• 基本信息
    导师姓名： 赵倩 学科代码： 100100
    性别： 女 学科名称： 基础医学
    培养单位： 基础医学院 三级学科
    导师类型： 博士生导师 专业领域名称：
    联系方式： 重庆南路280号西二楼905室 专业领域代码：
    邮编： 200025 邮箱地址： qzhao@shsmu.edu.cn
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    交通大学医学院病理生理学系副主任
    上海市病理生理学会副理事长
    上海市生物化学与分子生物学学会理事
    中国病理生理学会青年委员会委员
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    81772831长链非编码RNA Lnc268在乳腺癌转移中的功能及其作用机制国家自然科学基金 2018-01~2021-12 57万元  课题负责人
    81472463GAPDH在乳腺癌细胞EMT及乳腺癌转移中的表达与功能研究 国家自然科学基金 2015-01~2018-12 80万元  课题负责人
    81172521microRNA 在Snail/Twist诱导乳腺癌细胞发生上皮-间质转化中的表达调控及生物学功能国家自然科学基金 2012-01~2015-12 57万元  课题负责人
     miR-124在乳腺癌细胞EMT过程和小鼠乳腺癌转移中的功能研究 上海交通大学晨星青年学者奖励计划 2011-12~2013-12 15万元  主要责任人
    09SG18低氧诱导因子-1α（HIF-1α）调控microRNAs的功能学研究上海市教委曙光学者计划 2009-12~2012-12 15万元  课题负责人
    30870979低氧诱导因子-1α（HIF-1α）对microRNA的调控及其在白血病细胞分化中的作用国家自然基金委,面上项目 2009-01~2011-12 30万元  课题负责人
    08JC1413500白血病相关蛋白AML1-ETO剪切片断的生物学功能研究上海市基础研究重点项目 2008-10~2010-10 30万元  课题负责人
    2008AA02Z301利用小分子化合物和RNAi研究抗白血病蛋白PLSCR1的作用网络科技部863项目 2008-01~2010-12 86万元  课题负责人
    08JC1413500白血病相关蛋白AML1-ETO剪切片断的生物学功能研究上海市科委，基础重点项目 ~2010-09 30万元   
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Luo GT, Xia X, Wang XF, Zhang KD, Cao J, Jiang T,, Qiu ZJ.   miR-301a plays a pivotal role in hypoxia-induced gemcitabine resistance in pancreatic cancer  Exp Cell Res.  2018  369:120-128 
    Wang QY, Zhou CX, Zhan MN, Tang J, Wang CL, Ma CN, He M, Chen GQ, He JR,  MiR-133b targets Sox9 to control pathogenesis and metastasis of breast cancer.  Cell Death Dis.  2018   9(7): 752-765 
    Gong XF,Yu AL,Tang J,Wang CL,He JR,Chen GQ,,He M,Zhou CX. Exp Cell Res 2018; 362 (2):378-385.   MicroRNA-630 inhibits breast cancer progression by directly targeting BMI1.  Exp Cell Res.  2018  362:378-385 
    Zhan MN,Yu XT,Tang J,Zhou, CX,Wang CL,Yin QQ,Gong XF,He M,He JR,Chen GQ,  MicroRNA-494 inhibits breast cancer progression by directly targeting PAK1.  Cell Death Dis.  2017  8（1）：e2529~e2529 
    Mi L, Zhu F, Yang X, Lu J, Zheng Y,, Wen X, Lu A, Wang M , Zheng M, Ji J, Sun J.  The metastatic suppressor NDRG1 inhibits EMT, migration and invasion through interaction and promotion of caveolin-1 ubiquitylation in human colorectal cancer cells.  Oncogene  2017  36(30):4323-4335 
    Tang J, Zhan MN, Yin QQ, Zhou CX, Wang CL, Wo LL, He M, Chen GQ,  Impaired p65 degradation by decreased chaperone-mediated autophagy activity facilitates epithelial-to-mesenchymal transition.   Oncogenesis  2017  6(10):e387.  
    Liu Y, Li F, Gao F, Xing L, Qin P, Liang X, Zhang J, Qiao X, Lin L,, Du L.  Periostin promotes tumor angiogenesis in pancreatic cancer via Erk/VEGF signaling   Oncotarget.  2016  7(26):40148-40159 
    Zhou CX, Wang CL, Yu An-Lu, Wang QY, Zhan MN, Tang T, Yin QQ, He M, He JR, Chen GQ,  MiR-630 suppresses breast cancer progression by targeting metadherin.  Oncotarget  2016  7(2):1288-1299 
    Xia X,Zhang K,Cen G,Jiang T,Cao J,Huang K,Huang C,,Qiu Z  MicroRNA-301a-3p promotes pancreatic cancer progression via negative regulation?of?SMAD4.  Oncotarget  2015  6(25):21046-63 
    M He, Q-Y Wang, Q-Q Yin, J Tang, Y Lu, C-X Zhou, C-W Duan, D-L Hong, T Tanaka, G-Q Chen,  HIF-1α downregulates miR-17/20a directly targeting p21 and STAT3: a role in myeloid leukemic cell differentiation  Cell Death and Differentiation  2013  20(3):408-418 
    Liang YJ, Wang QY, Zhou CX, Yin QQ, He M, Yu XT, Cao DX, Chen GQ, He JR,  MiR-124 Targets Slug to Regulate Epithelial-to-Mesenchymal Transition and Metastasis of Breast Cancer  Carcinogenesis  2013  34(3):713-22 
    Zhang H,Wang Q,,Di W  MiR-124 inhibits the migration and invasion of ovarian cancer cells by targeting SphK1  J Ovarian Res.  2013  6(1):84 
    Sun J, Zhang D, Zheng Y,, Zheng M, Kovacevic Z, Richardson DR  Targeting the Metastasis Suppressor, NDRG1, Using Novel Iron Chelators: Regulation of Stress Fiber-Mediated Tumor Cell Migration via Modulation of the ROCK1/pMLC2 Signaling Pathway  Mol Pharmacol.  2013  83(2):454-69 
    Liu CX, Yin QQ, Zhou HC, Wu YL, Pu JX, Xia L, Liu W, Huang X, Jiang T, Wu MX, He LC, Zhao YX, Wang XL, Xiao WL, Chen HZ,, Zhou AW, Wang LS, Sun HD, Chen GQ  Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells  Nat Chem Biol  2012  8(5):486-93 
    Li D, Yang H, Nan H, Liu P, Pang S,, Karni R, Kamps MP, Xu Y, Zhou J, Wiedmer T, Sims PJ, Wang F  Identification of key regulatory pathways of myeloid differentiation using an mESC-based karyotypically normal cell model  Blood  2012  120(24):4712-9 
    Zhang B, Liu XX, He JR, Zhou CX, Guo M, He M, Li MF, Chen GQ,  Pathologically decreased miR-26a antagonizes apoptosis and facilitates carcinogenesis by targeting MTDH and EZH2 in breast cancer  Carcinogenesis  2011  32(1):2-9 
    Yan Z, Yang R, Jiang Y, Yang Z, Yang J,, Lu Y  Induction of Apoptosis in Human Promyelocytic Leukemia HL60 Cells by Panaxynol and Panaxydol  Molecules  2011  29;16 (7):5561-73 
    Chen CW, Sowden M,, Wiedmer T, Sims PJ   Nuclear phospholipid scramblase 1 prolongs the mitotic expansion of granulocyte precursors during G-CSF-induced granulopoiesis  J Leukoc Biol.  2011  90 (2):221-33 
    Liu XX, Li XJ, Zhang B, Liang YJ, Zhou CX, Cao DX, He M, Chen GQ, He JR,  MicroRNA-26b is underexpressed in human breast cancer and induces cell apoptosis by targeting SLC7A11  FEBS Lett.  2011  585(9):1363-1367 
    Chen GQ, Zhang J,  Active compounds-based discoveries about the differentiation and apoptosis of leukemic cells  Chinese Sci Bull  2009  54(18): 2759-2765 
    Chen S, Han YH, Zheng Y, Zhao M, Yan H,, Chen GQ, Li D  NDRG1 contributes to retinoic acid-induced differentiation of leukemic cells  Leuk Res.  2009  33(8):1108-1113 
    Song LP, Zhang J, Wu SF, Huang Y,, Cao JP, Wu YL, Wang LS, Chen GQ  Hypoxia-inducible factor-1alpha-induced differentiation of myeloid leukemic cells is its transcriptional activity independent   Oncogene  2008  27(4):519-27 
    Zhang J, Song LP, Huang Y,, Zhao KW, Chen GQ  Accumulation of hypoxia-inducible factor-1{alpha} protein and its role in the differentiation of myeloid leukemic cells induced by all-trans retinoic acid  Haematologica  2008  93(10):1480-7 
    Huang Y,, Zhou CX, Gu ZM, Li D, Xu HZ, Wiedmer T, Sims PJ, Zhao KW, Chen GQ.  Antileukemic roles of human phospholipid scramblase 1 gene, evidence from inducible PLSCR1-expressing leukemic cells.  Oncogene  2006  25(50):6618-27 
    Xue ZH, Jiang Y, Yu Y, Wang LS, Chen GQ,  Metavanadate suppresses desferrioxamine-induced leukemic cell differentiation with reduced hypoxia-inducible factor-1α protein  Biochem Biophys Res Commun  2005  332(4): 1140-1145 
    Yan H, Peng ZG, Wu YL, Jiang Y, Yu Y, Huang Y, Zhu YS,, Chen GQ  Hypoxia-simulating agents and selective stimulation of arsenic trioxide-induced growth arrest and cell differentiation in acute promyelocytic leukemic cells  Haematologica  2005  90(12): 1607-1616 
    Zhao KW, Li D,, Huang Y, Silverman RH, Sims PJ, Chen GQ   Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK  J Biol Chem.  2005  280(52): 42707-42714 
    , Tao J, Zhu Q, Jia PM, Dou AX, Li X, Cheng F, Waxman S, Chen GQ, Chen SJ, Lanotte M, Chen Z, Tong JH  Rapid induction of cAMP/PKA pathway during retinoic acid-induced acute promyelocytic leukemia cell differentiation  Leukemia  2004  18 (2)： 285-92 
    Zhao KW, Li X,, Huang Y, Peng ZG, Shen WZ, Zhao J, Zhou QS, Chen Z, Sims PJ, Wiedmer T, Chen GQ   Protein Kinase Cdelta Mediates Retinoic Acid and Phorbol Myristate Acetate-induced Phospholipid Scramblase 1 Gene Expression: Its Role in Leukemic Cell Differentiation  BLOOD  2004  104(12): 3731-8.