• 基本信息
    导师姓名: 刘俊岭 专业代码: 100100
    性别: 专业名称: 基础医学
    培养单位: 基础医学院 三级学科/
    专业领域:
    导师类型: 博士生导师 专业学位导师:
    联系方式:
    邮箱地址: liujl@shsmu.edu.cn 邮编: liujl@shsmu.edu.cn
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    中国科学技术协会 中国病理生理学会委员
    中华医学会细胞生物专业青年委员
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    91739302危重血管性疾病血栓事件的发生 、发展及干预研究国家自然科学基金委重大研究计划集成项目 2018-01~2020-12 210万元  课题负责人
    81525001血小板活化的分子调控机制国家自然基金国家杰出青年科学基金 2016-01~2020-12 350万元  课题负责人
    91439115血小板内皮聚集受体1调控血管稳态作用机制研究国家自然科学基金重大研究计划培育项目 2015-01~2017-12 150万元  课题负责人
    81170479整合素αIIb亚基介导信号在血小板活化和血栓形成中的作用国家自然科学基金面上项目 2012-01~2015-12 60万元  主要责任人
    2012CB518001GPCR介导的血管炎症和损伤科技部973重大科学研究计划 2012-01~2016-12 220万元  子课题负责人
    81030039血小板介导预转移微环境的形成及其在肺癌转移中的作用国家自然科学基金重点项目 2011-01~2014-12 200万元  课题负责人
    D0303100003血小板在肺癌预转移微环境形成中的作用研究上海市教育委员会,上海市教育发展基金 2011-01~2013-12 15万元  主要责任人
    KLTH-2009-01卫生部血栓止血重点实验室开放课题卫生部 2009-10~2012-09 3万元  主要责任人
    09PJ1406800整合素alpha 亚基介导外向内信号及其调控机制的研究上海市科委,浦江人才计划资助项目 2009-07~2011-07 30万元   
    NECT-08-0351新世纪优秀人才支持计划教育部 2009-07~2011-07 50万元  主要责任人
    09PJ1406800整合素alpha亚基介导信号及其调控机制研究上海市科委 2009-07~2011-07 30万元  主要责任人
    0720000030上海高校特聘教授上海市教委 2009-01~2011-12 50万元  主要责任人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Ma Q, Zhu C, Zhang W, Ta N, Zhang R, Liu L, Feng D, Cheng H,, and Chen Q.   Mitochondrial PIP3-binding protein FUNDC2 supports platelet survival via AKT signaling pathway.  Cell Death Differ.  2018  doi: 10.1038/s41418-018-0121-8. 
    Wang C, Cheng Y, Zhang X, Li N, Zhang L, Wang S, Tong X, Xu Y, Chen GQ, Cheng S, Fan X,  Vacuolar Protein Sorting 33B Is a Tumor Suppressor in Hepatocarcinogenesis.  Hepatology.  2018  doi: 10.1002/hep.30077.  
    Shen SM, Ji Y, Zhang C, Dong SS, Yang S, Xiong Z, Ge MK, Yu Y, Xia L, Guo M, Cheng J,, Yu J, and Chen GQ.   Nuclear PTEN safeguards pre-mRNA splicing to link Golgi apparatus for its tumor suppressive role.   Nat Commun.  2018  9(1):2392. 
    Fan X, Wang C, Shi P, Gao W, Gu J, Geng Y, Yang W, Wu N, Wang Y, Xu Y, Chen X, Zhang L, Wang K, Su B,  Platelet MEKK3 regulates arterial thrombosis and myocardial infarct expansion in mice.  Blood Advances  2018  2(12):1439-1448. 
    Shi P, Zhang L, Zhang M, Yang W, Wang K, Zhang J, Otsu K, Huang G, Fan X,  Platelet-Specific p38α Deficiency Improved Cardiac Function After Myocardial Infarction in Mice.  Arterioscler Thromb Vasc Biol.  2017  37(12):e185-e196. 
    Zhou J, Wu Y, Chen F, Wang L, Rauova L, Hayes VM, Poncz M, Li H, Liu T,, Essex DW.  The disulfide isomerase ERp72 supports arterial thrombosis in mice.  Blood.  2017  130(6):817-828. 
    Lai W, Cai Y, Zhou J, Chen S, Qin C, Yang C,, Xie X, and Du C.   Deficiency of the G protein Gαq ameliorates experimental autoimmune encephalomyelitis with impaired DC-derived IL-6 production and Th17 differentiation.  Cell Mol Immunol.  2017  14(6):557-567 
    Chen Y, Yang W, Guo L, Wu X, Zhang T,, and Zhang J.  Atractylodes lactone compounds inhibit platelet activation.  Platelets.  2017  28(2):194-202 
    Gao W, Wang K, Zhang L, Li J,, Chen X, and Luo X.   Pharmacological inhibition of S6K1 facilitates platelet activation by enhancing Akt phosphorylation.   Platelets.  2017  19:1-10 
    Wang Y, Jiang L, Mo X, Lan Y, Yang X, Liu X, Zhang J, Zhu L,, and Wu X. .  Megakaryocytic Smad4 Regulates Platelet Function through Syk and ROCK2 Expression.   Mol Pharmacol.  2017  92(3):285-296 
    Chen X, Fan X, Tan J, Shi P, Wang X, Wang J, Kuang Y, Fei J,, Dang S, and Wang Z.  Palladin is involved in platelet activation and arterial thrombosis.  Thromb Res.  2017  149:1-8 
    Gao W, Shi P, Chen X, Zhang L,, Fan X, and Luo X.   Clathrin-mediated integrin αIIbβ3 trafficking controls platelet spreading.   Platelets.   2017  1-12 
    Zhang J, Li Z, Hu X, Su Q, He C,, Ren H, Qian M, Liu J, Cui S, and Jiang W.   Knockout of P2Y12 aggravates experimental autoimmune encephalomyelitis in mice via increasing of IL-23 production and Th17 cell differentiation by dendritic cells.  Brain Behav Immun.  2017  62:245-255. 
    Zhang W, Ren H, Xu C, Zhu C, Wu H, Liu D, Wang J, Liu L, Li W, Ma Q, Du L, Zheng M, Zhang C,, and Chen Q.  Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injury.  Elife  2016  5. pii: e21407 
    Dai J, Lu Y, Wang C, Chen X, Fan X, Gu H, Wu X, Wang K, Gartner TK, Zheng J, Chen G, Wang X,  VPS33B Regulates VWF Positive Vesicular Trafficking to Megakaryocyte.  J Pathol.  2016  240(1):108-19. 
    Gu H, Chen C, Hao X, Wang C, Zhang X, Li Z, Shao H, Zeng H, Yu Z, Xie L, Xia F, Zhang F, Liu X, Zhang Y, Jiang H, Zhu J, Wan J, Wang C, Weng W, Xie J, Tao M, Zhang CC,, Chen GQ, and Zheng J  Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis.  J Clin Invest.  2016  126(12):4537-4553 
    Yao T, Ying X, Zhao Y, Yuan A, He Q, Tong H, Ding S,, Peng X, Gao E, Pu J, He B.  Vitamin D Receptor Activation Protects against Myocardial Reperfusion Injury through Inhibition of Apoptosis and Modulation of Autophagy.  Antioxid Redox Signal.  2015  22(8):633-50. 
    Cheng Z,  Receptor-mediated inhibitory mechanisms and the regulation of platelet function.  Sci China Life Sci.  2015  58(12):1299-301 
    Liang Y, Fu Y, Qi R, Wang M, Yang N, He L, Yu F, Zhang J, Yun CH, Wang X,, and Kong W.   Cartilage oligomeric matrix protein is a natural inhibitor of thrombin.  Blood.  2015  126(7):905-14 
    Di C, Lin X, Zhang Y, Zhong W, Yuan Y, Zhou T,, Xia Z.  ophils-associated OX40 Ligand Participates in the Initiation of Th2 Responses during Airway Inflammation.  J Biol Chem.   2015  Apr 3. 
    Zhi H, Dai J,, Zhu J, Newman DK, Gao C, and Newman PJ.  Platelet Activation and Thrombus Formation over IgG Immune Complexes Requires Integrin αIIbβ3 and Lyn Kinase.  PLoS One  2015  10(8):e0135738 
    Delaney MK,, Kim K, Shen B, Stojanovic-Terpo A, Zheng Y, Cho J, Du X.   Agonist-induced platelet procoagulant activity requires shear and a Rac1-dependent signaling mechanism.  Blood  2014  124(12):1957-67. 
    Fan X, Shi P, Dai J, Lu Y, Chen X, Liu X, Zhang K, Wu X, Sun Y, Wang K, Zhu L, Zhang CC, Zhang J, Chen GQ, Zheng J,  Paired immunoglobulin-like receptor B regulates platelet activation.   Blood  2014  124(15):2421-30 
    Xu Z, Chen X, Zhi H, Gao J, Bialkowska K, Byzova TV, Pluskota E, White GC 2nd,, Plow EF, Ma YQ.  Direct interaction of kindlin-3 with integrin αIIbβ3 in platelets is required for supporting arterial thrombosis in mice.  Arterioscler Thromb Vasc Biol.  2014  34(9):1961-7. 
    Chen X, Zhang Y, Wang Y, Li D, Zhang L, Wang K, Luo X, Yang Z, Wu Y,  PDK1 regulates platelet activation and arterial thrombosis.  Blood  2013  121(18): 3718-26. 
    Wang Y, Sun Y, Li D, Zhang L, Wang K, Zuo Y, Gartner TK,  Platelet P2Y12 is involved in murine pulmonary metastasis.  PLoS One.   2013  8(11):e80780 
    Wang L, Wu Y, Zhou J, Ahmad SS, Mutus B, Garbi N, H?mmerling G,, Essex DW.  Platelet-derived ERp57 mediates platelet incorporation into a growing thrombus by regulation of the αIIbβ3 integrin.  Blood  2013  122(22):3642-50 
    Zhang S, Ye J, Zhang Y, Xu X,, Zhang SH, Kunapuli SP, and Ding Z.  P2Y(12) protects platelets from apoptosis via PI3k-dependent Bak/Bax inactivation.  J. Thromb. Haemost.  2013  11(1):149-60 
    Delaney MK,, Zheng Y, Berndt MC, Du X.   The Role of Rac1 in Glycoprotein Ib-IX-Mediated Signal Transduction and Integrin Activation.  Arterioscler Thromb Vasc Biol  2012  32(11):2761-8. 
    Haixia Niu, Zhenlu Xu , Ding Li , Lin Zhang , Kemin Wang , Donald B. Taylor ,, T. Kent Gartner  Peptide LSARLAF induces integrin β3 dependent outside-in signaling in platelets  Thrombosis Research  2012  130(2):203-9 
    Delaney MK,, Zheng Y, Berndt MC, Du X.   The Role of Rac1 in Glycoprotein Ib-IX-Mediated Signal Transduction and Integrin Activation.  Arterioscler Thromb Vasc Biol  2012  32(11):2761-8. 
    Li D, Wang Y, Zhang L, Luo X, Li J, Chen X, Niu H, Wang K, Sun Y, Wang X, Yan Y, Chai W, Gartner TK,  Roles of purinergic receptor P2Y, G protein-coupled 12 in the development of atherosclerosis in apolipoprotein E-deficient mice.  Arterioscler Thromb Vasc Biol  2012  32(8):e81-9 
    Niu H, Chen X, Gruppo RA, Li D, Wang Y, Zhang L, Wang K, Chai W, Sun Y, Ding Z, Gartner TK,  Integrin αIIb-Mediated PI3K/Akt Activation in Platelets.Integrin αIIb-Mediated PI3K/Akt Activation in Platelets.  PLoS One  2012  7(10):e47356 
    Zhen Weng, Ding Li, Lin Zhang, Jian Chen, Changgeng Ruan, Guoqiang Chen, T. Kent Gartner,  PTEN regulates collagen-induced platelet activation.  Blood  2010  116(14):2579-81. 
    Xiang B, Zhang G,, Morris AJ, Smyth SS, Gartner TK, Li Z.   A G(i) -independent mechanism mediating Akt phosphorylation in platelets.  J Thromb Haemost.  2010  8(9):2032-41 
    Zhang S, Hu L, Du H, Guo Y, Zhang Y, Niu H, Jin J, Zhang J,, Zhang X, Kunapuli SP, Ding Z.   BF0801, a novel adenine derivative, inhibits platelet activation via phosphodiesterase inhibition and P2Y12 antagonism.  Thromb Haemost.  2010  104(4):845-57. 
    Zhenyu Li, Guoying Zhang,, Aleksandra Stojanovic, Changgeng Ruan, Clifford A Lowell, and Xiaoping Du.   An important role of the SRC family kinase LYN in stimulating platelet granule secretion.  Journal of Biological Chemistry.  2010  285(17):12559-70 
    Flevaris P, Li Z, Zhang G, Zheng Y, Liu J, Du X.  Two distinct roles of mitogen-activated protein kinases in platelets and a novel Rac1-MAPK-dependent integrin outside-in retractile signaling pathway.  Blood  2009  113(4):893-901. 
    Jose A. Guerrero, Mark Kyei, Susan Russell,, T. Kent Gartner, Brian Storrie, and Jerry Ware.   Visualizing the von Willebrand factor/glycoprotein Ib-IX axis with a platelet-type von Willebrand disease mutation.  Blood  2009  114(27):5541-6 
    Guerrero JA, Shafirstein G, Russell S, Varughese KI, Kanaji T,, Gartner TK, B?umler W, Jarvis GE, Ware J.  In vivo relevance for platelet glycoprotein Ibalpha residue Tyr276 in thrombus formation.   J Thromb Haemost.  2008  6(4):684-91. 
    , Jackson CW, Gartner TK  The Src requirement for washed platelet aggregation and dense granule secretion in response to stimulation by a low level gamma-thrombin   J Thromb Haemost.  2008  6(6):1035-7 
    , Joglekar M, Ware J, Fitzgerald ME, Lowell CA, Berndt MC, Gartner TK.  Evaluation of the physiological significance of botrocetin/ von Willebrand factor in vitro signaling.  J Thromb Haemost.  2008  6(11):1915-22. 
    Yin H,, Li Z, Berndt MC, Lowell CA, Du X.  Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway.   Blood  2008  112(4):1139-46. 
    Guerrero JA, Shafirstein G, Russell S, Varughese KI, Kanaji T,, Gartner TK, B?umler W, Jarvis GE, Ware J.  Platelet glycoprotein Ib alpha supports experimental lung metastasis.   Proc Natl Acad Sci U S A.  2007  104(21):9024-8 
    , Ware J, Jackson CW, Gartner TK.  FcRgamma-chain signals in the absence of glycoprotein VI.  J Thromb Haemost.  2007  5(1):201-3. 
    , Ware J, Jackson CW, Gartner TK.  FcRgamma-chain dependent alphallbbeta3 elicited outside-in signaling.   J Thromb Haemost.  2007  5(2):426-8. 
    , Fitzgerald ME, Berndt MC, Jackson CW, Gartner TK.  Bruton’s tyrosine kinase is essential for botrocetin/ vWf-induced signaling and GPIb-dependent thrombus formation in vivo.   Blood  2006  108(8):2596-603 
    , Jackson CW, Gruppo RA, Jennings LK, Gartner TK.  The beta3 subunit of the integrin alphaIIbbeta3 regulates alphaIIb-mediated outside-in signaling.  Blood.  2005  105(11):4345-52 
    Zhao M,, Wang C, Wang L, Liu H, Peng S.  Synthesis and Biological Activity of Nitronyl Nitroxide Containing Peptides.   J Med Chem.  2005  48(13):4285-92 
    , Pestina TI, Berndt MC, Steward SA, Jackson CW, and Gartner TK.  Botrocetin/vWf-induced signaling through GPIb-IX-V produces TxA2 in a Ca2+ and aggregation-independent manner without utilizing other receptors.   Blood  2005  106:2750-2756. 
    , Pestina TI, Berndt MC, Steward SA, Jackson CW, Gartner TK.  The roles of ADP and TXA2 in botrocetin/vWf- induced aggregation of washed platelets  J Thromb Haemost.  2004  2(12):2213-22. 
    Cho MJ,, Pestina TI, Steward SA, Thomas DW, Coffman TM, Wang D, Jackson CW, Gartner TK.  The roles of alpha IIb beta 3-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregation.   Blood  2003  101(7):2646-51. 
    , Zhao M, Wang C, and Peng S.  Synthesis and bioactivities of nitronylnitroxide and RGD containing pseudopeptides.  Bioorg. Med. Chem. Lett.  2003  13(22):4065-4069.