- 基本信息
导师姓名:
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薛峰
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学科代码:
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100210
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性别:
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女
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学科名称:
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外科学
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培养单位:
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附属仁济医院
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三级学科
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普外
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导师类型:
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博士生导师
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专业领域名称:
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外科学 专业学位
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联系方式:
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专业领域代码:
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105111
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邮编:
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xuefeng@renji.com
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邮箱地址:
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fengxue6879@163.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
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上海免疫学会会员
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上海抗癌协会儿童肿瘤专委会 常务委员
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Journal of Pediatric Gastroenterology and Nutrition, JPGN(中文版)编委
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上海医师协会儿科分会小儿肝病工作组 副组长
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中国医促会肝移植分会常务委员
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上海市健康科普专家库专家
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上海医师学会普外科分会门静脉高压与脾脏学组 委员
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儿童和遗传性肝病学组副组长
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上海移植分会病理组委员
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中国医药技术协会DILI防治专委会第一届常务委员
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中国器官移植病理委员会委员
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上海市欧美同学会浦东分会 秘书长
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日本肝脏病学会会员
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上海免疫学会移植免疫分会委员
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- 科研项目
PYI-17-002 | 构建肝移植儿童疫苗接种的免疫功能评价体系 | 仁济医院临床科研创新培育基金 |
2022-01~2024-12
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15万元
| 课题负责人 |
No.82170669 | EBV编码的MicroRNA在儿童肝移植术后PTLD中的机制研究 | 国家自然科学基金面上项目 |
2022-01~2025-12
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55万元
| 课题负责人 |
21410750400 | 中国-东南亚儿童终末期肝病转化研究中心中心 | 上海市科委国际联合实验室项目 |
2021-10~2024-09
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150万元
| 课题参与人 |
SHDC2020CR2003A | 中国儿童肝移植免疫抑制剂应用的精准医学研究 | 申康三年行动计划-重大临床研究项目 |
2020-10~2022-09
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300万元
| 课题参与人 |
| 基于器官衰竭分层验证评估乙肝相关终末期肝病肝移植治疗 | 国家科技部重大专项课题 |
2017-07~2020-12
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2000万元
| 子课题负责人 |
81670602 | MicroRNA-31影响肝移植术后免疫抑制剂疗效的分子遗传机制研究 | 国家自然科学基金面上项目 |
2017-01~2020-12
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58万元
| 课题负责人 |
81470847 | MicroRNA 31在决定药物性肝损发生的关键炎症信号通路中调控机理研究 | 国家自然科学基金面上项目 |
2015-01~2018-12
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76万元
| 课题负责人 |
12ZR1418300 | 婴幼儿肝移植后CD8+记忆性T细胞的免疫应答特征及机制研究 | 上海市科委自然基金项目 |
2012-07~2015-06
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10万元
| 课题负责人 |
| 肝细胞肝癌新的肿瘤标记物及转移机制研究 | 国际合作横向课题 |
2011-11~2015-10
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300万元
| 课题负责人 |
10410701100 | 器官移植术后真菌感染的细胞免疫监控及应用研究 | 上海市科委国际合作项目 |
2010-04~2012-03
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15万元
| 课题负责人 |
| 肝脏微粒体药物代谢的体外试验研究 | 医院横向课题 |
2008-11~2010-06
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8万元
| 课题负责人 |
| MSP-HGF嵌合生长因子对移植供肝缺血再灌注损伤的保护作用及机制研究 | 国家教育部归国留学人员启动基金 |
2008-01~2010-12
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3万元
| 课题负责人 |
07pj14069 | 重组肝细胞生长因子激活剂的研制及其防治急、慢性肝衰竭的动物实验研究 | 上海市科委,浦江人才 |
2007-09~2009-09
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20万元
| 课题负责人 |
- 学术论文
Ji H, Yang TH, Li CL, Zhu YW, Zheng ZG, Zhang JX, Liu Y, Gao YJ, Wu HM, Jiang JX, Yong JK, Chen MK, Tang YJ, Xia Q,
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EBV-encoded miRNAs BHRF1-1 and BART2-5p aggravate post-transplant lymphoproliferative disorder via LZTS2-PI3K-AKT axis.
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Biochem Pharmacol
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2023
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2023 July 5; 115676.
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周艾炜,刘源,
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儿童肝移植免疫耐受的研究进展。
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《器官移植》
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2022
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13(3):288-295.
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Wu J, Xie F, Ji H, Zhang Y, Luo Y, Xia L, Lu T, He K, Sha M, Zheng Z, Yong J, Li X, Zhao D, Yang Y, Xia Q,
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A Clinical-Radiomic Model for Predicting Indocyanine Green Retention Rate at 15 Min in Patients With Hepatocellular Carcinoma.
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Front Surg.
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2022
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24;9:857838.
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Zheng ZG*, Lu YF*, Wang M, Luo Y, Wan P, Zhou T, Feng MX, Zhu JJ, Wu J, Ji H, Song YY, Zhang T, Zhu YB, Cao Q, Chen J, Xia Q,
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Low COVID-19 Vaccine Coverage and Guardian Acceptance Among Pediatric Transplant Recipients.
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J Med Virol
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2022
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2022 Dec; 28377.
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贾丽燕,景懿磊,张千,吕晓颖,吴新瑞,马方晖,刘雯琼,,朱燕波*.
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新型冠状病毒肺炎爆发期间肝移植受者服药依从性与生命质量调查研究[
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肝脏
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2021
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26(6): 655-660
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, F, Gao W, Qin T, et al.
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Immune Cell Function Assays in the Diagnosis of Infection in Pediatric Liver Transplantation: An open-labeled, two center prospective cohort study.
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Translational Pediatrics
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2021
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10(2): 333-343.
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Liu JC, Fei Y, Zhou T, Ji H, Wu J, Gu XQ, Luo Y, Zhu JJ, Feng MX, Wan P, Qiu BJ, Lu YF, Yang T, Deng PF, Zhou CP, Gong DC, Deng J,, Xia Q.
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Bile acids impair vaccine response in children with biliary atresia.
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Frontiers in immunology
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2021
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12:642546
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Gu XQ, Tang D, Tang YJ, Wan P, Qin T, Yang TH, Wu J, Ji H, Liu JC,, Xia Q.
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Multiple microRNAs regulate tacrolimus metabolism through CYP3A5.
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Pharmacol Res.
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2021
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164:105382.
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Zheng JX, Zhou H, Yang TH, Liu JC, Qin T, Gu XQ, Wu J, Zhang Y, Wang HL, Tang YJ,, Mao YM and Xia Q.
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Protective role of microRNA-31 in acetaminophen-induced hepatic necrotic cell death: a negative regulator of c-Jun N-terminal kinase (JNK) signaling pathway.
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Cell Mol Gastroenterol Hepatol
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2021
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23;S2352-345X(21)00156-9.
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Zhu Y, Zhang Z, Song J, Qian W, Gu X, Yang C, Shen N,, and Tang Y.
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SARS-CoV-2-encoded microRNAs inhibit host type I interferon pathway and mediate allelic differential expression of susceptible gene.
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Frontiers in immunology
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2021
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23;12: 767726.
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Zheng J, Tang Y, Yang T, Qin T, Liu J, Gu X,, Xia Q
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The long non-coding RNAs exert regulatory roles in acetaminophen induced liver injury.
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J Dig Dis.
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2019
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20(6):308-317
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, Shi SJ, Zhang ZZ, et al
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Application of a novel liquid biopsy in patients with hepatocellular carcinoma undergoing liver transplantation.
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Oncol Lett
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2018
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15(4):5481-5488
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Shi S,
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Current Antioxidant Treatments in Organ Transplantation
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Oxidative Medicine and Cellular Longevity
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2016
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Volume 2016, 9 pages
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施少军,
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消化系统肿瘤外周血循环肿瘤细胞的研究进展
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胃肠病学
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2016
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2016, 21(2)
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Yang TH, Chen YK,, Han LZ, Shen CH, Zhou T, Luo Y, Zhang JJ, and Xia Q.
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Influence of CYP3A5 genotypes in tacrolimus dose requirement: age and its pharmacological interaction with ABCB1 genetics in Chinese pediatric liver transplantation.
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Int J Clin Pract
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2015
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69(Suppl.183):53-62.
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, Higgs BW, Huang J, Morehouse C, Zhu W, Yao X, Brohawn P, Xiao Z, Sebastian Y, Liu Z, Xia Y, Shen D, Kuziora M, Dong Z, Han H, Gu Y, Gu J, Xia Q, Yao Y.
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HERC5 is a prognostic biomarker for post-liver transplant recurrent human hepatocellular carcinoma.
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J Transl Med.
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2015
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13:379-93.
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Zhao Y,, Sun J, Guo S, Zhang H, Qiu B, Gu J, Wang W, Zhang Z, Tang N, Zhou X, Yu J and Xia Q.
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Genome-wide methylation profiling of different stages of HBV-related HCC development in plasma cell-free DNA reveals potential biomarkers for early detection and high-risk monitoring of HCC.
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Clin Epigenetics
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2014
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6:1-18.
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Chen Y, Han L,, Shen C, Lu J, Yang T, Zhang J, and Xia Q.
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Personalized tacrolimus dose requirement by CYP3A5 but not ABCB1 or ACE genotyping in both recipient and donor after pediatric liver transplantation.
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PLoS One
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2014
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9(10): e109464.
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, Han LZ, Chen YK, et al.
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CYP3A5 genotypes affect tacrolimus pharmacokinetics and infectious complications in Chinese pediatric liver transplant patients.
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Pediatr Transplant.
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2014
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18(2):166-76.
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Feng MX, Ma MZ, Fu Y, Li J, Wang T,, Zhang JJ, Qin WX, Gu JR, Zhang ZG, Xia Q.
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Elevated autocrine EDIL3 protects hepatocellular carcinoma from anoikis through RGD-mediated integrin activation.
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Mol Cancer.
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2014
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13(1):226.
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Li J, Yang XM, Wang YH, Feng MX, Liu XJ, Zhang YL, Huang S, Wu Z,, Qin WX, Gu JR, Xia Q, Zhang ZG.
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Monoamine oxidase A suppresses hepatocellular carcinoma metastasis by inhibiting the adrenergic system and its transactivation of EGFR signaling.
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J Hepatol
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2014
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60(6):1225-34.
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Long XD, Yao JG, Zeng Z, Ma Y, Huang XY, Wei ZH, Liu M, Zhang JJ,, Zhai B, Xia Q.
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Polymorphisms in the coding region of X-ray repair complementing group 4 and aflatoxin B1-related hepatocellular carcinoma.
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Hepatology
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2013
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58(1):171-81.
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Kawai K,, Takahara T, Kudo H, Yata Y, Zhang W, and Sugiyama T
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Matrix metalloproteinase-9 contributes to the mobilization of bone marrow cells in the injured liver
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Cell Transplant
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2012
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21(2-3):453-64
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, Li H, Zhang J, Lu J, Xia Y, and Xia Q
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miR-31 regulates interleukin 2 and kinase suppressor of ras 2 during T cell activation
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Genes and Immunity
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2012
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Zhou T,, Han LZ, Xi ZF, Li QG, Xu N, Zhang JJ, and Xia Q
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Invasive Fungal Infection after Liver Transplantation: Risk Factors and Significance of Immune Cell Function Monitoring
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J Dig Dis
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2011
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12(6):467-75
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邓维,刘蕾,,韩龙志,奚志峰,张建军,夏强
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肝移植早期他克莫司的药动学特征及干扰因素分析
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《中华器官移植杂志》
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2011
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32(12):730-734
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,邱德凯
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肝移植的内科指征及临床进展
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《胃肠病学》
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2011
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16(12):705-711
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Yata Y,, Takahara T, Kudo H, Hirano K, Yasumura S, Minemura M, Scanga AE, Sugiyama T
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Docetaxel inhibits progression of human hepatoma cell line in vitro and is effective in advanced hepatocellular carcinoma
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Hepatol Res
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2010
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40(3):304-10
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,徐龙妹,张程,邓维 夏韵,张建军,夏强
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重组人肝细胞生长因子激活因子(HGFA)质粒构建、表达及其功能研究
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《胃肠病学》
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2010
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15(1):8-11
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, Zhang JJ, Han LZ, Li QG, Xu N, Zhou T, Xi ZF, Wu YM and Xia Q
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Immune Cell Functional Assay in Monitoring of Liver Transplantation Recipients with Infection
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Transplantation
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2010
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89(8):620-26
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, Zhang JJ, Xu LM, Zhang C, Xia Q
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Protective Effects of HGF-MSP Chimer in a Rat Model of Liver Ischemia-reperfusion Injury
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J Dig Dis
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2010
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11(5):299-305
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,张建军,李齐根,张明,宋玉,徐宁,周韬,邓维,王思岳,夏强
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他克莫司缓释胶囊对肝移植术后稳定期患者的临床疗效分析
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《中华移植杂志》
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2009
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3:19-23
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张建军,,陈小松,韩龙志,周韬,王鑫,奚志峰,夏强
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ImmuKnowTM细胞免疫功能测定在监控肝移植术后感染中的应用
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《中华器官移植杂志》
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2009
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30:284-286
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, Takahara T, Yata Y, Xia Q, Nonome K, Shinno E, Kanayama M, Takahara S, and Sugiyama T
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Blockade of Rho/ROCK Signaling Can Prevent Progression of Hepatocellular Carcinoma in Matrix Metalloproteinase-dependent Manner
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Hepatol Res
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2008
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38:810-17
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Tahahara T,, Mazzone M, Yata Y, Nonome K, Kanayama M, Kawai K, Pisacane AM, Takahara S, Li XK and Michieli P
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Metron factor-1 prevent liver injury without promoting tumor growth and metastasis
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Hepatology
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2008
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47(6):2010-25
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