• 基本信息
    导师姓名： 王颖 专业代码： 100100
    性别： 女 专业名称： 基础医学
    培养单位： 基础医学院 三级学科/
    专业领域：
    导师类型： 博士生导师 专业学位导师：
    联系方式： 地址：重庆南路280号5号楼1208 电话：63846590-776319
    邮箱地址： ywang@sibs.ac.cn 邮编： 200025
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    上海市教委优青联谊会常务理事
    上海医学会结核病学专科分会委员
    上海市免疫学会第十届理事会肿瘤免疫专业委员会委员
    上海市免疫学学会理事/副秘书长
    中国医疗保健国际交流促进会结核病防治分会第一届委员会委员
    中国免疫学会第七届理事会理事
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    2016YFC1303300基于组学特征的肺癌免疫治疗疗效预测指标的构建和验证科技部“重大慢性非传染性疾病防控研究”重点专项 2017-09~2020-12 127万元  课题参与人
    2017ZX10301301-001-004结核新疫苗的免疫学特征研究“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项 2017-09~2020-12 121万元  子课题负责人
    31370884系统性红斑狼疮中T/B细胞黏附动力学特性及其对病理性抗体产生的作用机制探讨国家自然基金面上项目 2014-01~2017-12 80万元  课题负责人
    13ZZ083dCTP焦磷酸酶参与肿瘤核酸代谢和细胞学行为异常的分子机制研究科研创新（重点） 2013-01~2015-12 16万元  课题负责人
    2013ZX10003007-003-08. 结核分枝杆菌潜伏感染的免疫学特征及特异性防治策略（潜伏感染创新性疫苗）的研究卫生部 2013-01~20115-12 76万元  主要责任人
    31170828 I 型干扰素调节T 细胞免疫功能的新机制及其在系统性红斑狼疮中的作用国家自然科学基金项目 2012-01~2015-12 50万元  课题负责人
    10410701600TLRs调节系统性红斑狼疮中T细胞功能的可视化研究上海市科委国际合作项目 2010-04~2012-03 15万元  课题负责人
    30771965T细胞受体（TCR）介导的胞内信号对T细胞免疫自稳的负向调节作用和T细胞分化影响的分子机制研究国家自然基金委,面上项目 2008-01~2010-12 35万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Yang C, Khanniche A, DiSpirito JR, Ji P, Wang S,, Shen H*  Transcriptome Signatures Reveal Rapid Induction of Immune-Responsive Genes in Human Memory CD8(+) T Cells.   Sci Rep.   2016  6:27005 
    Ji P, Zhang Y, Wang SJ, Ge HL, Zhao GP, Xu YC,  CD44hiCD24lo mammosphere-forming cells from primary breast cancer display resistance to multiple chemotherapeutic drugs.   Oncol Rep.  2016  35(6):3293-302 
    Xiao XJ, Sha W, Tian ZF, Chen YY, Ji P, Sun Q, Wang HY, Wang SJ, Fang Y, Wen HL, Zhao HM, Lu J, Xiao HP, Fan XY*, Shen H* and Wang Y*  Adenylate kinase: a novel antigen for immunodiagnosis and subunit vaccine against tuberculosis.  J Mol Med  2016  94(7):823-34 
    Lin X, Liang Q, Lin L, Ding Q, Wang X,  Identification of anti-moesin antibodies in the serums of patients with antiphospholipid syndrome.  Thromb Res.   2015  135: 867-878  
    Ni C#, Chen YH#, Zeng MS#, Pei RJ, Du Y, Tang LQ, Wang MY, Hu YJ, Zhu HY, He MF, Wei XW, Wang S, Ning XK, Wang MN, Wang JF, Ma L,Chen XW, Sun Q, Tang H,  In-cell infection: a novel pathway for Epstein-Barr virus infection mediated by cell-in-cell structures  Cell Research  2015  25(7):785-800  
    Xu J, Wu B, Wang JH, Huang L, Wang DY, Zhao L, Zhao GP,  Pre-existing mutations in reverse transcriptase of hepatitis B virus in treatment-naive chinese patients with chronic hepatitis B.   Plos One  2015  10(3): e0117429.  
    Song FF#, Xia LL#, Ji P#, Tang YB, Huang ZM, Zhu L, Zhang J, Wang JQ, Zhao GP, Ge HL, Zhang Y*,  Human dCTP Pyrophosphatase 1 promotes breast cancer cell growth and stemness through modulation on 5-methyl-dCTP metabolism and global hypomethylation.  Oncogenesis  2015  Jun 15;4:e159 
    Wang S, Zhang Y, Saas P, Wang H, Xu Y, Chen K, Zhong J, Yuan Y,  Oridonin exerts therapeutic effect by suppressing Th1/Th17 simultaneously in a mouse model of Crohn's disease.   J Gastroenterol Hepatol.  2015  30: 504-512 
    Fan J, Zhang Y, Xiong H*,, Guo X.   Nucleotide analog-resistant mutations in hepatitis B viral genomes found in hepatitis B patients.   J Gen Virol.  2015  96(Pt 3):663-70.  
    Xiong FF, Xia LL, Wang JF, Wu B, Wang DY, Yuan LF, Cheng YT, Zhu HY, Che XY, Zhang QH, Zhao GP,  A High-affinity CDR-grafted Antibody against Influenza A H5N1 Viruses Recognizes a Conserved Epitope of H5 Hemagglutinin.  PLoS One.  2014  e88777 
    Zhang F, Zhou X, DiSpirito JR, Wang C,, Shen H  Epigenetic manipulation restores functions of defective CD8(+) T cells from chronic viral infection.   Mol Ther.  2014  22(9):1698-706 
    Zeng W,, Liu Z, Khanniche A, Hu Q, Feng Y, Ye W, Yang J, Wang S, Zhou L, Shen H, Wang Y.   Long-term exposure to decabrominated diphenyl ether impairs CD8 T-cell function in adult mice.   Cell Mol Immunol.  2014  11(4):367-76 
      Cell-in-cell: A virgin land of cell biology  OncoImmunology  2013  2(10): e25988 
    Chen YH, Wang S, He MF, Wang Y, Zhao H, Zhu HY, Yu XM, Ma J, Che XJ, Wang JF,, Wang XN*.   Prevalence of Heterotypic Tumor/Immune Cell-In-Cell Structure In Vitro and In Vivo Leading to Formation of Aneuploidy.  PLoS One.  2013  8(3): e59418-0 
    He MF, Wang S,, Wang XN*.  Modeling cell-in-cell structure into its biological significance.   Cell Death &Disease  2013  4, e630 
    Zhang Y, Ye WY, Wang JQ, Wang SJ, Ji P, Zhou GY, Zhao GP, Ge HL,  dCTP Pyrophosphohydrase Exhibits Nucleic Accumulation in Multiple Carcinomas  Eur J Histochemistry  2013  57 e29: 185-191 
    Wang S, He MF, Chen YH, Wang MY, Yu XM, Bai J, Zhu HY, Wang YY, Zhao H, Mei Q, Nie J, Ma J, Wang JF, Wen Q, Ma L,  Rapid reuptake of granzyme B leads to emperitosis: an apoptotic cell-in-cell death of immune killer cells inside tumor cells  Cell Death &Disease  2013  4, e856 
    Ouyang S, Gong B, Li JZ, Zhao LX, Wu W, Zhang FS, Sun L, Wang SJ, Pan M, Li C, Liang W, Shaw N, Zheng J, Zhao GP,, Liu ZJ, Liang M  Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus  J Mol Med (Berl)  2012  90(7):837-46 
    He M,, Shi WJ, Wang SJ, Sha HF, Feng JX, Wang J  Immunomodulation of inducible co-stimulator (ICOS) in human cytokine-induced killer cells against cholangiocarcinoma through ICOS/ICOS ligand interaction  J Dig Dis  2011  12(5):393-400 
    Mingueneau M, Roncagalli R, Gregoire C, Kissenpfennig A, Miazek A, Archambaud C,, Perrin P, Bertosio E, Sansoni A, Richelme S, Locksley RM, Aguado E, Malissen M, Malissen B  Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor.  Immunity  2009  31(2):197-208 
    Jin S,, Zhang Y, Zhang HZ, Wang SJ, Tang JQ, Chen HJ, Ge HL  Humoral immune responses against tumor-associated antigen OVA66 originally defined by serological analysis of recombinant cDNA expression libraries and its potentiality in cellular immunity  Cancer Sci  2008  99(8):1670-8 
    , Kissenpfennig A, Mingueneau M, Richelme S, Perrin P, Chevrier S, Genton C, Lucas B, DiSanto JP, Acha-Orbea H, Malissen B, Malissen M  Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells  J Immunol  2008  180(3):1565-75 
    Gregoire C, Simova S,, Sansoni A, Richelme S, Schmidt-Giese A, Simeoni L, Angelisova P, Reinhold D, Schraven B, Horejsi V, Malissen B, Malissen M  Deletion of the LIME adaptor protein minimally affects T and B cell development and function  Eur J Immunol  2007  37(11):3259-69