• 基本信息
    导师姓名: 蒋盛旦 学科代码: 100210
    性别: 学科名称: 外科学
    培养单位: 附属新华医院 三级学科 骨外
    导师类型: 博士生导师 专业领域名称: 外科学 专业学位
    联系方式: 上海市杨浦区控江路1665号 专业领域代码: 105111
    邮编: 200092 邮箱地址: jiangsd@126.com
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    新华医院脊柱中心行政副主任,党支部书记
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    82272535GRAMD2B在诱导髓核细胞铁死亡中的作用及机制研究国家自然科学基金面上项目 2023-01~2026-12 53万元  课题负责人
    SHDC2022CRD027聚甲基丙烯酸甲酯-水凝胶搭载地舒单抗在经皮椎体成形术治疗骨质疏松性椎体压缩性骨折中的作用研究上海申康医院发展中心 2022-07~2024-09 40万元  课题负责人
    2022008“医苑新星”杰出青年医学人才项目上海市卫生健康委员会 2022-01~2024-12 20万元  课题负责人
    20224Z0015经椎弓根外单侧双平面穿刺PVP治疗胸腰椎骨质疏松性椎体压缩性骨折的疗效分析上海市卫生健康委员会 2022-01~2024-12 30万元  课题负责人
    XH2476椎体成型术与关节突阻滞在骨质诉讼性椎体骨折中的疗效比较上海交通大学医学院 2018-10~2021-09 100万元  课题负责人
    81672206氧化应激诱导的线粒体自噬在椎间盘退变中的作用及机制研究 国家自然科学基金面上项目 2017-01~2020-12 57万元  课题负责人
    81000793缺氧对椎间盘代谢的影响及其机制研究国家自然科学基金 2011-01~2013-12 20万元  课题负责人
    XYQ2011026缺氧信号在椎间盘退变病理机制中的作用卫生局 2011-01~2013-12 60万元  课题负责人
    2008SG21谷氨酸及受体在脊髓损伤后骨质疏松中的作用市教委 2008-09~2010-08 6万元  课题负责人
    08QA1405000谷氨酸及其受体在脊髓损伤后骨质疏松中的作用上海市科委,启明星 2008-07~2010-07 15万元  课题负责人
    2007XJ026脊髓损伤后骨质疏松的分子和信号传导机制医学院 2008-01~2009-12 5万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Wen-Ning Xu, Chun Liu, Huo-Liang Zheng, Hai-Xia Xu, Run-Ze Yang,, Li-Xin Zhu  Sesn2 Serves as a Regulator between Mitochondrial Unfolded Protein Response and Mitophagy in Intervertebral Disc Degeneration  International journal of biological sciences  2023  19(2):571-592 
    Huo-Liang Zheng, Bo Li, Shao-Kuan Song, Peng-Bo Chen, Xin-Feng Zheng, Lei-Sheng Jiang,  Safety and Efficacy of Polyetheretherketone (PEEK) Cages and Cadaveric Allografts in Transforaminal Lumbar Interbody Fusion (TLIF) for Treating Lumbar Pyogenic Spondylodiscitis  Mediators of inflammation  2023  2023:5171620 
    Huo-Liang Zheng, Bo Li, Shao-Kuan Song, Peng-Bo Chen, Lei-Sheng Jiang,  Anterior cervical discectomy and fusion to treat cervical instability with vertigo and dizziness: A single center, retrospective, observational study  Frontiers in surgery   2023  9:1047504 
    Huo-Liang Zheng, Bo Li, Shao-Kuan Song, Lei-Sheng Jiang, Xin-Feng Zheng,  High Endplate Hounsfield Units Value Indicate Intervertebral Disc Degeneration Following Transforaminal Lumbar Interbody Fusion Surgery  Orthopaedic surgery   2023  15(9):2291-2299 
    Huo-Liang Zheng, Wen-Ning Xu, Peng-Bo Chen, Lei-Sheng Jiang, Xin-Feng Zheng,  Increased Expression of Prolyl Endopeptidase Induced by Oxidative Stress in Nucleus Pulposus Cells Aggravates Intervertebral Disc Degeneration  Oxidative medicine and cellular longevity  2022  2022:9731800 
    Run-Ze Yang, Huo-Liang Zheng, Wen-Ning Xu, Xin-Feng Zheng, Bo Li, Lei-Sheng Jiang,  Vascular endothelial cell-secreted exosomes facilitate osteoarthritis pathogenesis by promoting chondrocyte apoptosis  Aging  2021  13(3):4647-4662 
    Run-Ze Yang, Wen-Ning Xu, Huo-Liang Zheng, Xin-Feng Zheng, Bo Li, Lei-Sheng Jiang,  Involvement of oxidative stress-induced annulus fibrosus cell and nucleus pulposus cell ferroptosis in intervertebral disc degeneration pathogenesis  Journal of cellular physiology  2021  236(4):2725-2739 
    Run-Ze Yang, Wen-Ning Xu, Huo-Liang Zheng, Xin-Feng Zheng, Bo Li, Lei-Sheng Jiang,  Exosomes derived from vascular endothelial cells antagonize glucocorticoid-induced osteoporosis by inhibiting ferritinophagy with resultant limited ferroptosis of osteoblasts  Journal of cellular physiology  2021  ;236(9):6691-6705 
    Huo-Liang Zheng, Wen-Ning Xu, Wen-Sheng Zhou, Run-Ze Yang, Peng-Bo Chen, Tao Liu, Lei-Sheng Jiang,  Beraprost ameliorates postmenopausal osteoporosis by regulating Nedd4-induced Runx2 ubiquitination  Cell death & disease  2021  12(5):497 
    Huo-Liang Zheng, Run-Ze Yang, Wen-Ning Xu, Tao Liu, Peng-Bo Chen, Xin-Feng Zheng, Bo Li, Lei-Sheng Jiang,  Characterization of LncRNA SNHG22 as a protector of NKIRAS2 through miR-4492 binding in osteosarcoma  Aging  2020  12(18):18571-18587 
    Wen-Ning Xu, Run-Ze Yang, Huo-Liang Zheng, Lei-Sheng Jiang,  NDUFA4L2 Regulated by HIF-1α Promotes Metastasis and Epithelial-Mesenchymal Transition of Osteosarcoma Cells Through Inhibiting ROS Production  Frontiers in cell and developmental biology  2020  20;8:515051 
    Liu T, Li B, Zheng XF,, Zhou ZZ, Xu WN, Zheng HL, Wang CD, Zhang XL, Jiang LS  Chordin-Like 1 Improves Osteogenesis of Bone Marrow Mesenchymal Stem Cells Through Enhancing BMP4-SMAD Pathway  Front Endocrinol (Lausanne)   2019  10:360-374 
    Xu WN, Yang RZ, Zheng HL, Yu W, Zheng XF, Li B,, Jiang LS   PGC-1α acts as an mediator of Sirtuin2 to protect annulus fibrosus from apoptosis induced by oxidative stress through restraining mitophagy  International Journal of Biological Macromolecules  2019  136:1007-1017 
    Wen-Ning Xu, Huo-Liang Zheng, Run-Ze Yang, Lei-Sheng Jiang,  HIF-1α Regulates Glucocorticoid-Induced Osteoporosis Through PDK1/AKT/mTOR Signaling Pathway  Frontiers in endocrinology  2019  10:922 
    余炜,朱超,茅伟伟,赵恩典,孟胜伟,  神经肽P物质通过诱导RUNX2表达影响小鼠成骨细胞增殖能力  上海交通大学学报(医学版)  2017  37(1):15-21 
    Yu W, Zhu C, Xu W, Jiang L,  Neuropeptide Y1 Receptor Regulates Glucocorticoid-Induced Inhibition of Osteoblast Differentiation in Murine MC3T3-E1 Cells via ERK Signaling.  Int J Mol Sci  2016  17(12): E2150 
    Zhu C, Zheng XF, Yang YH, Li B, Wang YR,, Jiang LS  LGR4 acts as a key receptor for R-spondin 2 to promote osteogenesis through Wnt signaling pathway.  Cell Signal  2016  28(8):989-1000 
    Li B, Su YJ, Zheng XF, Yang YH,, Jiang LS  Evidence for an Important Role of Smad-7 in Intervertebral Disc Degeneration.  J Interferon Cytokine Res  2015  35(7):569-79 
    Chen JW, Ni BB, Zheng XF, Li B,, Jiang LS.  Hypoxia facilitates the survival of nucleus pulposus cells in serum deprivation by down-regulating excessive autophagy through restricting ROS generation  Int J Biochem Cell Biol  2015  59:1-10 
    Chen JW, Ni BB, Li B, Yang YH,, Jiang LS.  The responses of autophagy and apoptosis to oxidative stress in nucleus pulposus cells: implications for disc degeneration.  Cell Physiol Biochem  2014  34(4):1175-1189 
    Yang YH, Li B, Zheng XF, Chen JW, Chen K,, Jiang LS  Oxidative damage to osteoblasts can be alleviated by early autophagy through the endoplasmic reticulum stress pathway--implications for the treatment of osteoporosis  Free Radic Biol Med  2014  77:10-20 
    , Chen JW, Yang YH, Chen XD, Jiang LS  Intraobserver and interobserver reliability of measures of cervical sagittal rotation   BMC Musculoskeletal Disorders   2014  15():332-336 
    Yang YH, Wang YR,, Jiang LS  Proximal femoral nail antirotation and third-generation Gamma nail: which is a better device for the treatment of intertrochanteric fractures?  Singapore Med J  2013  54(8):446-450 
    Yang YH, Chen K, Li B, Chen JW, Zheng XF, Wang YR,, Jiang LS  Estradiol inhibits osteoblast apoptosis via promotion of autophagy through the ER-ERK-mTOR pathway  Apoptosis  2013  18(11):1363-1375 
    , Yang YH, Chen JW, Jiang LS  Isolated osteoblasts from spinal cord-injured rats respond less to mechanical loading as compared with those from hindlimb-immobilized rats.  J Spinal Cord Med  2013  36(3):224-226 
    , Chen JW, Jiang LS  Which procedure is better for lumbar interbody fusion: anterior lumbar interbody fusion or transforaminal lumbar interbody fusion?  Arch Orthop Trauma Surg  2012  132(9):1259-66 
    , Jiang LS, Dai LY.  Anterior cervical discectomy and fusion versus anterior cervical corpectomy and fusion for multilevel cervical spondylosis: a systematic review.  Arch Orthop Trauma Surg  2012  132(2):155-61 
    , Wu QZ, Lan SH, Dai LY  Reliability of the measurement of thoracolumbar burst fracture kyphosis with Cobb angle, Gardner angle, and sagittal index.  Arch Orthop Trauma Surg  2012  132(2):221-5 
    Yan J, Li B, Chen JW,, Jiang LS.   Spinal cord injury causes bone loss through peroxisome proliferator-activated receptor-γ and Wnt signalling.  J Cell Mol Med  2012  16(12):2968-77 
    , Jiang LS, Dai LY  Cervical spondylotic amyotrophy  Eur Spine J  2011  20(3):351-7 
    , Jiang LS, Dai LY   Degenerative cervical spondylolisthesis: a systematic review  Int Orthop  2011  35(6):869-75 
    , Yan J, Jiang LS, Dai LY  Down-regulation of the Wnt, estrogen receptor, insulin-like growth factor-I, and bone morphogenetic protein pathways in osteoblasts from rats with chronic spinal cord injury  Joint Bone Spine  2011  78(5):488-92 
    , Jiang LS, Dai LY  Extreme lateral lumbar disc herniation in a 12-year child: case report and review of the literature  Eur Spine J  2010  19(2):197-9 
    , Jiang LS, Zhao CQ, Dai LY  No advantages of Gamma nail over sliding hip screw in the management of peritrochanteric hip fractures: a meta-analysis of randomized controlled trials  Disabil Rehabil  2008  30(7):493-7 
    , Jiang LS, Dai LY   Surgical treatment of calcaneal fractures with use of beta-tricalcium phosphate ceramic grafting  Foot Ankle Int  2008  29(10):1015-9 
    Dai LY,, Wang XY, Jiang LS  A review of the management of thoracolumbar burst fractures  Surg Neurol  2007  67(3):221-31 
    , Jiang LS, Dai LY   Changes in bone mass, bone structure, bone biomechanical properties, and bone metabolism after spinal cord injury: a 6-month longitudinal study in growing rats  Calcif Tissue Int  2007  80(3):167-75 
    , Jiang LS, Dai LY  Effects of spinal cord injury on osteoblastogenesis, osteoclastogenesis and gene expression profiling in osteoblasts in young rats  Osteoporos Int  2007  18(3):339-49 
    , Jiang LS, Dai LY   Horner Syndrome due to a solitary osteochondroma of C7: a case report and review of the literature  Spine  2007  32(16):471-4 
    , Jiang LS, Dai LY   Differences of bone mass and bone structure in osteopenic rat models caused by spinal cord injury and ovariectomy  Osteoporos Int  2007  18(6):743-50 
    , Jiang LS, Dai LY  Mechanisms of osteoporosis in spinal cord injury  Clin Endocrinol   2006  65(5):555-65 
    , Jiang LS, Dai LY   Spinal cord injury causes more damage to bone mass, bone structure, biomechanical properties and bone metabolism than sciatic neurectomy in young rats  Osteoporos Int  2006  17(10):1552-61 
    , Jiang LS, Dai LY  Osteoporosis after spinal cord injury  Osteoporos Int  2006  17(2):180-92 
    , 戴力扬  脊髓损伤后骨代谢  临床骨科杂志  2004  7(2):237-239 
    ,戴力扬  糖皮质激素诱导的骨质疏松发生机制   中国矫形外科杂志  2004  12(6):459-460