- 基本信息
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导师姓名：
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王红霞
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学科代码：
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100214
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性别：
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女
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学科名称：
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肿瘤学
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培养单位：
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附属第一人民医院
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三级学科
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导师类型：
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博士生导师
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专业领域名称：
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肿瘤学 专业学位
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联系方式：
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whx365@126.com
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专业领域代码：
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105121
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邮编：
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201621
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邮箱地址：
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whx365@126.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
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中国宋庆龄基金会肿瘤诊疗及区域产学研联盟 副理事长
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中国生物医学工程学会肿瘤靶向治疗技术分会 委员
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中美华人医师肿瘤协会副主委
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中国抗癌协会青年理事会 常委
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中国抗癌协会胰腺癌专业委员会多学科临床研究协作组 委员
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中国抗癌协会化疗专业委员会 青年委员
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中国医师协会精准医疗专业委员会乳腺癌专委会 副主委
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中国肿瘤临床学会（CSCO）免疫治疗专家委员
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上海市抗癌协会青年理事会 副理事长
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中国女医师协会临床肿瘤学专业委员会 委员
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上海医疗事故鉴定专家库 委员
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中国医促会神经内分泌肿瘤分会 委员
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中国抗癌协会肿瘤异质性与个体化治疗专委会 主委
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中国抗癌协会肿瘤分子标记物专委会常委 转化研究专委会主委
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北京乳腺病防治学会肿瘤免疫治疗委员会 常委
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CSCO乳腺癌专家委员会委员
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中国抗癌协会肿瘤代谢专委会委员
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中国抗癌协会胰腺癌专业委员会多学科临床研究协作组 委员
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《临床肿瘤学》 杂志 编委
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中国研究型医师协会胰腺疾病专业委员会 常委
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Experimental of Hematology & Oncology 编委
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- 科研项目
| 82225038 | 乳腺癌复发转移 | 国家自然科学基金委杰出青年基金 |
2023-01~2027-12
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400万元
| 课题负责人 |
| 82073269 | 缺氧激活PRMT3-Wnt信号通路表观调控乳腺癌细胞干性的研究 | 国家自然科学基金 |
2021-01~2024-12
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57万元
| 课题负责人 |
| M-0349 | 转移性乳腺癌中循环肿瘤细胞的异质性与机制研究 | 国家自然科学基金委-中德科学中心 |
2021-01~2023-12
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150万元
| 课题负责人 |
| SHDC2020CR2065B | PD-1单抗SHR-1210联合阿帕替尼或卡培他滨治疗晚期胰腺癌的探索性研究 | 上海申康中心三年行动计划 2020.10.01-2022.9.30 |
2020-10~2022-09
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240万元
| 课题负责人 |
| CTCCR-2016B05 | PD-1单抗SHR-1210联合阿帕替尼或卡培他滨对比卡培他滨单药治疗晚期胰腺癌的随机开放临床研究 | 院级课题 |
2018-01~2021-12
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60万元
| 课题负责人 |
| XDA12020223 | 靶向TACSTD2的ADC分子的临床前及个性精准治疗方案研究 | 中国科学院战略性先导科技专项 |
2018-01~2020-09
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400万元
| 子课题负责人 |
| 81772802 | 外泌体-TM4SF3多阶段调控MSCs分化促进乳腺癌骨转移的机制研究 | 国自然面上项目 |
2018-01~2021-12
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55万元
| 课题负责人 |
| 17JC1404400 | 深度卷积神经网络用于胰腺肿瘤精准诊断的研究 | 上海市科委科技创新行动计划 |
2017-07~2019-06
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60万元
| 课题负责人 |
| YG2016MS22 | 生物可降解抗HER2单抗/PEG/PCL/紫杉醇纳米输送靶向治疗HER2阳性乳腺癌的研究 | 上海交通大学“医工交叉基金“ |
2017-01~2019-12
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21万元
| 课题负责人 |
| 81628011 | PKM2-RNF8-组蛋白H3多聚泛素化修饰促进乳腺癌发生发展的分子机制研究 | 国自然海外及港澳学者合作研究基金 |
2017-01~2018-12
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18万元
| 课题负责人 |
| 16DZ1910200 | 基于组合库技术的全人源新型单克隆抗体筛选平台 | 上海市科委科技创新行动计划 |
2017-01~2019-12
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100万元
| 课题负责人 |
| 16ZR1427400 | 外泌体－Tspan8调控上皮间质转化促进胰腺癌转移与治疗抵抗的机制研究 | 上海科委 |
2016-07~2019-06
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20万元
| 课题负责人 |
| / | 中国家族性和早发性乳腺癌易感基因群体筛查及与乳腺癌风险的关联性研究 | 国家临床重点专科 |
2015-08~2018-08
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80万元
| 课题负责人 |
| JTDYG | 乳腺癌干细胞特异性调控基因功能鉴定及其潜在临床意义 | 上海交通大学医工交叉基金 |
2013-01~2015-12
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15万元
| 课题负责人 |
| 81102015 | 乳腺癌干细胞microRNA 标签分子的临床意义及功能调控 | 国家自然科学基金 |
2012-01~2014-12
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21万元
| 课题负责人 |
| RJYY | 胰腺癌高表达关键分子群的验证 | 院士基金 |
2012-01~2015-12
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50万元
| 课题负责人 |
| 11PJ1406500 | 乳腺癌干细胞信号通路关键microRNA 的临床意义与功能调控 | 上海科委 浦江人才计划 |
2011-10~2013-09
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20万元
| 课题负责人 |
| 09ZR1417900 | 恶性间皮瘤信号通路蛋白高通量筛查及信号网络构建 | 上海市科委，自然科学基金项目资助 |
2009－08~2012-07
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10万元
| 课题负责人 |
| GJM7048110 | XELOX 与 EOX 方案在老年胃癌中的疗效评价和疗效预测研究 | 国家民政部 |
2007-01~2009-12
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9万元
| 课题负责人 |
- 学术论文
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Yida Huang, Shaoqian Du, Jun Liu, Weiyi Huang, Wanshan Liu, Mengji Zhang, Ning Li, Ruimin Wang, Jiao Wu, Wei Chen, Mengyi Jiang, Tianhao Zhou, Jing Cao, Jing Yang, Lin Huang, An Gu, Jingyang Niu, Yuan Cao, Wei-Xing Zong, Xin Wang, Jun Liu, Kun Qian,
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Diagnosis and prognosis of breast cancer by high-performance serum metabolic fingerprints
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Proc Natl Acad Sci U S A .
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2022
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119(12):e2122245119.
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Xiaoqing Lu, Liwei An, Guangjian Fan, Lijuan Zang, Weiyi Huang, Junjian Li, Jun Liu, Weiyu Ge, Yuwei Huang, Jingxuan Xv, Shaoqian Du, Yuan Cao, Tianhao Zhou, Huijing Yin, Li Yu, Shi Jiao,
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EGFR Signaling Promotes Nuclear Transloation of Plasma Membrane Protein TSPAN8 to Enhance Tumor Progression via STAT3-mediated Transcription.
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Cell Research
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2022
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32：359–374
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Yuwei Huang, Junjian Li, Wanqing Du, Siyang Li, Ying Li, Haozhi Qu, Jingxuan Xv, Li Yu, Rongxuan Zhu & Hongxia Wang.
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Nuclear translocation of the 4-pass transmembrane protein Tspan8.
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Cell Research.
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2021
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0: 1–4
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Yun Liu, Honglian Wang, Jiaqi Liu, Junjian Li, Xin Wang, Xiang Wang, Yun Zhang, Zhigang Bai, Qinghua Zhou, Ying Wu, Yi Shen, Xiaoling Weng, Fatao Liu, Jiancheng Guo, Lijun Di, Olivier Gires, Zhongtao Zhang, Yiding Chen,
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Prevalence and reclassification of BRCA1 and BRCA2 variants in a large, unselected Chinese Han breast cancer cohort.
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Journal of Hematology & Oncology.
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2021
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14: 18.
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Junjian Li,Xiaoliang Chen,Liqun Zhu,Zhenghong Lao,
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SOX9 is a critical regulator of TSPAN8-mediated metastasis in pancreatic cancer.
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Oncogene.
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2021
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Jun 23.
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Weiyu Ge, Mengyi Jiang, Fengchun Zhang, Yue Ma,, Yingchun Xu.
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ZGRF1 Is Associated with Poor Prognosis in Triple-Negative Breast Cancer and Promotes Cancer Stemness Based on Bioinformatics.
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OncoTargets and Therapy.
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2020
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13: 2843-2854.
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Yaoyao Liang, Jiahui Penga, Ning Li, Cynthia Yu-Wai-Man, Qian Wang, Yuhong Xu,, Aristides D. Tagalakis, Zixiu Du.
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Smart nanoparticles assembled by endogenous molecules for siRNA delivery and cancer therapy via CD44 and EGFR dual-targeting.
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Nanomedicine: Nanotechnology, Biology, and Medicine.
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2019
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15: 208–217.
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Rongxuan Zhu, Olivier Gires, Liqun Zhu, Jun Liu, Junjian Li, Hao Yang, Gaoda Ju, Jing Huang, Weiyu Ge, Yi Chen, Zhimin Lu,
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TSPAN8 Promotes Cancer Cell Stemness via Activation of Sonic Hedgehog Signaling
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Nature Communication.
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2019
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10:2863
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, Olivier Gires.
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Tumor-derived extracellular vesicles in breast cancer: From bench to bedside.
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Cancer Letters.
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2019
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460: 54–64.
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Xiao Liu, Junjian Li, Bruno Loureiro Cadilha, Anamarija Markota, Cornelia Voigt, Zhe Huang, Peter P. Lin, Daisy D. Wang, Juncheng Dai, Gisela Kranz, Anna Krandick, Darko Lib, Horst Zitzelsberger, Isabella Zagorski, Herbert Braselmann, Min Pan, Sibo Zhu, Yuanchi Huang, Sebastian Niedermeyer, Christoph A. Reichel, Bernd Uhl, Daria Briukhovetska, Javier Suárez Gosálvez, Sebastian Kobold, Olivier Gires,
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Epithelial-type systemic breast carcinoma cells with a restricted mesenchymal transition are a major source of metastasis.
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Science Advances.
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2019
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5: eaav4275.
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朱容萱,王坚,朱莉菲,
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促结缔组织增生性小圆细胞肿瘤的临床特征及预后因素分析
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上海交通大学学报（医学版）
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2018
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38 (3): 281-287
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Yue Ma, Wenwen Liu, Junjian Li, Yingchun Xu,
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Gastric cancer with breast metastasis: Clinical features and prognostic factors.
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Oncology Letters.
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2018
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16(5):5565-5574.
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Gaoda Ju, Rongxuan Zhu, Hanting Zhao, Fen Ye, Liaoran Zhang, Chaoyi Lin, Yanqiao Lu, Xiang Zhang, Ning Li, Peng Xue, Lifei Zhu,
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The discordance pattern of molecular sub-types between primary and metastatic sites in Chinese breast cancer patients.
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Int J Clin Exp Pathol
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2018
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11(12):5938-5947
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Jun Liu, Qiwen Ben, Eryi Lu, Xiangyi He, Xiaoqun Yang, Jun Ma, Wen Zhang, Zhiming Wang, Tianshu Liu, Jianjun Zhang and Hongxia Wang.
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Long noncoding RNA PANDAR blocks CDKN1A gene transcription by competitive interaction with p53 protein in gastric cancer.
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Cell Death & Disease
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2018
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9 (2):168.
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Lin PP, Gires O, Wang DD, Li L,
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Comprehensive in situ co-detection of aneuploid circulating endothelial and tumor cells.
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Sci Rep
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2017
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7(1):9789
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, Nikolas H. Stoecklein, Peter P. Lin and Olivier Gires
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Circulating and disseminated tumor cells: diagnostic tools and therapeutic targets in motion
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Oncotarget
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2017
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2017 Jan 3;8(1):1884-1912
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Yingchun Xu, Qi Xu, JunJian Li, XiaoFeng Gu, XiaoLin Lin, Li Sun, HongMin Lu, Lei Tang, Yue Ma, Zhimin Lu,
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Chemotherapy with or without autologous cytokine-induced killer cell transfusion as the first-line treatment for stage IV gastrointestinal cancer: a phase II clinical trial
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J Cancer Res Clin Oncol
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2016
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142:1315–1323
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Ying-Chun XU, Feng-Chun ZHANG, Jun-Jian LI, Jia-Qi DAI, Qiang LIU, Lei TANG,Yue MA, Qi XU, Xiao-lin LIN, Hong-Bin FAN and Hong-Xia WANG
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RRM1, TUBB3, TOP2A, CYP19A1, CYP2D6: Difference between mRNA and protein expression in predicting prognosis of breast cancer patients
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Oncology Reports
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2015
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34: 1883-1894
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Xu Ying-Chun, Liu Qiang, Dai Jia-Qi, et al.
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Tissue microarray analysis of X-linked inhibitor of apoptosis (XIAP) expression in breast cancer patients.
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Medical Oncology.
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2014
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31:764.
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Zhi-Qiang Yin, Jian-Jun Liu, Ying-Chun Xu, Jian Yu, Guo-Hui Ding, Feng Yang, Lei Tang, Bao-Hong Liu, Yue Ma, Yu-Wei Xia, Xiao-Lin Lin & Hong-Xia Wang.
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A 41-gene signature derived from breast cancer stem cells as a predictor of survival.
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Journal of Experimental & Clinical Cancer Research
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2014
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33:49
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Xu YC,, Tang L, et al.
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A systematic review of vinorelbine for the treatment of breast cancer.
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The Breast Journal.
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2013
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19 (2): 180–188
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Ma Y, Zhang Z, Tang L, Xu YC, Xie ZM, Gu XF,
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Cytokine-Induced Killer (CIK) Cells In The Treatment Of Patients With Solid Carcinomas: A Systematic Review And Pooled Analysis.
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Cytotherapy.
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2012
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Apr; 14(4): 483-93.
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Fang Ren, Ying-Chun Xu,, et al.
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Adjuvant chemotherapy, with or without postoperative radiotherapy, for resectable advanced pancreatic adenocarcinoma: continue or stop?
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Pancreatology.
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2012
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12(2):162-169.
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Ma Y, Tang L,, et al.
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Capecitabine for the treatment of advanced gastric cancer: efficacy, safety and ethnicity.
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J Clin Pharm Ther.
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2011
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Sep 26. doi: 10.1111/j.1365-2710.2011. 01289.x.
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, Zhang FC, Ye F, Ma Y, David YZ.
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The effect of coptis chinensis on the signaling network in the squamous carcinoma cells.
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Front Biosci
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2011
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Jan 1;3: 326-40.
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Hu J, Zhao G,
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A meta-analysis of gemcitabine containing chemotherapy for locally advanced and metastatic pancreatic adenocarcinoma.
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Journal of hematology & oncology.
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2011
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Mar 26, 4:11
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Ling W, Fan Jie, Yue M, Yuan M,
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Capecitabine-based chemotherapy for metastatic colorectal cancer.
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J Cancer Res Clin Oncol.
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2011
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Jun; 137(6): 927-38.
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, Huang M, Zhang DY, et al.
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Global Profiling of Signaling Networks: Study of Breast Cancer Stem Cells and Potential Regulation.
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The Oncologist.
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2011
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16(7): 966-979.
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, Gillis A, Zhao CY, et al.
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Crocidolite asbestos-induced signal pathway dysregulation in mesothelial cells.
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Mutat Res.
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2011
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16; 723(2): 171-176.
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Zhang FC, Song SL, Ma Y, Tang L, Xu YC,
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Effect of Fibroblasts on Breast Cancer Cell Mammosphere Formation and the Regulation of Stem Cell-Related Gene Expression.
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Int J Mol med.
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2011
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Sep; 28(3): 365-371
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