- 基本信息
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导师姓名：
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刘军
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学科代码：
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100204
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性别：
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男
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学科名称：
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神经病学
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培养单位：
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附属瑞金医院
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三级学科
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导师类型：
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博士生导师
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专业领域名称：
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神经病学 专业学位
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联系方式：
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专业领域代码：
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105104
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邮编：
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邮箱地址：
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jly0520@hotmail.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
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教育部“长江学者”特聘教授
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中国神经科学学会神经退行性疾病分会常委
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中国医师协会神经病学分会常委
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国际运动障碍协会亚太教育委员会委员
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中华医学会神经病学分会常委
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上海中西医结合学会神经内分泌委员会候任主任委员
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中华医学会神经病学分会帕金森及运动障碍学组委员
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中国医师协会神经病学分会帕金森及运动障碍专委会副组长
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中国老年保健协会脑保健专委会副主任委员
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- 科研项目
| 82071415 | VPS35基因突变激活线粒体未折叠蛋白反应调节多巴胺能神经元活性的机制研究 | 国家自然科学基金 |
2021-01~2024-12
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55万元
| 课题负责人 |
| 81873778 | VPS35调节α-突触核蛋白外泌体分泌的相关机制研究 | 国家自然科学基金 |
2019-01~2022-12
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56万元
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| 2016YFC1306505 | 帕金森病运动前期队列研究 | 科技部 |
2016-09~2020-12
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117.2万元
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| 81471287 | 寡聚型α-突触共核蛋白致小胶质细胞异常迁移的机制研究 | 国家自然科学基金（面上项目） |
2015-01~2018-12
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80万元
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- 学术论文
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Meng-sha Yao, Li-che Zhou, Yu-yan Tan, Hong Jiang, Zhi-chun Chen, Lin Zhu, Ning-di Luo, Quan-zhou Wu, Wen-yan Kang,
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Gait Characteristics and Brain Activity in Parkinson’s Disease with Concomitant Postural Abnormalities
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Aging and Diseae
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2020
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23;11(4):791-800
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Zhichun Chen, Guanglu Li,
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Autonomic dysfunction in Parkinson’s disease: Implications for pathophysiology, diagnosis, and treatment
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Neurobiology of Disease
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2020
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134: 104700
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Yuanyuan Li, Mengyue Niu, Aonan Zhao, Wenyan Kang, Zhichun Chen, Ningdi Luo, Liche Zhou, Xiongwei Zhu, Liming Lu and Jun Liu
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CXCL12 is involved in α-synuclein-triggered neuroinflammation of Parkinson’s disease
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Journal of Neuroinflammation
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2019
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16:263
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Yi Liu, Xiaopin Ma, Hisashi Fujiokac,, Shengdi Chen, Xiongwei Zhu
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DJ-1 regulates the integrity and function of ER-mitochondria association through interaction with IP3R3-Grp75-VDAC1
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Proceedings of the National Academy of Sciences
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2019
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116(50): 25322-25328
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Jiang Sirui, Nandy Priya, Wang Wenzhang, Ma Xiaopin, Hsia Jeffrey, Wang Chunyu, Wang Zhenlian, Niu Mengyue, Siedlak L Sandra, Torres Sandy, Fujioka Hisashi, Xu Ying, Lee Hyoung-gon, Perry George,, Xiongwei Zhu
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Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex
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Mol Neurodegener
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2018
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13(1):5
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Chen ZC, Chen SD,
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The role of T cells in the pathogenesis of Parkinson’s disease
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Prog Neurobiol
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2018
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169 (2018) 1-23
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Li Yuanyuan, Kang WY, Yang Qi, Zhang LN, Zhang LY, Dong FY, Chen SD,
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Predictive markers for early conversion of iRBD to Neurodegenerative Synucleinopathy diseases
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Neurology
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2017
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88(16):1493-1500
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Zhou LP, Wang W, Hoppel C,, Zhu XW
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Parkinson's disease-associated pathogenic VPS35 mutation causes complex I deficits
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Biochim Biophys Acta
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2017
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1863(11):2791-2795
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Qian Sun, Tian Wang, Tian-Fang Jiang, Pei Huang, Dun-Hui Li, Ying Wang, Qin Xiao,, Sheng-Di Chen
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Effect of a Leucine-rich Repeat Kinase 2 Variant on Motor and Non-motor Symptoms in Chinese Parkinson’s Disease Patients
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Aging and disease
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2016
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7(5)
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Wei Chen, Wen-Yan Kang, Shuai Chen, Ying Wang, Qin Xiao, Gang Wang,, Sheng-Di Chen
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Hyposmia correlates with SNCA variant and non-motor symptoms in Chinese patients with Parkinson’s disease
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Parkinsonism and Related Disorders
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2015
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6;21(6):610-4
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Dun-hui Li, Lin-yuan Zhang, Yun-yun Hu, Xu-feng Jiang, Hai-yan Zhou, Qiong Yang, Wen-yan Kang,, Sheng-Di Chen
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Transcranial sonography of the substantia nigra and its correlation with DAT-SPECT in the diagnosis of Parkinson's disease
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Parkinsonism and Related Disorders
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2015
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8;21(8):923-8
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Wenzhang Wang, Xinglong Wang, Hisashi Fujioka, Charles Hoppel, Alan L Whone, Maeve A Caldwell, Peter J Cullen,, Xiongwei Zhu
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Parkinson’s disease–associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes
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Nat Med
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2015
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30. doi: 10.1038/nm.3983
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Xiao-Ying Wang,Wen-Yan Kang,Qiong Yang,Lin-Yuan Zhang,Sheng-Di Chen,
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Using Gastrocnemius sEMG and Plasma a-Synuclein for the Prediction of Freezing of Gait in Parkinson’s Disease Patients
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PLOS ONE
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2014
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9(2):893-53
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Wen-YanKang,QiongYang,Xu-FengJiang,WeiChen,Lin-YuanZhang, Xiao-Ying Wang,Li-Na Zhang,ThomasJ.Quinn,,Sheng-DiChen
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Salivary DJ-1 could be an indicator of Parkinson’s disease progression
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Frontiers in Aging Neuroscience
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2014
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6(102):1-
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Hui Wu,Fangyi Dong,Ying Wang,Qin Xiao,Qiong Yang,Jing Zhao,
Thomas J. Quinn,Sheng-di Chen,
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Catechol-O-methyltransferase Val158Met polymorphism: Modulation of wearing-off susceptibility in a Chinese cohort of Parkinson's disease
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Parkinsonism and Related Disorders
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2014
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20():109-4
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,Qin Xiao,Ying Wang,Zhi-Min Xu,Ying Wang,Qiong Yang,
Gang Wang,Yu-Yan Tan,Jian-Fang Ma,Jin Zhang,Wei Huang,Sheng-Di Chen
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Analysis of Genome-wide Association Study-linked Loci in Parkinson’s Disease of Mainland China
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Movement Disorders
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2013
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28(13):189-2
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Ya-Xing Gui,Xin-Yi Wang, Wen-Yan Kang, Ying-Jie Zhang, Yu Zhang, Yong Zhou,Thomas J. Quinn,, Sheng-Di Chen
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Extracellular signal-regulated kinase is involved in
alpha-synuclein-induced mitochondrial dynamic disorders by
regulating dynamin-like protein 1
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Neurobiology of Aging
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2012
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33：2841–2854
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Bin Liu, Yu Zhang, Ying Wang, Qin Xiao, Qiong Yang, Gang Wang, Jianfang Ma, Jing Zhao, Thomas J. Quinn, Sheng-di Chen,
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Angiogenin variants are not associated with Parkinson’s disease in the ethnic Chinese population
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Parkinsonism Relat Disord
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2012
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11：1–6
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Wang Z,, Chen SD, Ding JQ
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DJ-1 modulates the expression of Cu/Zn-superoxide dismutase-1 through the Erk1/2-Elk1 pathway in neuroprotection
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Ann Neurol
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2011
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70(4):591-599
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, Shi M, Hong Z, Bradner J, Quinn T, Beyer RP, McGeer PL, Chen S, Zhang J.
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Identification of ciliary neurotrophic factor receptor alpha as a mediator of neurotoxicity induced by alpha-synuclein
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Proteomics
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2010
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25:1-7
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Hong Z,, Li Xia,Shengdi Chen.
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Identification of glial-cell-line-derived neurotrophic factor-regulated proteins of striatum in mouse model of Parkinson disease.
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Proteomics Clin Appl
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2009
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3:1–12.
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Hong Z, Zhang QY,, Wang ZQ, Zhang Y, Xiao Q, Lu J, Zhou HY, Chen SD.
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Phosphoproteome study reveals Hsp27 as a novel signaling molecule involved in GDNF-induced neurite outgrowth.
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Journal of Proteome Research
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2009
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8:2768-2787.
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, Zhang JP, Shi M, Quinn T, Bradner J, Beyer R, Chen S, Zhang J.
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Rab11a and HSP90 regulate recycling of extracellular alpha-synuclein.
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J Neurosci
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2009
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29(5):1480-5.
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,
Zhen Hong,
Jianqing Ding,
Jianrong Liu,
Jing Zhang
and Shengdi Chen.
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Predominant Release of Lysosomal Enzymes by Newborn Rat
Microglia After LPS Treatment Revealed by Proteomic Studies.
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Journal of proteome research
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2008
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(5):2033-49.
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, Zhou Y, Wang Y, Fong H, Murray TM, Zhang J.
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Identification of Proteins Involved in Microglial Endocytosis of
alpha-Synuclein
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Journal of proteome research
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2007
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6(9):3614-3627.
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Chen L, Jin J, Davis J, Zhou Y, Wang Y,, Lockhart PJ, Zhang J.
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Oligomeric alpha-synuclein inhibits tubulin polymerization.
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Biochem Biophys Res Commun
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2007
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356(3):548-553.
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Jin J, Shie FS,, Wang Y, Davis J, Schantz AM, Montine KS, Montine TJ, Zhang J.
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Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated alpha-synuclein.
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Journal of Neuroinflammation
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2007
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4(4):2-2.
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McLaughlin P, Zhou Y, Ma T,, Zhang W, Hong JS, Kovacs M, Zhang J.
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Proteomic analysis of microglial contribution to mouse strain-dependent dopaminergic neurotoxicity.
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Glia
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2006
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53(6):567-582.
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