• 基本信息
    导师姓名: 苏冰 专业代码: 100100
    性别: 专业名称: 基础医学
    培养单位: 基础医学院 三级学科/
    专业领域:
    导师类型: 博士生导师 专业学位导师:
    联系方式: 021-63846590-776207
    邮编: 200025 邮箱地址: bingsu@sjtu.edu.cn
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    JMCB和Cellular Immunology副主编
    国家自然基金委重点项目、面上项目、青年项目等评审
    濒危动植物保护生物学教育部重点实验室”学术委员会委员
    上海交通大学讲席教授、特聘教授晋升委员会委员 
    上海交通大学医学院医学科学研究高评委委员
    中国细胞生物学学会委员
    中国科学Science China Life Science/ Immunology and Cell Biology、BBRC等杂志编委
    上海交通大学研究生教育指导委员会 
    国家高层次人才计划评审专家
    上海市欧美同学会会员
    华人生物学家协会会员
    《现代免疫学》杂志主编
    美国免疫学协会会员
    上海交通大学长聘教轨晋升委员会
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    31930035固有淋巴细胞调控肠道免疫稳态的分子机制及生理病理功能国家自然科学基金委员会 2020-01~2024-12 308万元  课题负责人
    16410723300Sin1(mTORC2)在肿瘤发生中的作用及其分子机制上海市科委 2016-07~2019-06 30万元  课题负责人
    15GWZK0102上海市第四轮公共卫生三年行动计划重点学科建设项目传染病与卫生微生物学上海市卫计委 2016-01~2017-12 36万元  子课题负责人
    81430033外周免疫失衡与炎症性自身免疫病相关疾病发生发展的细胞分子机制国家自然基金委重点项目 2015-01~2019-12 320万元  课题负责人
    31470845MEKK2在固有免疫抗细菌感染中的调控机制国家自然基金委面上项目 2015-01~2018-12 95万元  课题负责人
    13JC1404700MEKK2/3参与炎症性肠病中Th17/Treg细胞分化和功能的分子机制上海市科委基础研究重点项目 2013-09~2016-08 50万元  课题负责人
    PR093728The Role of mTOR Signaling in the Regulation of RAG Expression and Genomic Stability during B Lymphocyte DevelopmentDOD Grant 2010-04~2013-04 754.6万元  课题负责人
    RO1AI063348Regulation and Function of MEKK3 in Dendritic CellsNIH 2005-04~2011-02 769.2万元  课题负责人
    RO1CA097159Mechanisms of relA Activation in Pancreatic CancerNIH 2003-09~2007-08 567万元  课题负责人
    RO1HL070225Molecular Mechanisms of MEKK3-Signaling in AngiogenesisNIH 2003-04~2007-05 771.8万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    X Ouyang, Y Han, G Qu, M Li, O Arojo, H Sun, X Liu, D Liu, LChen, Q Zou,  Metabolic regulation of T cell development by Sin1-mTORC2 is mediated by pyruvate kinase M2.  J Mol Cell Biol.  2019  2019 Feb 1;11(2):93-106 
    Hu ZL, Qu GJ, Yu XY, Jiang HJ, Teng XL, Ding L, Hu QW, Guo WX, Zhou Y,Wang F, Li HB, Chen L, Jiang J,, Liu JL, Zou Q.  Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+T Cells.   Cell Metabolism.  2019  https://doi.org/10.1016/j.cmet.2019.05.016 
    Zhaoyuan Liu, Yaqi Gu, Svetoslav Chakarov, Camille Bleriot, Immanuel Kwok, Xin Chen, Amanda Shin, Weijie Huang, Regine J. Dress, Charles-Antoine Dutertre, Andreas Schlitzer, Jinmiao Chen, Lai Guan Ng, Honglin Wang, Zhiduo Liu,, and Florent Ginhoux.  Fate mapping via Ms4a3 expression history traces monocyte-derived cells.  Cell  2019  accepted 
    M Li, AS Lazorchak, X Ouyang, H Zhang, H Liu, O.A Arojo, G Qu, X Xu, X Liu, W Zhang, Q Wang, D Liu, F Li,  Sin1/mTORC2 regulates B cell growth and metabolism via mTORC1 and Myc activation.   Cell Mol Immunol.  2019  2019 Jan 31. doi: 10.1038/s41423-018-0185-x. 
    OA. Arojo, X Ouyang, D Liu, T Meng, SM. Kaech, JP. Pereira and B Su.   Active mTORC2 Signaling in Naive T Cells Suppresses Bone Marrow Homing by Inhibiting CXCR4 Expression.  J Immunol   2018  2018; 201:908-915 
    Wu ZR, Yan LC, Liu YT, Cao L, Guo YH, Zhang Y, Yao H, Cai L, Shang HB, Rui WW, Yang G, Zhang XB, Tang H, Wang Y, Huang JY, Wei YX, Zhao WG,, Wu ZB.   Inhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours.  Nature Communications.   2018  2018 9:4624.  
    Jiyu Tong, Guangchao Cao, Ting Zhang, Esen Sefik, Maria Carolina Amezcua Vesely, James P Broughton, Shu Zhu, Huabin Li, Bin Li, Lei Chen, Howard Y Chang,, Richard A Flavell, Hua-Bing Li.  m6A mRNA methylation sustains Treg suppressive functions  Cell Research  2018  82.10.1038/cr.2018.7. 
    XYYu, XL Teng, FX Wang, YH Zheng, GJ Qu, Y Zhou, ZLHu, ZQ Wu, YZChang, L Chen, HB Li,, LM Lu, ZD Liu, SC Sun, and Q Zou.  Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome.  J. Exp. Med.  2018  90. 2018. 3;215(9):2463-2476. 
    Xu YY, Ouyang XX,Yan LC, Zhang ML, Hu ZL, Gu JM, Fan XM, Zhang L, Zhang JF, Xue S, Chen GQ,, and Liu JL  Sin1 regulates ischaemia-induced microthrombosis through integrin?αIIbβ3-mediated outside-in signaling and hypoxia responses in platelets. Arteriosclerosis, Thrombosis, and Vascular Biology.  Arteriosclerosis, Thrombosis, and Vascular Biology.   2018  2018 Dec;38(12):2793-2805.  
    XM Fan, CH Wang,PL Shi,W Gao, JMGu,Y Geng,WL Yang,NB Wu,Y Wang,Y Xu,X Chen, L Zhang,KM Wang,, JL Liu.  Platelet MEKK3 regulates arterial thrombosis and myocardial infarct expansion in mice.   Blood Adv.  2018  2018 Jun 26;2(12):1439-1448.  
    XY Yu, YM Lao, XL Teng, S Li, Y Zhou, FX Wang, XWGuo, SY Deng,YZ Chang, XF Wu, ZD Liu, L Chen, LM Lu, JK Cheng, B Li,, J Jiang,HB Li , CX Huang, J Yi , Q Zou.   ENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation.   Nature Communications.   2018  2018: 9:3157 
    Tan R, Nakajima S, Wang Q, Sun H, Xue J, Wu J, Hellwig S, Zeng X,?Yates NA, Smithgall TE, Lei M, Jiang Y, Levine AS,, Lan L.   Nek7 protects telomeres from oxidative DNA damage by phosphorylation and stabilization of TRF1  Mol Cell  2017  2765(17):30041-2. 
    Zhu H, Lou F, Yin Q, Gao Y, Sun Y, Bai J, Xu Z, Liu Z, Cai W, Ke F, Zhang L, Zhou H, Wang H, Wang G, Chen X, Zhang H, Wang Z, Ginhoux F, Lu C,, Wang H.  RIG‐I antiviral signaling drives interleukin‐23 production and psoriasis‐like skin disease.   EMBO Mol Med.  2017  9(5):589-604 
    Liu W, Liu X, Li Y, Zhao J, Liu Z, Hu Z, Wang Y, Yao Y, Miller AW2,, Cookson MR, Li, KangZ  LRRK2?promotes?the?activation?of?NLRC4?inflammasome?during?Salmonella?  J Exp Med.  2017  214(10):3051-3066. 
    Zepp JA,Zhao J,Liu C,Bulek K,?Wu L,Chen X,Hao Y,Wang Z,Wang X,Ouyang W,Kalady MF,Carman J,?Yang WP,Zhu J, Blackburn C Huang YH, Hamilton TA1,, LiX.  IL-17A-Induced PLET1 Expression Contributes to Tissue?Repair and Colon  J Immunol.  2017  199(11):3849-3857. 
    Greenblatt MB, Shin DY, Oh H, Lee KY, Zhai B, Gygi SP, Lotinun S, Baron R, Liu D,, Glimcher LH, Shim JH  MEKK2 mediates an alternative β-catenin pathway that promotes bone formation  Proc Natl Acad Sci U S A  2016  113(9):E1226-35 
    Wang Q, Tan R, Zhu X, Zhang Y, Tan Z,, Li Y  Oncogenic K-ras confers SAHA resistance by up-regulating HDAC6 and c-myc expression  Oncotarget  2016  7(9):10064-72 
    Fisher OS, Deng H, Liu D, Zhang Y, Wei R, Deng Y, Zhang F, Louvi A, Turk BE, Boggon TJ,  Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex  Nature Communications  2015  6:7937 
    Pengda Liu, Wenjian Gan, Y. Rebecca Chin, Kohei Ogura, Jianping Guo, Jinfang Zhang, Bin Wang, John Blenis, Lewis C. Cantley, Alex Toker,, Wenyi Wei  PtdIns(3,4,5)P3-dependent activation of the mTORC2 kinase complex  Cancer Discov  2015  5 (11): 1194-209 
    Kaur S, Kroczynska B, Sharma B, Sassano A, Arslan AD, Majchrzak-Kita B, Stein BL, McMahon B, Altman JK,, Calogero RA, Fish EN, Platanias LC  Critical roles for Rictor/Sin1 complexes in IFN-dependent gene transcription and generation of antiproliferative responses  J Biol Chem  2014  289(10):6581-91 
    Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, Lee TH, Asara JM, Manning BD, Blenis J,, Wei W.  Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis  Nat Cell Biol  2013  15(11):1340-50 
    Zhou XT, Chen DN, Xie ZQ, Peng Z, Xia KD, Liu HD, Liu W,, Li JD.  Functional analysis of the distal region of the third intracellular loop of PROKR2  Biochem Biophys Res Commun  2013  439(1):12-7 
    Fan Zhang, Adam Lazorchak, Dou Liu, Fanping Chen,  Inhibition of the mTORC2 and chaperone pathways to treat leukemia  Blood  2012  119(25):6080-8 
    Xing Chang, Adam S. Lazorchak, Dou Liu,  Sin1 regulates Treg-cell development but is not required for T-cell growth and proliferation  Eur J Immunol  2012  42(6):1639-47 
    Xiaofang Wang, Fan Zhang, Fanping Chen, Dou Liu, Yi Zheng, Yongliang Zhang, Chen Dong,  MEKK3 regulates IFNg production in T cells through the Rac1/2 dependent MAPK cascades  J Immunol  2011  186:5791-5800 
    , Estela Jacinto  Mammalian TOR signaling to the AGC kinases  Crit Rev Biochem Mol Biol  2011  46(6):527-47 
    Adam S. Lazorchak,  Perspectives on the role of mTORC2 in B lymphocyte development, immunity and tumorigenesis  Protein & Cell  2011  2(7):523-530 
    Xing Chang, Fang Liu, Xiaofang Wang,  MEKK2 and MEKK3 regulate TGF-b-mediated helper T cell differentiation  Immunity  2011  34:201-212 
    You-Tong Wu, Weiming Ouyang, Adam S Lazorchak, Dou Liu, Han-Ming Shen,  mTOR complex 2 targets Akt for proteasomal degradation via phosphorylation at the hydrophobic motif  J Biol Chem  2011  286:14190-14198 
    Adam S Lazorchak, Dou Liu, Valeria Facchinetti, Annarita Di Lorenzo, William C Sessa, David G Schatz,  Sin1 suppresses rag1/2 and il7r gene expression through Akt2 in B cells  Mol Cell  2010  39:433-443 
    Xiaofang Wang, Yongliang Zhang, Valeria Facchinetti, Yuan Zhuang,  MEKK3 Is Essential for Lymphopenia-Induced T cell Proliferation and Survival  J Immunol  2009  182(6):3597-3608 
    Valeria Facchinetti, Weiming Ouyang, Hua Wei, Nelyn Soto, Adam Lazorchak, Christine Gould, Carolyn Lowry, Alexandra C. Newton, Yuxin Mao, Robert Q. Miao, William C. Sessa, Jun Qin, Pumin Zhang,, Estela Jacinto  The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C  EMBO J  2008  27(14):1932-43 
    Kihwan Kim, Omar Duramad, Xiaofeng Qin and Su B.  MEKK3 is essential for lipopolysaccharide-induced il-6 and gm-csf production in macrophages.  Immunology.   2007  120(2):242-50 
    Dongyu Zhang, Valeria Fachinnetti, Xiaofang Wang, Qiaojia Huang, Jun Qin,  Identification of MEKK2/3 serine phosphorylation site targeted by the Toll-like receptor- and stress-pathways  EMBO J  2006  25:97-107 
    Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, Huang Q, Qin J,  SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.   Cell  2006  127(1):125-3 
    Jinke Cheng, Dongyu Zhang, Kihwan Kim, Yingxin Zhao, Yingming Zhao,  Mip1, an MEKK2 interacting protein, regulates MEKK2 dimerization and activation  Mol Cell Biol  2005  25(14):5955-5964 
    Jinke Cheng, Ling Yu, Dongyu Zhang, Qiaojia Huang, David Spencer,  Dimerization through the catalytic domain is essential for MEKK2 activation  J. Biol. Chem.  2005  280:13477-82 
    Jinke Cheng, Ling Yu, Dongyu Zhang, Qiaojia Huang, David Spencer,  Dimerization through the catalytic domain is essential for MEKK2 activation.  J. Biol. Chem  2005  280:13477-82 
    Qiaojia Hunag, Jianhua Yang, Jinke Cheng, CM Walker, Z.G. Liu,  Differential regulation of interleukin-1 receptor and toll like receptor (TLR) signaling by MEKK3.  Nature Immunology  2004  5:95-103 
    Zijian Guo, Gavin Clydesdale, Jinke Cheng, Kihwan Kim, Lin Gan, David J. McConkey, Stephen E. Ullrich, Yuan Zhuang*,  Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-Cell receptor signal transduction  Mol Cell Biol  2002  22(16):5761-5768 
    Xu X,, Barndt RJ, Chen H, Xin H, Yan G, Chen L, Cheng D, Heitman J, Zhuang Y, Fleischer S, Shou W.  FKBP12 is the only FK506 binding protein mediating T-cell inhibition by the immunosuppressant FK506.   Transplantation   2002  Jun 15;73(11):1835-8 
    , Cheng JK, Yang J  MEKK2 mediates T cell co-stimulation of the JNK cascade and IL-2 gene expression  J Biol Chem  2001  276:14784-90 
    Yang J, Lin Y, Guo Z, Cheng J, Huang H, Liao W, Chen Z, Liu Z,  The essential role of MEKK3 in TNF-induced NF-kB activation  Nature Immunology  2001  2:620-624 
    Cheng J, Yang J, Xia Y, Karin, M.,  Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation.   Mol Cell Biol  2000  20(7):2334-2341 
    Xia Y, Makris C,, Li EG, Yang JH, Nemerow GR, Karin M.  MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration.   PNAS  2000  97(10): 5243-5248 
    Yang J, Boerm M, McCarty M, Bucana C, Fidler J, Zhuang Y,  Essential role of MEKK3 in early embryonic cardiovascular development  Nature Genetics  2000  24:309-313 
    Lee H, Jiang F, Wang Q, Nicosia SV, Yang J,, Bai W.  MEKK1 activation of human Estrogen receptor a and stimulation of the agonisttic activity of 4-hydroxytamoxifen in endometrial and ovarian cancer cells.  Molecular Endocrinology  2000  14(11):1882-96 
    Dong Z, Killion JJ, Kumar R, Eue I, Yang X, Lu W,, Fidler IJ.  Activation of cytokine production, tumoricidal properties, and tyrosine phosphorylation of MAPKs in human monocytes by a new synthetic lipopeptide, JBT3002  J Leukocyte Biol  1998  63(6):766-774 
    Wang Y,, Sah VP, Brown JH, Han J, Chien KR.  Cardiac hypertrophy induced by Mitogen-activated Protein Kinase Kinase , a specific activator for c-jun NH2-terminal kinase in ventricular muscle cells.  J. Biol. Chem.   1998  273:5423-5426 
    Xia Y, Wu Z,, Murray B, and Karin, M.  JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components: MEKK1 and JNK.   J Leukocyte Bio  1998  63(6):766-774, 
    Xia Y, Wu Z,, Murray B, and Karin, M.   JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components: MEKK1 and JNK.   Genes & Dev  1998  12(21):3369-3381 
    Li YS, Shyy JY, Li S, Lee J,, Karin M, Chien S.  Shear stress activates both JNK and Erk kinase pathways. Mole.  Mole. Cell. Biol.  1996  16:5947-5954 
    Cavigelli M, Dolfi F,, Yoshioka K and Karin M  The tumor promoter arsenite stimulates AP-1 activity through inhibition of a JNK phosphatase.   EMBO J  1996  15:6269-6279 
    Derijard, B., Hibi, M., Wu, I-Huan, Barrett, T.,, Deng, T., Karin, M., and Davis, R.J  JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphrylates the cJun activation domain  Cell   1994  76:1025-1037 
    Lee, S.,, Maher, S., and Bothwell, A.L.M.  Ly6A is required for antigen-specific response and expression of T cell receptor  EMBO J  1994  13:2167-2176 
    , Jacinto, E., Hibi, M., Kallunki, T., Karin, M., and Ben-Neriah, Y  JNK mediates signal integration during costimulation of T lymphocytes  Cell  1994  77:727-736 
    , Waneck, G.L., Flavell, R.A. and Bothwell, A.L.M.   The glycosyl phosphatidylinositol anchor is critical for Ly-6A/E mediated T cell activation.  J. Cell Biol.  1991  2.112:337-384 
    , Bothwell, A.L.M  Biosynthesis of a phosphatidylinositol-glycan-linked membrane protein: signals for posttranslational processing of the Ly-6E antigen  Mol. Cell. Biol.  1989  9: 3369-3376