- 基本信息
导师姓名:
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苏冰
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学科代码:
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100100
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性别:
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男
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学科名称:
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基础医学
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培养单位:
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基础医学院
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三级学科
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导师类型:
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博士生导师
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专业领域名称:
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联系方式:
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021-63846590-776207
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专业领域代码:
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邮编:
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200025
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邮箱地址:
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bingsu@sjtu.edu.cn
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- 研究方向 (点击浏览详细信息)
- 社会任职
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JMCB和Cellular Immunology副主编
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国家自然基金委重点项目、面上项目、青年项目等评审
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濒危动植物保护生物学教育部重点实验室”学术委员会委员
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上海交通大学讲席教授、特聘教授晋升委员会委员
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上海交通大学医学院医学科学研究高评委委员
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中国细胞生物学学会委员
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中国科学Science China Life Science/ Immunology and Cell Biology、BBRC等杂志编委
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上海交通大学研究生教育指导委员会
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国家高层次人才计划评审专家
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上海市欧美同学会会员
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华人生物学家协会会员
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《现代免疫学》杂志主编
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美国免疫学协会会员
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上海交通大学长聘教轨晋升委员会
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- 科研项目
31930035 | 固有淋巴细胞调控肠道免疫稳态的分子机制及生理病理功能 | 国家自然科学基金委员会 |
2020-01~2024-12
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308万元
| 课题负责人 |
16410723300 | Sin1(mTORC2)在肿瘤发生中的作用及其分子机制 | 上海市科委 |
2016-07~2019-06
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30万元
| 课题负责人 |
15GWZK0102 | 上海市第四轮公共卫生三年行动计划重点学科建设项目传染病与卫生微生物学 | 上海市卫计委 |
2016-01~2017-12
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36万元
| 子课题负责人 |
81430033 | 外周免疫失衡与炎症性自身免疫病相关疾病发生发展的细胞分子机制 | 国家自然基金委重点项目 |
2015-01~2019-12
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320万元
| 课题负责人 |
31470845 | MEKK2在固有免疫抗细菌感染中的调控机制 | 国家自然基金委面上项目 |
2015-01~2018-12
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95万元
| 课题负责人 |
13JC1404700 | MEKK2/3参与炎症性肠病中Th17/Treg细胞分化和功能的分子机制 | 上海市科委基础研究重点项目 |
2013-09~2016-08
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50万元
| 课题负责人 |
PR093728 | The Role of mTOR Signaling in the Regulation of RAG Expression and Genomic Stability during B Lymphocyte Development | DOD Grant |
2010-04~2013-04
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754.6万元
| 课题负责人 |
RO1AI063348 | Regulation and
Function of MEKK3
in Dendritic Cells | NIH |
2005-04~2011-02
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769.2万元
| 课题负责人 |
RO1CA097159 | Mechanisms of relA
Activation in
Pancreatic Cancer | NIH |
2003-09~2007-08
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567万元
| 课题负责人 |
RO1HL070225 | Molecular Mechanisms of MEKK3-Signaling in Angiogenesis | NIH |
2003-04~2007-05
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771.8万元
| 课题负责人 |
- 学术论文
X Ouyang, Y Han, G Qu, M Li, O Arojo, H Sun, X Liu, D Liu, LChen, Q Zou,
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Metabolic regulation of T cell development by Sin1-mTORC2 is mediated by pyruvate kinase M2.
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J Mol Cell Biol.
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2019
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2019 Feb 1;11(2):93-106
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Hu ZL, Qu GJ, Yu XY, Jiang HJ, Teng XL, Ding L, Hu QW, Guo WX, Zhou Y,Wang F, Li HB, Chen L, Jiang J,, Liu JL, Zou Q.
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Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+T Cells.
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Cell Metabolism.
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2019
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https://doi.org/10.1016/j.cmet.2019.05.016
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Zhaoyuan Liu, Yaqi Gu, Svetoslav Chakarov, Camille Bleriot, Immanuel Kwok, Xin Chen, Amanda Shin, Weijie Huang, Regine J. Dress, Charles-Antoine Dutertre, Andreas Schlitzer, Jinmiao Chen, Lai Guan Ng, Honglin Wang, Zhiduo Liu,, and Florent Ginhoux.
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Fate mapping via Ms4a3 expression history traces monocyte-derived cells.
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Cell
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2019
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accepted
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M Li, AS Lazorchak, X Ouyang, H Zhang, H Liu, O.A Arojo, G Qu, X Xu, X Liu, W Zhang, Q Wang, D Liu, F Li,
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Sin1/mTORC2 regulates B cell growth and metabolism via mTORC1 and Myc activation.
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Cell Mol Immunol.
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2019
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2019 Jan 31. doi: 10.1038/s41423-018-0185-x.
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OA. Arojo, X Ouyang, D Liu, T Meng, SM. Kaech, JP. Pereira and B Su.
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Active mTORC2 Signaling in Naive T Cells Suppresses Bone Marrow Homing by Inhibiting CXCR4 Expression.
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J Immunol
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2018
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2018; 201:908-915
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Wu ZR, Yan LC, Liu YT, Cao L, Guo YH, Zhang Y, Yao H, Cai L, Shang HB, Rui WW, Yang G, Zhang XB, Tang H, Wang Y, Huang JY, Wei YX, Zhao WG,, Wu ZB.
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Inhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours.
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Nature Communications.
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2018
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2018 9:4624.
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Jiyu Tong, Guangchao Cao, Ting Zhang, Esen Sefik, Maria Carolina Amezcua Vesely, James P Broughton, Shu Zhu, Huabin Li, Bin Li, Lei Chen, Howard Y Chang,, Richard A Flavell, Hua-Bing Li.
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m6A mRNA methylation sustains Treg suppressive functions
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Cell Research
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2018
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82.10.1038/cr.2018.7.
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XYYu, XL Teng, FX Wang, YH Zheng, GJ Qu, Y Zhou, ZLHu, ZQ Wu, YZChang, L Chen, HB Li,, LM Lu, ZD Liu, SC Sun, and Q Zou.
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Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome.
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J. Exp. Med.
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2018
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90. 2018. 3;215(9):2463-2476.
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Xu YY, Ouyang XX,Yan LC, Zhang ML, Hu ZL, Gu JM, Fan XM, Zhang L, Zhang JF, Xue S, Chen GQ,, and Liu JL
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Sin1 regulates ischaemia-induced microthrombosis through integrin?αIIbβ3-mediated outside-in signaling and hypoxia responses in platelets. Arteriosclerosis, Thrombosis, and Vascular Biology.
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Arteriosclerosis, Thrombosis, and Vascular Biology.
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2018
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2018 Dec;38(12):2793-2805.
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XM Fan, CH Wang,PL Shi,W Gao, JMGu,Y Geng,WL Yang,NB Wu,Y Wang,Y Xu,X Chen, L Zhang,KM Wang,, JL Liu.
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Platelet MEKK3 regulates arterial thrombosis and myocardial infarct expansion in mice.
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Blood Adv.
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2018
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2018 Jun 26;2(12):1439-1448.
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XY Yu, YM Lao, XL Teng, S Li, Y Zhou, FX Wang, XWGuo, SY Deng,YZ Chang, XF Wu, ZD Liu, L Chen, LM Lu, JK Cheng, B Li,, J Jiang,HB Li , CX Huang, J Yi , Q Zou.
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ENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation.
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Nature Communications.
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2018
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2018: 9:3157
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Tan R, Nakajima S, Wang Q, Sun H, Xue J, Wu J, Hellwig S, Zeng X,?Yates NA, Smithgall TE, Lei M, Jiang Y, Levine AS,, Lan L.
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Nek7 protects telomeres from oxidative DNA damage by phosphorylation and stabilization of TRF1
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Mol Cell
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2017
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2765(17):30041-2.
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Zhu H, Lou F, Yin Q, Gao Y, Sun Y, Bai J, Xu Z, Liu Z, Cai W, Ke F, Zhang L, Zhou H, Wang H, Wang G, Chen X, Zhang H, Wang Z, Ginhoux F, Lu C,, Wang H.
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RIG‐I antiviral signaling drives interleukin‐23 production and psoriasis‐like skin disease.
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EMBO Mol Med.
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2017
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9(5):589-604
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Liu W, Liu X, Li Y, Zhao J, Liu Z, Hu Z, Wang Y, Yao Y, Miller AW2,, Cookson MR, Li, KangZ
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LRRK2?promotes?the?activation?of?NLRC4?inflammasome?during?Salmonella?
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J Exp Med.
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2017
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214(10):3051-3066.
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Zepp JA,Zhao J,Liu C,Bulek K,?Wu L,Chen X,Hao Y,Wang Z,Wang X,Ouyang W,Kalady MF,Carman J,?Yang WP,Zhu J, Blackburn C Huang YH, Hamilton TA1,, LiX.
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IL-17A-Induced PLET1 Expression Contributes to Tissue?Repair and Colon
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J Immunol.
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2017
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199(11):3849-3857.
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Greenblatt MB, Shin DY, Oh H, Lee KY, Zhai B, Gygi SP, Lotinun S, Baron R, Liu D,, Glimcher LH, Shim JH
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MEKK2 mediates an alternative β-catenin pathway that promotes bone formation
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Proc Natl Acad Sci U S A
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2016
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113(9):E1226-35
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Wang Q, Tan R, Zhu X, Zhang Y, Tan Z,, Li Y
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Oncogenic K-ras confers SAHA resistance by up-regulating HDAC6 and c-myc expression
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Oncotarget
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2016
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7(9):10064-72
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Fisher OS, Deng H, Liu D, Zhang Y, Wei R, Deng Y, Zhang F, Louvi A, Turk BE, Boggon TJ,
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Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex
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Nature Communications
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2015
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6:7937
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Pengda Liu, Wenjian Gan, Y. Rebecca Chin, Kohei Ogura, Jianping Guo, Jinfang Zhang, Bin Wang, John Blenis, Lewis C. Cantley, Alex Toker,, Wenyi Wei
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PtdIns(3,4,5)P3-dependent activation of the mTORC2 kinase complex
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Cancer Discov
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2015
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5 (11): 1194-209
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Kaur S, Kroczynska B, Sharma B, Sassano A, Arslan AD, Majchrzak-Kita B, Stein BL, McMahon B, Altman JK,, Calogero RA, Fish EN, Platanias LC
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Critical roles for Rictor/Sin1 complexes in IFN-dependent gene transcription and generation of antiproliferative responses
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J Biol Chem
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2014
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289(10):6581-91
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Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, Lee TH, Asara JM, Manning BD, Blenis J,, Wei W.
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Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis
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Nat Cell Biol
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2013
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15(11):1340-50
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Zhou XT, Chen DN, Xie ZQ, Peng Z, Xia KD, Liu HD, Liu W,, Li JD.
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Functional analysis of the distal region of the third intracellular loop of PROKR2
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Biochem Biophys Res Commun
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2013
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439(1):12-7
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Fan Zhang, Adam Lazorchak, Dou Liu, Fanping Chen,
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Inhibition of the mTORC2 and chaperone pathways to treat leukemia
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Blood
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2012
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119(25):6080-8
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Xing Chang, Adam S. Lazorchak, Dou Liu,
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Sin1 regulates Treg-cell development but is not required for T-cell growth and proliferation
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Eur J Immunol
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2012
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42(6):1639-47
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Xiaofang Wang, Fan Zhang, Fanping Chen, Dou Liu, Yi Zheng, Yongliang Zhang, Chen Dong,
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MEKK3 regulates IFNg production in T cells through the Rac1/2 dependent MAPK cascades
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J Immunol
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2011
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186:5791-5800
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, Estela Jacinto
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Mammalian TOR signaling to the AGC kinases
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Crit Rev Biochem Mol Biol
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2011
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46(6):527-47
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Adam S. Lazorchak,
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Perspectives on the role of mTORC2 in B lymphocyte development, immunity and tumorigenesis
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Protein & Cell
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2011
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2(7):523-530
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Xing Chang, Fang Liu, Xiaofang Wang,
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MEKK2 and MEKK3 regulate TGF-b-mediated helper T cell differentiation
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Immunity
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2011
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34:201-212
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You-Tong Wu, Weiming Ouyang, Adam S Lazorchak, Dou Liu, Han-Ming Shen,
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mTOR complex 2 targets Akt for proteasomal degradation via phosphorylation at the hydrophobic motif
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J Biol Chem
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2011
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286:14190-14198
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Adam S Lazorchak, Dou Liu, Valeria Facchinetti, Annarita Di Lorenzo, William C Sessa, David G Schatz,
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Sin1 suppresses rag1/2 and il7r gene expression through Akt2 in B cells
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Mol Cell
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2010
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39:433-443
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Xiaofang Wang, Yongliang Zhang, Valeria Facchinetti, Yuan Zhuang,
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MEKK3 Is Essential for Lymphopenia-Induced T cell Proliferation and Survival
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J Immunol
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2009
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182(6):3597-3608
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Valeria Facchinetti, Weiming Ouyang, Hua Wei, Nelyn Soto, Adam Lazorchak, Christine Gould, Carolyn Lowry, Alexandra C. Newton, Yuxin Mao, Robert Q. Miao, William C. Sessa, Jun Qin, Pumin Zhang,, Estela Jacinto
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The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C
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EMBO J
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2008
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27(14):1932-43
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Kihwan Kim, Omar Duramad, Xiaofeng Qin and Su B.
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MEKK3 is essential for lipopolysaccharide-induced il-6 and gm-csf production in macrophages.
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Immunology.
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2007
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120(2):242-50
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Dongyu Zhang, Valeria Fachinnetti, Xiaofang Wang, Qiaojia Huang, Jun Qin,
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Identification of MEKK2/3 serine phosphorylation site targeted by the Toll-like receptor- and stress-pathways
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EMBO J
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2006
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25:97-107
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Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, Huang Q, Qin J,
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SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.
|
Cell
|
2006
|
127(1):125-3
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Jinke Cheng, Dongyu Zhang, Kihwan Kim, Yingxin Zhao, Yingming Zhao,
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Mip1, an MEKK2 interacting protein, regulates MEKK2 dimerization and activation
|
Mol Cell Biol
|
2005
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25(14):5955-5964
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Jinke Cheng, Ling Yu, Dongyu Zhang, Qiaojia Huang, David Spencer,
|
Dimerization through the catalytic domain is essential for MEKK2 activation
|
J. Biol. Chem.
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2005
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280:13477-82
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Jinke Cheng, Ling Yu, Dongyu Zhang, Qiaojia Huang, David Spencer,
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Dimerization through the catalytic domain is essential for MEKK2 activation.
|
J. Biol. Chem
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2005
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280:13477-82
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Qiaojia Hunag, Jianhua Yang, Jinke Cheng, CM Walker, Z.G. Liu,
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Differential regulation of interleukin-1 receptor and toll like receptor (TLR) signaling by MEKK3.
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Nature Immunology
|
2004
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5:95-103
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Zijian Guo, Gavin Clydesdale, Jinke Cheng, Kihwan Kim, Lin Gan, David J. McConkey, Stephen E. Ullrich, Yuan Zhuang*,
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Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-Cell receptor signal transduction
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Mol Cell Biol
|
2002
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22(16):5761-5768
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Xu X,, Barndt RJ, Chen H, Xin H, Yan G, Chen L, Cheng D, Heitman J, Zhuang Y, Fleischer S, Shou W.
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FKBP12 is the only FK506 binding protein mediating T-cell inhibition by the immunosuppressant FK506.
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Transplantation
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2002
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Jun 15;73(11):1835-8
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, Cheng JK, Yang J
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MEKK2 mediates T cell co-stimulation of the JNK cascade and IL-2 gene expression
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J Biol Chem
|
2001
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276:14784-90
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Yang J, Lin Y, Guo Z, Cheng J, Huang H, Liao W, Chen Z, Liu Z,
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The essential role of MEKK3 in TNF-induced NF-kB activation
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Nature Immunology
|
2001
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2:620-624
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Cheng J, Yang J, Xia Y, Karin, M.,
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Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation.
|
Mol Cell Biol
|
2000
|
20(7):2334-2341
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Xia Y, Makris C,, Li EG, Yang JH, Nemerow GR, Karin M.
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MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration.
|
PNAS
|
2000
|
97(10): 5243-5248
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Yang J, Boerm M, McCarty M, Bucana C, Fidler J, Zhuang Y,
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Essential role of MEKK3 in early embryonic cardiovascular development
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Nature Genetics
|
2000
|
24:309-313
|
Lee H, Jiang F, Wang Q, Nicosia SV, Yang J,, Bai W.
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MEKK1 activation of human Estrogen receptor a and stimulation of the agonisttic activity of 4-hydroxytamoxifen in endometrial and ovarian cancer cells.
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Molecular Endocrinology
|
2000
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14(11):1882-96
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Dong Z, Killion JJ, Kumar R, Eue I, Yang X, Lu W,, Fidler IJ.
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Activation of cytokine production, tumoricidal properties, and tyrosine phosphorylation of MAPKs in human monocytes by a new synthetic lipopeptide, JBT3002
|
J Leukocyte Biol
|
1998
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63(6):766-774
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Wang Y,, Sah VP, Brown JH, Han J, Chien KR.
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Cardiac hypertrophy induced by Mitogen-activated Protein Kinase Kinase , a specific activator for c-jun NH2-terminal kinase in ventricular muscle cells.
|
J. Biol. Chem.
|
1998
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273:5423-5426
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Xia Y, Wu Z,, Murray B, and Karin, M.
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JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components: MEKK1 and JNK.
|
J Leukocyte Bio
|
1998
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63(6):766-774,
|
Xia Y, Wu Z,, Murray B, and Karin, M.
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JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components: MEKK1 and JNK.
|
Genes & Dev
|
1998
|
12(21):3369-3381
|
Li YS, Shyy JY, Li S, Lee J,, Karin M, Chien S.
|
Shear stress activates both JNK and Erk kinase pathways. Mole.
|
Mole. Cell. Biol.
|
1996
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16:5947-5954
|
Cavigelli M, Dolfi F,, Yoshioka K and Karin M
|
The tumor promoter arsenite stimulates AP-1 activity through inhibition of a JNK phosphatase.
|
EMBO J
|
1996
|
15:6269-6279
|
Derijard, B., Hibi, M., Wu, I-Huan, Barrett, T.,, Deng, T., Karin, M., and Davis, R.J
|
JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphrylates the cJun activation domain
|
Cell
|
1994
|
76:1025-1037
|
Lee, S.,, Maher, S., and Bothwell, A.L.M.
|
Ly6A is required for antigen-specific response and expression of T cell receptor
|
EMBO J
|
1994
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13:2167-2176
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, Jacinto, E., Hibi, M., Kallunki, T., Karin, M., and Ben-Neriah, Y
|
JNK mediates signal integration during costimulation of T lymphocytes
|
Cell
|
1994
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77:727-736
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, Waneck, G.L., Flavell, R.A. and Bothwell, A.L.M.
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The glycosyl phosphatidylinositol anchor is critical for Ly-6A/E mediated T cell activation.
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J. Cell Biol.
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1991
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2.112:337-384
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Biosynthesis of a phosphatidylinositol-glycan-linked membrane protein: signals for posttranslational processing of the Ly-6E antigen
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1989
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9: 3369-3376
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