• 基本信息
    导师姓名: 刘俊岭 专业代码: 100100
    性别: 专业名称: 基础医学
    培养单位: 基础医学院 三级学科/
    专业领域:
    导师类型: 博士生导师 专业学位导师:
    联系方式: 021-63846590-776345
    邮编: 200025 邮箱地址: liujl@shsmu.edu.cn
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    中国科学技术协会 中国病理生理学会血管医学专业委员会委员
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    31830050代谢调控血小板衰老死亡的分子机制国家自然科学基金重点项目 2019-01~2023-12 288万元  课题负责人
    91739302危重血管性疾病血栓事件的发生 、发展及干预研究国家自然科学基金委重大研究计划集成项目 2018-01~2020-12 210万元  课题负责人
    81525001血小板活化的分子调控机制国家自然基金国家杰出青年科学基金 2016-01~2020-12 400万元  课题负责人
    91439115血小板内皮聚集受体1调控血管稳态作用机制研究国家自然科学基金重大研究计划培育项目 2015-01~2017-12 150万元  课题负责人
    81170479整合素αIIb亚基介导信号在血小板活化和血栓形成中的作用国家自然科学基金面上项目 2012-01~2015-12 60万元  课题负责人
    2012CB518001GPCR介导的血管炎症和损伤科技部973重大科学研究计划 2012-01~2016-12 270万元  子课题负责人
    81030039血小板介导预转移微环境的形成及其在肺癌转移中的作用国家自然科学基金重点项目 2011-01~2014-12 200万元  课题负责人
    D0303100003血小板在肺癌预转移微环境形成中的作用研究上海市教育委员会,上海市教育发展基金 2011-01~2013-12 15万元  课题负责人
    09PJ1406800整合素alpha 亚基介导外向内信号及其调控机制的研究上海市科委,浦江人才计划资助项目 2009-07~2011-07 30万元  课题负责人
    NECT-08-0351新世纪优秀人才支持计划教育部 2009-07~2011-07 50万元  课题负责人
    0720000030上海高校特聘教授上海市教委 2009-01~2011-12 50万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Xu Y, Jiang H, Li L, Chen F, Liu Y, Zhou M, Wang J, Jiang J, Li X, Fan X, Zhang L, Zhang J, Qiu J, Wu Y, Fang C, Sun H,  Branched-Chain Amino Acid Catabolism Promotes Thrombosis Risk by Enhancing Tropomodulin-3 Propionylation in Platelets.  Circulation  2020  doi: 10.1161/CIRCULATIONAHA.119.043581. 
    Jiang H, Yu Z, Ding N, Yang M, Zhang L, Fan X, Zhou Y, Zou Q, Hou J, Zheng J, Zhang L, Xu Y,  The role of AGK in thrombocytopoiesis and possible therapeutic strategies  Blood  2020  https://doi.org/10.1182/blood.2019003851 
    Hu Z, Qu G, Yu X, Jiang H, Teng XL, Ding L, Hu Q, Guo X, Zhou Y, Wang F, Li HB, Chen L, Jiang J, Su B,, Zou Q.  Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells.  Cell Metabolism  2019  S1550-4131(19)30256-6 
    Wang C, Cheng Y, Zhang X, Li N, Zhang L, Wang S, Tong X, Xu Y, Chen GQ, Cheng S, Fan X,  Vacuolar Protein Sorting 33B Is a Tumor Suppressor in Hepatocarcinogenesis.  Hepatology  2018  68(6):2239-2253. 
    Shen SM, Ji Y, Zhang C, Dong SS, Yang S, Xiong Z, Ge MK, Yu Y, Xia L, Guo M, Cheng J,, Yu J, and Chen GQ.   Nuclear PTEN safeguards pre-mRNA splicing to link Golgi apparatus for its tumor suppressive role.   Nat Commun  2018  9(1):2392. 
    Zhou J, Wu Y, Chen F, Wang L, Rauova L, Hayes VM, Poncz M, Li H, Liu T,, Essex DW.  The disulfide isomerase ERp72 supports arterial thrombosis in mice.  Blood  2017  130(6):817-828. 
    Gu H, Chen C, Hao X, Wang C, Zhang X, Li Z, Shao H, Zeng H, Yu Z, Xie L, Xia F, Zhang F, Liu X, Zhang Y, Jiang H, Zhu J, Wan J, Wang C, Weng W, Xie J, Tao M, Zhang CC,, Chen GQ, and Zheng J  Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis.  J Clin Invest  2016  126(12):4537-4553 
    Liang Y, Fu Y, Qi R, Wang M, Yang N, He L, Yu F, Zhang J, Yun CH, Wang X,, and Kong W.   Cartilage oligomeric matrix protein is a natural inhibitor of thrombin.  Blood  2015  126(7):905-14 
    Delaney MK,, Kim K, Shen B, Stojanovic-Terpo A, Zheng Y, Cho J, Du X.   Agonist-induced platelet procoagulant activity requires shear and a Rac1-dependent signaling mechanism.  Blood  2014  124(12):1957-67. 
    Fan X, Shi P, Dai J, Lu Y, Chen X, Liu X, Zhang K, Wu X, Sun Y, Wang K, Zhu L, Zhang CC, Zhang J, Chen GQ, Zheng J,  Paired immunoglobulin-like receptor B regulates platelet activation.   Blood  2014  124(15):2421-30 
    Chen X, Zhang Y, Wang Y, Li D, Zhang L, Wang K, Luo X, Yang Z, Wu Y,  PDK1 regulates platelet activation and arterial thrombosis.  Blood  2013  121(18): 3718-26. 
    Wang L, Wu Y, Zhou J, Ahmad SS, Mutus B, Garbi N, H?mmerling G,, Essex DW.  Platelet-derived ERp57 mediates platelet incorporation into a growing thrombus by regulation of the αIIbβ3 integrin.  Blood  2013  122(22):3642-50 
    Weng Z, Li D, Zhang L, Chen J, Ruan C, Chen G, Gartner TK,  PTEN regulates collagen-induced platelet activation.  Blood  2010  116(14):2579-81. 
    Flevaris P, Li Z, Zhang G, Zheng Y,, Du X.  Two distinct roles of mitogen-activated protein kinases in platelets and a novel Rac1-MAPK-dependent integrin outside-in retractile signaling pathway.  Blood  2009  113(4):893-901. 
    Jose A. Guerrero, Mark Kyei, Susan Russell,, T. Kent Gartner, Brian Storrie, and Jerry Ware.   Visualizing the von Willebrand factor/glycoprotein Ib-IX axis with a platelet-type von Willebrand disease mutation.  Blood  2009  114(27):5541-6 
    Yin H,, Li Z, Berndt MC, Lowell CA, Du X.  Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway.   Blood  2008  112(4):1139-46. 
    , Fitzgerald ME, Berndt MC, Jackson CW, Gartner TK.  Bruton’s tyrosine kinase is essential for botrocetin/ vWf-induced signaling and GPIb-dependent thrombus formation in vivo.   Blood  2006  108(8):2596-603 
    , Jackson CW, Gruppo RA, Jennings LK, Gartner TK.  The beta3 subunit of the integrin alphaIIbbeta3 regulates alphaIIb-mediated outside-in signaling.  Blood.  2005  105(11):4345-52 
    , Pestina TI, Berndt MC, Steward SA, Jackson CW, and Gartner TK.  Botrocetin/vWf-induced signaling through GPIb-IX-V produces TxA2 in a Ca2+ and aggregation-independent manner without utilizing other receptors.   Blood  2005  106:2750-2756. 
    Cho MJ,, Pestina TI, Steward SA, Thomas DW, Coffman TM, Wang D, Jackson CW, Gartner TK.  The roles of alpha IIb beta 3-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregation.   Blood  2003  101(7):2646-51.