- 基本信息
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导师姓名：
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王侃侃
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学科代码：
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100201
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性别：
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女
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学科名称：
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内科学
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培养单位：
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附属瑞金医院
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三级学科
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血液病
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导师类型：
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博士生导师
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专业领域名称：
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联系方式：
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上海交通大学医学院附属瑞金医院
上海血液学研究所/医学基因组学国家重点实验室
上海市瑞金二路197号科技楼1109室
电话：021-64370045 分机 611109
邮箱：kankanwang@shsmu.edu.cn
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专业领域代码：
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邮编：
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200025
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邮箱地址：
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kankanwang@hotmail.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
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中国遗传学会遗传咨询分会委员
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上海生物信息学会理事
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中国抗癌协会血液病转化分会委员
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- 科研项目
| 81890994 | 基于血液肿瘤细胞异质性的治疗策略探索 | 国家自然科学基金重大项目（子课题） |
2019-01~2023-12
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450万元
| 课题负责人 |
| 81770153 | 环形RNA在急性早幼粒细胞白血病发病及治疗中的功能和机制研究 | 国家自然科学基金面上项目 |
2018-01~2021-12
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58万元
| 课题负责人 |
| 81530003 | 整合多层次高通量技术研究长链非编码RNA介导的转录调控在急性髓细胞白血病发生中的功能和机制 | 国家自然科学基金重点项目 |
2016-01~2020-12
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274万元
| 课题负责人 |
| 15XD1502700 | 应用系统生物学方法研究长链非编码RNA在白血病中的功能与机制 | 上海市优秀学术带头人计划 |
2015-05~2018-04
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40万元
| 课题负责人 |
| 2014041 | 上海领军人才计划 | 上海领军人才队伍建设专项资金 |
2014-12~2017-11
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25万元
| 课题负责人 |
| 81270625 | Fenretinide特异性诱导急性髓系白血病干细胞凋亡的研究 | 国家自然科学基金面上项目 |
2013-01~2016-12
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70万元
| 课题负责人 |
| 31171257 | IRF1在诱导分化过程中全基因组水平调控机制的研究 | 国家自然科学基金面上项目 |
2012-01~2015-12
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70万元
| 课题负责人 |
| 2012AA02A211 | 白血病的“组学”研究 | 科技部863计划 |
2012-01~2015-12
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235万元
| 子课题负责人 |
| 2009CB825607 | 染色质修饰鉴定分析的方法学研究 | 科技部973计划 |
2009-01~2013-12
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435万元
| 课题负责人 |
- 学术论文
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Xuefei Ma, Wei Zhang, Rong Zhang, Jingming Li, Shufen Li, Yunlin Ma, Wen Jin,
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Overexpressed long noncoding RNA CRNDE with distinct alternatively spliced isoforms in multiple cancers.
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Frontiers of Medicine.
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2019
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13(3): 330–343
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Li S, Ma Y, Tan Y, Ma X, Zhao M, Chen B, Zhang R, Chen Z,
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Profiling and functional analysis of circular RNAs in acute promyelocytic leukemia and their dynamic regulation during all-trans retinoic acid treatment.
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Cell Death & Disease
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2018
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9:651
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Yang X, Tan Y, Wang P, Zhang H, Zhao M, Zhao X,
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PML-RARα interferes with erythropoiesis by repressing LMO2 in acute promyelocytic leukaemia
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J Cell Mol Med.
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2018
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22(12):6275-6284
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Fang H,
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Regulatory Genomic Data Cubism
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iScience
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2018
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3: 217-225
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Shufen Li, Jingming Li, Chen Chen, Rongsheng Zhang,
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Pan-cancer analysis of long non-coding RNA NEAT1 in various cancers.
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Genes & Diseases
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2018
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5(1);27-35
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Li S, Chen L, Jin W, Ma X, Ma Y, Dong F, Zhu H, Li J,
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Influence of body mass index on incidence and prognosis of acute myeloid leukemia and acute promyelocytic leukemia: A meta-analysis
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Scientific Reports
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2017
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7(1): 17998
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Wei S,
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Long noncoding RNAs: pivotal regulators in acute myeloid leukemia.
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Experimental Hematology & Oncology
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2016
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5:30
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Li Y, Wang H, Wang X, Jin W, Tan Y, Fang H, Chen S, Chen Z,
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Genome-wide studies identify a novel interplay between AML1 and AML1/ETO in t(8;21) acute myeloid leukemia.
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Blood
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2016
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127(2):233-42
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Wang X, Tan Y, Li Y, Li J, Jin W,
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Repression of CDKN2C caused by PML/RARα binding promotes the proliferation and differentiation block in acute promyelocytic leukemia.
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Frontiers of Medicine
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2016
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10(4):420-9.
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Wei S, Zhao M, Wang X, Li Y,
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PU.1 controls the expression of long noncoding RNA HOTAIRM1 during granulocytic differentiation.
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Journal of Hematology Oncology
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2016
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9:44
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Yang X, Wang P, Liu J, Zhang H, Xi W, Jia X,
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Coordinated regulation of the immunoproteasome subunits by PML/RARα and PU.1 in acute promyelocytic leukemia
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Oncogene
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2014
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33(21):2700-8
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Wang Y, Jin W, Jia X, Luo R, Tan Y, Zhu X, Yang X, and Wang X,
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Transcriptional repression of CDKN2D by PML/RARα contributes to the altered proliferation and differentiation block of acute promyelocytic leukemia cells
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Cell Death & Disease
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2014
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5(e1431):
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Zhang H, Mi J, Fang H, Wang Z, Wang C, Wu L, Zhang B, Yang W, Wang H, Minden M, Li J, Xi X, Chen S, Zhang J, Chen Z,
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Preferential eradication of acute myelogenous leukemia stem cells by fenretinide
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Proc Natl Acad Sci USA.
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2013
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110(14):5606-11
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Luo R, Ye L, Tao C,
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Simulation of E. coli gene regulation including overlapping cell cycles, growth, division, time delays and noise
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PLoS One
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2013
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8(4):-
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Jin W, Wu K, Li Y, Yang W, Zou B, Zhang F, Zhang J,
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AML1-ETO targets and suppresses cathepsin G, a serine protease, which is able to degrade AML1-ETO in t(8;21) acute myeloid leukemia
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Oncogene
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2013
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32(15):1978-87
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Qian M, Jin W, Zhu X, Jia X, Yang X, Du Y,, Zhang J
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Structurally differentiated cis-elements that interact with PU.1 are functionally distinguishable in acute promyelocytic leukemia
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J Hematol Oncol.
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2013
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6():25-
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Guo L, Li X, Huang J, Huang H, Zhang Y, Qian S, Zhu H, Zhang Y, Liu Y, Liu Y,, Tang Q
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Histone demethylase Kdm4b functions as a co-factor of C/EBPβ to promote mitotic clonal expansion during differentiation of 3T3-L1 preadipocytes
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Cell Death Differ.
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2012
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19(12):1917-27
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Zhu X, Zhang H, Qian M, Zhao X, Yang W, Wang P, Zhang J,
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The significance of low PU.1 expression in patients with acute promyelocytic leukemia
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J Hematol Oncol.
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2012
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5():22-
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Zou D, Yang X, Wang P, Zhu X, Yang W, Jia X, Zhang J,
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Regulation of the hematopoietic cell kinase gene by PML/RARα and PU.1 in acute promyelocytic leukemia
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Leukemia Res.
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2012
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36():219-23
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Zhang Y, Du Y, Le W,, Kieffer N, Zhang J
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Redox Control of the Survival of Healthy and Diseased Cells
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Antioxid Redox Signal.
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2011
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15(11):2867-2908
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Shi J, Yang W, Chen M, Du Y, Zhang J,
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AMD, an Automated Motif Discovery Tool Using Stepwise Refinement of Gapped Consensuses
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PLoS One
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2011
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6(9):e24576
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Fang H, Du Y, Xia L, Li J, Zhang J,
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A Topology-Preserving Selection and Clustering Approach to Multi-Dimensional Biological Data
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OMICS JIB
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2011
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15(7-8):483-494
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Fang H, Jin W, Yang Y, Jin Y, Zhang J,
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An organogenesis network-based comparative transcriptome analysis for understanding early human development in vivo and in vitro
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BMC Syst Biol.
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2011
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5():108-
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Yan J,, Dong L, Liu H, Chen W, Xi W, Ding Q, Kieffer N, Caen J, Chen S, Chen Z, Xi X
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PML/RARα fusion protein transactivates the tissue factor promoter through a GAGC-containing element without direct DNA association
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Proc Natl Acad Sci USA.
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2010
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107(8):3716-21
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, Wang P, Shi J, Zhu X, He M, Jia X, Yang X, Qiu F, Jin W, Qian M, Fang H, Mi J, Yang X, Xiao H, Mark Minden, Du Y, Chen Z, Zhang J
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PML/RARα Targets Promoter Regions Containing PU.1 Consensus and RARE Half Sites in Acute Promyelocytic Leukemia
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Cancer Cell
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2010
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17(2):186-197
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