL-associated paraoxonase 1,3 activity, and their interaction with angiographic severity of coronary artery disease in patients with type 2 diabetes mellitus.  Cardiovasc Diabetol  2015  14:52 
    Yang ZK, Shen Y, Shen WF, Pu LJ, Meng H, Zhang RY, Zhang Q, Chen QJ, De Caterina R,  Elevated glycated albumin and reduced endogenous secretory receptor for advanced glycation end products levels in serum predict major adverse cardiocerebral events in patients with type 2 diabetes and stable coronary artery disease.  Int J Cardiol  2015  197:241-247 
    , Wang YN, Sun WH, Liu ZH, Zhang Q, Pu LJ, Yang K, Zhu ZB, Meng H, Yang P, Du R, Chen QJ, Wang LS, Yu H, Shen WF.  Two-dimensional fluorescence in-gel electrophoresis of coronary restenosis tissues in minipigs: increased adipocyte fatty acid binding protein induces reactive oxygen species-mediated growth and migration in smooth muscle cells.   Arterioscler Thromb Vasc Biol  2013  33:572-580 
    Pu LJ,, Zhang RY, Du R, Shen Y, Zhang Q, Yang ZK, Chen QJ, Shen WF.  Glycation of apoprotein a-I is associated with coronary artery disease plaque progression in type 2 diabetic patients.  Diabetes Care  2013  36:1312-1320 
    , Wang YN, Li MC, Wang HB, Pu LJ, Niu WQ, Meng H, Yang EL, Zhang RY, Zhang Q, Zhao Q, Chen QJ, De Caterina R, Shen WF  Reduced serum levels of vasostatin-2, an anti-inflammatory peptide derived from chromogranin A, are associated with the presence and severity of coronary artery disease.  Eur Heart J  2012  33:2297-2306 
    Cai XY,, Wang YN, Jin C, Zhang RY, Zhang Q, Chen QJ, Shen WF  Association of increased S100B, S100A6 and S100P in serum levels with acute coronary syndrome and also with the severity of myocardial infarction in cardiac tissue of rat models with ischemia-reperfusion injury.   Atherosclerosis  2011  217:536-542 
    Wang LJ,, Zhang FR, Chen QJ, De Caterina R, Shen WF  Increased serum high-mobility group box-1 and cleaved receptor for advanced glycatin endproducts levels and decreased endogenous secretory receptor for advanced glycation endproducts levels in diabetic and non-diabetic patients with heart failure.   Eur J Heart Fail  2011  13:440-449 
    Zheng JL,, Hu J, Zhang RY, Zhang Q, Chen QJ, Shen WF  Increased serum YKL-40 and C-reactive protein levels are associated with angiographic lesion progression in patients with coronary artery disease.  Atherosclerosis  2010  210:590-595 
    Wang L,, Zhang F, Chen Q, Shen W  Polymorphisms of beta-adrenoceptor and natriuretic peptide receptor genes influence the susceptibility to and the severity of idiopathic dilated cardiomyopathy in a Chinese cohort.  J Card Fail  2010  16:36-44 
    , Zhang Q, Xu Y, Zhu ZB, Geng L, Wang LJ, Jin C, Chen QJ, Schmidt AM, Shen WF.   Intra-coronary administration of sRAGE attenuates cardiac remodeling with decreased myocardial TGF-beta1 expression and fibrosis in minipigs with ischemia-reperfusion injury  Chin Med J.  2010  123:594-598 
    Peng WH,, Hu J, Yan XX, Zhang Q, Zhang RY, Chen QJ, Shen WF.   Decreased serum esRAGE level is associated with angiographically determined coronary plaque progression in diabetic patients.  Clin Biochem  2009  42:1252-1259 
    Peng WH,, Zhang Q, Zhang RY, Wang LJ, Yan XX, Chen QJ, Shen WF.   Chromosome 9p21 polymorphism is associated with myocardial infarction but not with clinical outcome in Han Chinese.   Clin Chem Lab Med.  2009  47:917-922 
    , Pu LJ, Zhang Q, Wang LJ, Kang S, Zhang RY, Chen QJ, Wang JG, De Caterina, Shen WF.  Increased glycated albumin and decreased esRAGE levels are related to angiographic severity and extent of coronary artery disease in patients with type 2 diabetes.   Atherosclerosis  2009  206:540-545 
    Yan XX,, Peng WH, Wang LJ, Zhang Q, Zhang RY, Chen QJ, Shen WF.  Increased serum HMGB1 level is associated with coronary artery disease in nondiabetic and type 2 diabetic patients.  Atherosclerosis  2009  205:544-548 
    Chen QJ,, Peng WH, Hu J, Yan XX, Wang LJ, Zhang Q, Zhang RY, Shen WF.   Polymorphisms of MMP-3 and TIMP4 genes affect angiographic coronary plaque progression in non-diabetic and type 2 diabetic patients.   Clin Chim Acta  2009  405:97-103 
    Jin C,, Zhang RY, Zhang Q, Ding FH, Chen QJ, Shen WF.   Association of serum glycated albumin, C-reactive protein and ICAM-1 levels with diffuse coronary artery disease in patients with type 2 diabetes mellitus.  Clin Chem Acta  2009  408:45-49 
    Ruan W,,Zhang Q, Cao M, Zhu ZB, Wang LJ, Shen WF.   Serial assessment of left ventricular remodeling and function by echo-tissue Doppler imaging after myocardial infarction in streptozotocin-induced diabetic swine.   J Am Soc Echocardiogr  2009  22:530-536 
    , Zhang Q, Pu LJ, Peng WH, Yan XX, Wang LJ, Chen QJ, Zhu ZB, Michel JB, Shen WF.  Dysregulation of matrix metalloproteinases and their tissue inhibitors is related to abnormality of left ventricular geometry and function in streptozotocin-induced diabetic minipigs.  Int J Exp Pathol  2008  89:125-137 
    , Pu LJ, Chen QJ, Wang L, Peng WH, Yan X, Zhang Q, Zhang RY, Gong PH, Qiu JP, Shen WF.  Increased glycated albumin and decreased esRAGE concentrations are associated with in-stent restenosis in Chinese diabetic patients.  Clin Chim Acta  2008  396:33-37 
    Zhang Q,, Pu L, Zhang R, Shen J, Zhu Z, Hu J, Yang Z, Chen Q, Shen W.  Neointimal hyperplasia persists at six months after sirolimus-eluting stent implantation in diabetic porcine  Cardiovasc Diabetol  2007   
    , Zhang Q, Pu LJ, Xu XW, Zhang RY, Zhang JS, Hu J, Yang ZK, Lv AK, Ding FH, Chen QJ, Lou S, Fang DH, Shen WF.  Elevation of tumor necrosis factor-alpha, interleukin-1beta and interleukin-6 levels in aortic intima of Chinese Guizhou minipigs with streptozotocin-induced diabetes  Chin Med J  2007  120:479-484 
    Pu LJ,, Shen WF, et al.  Increased serum glycated albumin level is associated with the presence and severity of coronary artery disease in type 2 diabetic patients.  Circ J  2007  71:1067-1073 
    , Pu LJ, Xu XW, Zhang Q, Zhang RY, Zhang JS, Hu J, Yang ZK, Lv AK, Ding FH, Shen J, Lou S, Fang DH, Shen WF.  Association of serum levels of glycated albumin, C-reactive protein and tumor necrosis factor-alpha with severity of coronary artery disease.   Clin Biochem  2007  40:810-816