- 基本信息
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导师姓名：
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刘炳亚
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学科代码：
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100210
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性别：
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男
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学科名称：
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外科学
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培养单位：
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附属瑞金医院
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三级学科
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普外
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导师类型：
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博士生导师
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专业领域名称：
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联系方式：
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liubingya@sjtu.edu.cn
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专业领域代码：
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邮编：
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200025
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邮箱地址：
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liubingya@sjtu.edu.cn
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- 研究方向 (点击浏览详细信息)
- 社会任职
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国际肿瘤细胞基因治疗学会（ISCGTC）会员
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美国癌症研究学会（AACR)会员
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中国普通外科杂志编委
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ESMO会员
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外科理论与实践杂志编委
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上海市抗癌协会理事
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世界华人消化杂志编委
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国际胃癌学会（IGCA）会员
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中华胃肠外科杂志编委
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EACR会员
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上海市抗癌协会胃肠肿瘤专业委员会委员
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中国抗癌协会胃癌专业委员会副主任委员
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中华医学会肿瘤学分会胃肠肿瘤委员会委员
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中华医学会上海分会外科专科委员会常务委员
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- 科研项目
| 82072605 | BPTF介导的染色质重塑增强AR调控Snail转录促进胃癌侵袭转移的分子机制研究 | 国家自然科学基金 |
2021-01~2024-12
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55万元
| 课题负责人 |
| 81772509 | 雄激素受体（AR）通过调控CDX1/Snail致分化障碍促进慢性胃炎恶性转化的分子机制研究 | 国家自然科学基金（面上）
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2018-01~2021-12
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50万元
| 课题负责人 |
| 91529302 | 慢性胃炎恶性转化的基因调控网络及其关键节点的研究 | 国家自然科学基金-重大研究计划-重点项目 |
2015-11~2018-12
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300万元
| 课题负责人 |
| 2014BAI09B03 | 基于分子标志物的胃癌早期诊断、分子分型 | 科技部国家支撑计划 |
2014-01~2017-12
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187万元
| 课题负责人 |
| 91229106 | 慢性胃炎向胃癌转化的转录调控网络及其关键节点的研究 | 国家自然基金（重大研究计划） |
2013-01~2016-12
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90万元
| 课题负责人 |
| 12XD1403700 | 胃癌功能性抗原的鉴定及生物学功能和分子机制的研究 | 市科委（优秀学术带头人） |
2012-07~2012-06
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40万元
| 课题负责人 |
| 20110073110071 | miR-409-3p对PHF10表达失调促进胃癌进展及其分子机制研究 | 教育部博士点基金（博导类） |
2012-01~2014-12
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12万元
| 课题负责人 |
| 81172324 | mir-409-3p对PHF10表达失调促进胃癌进展及其分子机制研究 | 国家自然科学基金 |
2012-01~2015-12
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53万元
| 课题负责人 |
| 30872476 | 肿瘤相关成纤维细胞中TAGLN在胃癌转移中的作用及其分子机制研究 | 国家自然基金委,面上项目 |
2009-01~2011-12
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34万元
| 课题负责人 |
| 2008BAI52B03 | 胃癌预警指标体系研究与预警模型的开发 | 国家支撑计划 |
2008-09~2011-12
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160万元
| 课题负责人 |
- 学术论文
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Pan T, Jin Z, Yu Z, Wu X, Chang X, Fan Z, Li F, Wang X, Li Z, Zhou Q, Li J,, Su L.
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Cathepsin L promotes angiogenesis by regulating the CDP/Cux/VEGF-D pathway in human gastric cancer.
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Gastric Cancer.
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2021
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23(6):974-987.
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Wang X, Chang X, He C, Fan Z, Yu Z, Yu B, Wu X, Hou J, Li J, Su L,, Zhu Z.
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ATP5B promotes the metastasis and growth of gastric cancer by activating the FAK/AKT/MMP2 pathway.
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FASEB J.
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2021
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35(4):e20649.
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Pan T, Yu Z, Jin Z, Wu X, Wu A, Hou J, Chang X, Fan Z, Li J, Yu B, Li F, Yan C, Yang Z, Zhu Z,, Su L.
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Tumor suppressor lnc-CTSLP4 inhibits EMT and metastasis of gastric cancer by attenuating HNRNPAB-dependent Snail transcription
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Mol Ther Nucleic Acids.
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2021
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23:1288-1303
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Li F, Li J, Yu J, Pan T, Yu B, Sang Q, Dai W, Hou J, Yan C, Zang M, Zhu Z, SuL, Li YY,
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Identification of ARGLU1 as a potential therapeutic target for gastric cancer based on genome-wide functional screening data.
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EBioMedicine
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2021
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69:103436.
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Zhou Q, Wu X, Wang X, Yu Z, Pan T, Li Z, Chang X, Jin Z, Li J, Zhu Z,,Su L.
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The reciprocal interaction between tumor cells and activated fibroblasts mediated by TNF-伪/IL-33/ST2L signaling promotes gastric cancer metastasis.
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Oncogene.
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2020
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39(7):1414-1428.
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Chen J, Zhu C, Wang C, Hu C, Czajkowsky DM, Guo Y,, Shao Z.
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Evidence for heightened genetic instability in precancerous spasmolytic polypeptide expressing gastric glands.
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J Med Genet.
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2020
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57(6):385-388.
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Hu L, Zang MD, Wang HX, Zhang BG, Wang ZQ, Fan ZY, Wu H, Li JF, Su LP, Yan M, Zhu ZQ, Yang QM, Huang Q,, Zhu ZG
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G9A promotes gastric cancer metastasis by upregulating ITGB3 in a SET domain-independent manner
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Cell Death Dis
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2018
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9(3):278
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Song R, Gu D, Zhang L, Zhang X, Yu B,, Xie J
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Functional significance of Hippo/YAP signaling for drug resistance in colorectal cancer
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Mol Carcinog
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2018
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57(11):1608-1615
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Pang L, Li JF, Su L, Zang M, Fan Z, Yu B, Wu X, Li C, Yan M, Zhu ZG,
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ALEX1, a novel tumor suppressor gene, inhibits gastric cancer metastasis via the PAR-1/Rho GTPase signaling pathway
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J Gastroenterol
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2018
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53(1):71-83
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Zang MD, Hu L, Fan ZY, Wang HX, Zhu ZL, Cao S, Wu XY, Li JF, Su LP, Li C, Zhu ZG, Yan M,
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Luteolin suppresses gastric cancer progression by reversing epithelial-mesenchymal transition via suppression of the Notch signaling pathway
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J Transl Med
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2017
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15(1):52
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Zang M, Hu L, Zhang B, Zhu Z, Li J, Zhu Z, Yan M,
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Luteolin suppresses angiogenesis and vasculogenic mimicry formation through inhibiting Notch1-VEGF signaling in gastric cancer
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Biochem Biophys Res Commun
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2017
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490(3):913-919
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Zhou Q, Wang X, Yu Z, Wu X, Chen X, Li J, Zhu Z,, Su L
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Transducin(β)-like 1 X-linked receptor 1 promotes gastric cancer progression via the ERK1/2 pathway
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Oncogene
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2017
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36(13):1873-1886
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Wang ZQ, He CY, Hu L, Shi HP, Li JF, Gu QL, Su LP,, Li C, Zhu Z
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Long noncoding RNA UCA1 promotes tumour metastasis by inducing GRK2 degradation in gastric cancer
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Cancer Lett
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2017
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408:10-21
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Zang M, Hu L, Cao S, Fan Z, Pang L, Li J, Su L, Li C, Liu W, Gu Q, Zhu Z, Yan M,
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Dual role of carcinoembryonic antigen-related cell adhesion molecule 6 expression in predicting the overall survival of gastric cancer patients
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Sci Rep
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2017
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7(1):10773
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Yu B, Gu D, Zhang X,, Xie J
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The role of GLI2-ABCG2 signaling axis for 5Fu resistance in gastric cancer
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J Genet Genomics
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2017
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44(8):375-383
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Zhang L, Song R, Gu D, Zhang X, Yu B,, Xie J
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The role of GLI1 for 5-Fu resistance in colorectal cance
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Cell Biosci
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2017
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7:17
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Guo Y, Huang A, Hu C, Zhou Y, Zhang X, Czajkowsky DM, Li J, Cheng S, Shen R, Gu J,, Shao Z
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Complex clonal mosaicism within microdissected intestinal metaplastic glands without concurrent gastric cancer
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J Med Genet
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2016
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53(9):643-6
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Du T, Zhang B, Zhang S, Jiang X, Zheng P, Li J, Yan M, Zhu Z,
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Decreased expression of long non-coding RNA WT1-AS promotes cell proliferation and invasion in gastric cancer
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Biochim Biophys Acta
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2016
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1862(1):12-9
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Hu L, Zang MD, Wang HX, Li JF, Su LP, Yan M, Li C, Yang QM,, Zhu ZG
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Biglycan stimulates VEGF expression in endothelial cells by activating the TLR signaling pathway
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Mol Oncol
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2016
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10(9):1473-1484
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Yang L, Wang J, Li J, Zhang H, Guo S, Yan M, Zhu Z, Lan B, Ding Y, Xu M, Li W, Gu X, Qi C, Zhu H, Shao Z,, Tao SC
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Identification of Serum Biomarkers for Gastric Cancer Diagnosis Using a Human Proteome Microarray
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Mol Cell Proteomics
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2016
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15(2):614-23
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Zang M, Zhang Y, Zhang B, Hu L, Li J, Fan Z, Wang H, Su L, Zhu Z, Li C, Yan C, Gu Q,, Yan M.
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CEACAM6 promotes tumor angiogenesis and vasculogenic mimicry in gastric cancer via FAK signaling.
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Biochim Biophys Acta.
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2015
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1852(5):1020-8
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, Ezeogu L, Zellmer L, Yu B, Xu N, Joshua Liao D.
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Protecting the normal in order to better kill the cancer.
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Cancer Med.
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2015
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2015 Jul 14.
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Yang L, Wang J, Li J, Zhang H, Guo S, Yan M, Zhu Z, Lan B, Ding Y, Xu M, Li W, Gu X, Qi C, Zhu H, Shao Z,, Tao SC.
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Identification of serum biomarkers for gastric cancer diagnosis using a human proteome microarray.
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Mol Cell Proteomics.
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2015
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2015 Nov 23. pii: mcp.M115.051250
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Huang J, Zhang L, He C, Qu Y, Li J, Zhang J, Du T, Chen X, Yu Y,, Zhu Z.
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Claudin-1 enhances tumor proliferation and metastasis by regulating cell anoikis in gastric cancer.
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Oncotarget.
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2015
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6(3):1652-65.
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Li P, Shan JX, Chen XH, Zhang D, Su LP, Huang XY, Yu BQ, Zhi QM, Li CL, Wang YQ, Tomei S, Cai Q, Ji J, Li JF, Chouchane L, Yu YY, Sun FZ, Xu ZH,, Zhu ZG.
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Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment.
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Cell Res.
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2015
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25:588-603.
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Guo Y, Zhou J, Huang A, Li J, Yan M, Zhu Z, Zhao X, Gu J,, Shao Z.
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Spatially defined microsatellite analysis reveals extensive genetic mosaicism and clonal complexity in intestinal metaplastic glands.
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Int J Cancer.
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2015
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136(12):2973-9
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Wang C, Zhou Q, Wang X, Wu X, Chen X, Li J, Zhu Z,, Su L.
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The TLR7 agonist induces tumor regression both by promoting CD4+T cells proliferation and by reversing T regulatory cell-mediated suppression via dendritic cells.
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Oncotarget.
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2015
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6(3):1779-89.
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Zhou Q, Wang C, Wang X, Wu X, Zhu Z,, Su L.
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Association between TLR4 (+896A/G and +1196C/T) Polymorphisms and Gastric Cancer Risk: An Updated Meta-Analysis.
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PLoS One.
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2014
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9(10):e109605.
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Li H, Yu B, Li J, Su L, Yan M, Zhu Z,
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Overexpression of lncRNA H19 enhances carcinogenesis and metastasis of gastric cancer.
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Oncotarget.
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2014
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5(8):2318-29.
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Zang M, Zhang B, Zhang Y, Li J, Su L, Zhu Z, Gu Q,, Yan M.
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CEACAM6 promotes gastric cancer invasion and metastasis by inducing epithelial-mesenchymal transition via PI3K/AKT signaling pathway.
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PLoS One.
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2014
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9(11):e112908.
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Qu Y, Zhou C, Zhang J, Cai Q, Li J, Du T, Zhu Z, Cui X,
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The metastasis suppressor SOX11 is an independent prognostic factor for improved survival in gastric cancer.
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Int J Oncol.
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2014
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44(5):1512-20.
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Zang M, Zhang B, Zhang Y, Li J, Su L, Zhu Z, Gu Q,, Yan M.
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CEACAM6 Promotes Gastric Cancer Invasion and Metastasis by Inducing Epithelial-Mesenchymal Transition via PI3K/AKT Signaling Pathway.
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PLoS One.
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2014
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9(11):e112908
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Duan Y, Hu L, Liu B, Yu B, Li J, Yan M, Yu Y, Li C, Su L, Zhu Z, Xiang M,, Yang Q.
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Tumor suppressor miR-24 restrains gastric cancer progression by downregulating RegIV.
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Mol Cancer.
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2014
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13(1):127.
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Tao Du, Ying Qu, Jianfang Li, Hao Li, Liping Su, Quan Zhou, Min Yan, Chen Li, Zhenggang Zhu,
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Maternal embryonic leucine zipper kinase enhances gastric cancer progression via the FAK/Paxillin pathway.
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Molecular Cancer.
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2014
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13:100
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Zhang BG, Du T, Zang MD, Chang Q, Fan ZY, Li JF, Yu BQ, Su LP, Li C, Yan C, Gu QL, Zhu ZG, Yan M,
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Androgen receptor promotes gastric cancer cell migration and invasion via AKT-phosphorylation dependent upregulation of matrix metalloproteinase 9.
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Oncotarget.
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2014
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5(21):10584-95.
|
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Qu Y, Li J, Cai Q,
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Hec1/Ndc80 is overexpressed in human gastric cancer and regulates cell growth.
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J Gastroenterol.
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2014
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49(3):408-18.
|
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Zhang Y, Zang M, Li J, Ji J, Zhang J, Liu X, Qu Y, Su L, Li C, Yu Y, Zhu Z,, Yan M.
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CEACAM6 promotes tumor migration, invasion, and metastasis in gastric cancer.
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Acta Biochim Biophys Sin (Shanghai).
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2014
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46(4):283-90.
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Zheng Z, He X, Xie C, Hua S, Li J, Wang T, Yao M, Vignarajan S, Teng Y, Hejazi L,, Dong Q.
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Targeting cytosolic phospholipase A2 α in colorectal cancer cells inhibits constitutively activated protein kinase B (AKT) and cell proliferation.
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Oncotarget.
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2014
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5(23):12304-16.
|
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Zhao Y, Huang J, Zhang L, Qu Y, Li J, Yu B, Yan M, Yu Y,, Zhu Z.
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MiR-133b is frequently decreased in gastric cancer and its overexpression reduces the metastatic potential of gastric cancer cells.
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BMC Cancer.
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2014
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14:34.
|
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Hu L, Duan YT, Li JF, Su LP, Yan M, Zhu ZG,, Yang QM.
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Biglycan enhances gastric cancer invasion by activating FAK signaling pathway.
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Oncotarget.
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2014
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5(7):1885-96.
|
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Li C, Li JF, Cai Q, Qiu QQ, Yan M,, Zhu ZG.
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MiRNA-199a-3p: A Potential Circulating Diagnostic Biomarker for Early Gastric Cancer.
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J Surg Oncol.
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2013
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108(2):89-92.
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Wu XY, Chen XH, Zhou Q, Li P, Yu PQ, Li JF, Qu Y, Yan J, Yu YY, Yan M, Zhu ZG,, Su LP.
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Hepatocyte growth factor activates tumor stromal fibroblasts to promote tumorigenesis in gastric cancer.
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Cancer Letters.
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2013
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335(1):128-35.
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Li P, Chen X, Su L, Li C, Zhi Q, Yu B, Sheng H, Wang J, Feng R, Cai Q, Li J, Yu Y, Yan M,, Zhu Z.
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Epigenetic Silencing of miR-338-3p Contributes to Tumorigenicity in Gastric Cancer by Targeting SSX2IP.
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PLoS One.
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2013
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8(6):e66782.
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Yu BQ, Chen XH, Li JF, Qu Y, Su LP, Peng YB, Huang J, Yan J, Yu YY, Gu QL, Zhu ZG,
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Stromal fibroblasts in the microenvironment of gastric carcinomas promote tumor metastasis via upregulating TAGLN expression.
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BMC Cell Biol.
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2013
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14(1):17
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Zhao Y., Li CL., Wang M.,Su LP.,Qu Y.,Li JF, Yu BQ., Yan M.,Yu YY.,,Zhu ZG.
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Decrease of miR-202-3p expression, a novel tumor suppressor, in gastric cancer.
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PLoS One.
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2013
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8(7):e69756
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Wang J, Chen X, Su L, Li P,, Zhu Z.
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LAT-1 functions as a promotor in gastric cancer associated with clinicopathologic features.
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Biomed Pharmacother.
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2013
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67(8):693-9.
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Zhang Q, Jin XS, Yang ZY, Wei M, Zhu XC, Wang P,, Gu QL.
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Upregulated expression of LOX is a novel independent prognostic marker of worse outcome in gastric cancer patients after curative surgery.
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Oncol Lett.
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2013
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5(3):896-902.
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Wang M, Li C, Yu B, Su L, Li J, Ju J, Yu Y, Gu Q, Zhu Z,
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Overexpressed miR-301a promotes cell proliferation and invasion by targeting RUNX3 in gastric cancer
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J Gastroenterol.
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2013
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48(9):1023-33.
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Wang J, Chen X, Li P, Su L, Yu B, Cai Q, Li J, Yu Y,, Zhu Z.
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CRKL promotes cell proliferation in gastric cancer and is negatively regulated by miR-126. Chem Biol Interact.
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Chem Biol Interact.
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2013
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206(2):230-238.
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Zheng Z, He XY, Li JF, Yu BQ, Chen XH, Ji J, Zhang JN, Gu QL, Zhu ZG,
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RhoGDI2 confers resistance to 5-fluorouracil in human gastric cancer cells.
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Oncol Lett.
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2013
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5(1):255-260.
|
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Tang X, Li J, Yu B, Su L, Yu Y, Yan M,, Zhu Z.
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Osteopontin splice variants differentially exert clinicopathological features and biological functions in gastric cancer.
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Int J Biol Sci.
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2013
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9(1):55-66.
|
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Ying Q,Partha S.R., Jianfang L,Qu C,Sanjay P.B.,Christopher M.,Myung-Shin S.,Jianian Z., Roderick R.T., Zhenggang Z., Xiaojiang C.,
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High levels of secreted frizzled-related protein 1 correlate with poor prognosis and promote tumourigenesis in gastric cancer.
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Eur J Cancer
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2013
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49(17):3718-28.
|
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Zhang BG, Li JF, Yu BQ, Zhu ZG,, Yan M.
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microRNA-21 promotes tumor proliferation and invasion in gastric cancer by targeting PTEN.
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Oncol Rep.
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2012
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27(4):1019-26.
|
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Chen L, Su L, Li J, Zheng Y, Yu B, Yu Y, Yan M, Gu Q, Zhu Z,
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Hypermethylated FAM5C and MYLK in serum as diagnosis and pre-warning markers for gastric cancer.
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Dis Markers.
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2012
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32(3):195-202.
|
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Wang M, Li C, Nie H, Lv X, Qu Y, Yu B, Su L, Li J, Chen X, Ju J, Yu Y, Yan M, Gu Q, Zhu Z,
|
Down-regulated miR-625 suppresses invasion and metastasis of gastric cancer by targeting ILK.
|
FEBS Lett.
|
2012
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586(16):2382-8.
|
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Li CL, Nie H, Wang M, Su L, Li J, Yu B, Wei M, Ju J, Yu Y, Yan M, Gu Q, Zhu Z,
|
MicroRNA-409-3p regulates cell proliferation and apoptosis by targeting PHF10 in gastric cancer.
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Cancer Lett.
|
2012
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320(2):189-97.
|
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Yu BQ, Su LP, Li JF, Cai Q, Yan M, Chen XH, Yu YY, Gu QL, Zhu ZG,
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microrna expression signature of gastric cancer cells relative to normal gastric mucosa
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Mol Med Report.
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2012
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6(4):821-6.
|
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Li CL, Nie H, Wang M, Su LP, Li JF, Yu YY, Yan M, Qu QL, Zhu ZG,
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microRNA-21 promotes tumor microRNA-155 is downregulated in gastric cancer cells and involved in cell metastasis.
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Oncol Rep.
|
2012
|
27(6):1960-6.
|
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Li C, Li JF, Cai Q, Qiu QQ, Yan M,, Zhu ZG.
|
MicroRNA-409-3p regulates cell proliferation and apoptosis by targeting PHF10 in gastric cancer.
|
Ann Surg Oncol.
|
2012
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Sep 7.
|
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Wei M, Zhu L, Li Y, Chen W, Han B, Wang Z, He J, Yao H, Yang Z, Zhang Q, Liu B, Gu Q, Zhu Z, Shen K.
|
Knocking down cyclin D1b inhibits breast cancer cell growth and suppresses tumor development in a breast cancer model.
|
Cancer Sci
|
2011
|
102(8):1537-44.
|
|
Lei KF, Liu BY, Wang YF, Chen XH, Yu BQ, Guo Y, Zhu ZG.
|
SerpinB5 interacts with KHDRBS3 and FBXO32 in gastric cancer cells.
|
Oncol Rep.
|
2011
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26(5):1115-20.
|
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Chen L, Lan B, Chen XH, Li JF, Qu Y, Yu BQ, Yu YY, Gu QL, Zhu ZG, Liu BY.
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Cell cycle dependent genes from the gastric cancer cell MKN45 can affect tumorigenesis.
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Hepatogastroenterology.
|
2011
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58(106):674-81.
|
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Ke-Feng Lei, Bing-Ya Liu, Xiao-Qing Zhang, Xiao-Long Jin, Yan Guo, Min Ye, Zheng-Gang Zhu.
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Development of a survival prediction model for gastric cancer using serine proteases and their inhibitors.
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Expreimental and Therapeutic Medicine
|
2011
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9:21-27
|
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Zheng YN, Chen L, Li JF, Yu BQ, Su LP, Chen XH, Yu YY, Yan M,, Zhu ZG.
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Hypermethylated DNA as potential biomarkers for gastric cancer diagnosis.
|
Clinical Biochemistry
|
2011
|
44:1405-11.
|
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Wei M, Wang Z, Yao H, Yang Z, Zhang Q, Liu B, Yu Y, Su L, Zhu Z, Gu Q.
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P27(Kip1), regulated by glycogen synthase kinase-3β, results in HMBA-induced differentiation of human gastric cancer cells.
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BMC Cancer.
|
2011
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11:109-120.
|
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Feng RH, Chen XH, Yu YY, Su LP, Yu BQ, Li JF, Cai Q, Yan M, Liu BY, Zhu ZG.
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miR-126 functions as a tumour suppressor in human gastric cancer.
|
Cancer Letters
|
2010
|
298:50-63.
|
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Qu Y, Wang J, Sim MS,, Giuliano A, Barsoum J, Cui X.
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Elesclomol, counteracted by Akt survival signaling, enhances the apoptotic effect of chemotherapy drugs in breast cancer cells
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Breast Cancer Res Treat
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2010
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121(2):311-21.
|
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Ke S, Chen XH, Zhu ZG, Li JF, Yu BQ, Gu QL, Liu BY.
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Silencing invariant chains of dendritic cells enhances anti-tumor immunity using small-interfering RNA.
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Chin Med J (Engl).
|
2010
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