• 基本信息
    导师姓名: 狄文 学科代码: 100211
    性别: 学科名称: 妇产科学
    培养单位: 附属仁济医院 三级学科
    导师类型: 博士生导师 专业领域名称: 妇产科学 专业学位
    联系方式: 021-68383801 专业领域代码: 105115
    邮编: 200127 邮箱地址: diwen163@163.com
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    中华医学会妇产科学分会副主任委员
    《中国实用妇科与产科杂志》副主编
    《上海医学》副主编
    《中华妇产科杂志》副总编辑
    上海市母婴安全专家委员会主任委员
    上海市医师协会妇产科医师分会会长
    中国医师协会妇产科医师分会会长
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    RJTJ22-ZD-007遗传性卵巢癌核酸感受器通路功能紊乱机制及干预策略仁济医院 2023-09~2023-09 20万元  课题负责人
    2021YFC2700401生育健康及妇女儿童健康保障专项:女性重大生殖内分泌代谢性疾病的精细化诊治(子课题1:基于PCOS专病队列的AI分型诊断与标志物筛选)科技部国家重点研发计划 2021-12~2024-11 160万元  子课题负责人
    SHDC2020CR6009-002宫颈癌标准化专病数据库及共享机制的建立和管理申康发展中心 2020-12~2022-09 62.3万元  课题负责人
    81974454BRD4通过超级增强子促进卵巢癌化疗耐药的作用与机制国家自然科学基金面上项目 2020-01~2024-12 55万元  课题负责人
    19dz2340100基于“女性全生命周期生殖健康管理”的科普教育工程上海市科委 2019-12~2021-08 98万元  课题负责人
    /上海市临床重点专科建设项目-女性肿瘤上海市卫生和计划生育委员会 2019-10~2022-12 150万元  课题负责人
    RJLJHZ-07卵巢癌天然免疫识别与治疗研究仁济医院 2019-01~2019-12 97.5万元  课题负责人
    /上海市临床重点专科建设项目-妇产科学上海市卫生和计划生育委员会 2018-10~2020-12 469万元  课题负责人
    ZY(2018-2020)-FWTX-3006中西医联合治疗免疫“窗口期”上皮性卵巢癌的临床研究(上海市综合医院中西医结合专项重点项目)上海市卫生和计划生育委员会、上海市申康医药发展办公室 2018-09~2020-12 44.36万元  课题负责人
    18441904800一种妊娠合并免疫性疾病病情监测试剂盒的开发上海市科委 2018-04~2021-06 35万元  课题负责人
    81772770顺铂诱导的卵巢癌细胞自噬对TAM极化的调控作用及机制研究国自然面上项目 2018-01~2021-12 55万元  课题负责人
    /上海市妇科肿瘤重点实验室(地高大建设项目)上海交通大学医学院 2018-01~2020-12 50万元  课题负责人
    2017ZZ02016上海市重中之重临床重点学科--妇产科学上海市卫生和计划生育委员会 2017-07~2020-06 100万元  课题负责人
    14DZ2270900上海市妇科肿瘤重点实验室上海市科委 2017-01~2020-12 150万元  课题负责人
    16CR2001A基于精准医学的筛选靶向药物联合治疗在晚期卵巢癌中的临床研究上海申康医院发展中心 2016-10~2018-10 80万元  课题负责人
    2016YFC1302900宫颈癌筛查与干预新技术及方案的研究--基于分子的癌前病变“无创”干预的研究国家重点研发计划 2016-09~2020-10 100万元  课题负责人
    DLY201505基于分子诊断选择复发性卵巢癌治疗方案的前瞻性、随机、多中心临床研究上海交通大学医学院 2016-01~2020-12 100万元  课题负责人
    15GWZK0701公共卫生三年行动计划重点学科——妇产科学上海市卫生和计划生育委员会 2016-01~2017-12 1078.6万元  课题负责人
    81472426EGF修饰的靶向性载miR-7脂质体的构建及其抗卵巢癌作用研究国家自然科学基金面上项目 2015-01~2018-12 80万元  课题负责人
    14DZ2270900上海市妇科肿瘤重点实验室上海市科委 2014-01~2016-12 150万元  课题负责人
    2013ZYJB0202上海市卫生系统重要疾病联合攻关项目(重大项目)——建立在蛋白质组/转录组基础上的卵巢癌早期诊断和个体化综合治疗研究上海市卫生和计划生育委员会 2014-01~2016-12 150万元  课题负责人
    2013-KJ-03基于社区的健康促进项目(更年期、老年期女性及男性)上海市卫生和计划生育委员会 2013-03~2013-12 90万元  课题负责人
    81272882卵巢癌自噬现象对化疗后免疫窗口期抗肿瘤CD8+CD45R0+T细胞生成调控作用的研究国家自然科学基金面上项目 2013-01~2016-12 75万元  课题负责人
    12411950200卵巢癌综合治疗的多中心临床研究上海市科委 2012-10~2015-09 100万元  课题负责人
    12GWZX0302上海市公共卫生重点学科——妇幼卫生和儿童保健学上海市卫生局 2012-01~2013-12 75万元  课题负责人
    11nm0503000靶向EGFR的载顺铂免疫纳米海藻酸钠脂质体改善卵巢癌耐药的机制研究上海市科委 2011-12~2014-09 30万元  课题负责人
     上海市领军人才建设专项上海市科委 2011-12~2014-09 25万元  课题负责人
    11DZ2211002卵巢癌物理治疗临床转化研究示范基地上海市科委 2011-12~2013-09 60万元  课题负责人
    201002013卫生行业科研专项:生殖与生育重大疾病诊治的规范化与推广——任务单元(宫颈疾病的诊治的规范化和功能保护)卫生部科技教育司 2011-07~2014-06 18.72万元  课题负责人
    20100073110075自噬对卵巢癌细胞耐药及侵袭转移的调控作用教育部博士点基金 2011-01~2013-12 6万元  课题负责人
    新型抗血管生成药物靶向治疗卵巢癌的研究上海交通大学理工交叉 2011-01~2012-12 12.5万元  课题负责人
    81072137自噬对卵巢癌细胞耐药及失巢凋亡抵抗的调控研究国家自然科学基金面上项目 2011-01~2013-12 34万元  课题负责人
    BXJ201023ACC活性与上皮性卵巢癌治疗的相关性研究交大医学院研究生院博士点基金 2010-10~2011-11 2万元  课题负责人
    CAMB022010液基细胞学、HPV检测及hTERC、C-MYC基因检测在宫颈癌筛查中的相关性研究中华医学会 2010-08~2012-08 8万元  课题负责人
    CAMB012010FISH术技检测自然流产或死胎死产组织中染色体及基因异常临床应用研究中华医学会 2010-08~2012-09 6万元  课题负责人
    10dz2212100卵巢肿瘤标志物筛选和机制研究上海市科委 2010-06~2012-05 50万元  课题负责人
    B-0801-10-00012009交大优秀学科带头人培养计划上海交通大学医学院 2009-10~2012-12 150万元  课题负责人
    0952mm04100EGF修饰的装载顺铂的PEG-PLA纳米粒靶向特异性治疗卵巢癌的研究上海市科委 2009-07~2011-06 50万元  课题负责人
    09dz2200300卵巢癌早期诊断和有效治疗研究平台建设上海市科委(重点实验室) 2009-06~2011-06 50万元  主要责任人
    PKY2009-Y15宫颈病变早期诊断、早期干预及信息平台建设浦东新区科委 2009-01~2011-12 10万元  课题负责人
    08DZ2230100上海市妇科肿瘤重点实验室建设上海市科委 2008-09~2010-09 200万元  课题负责人
    08XD14027 调控ACC活性作为上皮性卵巢癌治疗标靶的可行性研究 上海市科委(学科带头人) 2008-08~2010-08 40万元  课题负责人
    2008BAI57B00 妇科疾病现代治疗规范化研究:宫颈病变发病及诊治规范化研究和推广 国家科技部“十一五”科技支撑重点项目课题 2008-06~2011-12 50万元  课题负责人
    30772306缺氧环境下LOX和TrkB促进上皮性卵巢癌转移的相互调控机制研究国家自然科学基金面上项目 2008-01~2010-12 29万元  课题负责人
    074119517宫颈癌及子宫内膜异位症早期诊断与多中心临床研究上海市科委重大项目 2008-01~2010-12 90万元  课题负责人
    08YZ43上海市教委第5期重点学科上海市教委 2007-12~2013-12 490万元  课题负责人
    2006DFA32780抑制卵巢癌腹膜转移的靶向治疗研究科技部国际合作重点项目 2007-01~2009-12 55万元  课题负责人
    07ZZ40一线化疗对卵巢癌患者免疫功能影响的研究上海市教委 2007-01~2009-12 10万元  课题负责人
    30471808BRMSI转移抑制基因和缺氧诱导因子HIF-1与卵巢上皮癌转移关系的研究国家自然科学基金面上项目 2005-01~2007-12 21万元  课题负责人
    2005ZD004宫颈癌早期诊断及有效干预的实验及临床多中心研究上海市卫生局 2005-01~2008-12 30万元  课题负责人
    2004BA720A05-01女性生殖道感染的相关研究国家十五攻关课题子课题 2004-01~2006-12 10万元  课题负责人
    04JC14045转移抑制基因BRMSI和缺氧诱导因子HIF-1与卵巢上皮癌转移关系的研究上海市科委 2004-01~2007-12 30万元  课题负责人
    03-07-03细胞信号传导对卵巢癌生物学行为的影响上海市卫生局 2003-01~2006-12 20万元  课题负责人
    34002妊娠期糖尿病与瘦素关系的研究上海市卫生局 2003-01~2005-12 3万元  课题负责人
    02JC14028三氧化二砷抗卵巢癌细胞及耐药细胞系的机理研究上海市科委 2003-01~2005-12 15万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Wenwen Li#, Lu Lu#, Juanjuan Lu, Xinran Wang, Chao Yang, Jingsi Jin, Lingling Wu, Xiaochuan Hong, Fanlin Li, Dongqing Cao, Yuanqin Yang, Meng Wu, Bing Su, Jinke Cheng, Xuanming Yang*,, Liufu Deng*  cGAS-STING-mediated DNA sensing maintains CD8 T cell stemness and promotes antitumor T cell therapy  Sci Transl Med  2020  12(eaay9013):1-14 
    Wan Liu, Wenjing Wang, Xinran Wang, Cong Xua, Ning Zhang*,  Cisplatin-stimulated macrophages promote ovarian cancer migration via the CCL20-CCR6 axis  Cancer Letters  2020  472(1):59-69 
    Sihan Lin#, You Wang#, Xinran Wang#, Bin Yan, Weihua Lou*,  Serum immunoglobulin G N-glycome: a potential biomarker in endometrial cancer  Ann Transl Med  2020  8(12):748 
    Qiaohong Wang#, Jingze Gao#,  Anti-angiogenesis therapy overcomes the innate resistance to PD-1/PD-L1 blockade in VEGFA-overexpressed mouse tumor models  Cancer Immunol. Immunother.  2020  69(9):1781–1799 
    Wei Cang,?Qing Li,?Liying Gu,?Zubei Hong,?Yuan Hu,,?Lihua Qiu  Clinical Evaluation of DNA Ploidy for the Triage of HPV-positive Chinese Women During Cervical Cancer Screening  Cancer prevention research (Philadelphia, Pa.)  2020  Nov 23 
    Chaojun Wang#,,Zhuowei Gu*  Endocrine and glycolipid metabolism characteristics of diminished ovarian reserve in Chinese women with polycystic ovary syndrome  Journal of International Medical Research  2020  48(3) 1–6 
    Lin Qiu, Abraham Morse,, Lei Song, Beihua Kong, Zehua Wang, Jinghe Lang, Wenzhao Chai, Lan Zhu*, and Experts from the Chinese Obstetricians and Gynecologists Association  Management of gynecology patients during the coronavirus disease 2019 pandemic: Chinese expert consensus  American Journal of Obstetrics & Gynecology  2020  223(1):3-8 
    Cong Xu, Wan Liu, Yuan Hu, Weiping L*,  Bioinspired tumor-homing nanoplatform for co-delivery of paclitaxel and siRNA-E7 to HPV-related cervical malignancies for synergistic therapy  Theranostics  2020  10(7): 3325-3339 
    Jie Cheng*, Jiaxin Niu, You Wang, Chuan Wang, Qiong Zhou, Yunyan Chen, Yu Zhang, Jianhua Lin,  Hemophagocytic lymphohistiocytosis in pregnancy: a case report and review of the literature  journal of obstetrics and gynaecology  2020  40(2):153‐159 
    Song K, Dai L, Long X, Wang W,  Follicle-stimulating hormone promotes the proliferation of epithelial ovarian cancer cells by activating sphingosine kinase  Sci Rep  2020  Aug 14;10(1):13834 
    Liu W, Wang W, Zhang N,  The Role of CCL20-CCR6 Axis in Ovarian Cancer Metastasis  OncoTargets Ther  2020  Dec 11;13:12739-12750 
    Xiaoyan Wan, Zubei Hong, Yuhong Mao,  Correlations of AKIP1, CXCL1 and CXCL2 expressions with clinicopathological features and survival profiles in cervical cancer patients  Translational Cancer Research  2020  9(2):726-734 
    Yuan Hu, Huaimin Wang, Chenge Li, Jinyao Liu*, Bing Xu*,  Enzyme-instructed assembly of a cholesterol conjugate promotes pro-inflammatory macrophages and induces apoptosis of cancer cells  Biomaterials Science  2020  8, 2007–2017 
    Yanling Chang#, Yunyan Chen#, Qiong Zhou, Chuan Wang, Lei Chen,, Yu Zhang*   Short-chain fatty acids accompanying changes in the gut microbiome contribute to the development of hypertension in patients with preeclampsia  Clinical Science  2020  134 (2): 289–302 
    Hu Y, Hong Z, Gu L, Xie L, Yang B, Dai H, Chen H, Zhang B, Huang L, Liu Z, Cheng J, Zhang Y, Zhang Y, Lin J, Qiu L,  Evaluation of p16/Ki-67 Dual-Stained Cytology in Triaging HPV-Positive Women during Cervical Cancer Screening  Cancer Epidemiol Biomarkers Prev  2020  Jun;29(6):1246-1252 
    Jiang M, Wang Y, Fu Q, Lin S, Wu J,  Preeclampsia risk prediction model for Chinese pregnant patients with systemic lupus erythematosus  Arthritis Care Res  2020  May 20 
    Minhua Yu, Shanji Li, Jie Cheng, Liche Zhou, Zhou Jiang,  Ovarian teratoma-associated anti-NMDAR encephalitis: a single-institute series of six patients from China  Arch Gynecol Obstet  2020  Nov 20 
    Yi Zhang, Minhua Yu, Ying Jing, Jiejun Cheng, Caiyan Zhang, Lin Cheng, Haijiao Lu, Mei-Chun Cai, Jie Wu,Wenjing Wang, Weihua Lou, Lihua Qiu, Li Tan, Huaiwu Lu, Xia Yin, Guanglei Zhuang,  Baseline immunity and impact of chemotherapy on immune microenvironment in cervical cancer  British Journal of Cancer  2020  Oct 22. doi: 10.1038/s41416-020-01123-w.  
    Dai L, Song K,  Adipocytes: active facilitators in epithelial ovarian cancer progression?  J Ovarian Res  2020  Sep 23;13(1):115 
    Chen Y, Qiu X, Wang W, Li D, Wu A, Hong Z,, Qiu L  Human papillomavirus infection and cervical intraepithelial neoplasia progression are associated with increased vaginal microbiome diversity in a Chinese cohort  BMC Infect Dis  2020  Aug 26;20(1):629 
    Xin Sun, Fangbo Qian, Yaojuan He, Xiangying Gu,  Safety and Efficacy of Combined Oral Contraceptive Ethinyl Estradiol/Drospirenone (YAZ) in Chinese Women: A Single-Arm, Open-Label, Multicenter, Post-Authorization Study  Adv Ther  2020  Feb;37(2):906-917 
    Li LY#, Yin KM#,Bai YH, Zhang ZG,, Zhang S*   CTHRC1 promotes M2-like macrophage recruitment and myometrial invasion in endometrial carcinoma by integrin-Akt signaling pathway  clinical & experimental metastasis  2019  Aug;36(4):351-363 
    Yifeng He#*, Zhuowei Gu#, Qiujing Zhu, Mo Chen, Chenghui He, Yuting Huang, Qing Li,  CA125 over-release behavior following a 75-gram oral glucose test as a predictive biomarker of multidrug resistance in patients with ovarian cancer  international journal of cancer  2019  145(6):1690-1700 
    Keqi Song#, Lan Dai#*, Xiaoran Long, Xiaojuan Cui, Yixuan Liu,  Sphingosine kinase 2 inhibitor ABC294640 displays anti-epithelial ovarian cancer activities in vitro and in vivo  OncoTargets and Therapy  2019  12 4437–4449 
    Liying Gu#, Zubei Hong#, Hua Gao,Lihua Qiu*,  Incidence of cervical high‐grade squamous intraepithelial lesions and squamous cell carcinoma in women with highrisk human papillomavirus and normal cervical cytology A retrospective analysis of 1858 cases stratified by age and human papillomavirus genotype  Cytopathology  2019  30:419–425. 
    wenting ji, weihua lou, zubei hong, lihua qiu,  Genomic amplification of HPV, h-TERC and c-MYC in liquid-based cytological specimens for screening of cervical intraepithelial neoplasia and cancer  oncology letters  2019  17: 2099-2106 
    Chen Y#,Hong Z#,Wang W,Gu L,Gao H,Qiu L*,  Association between the vaginal microbiome and high-risk human papillomavirus infection in pregnant Chinese women  BMC infectious diseases  2019  Aug 1/19(1):677- 
    Jun Shi, Rongfen Huo,Ningli Li, Haichuan Li,Tianhang Zhai, Huidan Li, Baihua Shen, Jing Ye, Ruojin Fu,  CYR61, a Potential Biomarker of Tumor Inflammatory Response in Epithelial Ovarian Cancer Microenvironment of Tumor Progress  BMC Cancer  2019  19/1/1140 
    Qi Wang#, Xiangyu Zhang#, Ying Sun, Liting Wang, Li Ding, Wei-Hong Zhu* ,, You-Rong Duan*   Gold-caged copolymer nanoparticles as multimodal synergistic photodynamic/photothermal/chemotherapy platform against lethality androgen-resistant prostate cancer  Biomaterials  2019  Volume 212, August 2019, Pages 73-86 
    Xia Yin#, RuiBi#, PengfeiMa#, Shengzhe Zhang#,Yang Zhang, Yunheng Sun,Yi Zhang, Ying Jing, Minhua Yu, Wenjing Wang, Li Tan,, Guanglei Zhuang*, Mei-Chun Cai*   Multiregion whole-genome sequencing depicts intratumor heterogeneity and punctuated evolution in ovarian clear cell carcinoma  Journal of Medical Genetics  2019  jmedgenet-2019-106418 
    shanshan Zhong#, Yi Zhang#, Xia Yin,  cDK7 inhibitor suppresses tumor progression through blocking the cell cycle at the Gg2/M phase and inhibiting transcriptional activity in cervical cancer  OncoTargets and Therapy  2019  12 2137–2147 
    Chen Y#,Hong Z#,Wang W,Gu L,Gao H,Qiu L*,  Association between the vaginal microbiome and high-risk human papillomavirus infection in pregnant Chinese women  BMC infectious diseases  2019  Aug 1/19(1):677- 
    Keqi Song#, Lan Dai#*, Xiaoran Long, Xiaojuan Cui, Yixuan Liu,  Sphingosine kinase 2 inhibitor ABC294640 displays anti-epithelial ovarian cancer activities in vitro and in vivo  OncoTargets and Therapy  2019  12 4437–4449 
    Qi Tian#, He-FenSun, Wen-Jing Wang, Qing Li, JieDing,  miRNA-365b promotes hepatocellular carcinoma cell migration and invasion by downregulating SGTB  Future Oncol.  2019  15(17), 2019–2028 
    Xiaoran Long#, Keqi Song#, Hao Hu#, Qi Tian, Wenjing Wang, Qian Dong, Xia Yin,  Long non-coding RNA GAS5 inhibits DDPresistance and tumor progression of epithelial ovarian cancer via GAS5-E2F4-PARP1-MAPK axis  Journal of Experimental & Clinical Cancer Research  2019  38:345  
    Kaixuan Shi, Xia Yin, Mei-Chun Cai, Ying Yan, Chenqiang Jia, Pengfei Ma, Shengzhe Zhang, Zhenfeng Zhang, Zhenyu Gu, Meiying Zhang*,, Guanglei Zhuang*   PAX8 regulon in human ovarian cancer links lineage dependency with epigenetic vulnerability to HDAC inhibitors   eLife  2019  8:e44306. 
    Kaixuan Shi, Xia Yin, Mei-Chun Cai, Ying Yan, Chenqiang Jia, Pengfei Ma, Shengzhe Zhang, Zhenfeng Zhang, Zhenyu Gu, Meiying Zhang*,, Guanglei Zhuang*   PAX8 regulon in human ovarian cancer links lineage dependency with epigenetic vulnerability to HDAC inhibitors   eLife  2019  8:e44306. 
    Zhuo-wei GU, Yi-feng HE, Wen-jing WANG, Qi TIAN,  MiR-1180 from bone marrow-derived mesenchymal stem cells induces glycolysis and chemoresistance in ovarian cancer cells by upregulating the Wnt signaling pathway*  Zhejiang Univ-Sci B (Biomed & Biotechnol)   2019  20(3):219-237 
    Jiayue WU, Wei-Hong ZHANG, Jinghang MA, Chunde BAO ,Jinlin LIU,  Prediction of fetal loss in Chinese pregnant patients with systemic lupus erythematosus: a retrospective cohort study   BMJ-Open  2019  Feb 11;9(2):e023849 
    Jiayue Wu,  Pregnancy outcome in Chinese women with systemic lupus erythematosus: a retrospective study of 255 cases in a single center  Int J Clin Exp Med  2018  11(2):966-974 
    Zhouzhou Bao,Yuqing Zhang,Ziyang Tan,Xia Yin,,Jian Ye  Gap-enhanced Raman tags for high-contrast sentinel lymph node imaging  Biomaterials  2018  163:105-115 
    Zhuowei Gu,Yifeng He,Yue Zhang,Mo Chen,Keqi Song,Yuting Huang,Qing Li,  Postprandial increase in serum CA125 as a surrogate biomarker for early diagnosis of ovarian cancer  Journal of Translational Medicine  2018  16: 114 
    You Wang, Zhicheng Zhou, Xinran Wang, Xuping Zhang, Yansu Chen, Jin Bai?,  TRIM59 Is a Novel Marker of Poor Prognosis and Promotes Malignant Progression of Ovarian Cancer by Inducing Annexin A2 Expression  International Journal of Biological Sciences  2018  14(14): 2073-2082 
    Yuqing Zhang,Zhiyang Liu,Benjamin D. Thackray,Zhouzhou Bao,Xia Yin,Fenglei Shi,Jianbo Wu,Jian Ye,  Intraoperative Raman‐Guided Chemo‐Photothermal Synergistic Therapy of Advanced Disseminated Ovarian Cancers  Small  2018  2018 Jul 4:e1801022 
    Zhang Shengzhe,Zhang Meiying, Jin Ying, Yin Xia, Ma Pengfei, Zhang zhenfeng, Wang Xiaojie,, Zhuang Guanglei  Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhititors  Nature communications  2018  9:215 
    Jiayue Wu,Jinghang Ma,Wei-Hong Zhang,  Management and outcomes of pregnancy with or without lupus nephritis: a systematic review and meta-analysis  Therapeutics and Clinical Risk Management  2018  14: 885–901 
    Jiayue Wu,Jinghang Ma,Chunde Bao,Wen Di,  Pregnancy outcomes among Chinese women with and without systemic lupus erythematosus: a retrospective cohort study  BMJ OPEN  2018  13;8(4):e020909 
    Cui X,Sun Y,Shen M,Song K,Yin X,,Duan Y  Enhanced Chemotherapeutic Efficacy of Paclitaxel Nanoparticles Co-delivered with MicroRNA-7 by Inhibiting Paclitaxel-Induced EGFR/ERK pathway Activation for Ovarian Cancer Therapy  ACS applied materials & interfaces  2018  10(9):7821-7831 
    Huifen Yin#, Jing Ye#, Hua Gao, Qing Li, Qi tian, Wenjing Wang,  Knowledge, attitude and practice about reproductive health of perimenpausal and postmenopausal Women in Shanghai:a cross-sectional and intervention study  Int J Clin Exp Med   2017  10(7)10944-10951 
    Xia Yin#, Ying Jing#, Mei-Chun Cai#, Pengfei Ma, Yi Zhang, Cong Xu, Meiying Zhang,, Guanglei Zhuang*   Clonality, Heterogeneity, and Evolution of Synchronous Bilateral Ovarian Cancer  cancer research  2017  Dec 1;77(23):6551-6561 
    Lan Dai#*, Yixuan Liu#, Lei Xie#, Xia Wu, Lihua Qiu,  Sphingosine kinase 1/sphingosine-1-phosphate (S1P)/S1P receptor axis is involved in ovarian cancer angiogenesis  Oncotarget  2017  Aug 24;8(43):74947-74961 
    Yun-Yan Chen#, Li-Ying Gu#,, Jian-Hua Lin*   Acute fatty liver of pregnancy: a retrospective analysis of 13 cases  International Journal of Clinical and Experimental Pathology  2017  10(6):7075-7081 
    Lan Dai, Lei Xie, Yixuan Liu, Lihua Qiu,  Clinicopathological and prognostic significance of serum interleukin-8 in ovarian cancer: a meta-analysis  Int J Clin Exp Med   2017  10(1):97-105 
    Zhang N#, Lou WH#, Zhang XB, Lin JH,  Antepartum hemorrhage from previous-cesarean-sectioned uterus as a potential sign of uterine artery pseudoaneurysm  J Zhejiang Univ Sci B  2017  May;18(5):441-444 
    Wenting Ji#, Jiayue Wu#, Jiejun Cheng,  Serous adenocarcinoma arising from endometriosis in cesarean section abdominal wall scar: a case report and literature review  Int J Clin Exp Med   2017  10(7):7534-7541 
    Meiying Zhang, Guanglei Zhuang, Xiangjun Sun, Yanying Shen, Wenjing Wang, Qing Li,  TP53 mutation-mediated genomic instability induces the evolution of chemoresistance and recurrence in epithelial ovarian cancer  Diagnostic Pathology  2017  Feb 2;12(1):16 
    Xia Yin, Xiaojie Wang, Boqiang Shen, Ying Jing, Qing Li, Mei-Chun Cai, Zhuowei Gu, Qi Yang, Zhenfeng Zhang, Jin Liu, Hongxia Li,, Guanglei Zhuang  A VEGF-dependent gene signature enriched in mesenchymal ovarian cancer predicts patient prognosis  Scientific Reports  2016  Aug 8;6:31079 
    Ning Zhang, Weihua Lou, Fang Ji, Lihua Qiu, Benjamin K. Tsang,  Low molecular weight heparin and cancer survival: clinical trials and experimental mechanisms  J Cancer Res Clin Oncol  2016  142(8):1807-16 
    Yifeng He, Qiujing Zhu, Mo Chen, Qihong Huang, Wenjing Wang, Qing Li, Yuting Huang,  The changing 50% inhibitory concentration (IC50) of cisplatin: a pilot study on the artifacts of the MTT assay and the precise measurement of density-dependent chemoresistance in ovarian cancer  Oncotarget  2016  Oct 25;7(43):70803-70821 
    Meiying Zhang, Guanglei Zhuang, Xiangjun Sun, Yanying Shen, Aimin Zhao,  Risk prediction model for epithelial ovarian cancer using molecular markers and clinical characteristics  Journal of Ovarian Research   2015  2015, 8 :67 
    Yijie chen*, Xinran Wang*, Ting liu, Ding sheng-zi Zhang, Yunfei Wang, hongchen gu,  highly effective antiangiogenesis via magnetic mesoporous silica-based sirNavehicle targeting the VegF gene for orthotopic ovarian cancer therapy  International Journal of Nanomedicine  2015  Mar 31;10:2579-94 
    Lan Dai, Weihua Lou, Jie Zhu, Xingchen Zhou,  MiR-199a inhibits the angiogenic potential of endometrial stromal cells under hypoxia by targeting HIF-1α/VEGF pathway  Int J Clin Exp Pathol  2015  May;8(5):4735-44 
    Zhang Y, Zhu HP, Fan JX, Yu H, Sun LZ, Chen L, Chang Q, Zhao NQ,  Intravaginal Misoprostol for Cervical Ripening and Labor Induction in Nulliparous Women: A Double-blinded, Prospective Randomized Controlled Study  Chin Med J   2015  128(20):2736-2742 
    Dai L, Qi Y, Chen J, Kaczorowski D,, Wang W, Xia P  Sphingosine Kinase (SphK) 1 and SphK2 Play Equivalent Roles in Mediating Insulin's Mitogenic Action.   Molecular endocrinology  2014  28(2):197-207 
    You Wang, Yingying Wang, Jingying Xiang, Fang Ji, Yan Deng, Chunhui Tang, Shuyun Yang, Qinghua Xi, Rong Liu,  Knockdown of CRM1 inhibits the nuclear export of p27Kip1 phosphorylated at serine 10 and plays a role in the pathogenesis of epithelial ovarian cancer  Cancer Letters  2014  343: 6–13 
    Lilan Chen, Ting Liu, Jinhua Zhou, Yunfei Wang, Xinran Wang,, Shu Zhang  Citrate Synthase Expression Affects Tumor Phenotype and Drug Resistance in Human Ovarian Carcinoma  PLOS One  2014  2014 Dec 29;9(12):e115708. 
    Yunfei Wang, Jinhua Zhou, Lihua Qiu, Xinran Wang, Lilan Chen, Ting Liu,  Cisplatin–alginate conjugate liposomes for targeted delivery to EGFR-positive ovarian cancer cells  Biomaterials   2014  35(14): 4297-4309 
    Lan Dai, Pu Xia,  Sphingosine 1-phosphate: A Potential Molecular Target for Ovarian Cancer Therapy?  Cancer Investigation  2014  32(3): 71-80 
    Lilan Chen, Ting Liu, Shu Zhang, Jinhua Zhou, Yunfei Wang,  Succinate dehydrogenase subunit B inhibits the AMPK-HIF-1αpathway in human ovarian cancer in vitro  International Journal of Nanomedicine   2014  7:115 
    Yifeng He*, Xin Wu*, Qiujing Zhu, Xuezhe Wu, Lingda Feng, Xia Wu, Aimin Zhao,  Combined laparoscopy and hysteroscopy vs. uterine curettage in the uterine artery embolization-based management of cesarean scar pregnancy: a retrospective cohort study   BMC Womens Health  2014  Sep 24;14:116 
    Yunfei Wang, Peifeng Liu, Yourong Duan, Xia Yin, Qi Wang, Xiaofei Liu, Xinran Wang, Jinhua Zhou, Wenwen Wang, Lihua Qiu,  Specific cell targeting with APRPG conjugated PEG-PLGA nanoparticles for treating ovarian cancer  Biomaterials  2014  Jan;35(3):983-92 
    Ting Liu*, Lilan Chen*, Xiangjun Sun, You Wang, Shu Li, Xia Yin, Xinran Wang, Chenhuan Ding, He Li,  Progesterone receptor PROGINS and +331G/A polymorphisms confer susceptibility to ovarian cancer: a meta-analysis based on 17 studies.   Tumor Biology  2014  35, 2427-36 
    YaoWang,Osamu Okitsu,Xiao-Ming Zhao,Yun Sun,,Ri-Cheng Chian  The effect of minimal concentration of ethylene glycol (EG) combined with polyvinylpyrrolidone (PVP) on mouse oocyte survival and subsequent embryonic development following vitrification  Journal of assisted reproduction and genetics  2014  31:55–63 
    Jinhua Zhou*, Yunfei Wang*, You Wang, Xia Yin, Yifeng He, Lilan Chen, Wenwen Wang, Ting Liu,  FOXM1 Modulates Cisplatin Sensitivity by Regulating EXO1 in Ovarian Cancer  PLoS One  2014  9(5): e96989 
    Zhang M, He Y, Sun X,  A high M1/M2 ratio of tumor-associated macrophages is associated with extended survival in ovarian cancer patients  Journal of Ovarian Research  2014  7(1): 19 
    Liang Zhou, Zhu Jing, Wang Yunfei, Wang You, Lin Jianhua,  Three transcription factors and the way immune cells affected by different plasma change in opposite ways in the development of the syndrome of pre-eclampsia  chinese medical journal  2014  12(20):2252-2258 
    Yin X, Zhang N,  Regulation of LC3-dependent protective autophagy in ovarian cancer cells by protein phosphatase 2A.  Int J Gynecol Cancer  2013  23(4): 630-641 
    Brum G, Carbone T, Still E, Correia V, Szulak K, Calianese D, Best C, Cammarata G, Higgins K, Ji F,, Wan Y  N-acetylcysteine potentiates doxorubicin-induced ATM and p53 activation in ovarian cancer cells  Int J Oncol  2013  42(1): 211-218 
    Yi-feng He、Mei-ying Zhang、Xin Wu、Xiang-jun Sun、 Ting Xu、Qi-zhi He、Wen Di  High MUC2 Expression in Ovarian Cancer Is Inversely Associated with the M1/M2 Ratio of Tumor-Associated Macrophages and Patient Survival Time  PLoS One  2013  8(12): e79769 
    Gu L, Dai L, Cao C, Zhu J, Ding C, Xu HB, Qiu L,  Functional expression of TWEAK and the receptor Fn14 in human malignant ovarian tumors: possible implication for ovarian tumor intervention  PLoS One  2013  8(3): e57436 
    Ning Zhang,Lan Dai,Yanfei Qi,, Pu Xia  Combination of FTY720 with cisplatin exhibits antagonistic effects in ovarian cancer cells: Role of autophagy  International Journal of Oncology  2013  42(6): 2053 
    Hanwen Zhang, Qiuyu Wang, Qian Zhao,  MiR-124 inhibits the migration and invasion of ovarian cancer cells by targeting SphK1  Journal of ovarian research  2013  6(1): 84 
    Charles Best, David Calianese, Kevin Szulak, Garret Cammarata,Gabriella Brum, Thomas Carbone, Eric Still, Katelyn Higgins,Fang Ji,, Harold Wanebo, Yinsheng Wan  Paclitaxel disrupts polarized entry of membrane?permeable C6 ceramide into ovarian cancer cells resulting in synchronous induction of cell death  Oncology Letters  2013  5(6): 1854-1858 
    Li S, Qiu L, Wu B, Shen H, Zhu J, Zhou L, Gu L,  TOFA suppresses ovarian cancer cell growth in vitro and in vivo  Molecular medicine reports  2013  8(2): 373-378 
    Shen HR, Qiu LH, Zhang ZQ, Qin YY, Cao C#,  Genome-wide methylated DNA immunoprecipitation analysis of patients with polycystic ovary syndrome.  PLoS One.  2013  8(5): e64801 
    Fang Ji, You Wang, Lihua Qiu, Shu Li, Jing Zhu, Zhou Liang, Yinsheng Wan#,  Hypoxia inducible factor 1α-mediated LOX expression correlates with migration and invasion in epithelial ovarian cancer  International Journal of Oncology  2013  42(5): 1578-1588 
    Yunfei Wang, Peifeng Liu, Lihua Qiu, Ying Sun, Mingjie Zhu, Liying Gu,, Yourong Duan   Toxicity and therapy of cisplatin-loaded EGF modified mPEG-PLGA-PLL nanoparticles for SKOV3 cancer in mice  Biomaterials   2013  34(16): 4068-4077 
    Buchu Wu, Ke Hu, Shu Li, Jing Zhu, Liying Gu, Haoran Shen, Brett D. Hambly, Shisan Bao,  Dihydroartiminisin inhibits the growth and metastasis of epithelial ovarian cancer  ONCOLOGY REPORTS  2012  27:101-108 
    Zhu J, Zhang S, Gu L,  Epigenetic silencing of DKK2 and Wnt signal pathway components in human ovarian carcinoma.  Carcinogenesis  2012  33(12):2334-43 
    Dai L, Gu L,  MiR-199a attenuates endometrial stromal cell invasiveness through  Mol Hum Reprod  2012  18(3):136-45 
    Li H, Wen XS,  A simple LC-MS/MS method for determination of magnolol in rat blood and its application in a pharmacokinetic study.  Arzneimittelforschung  2012  62(2):83-7 
    Buchu Wu, Shu Li, Lili Sheng, Jing Zhu, Liying Gu, Haoran Shen, Duanduan La, Brett D. Hambly, Shisan Bao,  Metformin inhibits the development and metastasis of ovarian cancer  ONCOLOGY REPORTS  2012  27:101-108 
    Xia Wu, Xuebin Zhang, Jie Zhu,  Caesarean scar pregnancy comparative efficacy and safety of treatment by uterine artery chemoembolization and systemic methotrexate inject  Eur J Obstet Gynecol Reprod Biol.  2012  161(1):75-9 
    Li H, Wen XS,  In vitro and in vivo evaluation of Triptolide-loaded pluronic P105 polymeric micelles.  Arzneimittelforschung  2012  62(7):340-4. 
    Wu J, Ji F,, Chen H, Wan Y  Activation of acetyl-coenzyme A carboxylase is involved in Taxol-induced ovarian cancer cell death  Oncol Lett  2011  2(3):543-547. 
    Findlay JY,, Mandell MS  Cardiac risk evaluation for abdominal transplantation  Curr Opin Organ Transplant  2010  15(3):363-7. 
    Wu X, Feng QM, Wang Y, Shi J, Ge HL,  The immunologic aspects in advanced ovarian cancer patients treated with paclitaxel and carboplatin chemotherapy.  Cancer Immunol Immunother.  2010  59(2):279-291 
    Wang X, Zhang H,, Li W  Clinical factors affecting the diagnostic accuracy of assessing dilation and curettage vs frozen section specimens for histologic grade and depth of myometrial invasion in endometrial carcinoma.  Am J Obstet Gynecol  2009  201(2):194.e1-194 
    Lan Dai, Liying Gu, Chuanwei Ding, Lihua Qiu ,  TWEAK promotes ovarian cancer cell metastasis via NF-jB pathway activation and VEGF expression  Cancer Letters  2009  283(2) :159-167 
    Zhang N, Wu ZM, McGowan E, Shi J, Hong ZB, Ding CW, Xia P,  Arsenic trioxide and cisplatin synergism increase cytotoxicity in human ovarian cancer cells: therapeutic potential for ovarian cancer.  Cancer Sci.  2009  100(12):2459-64 
    Ning Zhang ,Hanwen Zhang ,Li Xia ,Ying Zheng ,Yun Yu,Yuanshan Zhu ,Guoqiang Chen,  NSC606985 induces apoptosis, exerts synergistic effects with cisplatin, and inhibits hypoxia-stabilized HIF-1a protein in human ovarian cancer cells  Cancer Letters   2009  278:139-144 
    Ji C, Cao C, Lu S, Kivlin R, Amaral A, Kouttab N, Yang H, Chu W, Bi Z,, Wan Y.  Proportional change of CD4+CD25+ regulatory T cells after lymphocyte therapy in unexplained recurrent spontaneous abortion patients.  Fertil Steril.  2009  Jul;92(1):301-5. 
    Wei Pan, Hui Yang ,Cong Cao, Xiuzu Song,Brittany Wallin, Rebecca Kivlin, Shan Lu, Gang Hu ,, Yinsheng Wan  AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells  Oncology Reports  2008  20:1553-1559 
    Bao SH, Wang XP, Lin QD,, Xu L, Ding CW  The investigation on the value of repeat and combination test of ACA and anti-beta2-GPI antibody in women with recurrent spontaneous abortion.  Am J Reprod Immunol  2008  60(4):372-8 
    Cong Cao , Shan Lu , Alex Sowa , Rebecca Kivlin , Ashley Amaral ,Wenming Chu , Hui Yang ,, Yinsheng Wan  Priming with EGFR tyrosine kinase inhibitor and EGF sensitizes ovarian cancer cells to respond to chemotherapeutical drugs  Cancer Letter  2008  266(2):249-262 
    Chao Ji, Cong Cao, Shan Lu, Rebecca Kivlin, Ashley Amaral, Nicola Kouttab, Hui Yang, Wenming Chu, Zhigang Bi,, Yinsheng Wan  Curcumin attenuates EGF-induced AQP3 up-regulation and cell migration in human ovarian cancer cells.  Cancer Chemother Pharmacol  2008  62:857-865 
    Shi J, Wan Y,  Effect of hypoxia and re-oxygenation on cell invasion and adhesion in human ovarian carcinoma cells.  Oncol Rep  2008  20(4):803-807 
    Shi J, Wan Y,  Effect of hypoxia and re-oxygenation on cell invasion and adhesion in human ovarian carcinoma cells.  Oncol Rep  2008  20(4):803-807 
    WU Zhen-ming ,  Clinical Diagnosis And Treatment Of Small Ovarian Tumor In Postmenopausal Women  Chinese Journal of Cancer Research  2006  18(3):229-234 
    Qiu L, Zhou C, Sun Y,, Scheffler E, Healey S, Kouttab N, Chu W, Wan Y  Crosstalk between EGFR and TrkB enhances ovarian cancer cell migration and proliferation  Int J Oncol.  2006  29(4):1003-11 
    WU Zhen-ming ,  Clinical Diagnosis And Treatment Of Small Ovarian Tumor In Postmenopausal Women  Chinese Journal of Cancer Research  2006  18(3):229-234 
    Changlin Zhou,Lihua Qiu,Yun Sun,Sarah Healey,Harold Wanebo,Nicola Kouttab,,Bingfang Yan and Yinsheng Wan   Inhibition of EGFR/PI13/AKT cell survival pathway promotes TSA’s effect on cell death and migration in human ovarian cancer cells.  International Journal of Oncology  2006  29(1):269-78 
    Qiu L, Zhou C, Sun Y,, Scheffler E, Healey S, Wanebo H, Kouttab N, Chu W, Wan Y.  Paclitaxel and ceramide synergistically induce cell death with transient activation of EGFR and ERK pathway in pancreatic cancer cells.   Oncology Reports  2006  16(4):907-13.