- 基本信息
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导师姓名：
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王颖
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学科代码：
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100100
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性别：
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女
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学科名称：
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基础医学
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培养单位：
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基础医学院
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三级学科
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导师类型：
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博士生导师
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专业领域名称：
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联系方式：
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地址：重庆南路280号5号楼1208
电话：63846590-776319
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专业领域代码：
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邮编：
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200025
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邮箱地址：
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ywang@sibs.ac.cn
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- 研究方向 (点击浏览详细信息)
- 社会任职
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上海医学会结核病学专科分会委员
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上海市免疫学会第十届理事会肿瘤免疫专业委员会委员
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上海市免疫学学会第十二届理事会 副理事长/青年工作委员会主任
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中国医疗保健国际交流促进会结核病防治分会第一届委员会委员
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中国免疫学会第八届理事会理事
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- 科研项目
| 81930051 | 可注射水凝胶微球治疗卒中的免疫兼容性机制研究 | 国家自然科学基金委重点项目 |
2020-01~2024-12
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97万元
| 课题参与人 |
| 19411950500 | 标志物指导下的肺癌免疫治疗人群选择策略的前瞻性研究 | 上海市科学技术委员会临床重点项目 |
2019-09~2022-06
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50万元
| 子课题负责人 |
| 81873868 | 结核抗原特异性免疫记忆T细胞功能的代谢调控机制及其临床意义 | 国家自然科学基金面上项目 |
2019-01~2022-12
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56万元
| 课题负责人 |
| 18XD1403300 | 抗结核免疫记忆应答调控新机制与新型疫苗设计策略 | 上海市科委优秀学术带头人计划 |
2018-05~2021-05
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40万元
| 课题负责人 |
| 2016YFC1303300 | 基于组学特征的肺癌免疫治疗疗效预测指标的构建和验证 | 科技部“重大慢性非传染性疾病防控研究”重点专项 |
2017-09~2020-12
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127万元
| 课题参与人 |
| 2017ZX10301301-001-004 | 结核新疫苗的免疫学特征研究 | “艾滋病和病毒性肝炎等重大传染病防治”科技重大专项 |
2017-09~2020-12
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121万元
| 子课题负责人 |
| 31370884 | 系统性红斑狼疮中T/B细胞黏附动力学特性及其对病理性抗体产生的作用机制探讨 | 国家自然基金面上项目 |
2014-01~2017-12
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80万元
| 课题负责人 |
| 13ZZ083 | dCTP焦磷酸酶参与肿瘤核酸代谢和细胞学行为异常的分子机制研究 | 科研创新（重点） |
2013-01~2015-12
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16万元
| 课题负责人 |
| 2013ZX10003007-003-0 | 8. 结核分枝杆菌潜伏感染的免疫学特征及特异性防治策略（潜伏感染创新性疫苗）的研究 | 卫生部 |
2013-01~20115-12
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76万元
| 主要责任人 |
| 31170828 | I 型干扰素调节T 细胞免疫功能的新机制及其在系统性红斑狼疮中的作用 | 国家自然科学基金项目 |
2012-01~2015-12
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50万元
| 课题负责人 |
| 10410701600 | TLRs调节系统性红斑狼疮中T细胞功能的可视化研究 | 上海市科委国际合作项目 |
2010-04~2012-03
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15万元
| 课题负责人 |
| 30771965 | T细胞受体（TCR）介导的胞内信号对T细胞免疫自稳的负向调节作用和T细胞分化影响的分子机制研究 | 国家自然基金委,面上项目 |
2008-01~2010-12
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35万元
| 课题负责人 |
- 学术论文
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Khanniche A, Zhou L, Jiang B, Song J, Jin Y, Yin J, Wang S, Ji P, Shen H,, Xu H*.
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Restored and enhanced memory T cell immunity in Rheumatoid Arthritis after TNFa blocker treatment.
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Front Immunol
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2019
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10:887
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Xia LL#, Liu YY#,
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PD-1/PD-L1 Blockade Therapy in Advanced Non-Small-Cell Lung Cancer: Current Status and Future Directions.
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The Oncologist
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2019
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24(Specical Issue):S31-S41
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Jin Y*, Dong H*, Xia LL, Yang Y, Zhu Y, Shen Y, Zheng H, Yao C,, Lu S*.
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The Diversity of Gut Microbiome is Associated With Favorable Responses to Anti-Programmed Death 1 Immunotherapy in Chinese Patients With NSCLC.
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J Thorac Oncol
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2019
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14(8):1378-1389.
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Zhang MY, Xia LL, Yang Y, Liu S, Ji P, Wang SJ, Chen YY, Liu ZD, Zhang YY, Lu S,
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PD-1 blockade augments humoral immunity through ICOS-mediated CD4+ T cell instruction.
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Int Immunopharmacol
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2019
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66:127-138
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Chen YY#, Xiao JN#, Li Y#, Xiao YJ#, Xiong YQ, Liu Y, Wang SJ, Ji P, Zhao GP, Shen H, Lu SH, Fan XY*,
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Mycobacterial lipoprotein Z triggers efficient innate and adaptive immunity for protection against Mycobacterium tuberculosis infection
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Front Immunol
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2019
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9:3190
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Zhang MY#, Yao CC#, Cai J#, Liu S, Liu XN, Chen YY, Wang SJ, Ji P, Pan M, Kang ZJ*,
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LRRK2 is involved in the pathogenesis of system lupus erythematosus through promoting pathogenic antibody production
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Journal of Translational Medicine
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2019
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17(1):37
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Liu YY#, Sha W#, Xu SQ, Gui XW, Xia LL, Ji P, Wang SJ, Zhao GP, Zhang X*, Chen YY*,
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Identification of HLA-A2-restricted mycobacterial lipoprotein Z peptides recognized by T Cells from patients with active tuberculosis infection.
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Front Microbiol
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2018
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9:3131
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Li W#, Zhang X#, Yang Y, Yin Q, Wang Y, Li Y, Wang C, Wong SM,, Goldfine H, Akerley BJ, Shen H.
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Recognition of conserved antigens by Th17 cells provides broad protection against pulmonary Haemophilus influenzae infection.
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Proc Natl Acad Sci U S A.
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2018
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115(30):E7149-E7157
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Xiao JN#, XiongYQ#, Chen YY#, Xiao YJ, Ji P, Li Y, Wang SJ, Zhao GP, Cheng QJ, Lu SH*,
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Determination of Lipoprotein Z-specific IgA in tuberculosis and latent tuberculosis infection.
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Front Cell Infect Mcrobiol
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2017
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7:495
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Zhang R, Wu X, Xia X, Khanniche A, Song F, Zhang B*,, Ge H*
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OVA12 promotes tumor growth by regulating p53 expression in human cancer cells.
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Oncotarget
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2017
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8(32):52854-52865
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Liu Z, Zeng W, Huang X, Wang S, Zheng J, Pan M,
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Peripheral CD19hi B cells exhibit activated phenotype and functionality in promoting IgG and IgM production in human autoimmune diseases.
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Sci Rep
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2017
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7(1):13921
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Yang XY#, Wu JB#, Liu Y, Xiong Y, Ji P, Wang SJ, Chen YY, Zhao GP, Lu SH,
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Identification of mycobacterial bacterioferritin B for immune screening of tuberculosis and latent tuberculosis infection.
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Tuberculosis (Edinb)
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2017
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107:119-125
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Yang C#, Khanniche A#, DiSpirito JR, Ji P, Wang S,, Shen H*
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Transcriptome Signatures Reveal Rapid Induction of Immune-Responsive Genes in Human Memory CD8(+) T Cells.
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Sci Rep.
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2016
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6:27005
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Ji P#, Zhang Y#, Wang SJ, Ge HL, Zhao GP, Xu YC,
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CD44hiCD24lo mammosphere-forming cells from primary breast cancer display resistance to multiple chemotherapeutic drugs.
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Oncol Rep.
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2016
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35(6):3293-302
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Xiao YJ#, Sha W#, Tian ZF#, Chen YY, Ji P, Sun Q, Wang HY, Wang SJ, Fang Y, Wen HL, Zhao HM, Lu J, Xiao HP, Fan XY*, Shen H*,
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Adenylate kinase: a novel antigen for immunodiagnosis and subunit vaccine against tuberculosis.
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J Mol Med
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2016
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94(7):823-34
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Lin X, Liang Q, Lin L, Ding Q, Wang X,
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Identification of anti-moesin antibodies in the serums of patients with antiphospholipid syndrome.
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Thromb Res.
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2015
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135: 867-878
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Ni C#, Chen YH#, Zeng MS#, Pei RJ, Du Y, Tang LQ, Wang MY, Hu YJ, Zhu HY, He MF, Wei XW, Wang S, Ning XK, Wang MN, Wang JF, Ma L,Chen XW, Sun Q, Tang H,, Wang XN*.
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In-cell infection: a novel pathway for Epstein-Barr virus infection mediated by cell-in-cell structures
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Cell Research
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2015
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25(7):785-800
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Xu J, Wu B, Wang JH, Huang L, Wang DY, Zhao L, Zhao GP,
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Pre-existing mutations in reverse transcriptase of hepatitis B virus in treatment-naive chinese patients with chronic hepatitis B.
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Plos One
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2015
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10(3): e0117429.
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Song FF#, Xia LL#, Ji P#, Tang YB, Huang ZM, Zhu L, Zhang J, Wang JQ, Zhao GP, Ge HL, Zhang Y*,
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Human dCTP Pyrophosphatase 1 promotes breast cancer cell growth and stemness through modulation on 5-methyl-dCTP metabolism and global hypomethylation.
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Oncogenesis
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2015
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Jun 15;4:e159
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Wang S, Zhang Y, Saas P, Wang H, Xu Y, Chen K, Zhong J, Yuan Y,, Sun Y*
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Oridonin exerts therapeutic effect by suppressing Th1/Th17 simultaneously in a mouse model of Crohn's disease.
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J Gastroenterol Hepatol.
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2015
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30: 504-512
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Fan J, Zhang Y, Xiong H*,, Guo X.
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Nucleotide analog-resistant mutations in hepatitis B viral genomes found in hepatitis B patients.
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J Gen Virol.
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2015
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96(Pt 3):663-70.
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Xiong FF, Xia LL, Wang JF, Wu B, Wang DY, Yuan LF, Cheng YT, Zhu HY, Che XY, Zhang QH, Zhao GP,
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A High-affinity CDR-grafted Antibody against Influenza A H5N1 Viruses Recognizes a Conserved Epitope of H5 Hemagglutinin.
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PLoS One.
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2014
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e88777
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Zhang F, Zhou X, DiSpirito JR, Wang C,, Shen H
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Epigenetic manipulation restores functions of defective CD8(+) T cells from chronic viral infection.
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Mol Ther.
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2014
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22(9):1698-706
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Zeng W,, Liu Z, Khanniche A, Hu Q, Feng Y, Ye W, Yang J, Wang S, Zhou L, Shen H*, Wang Y*.
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Long-term exposure to decabrominated diphenyl ether impairs CD8 T-cell function in adult mice.
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Cell Mol Immunol.
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2014
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11(4):367-76
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Cell-in-cell: A virgin land of cell biology
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OncoImmunology
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2013
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2(10): e25988
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Chen YH, Wang S, He MF, Wang Y, Zhao H, Zhu HY, Yu XM, Ma J, Che XJ, Wang JF,, Wang XN*.
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Prevalence of Heterotypic Tumor/Immune Cell-In-Cell Structure In Vitro and In Vivo Leading to Formation of Aneuploidy.
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PLoS One.
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2013
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8(3): e59418-0
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He MF, Wang S,, Wang XN*.
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Modeling cell-in-cell structure into its biological significance.
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Cell Death &Disease
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2013
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4, e630
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Zhang Y, Ye WY, Wang JQ, Wang SJ, Ji P, Zhou GY, Zhao GP, Ge HL,
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dCTP Pyrophosphohydrase Exhibits Nucleic Accumulation in Multiple Carcinomas
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Eur J Histochemistry
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2013
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57 e29: 185-191
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Wang S, He MF, Chen YH, Wang MY, Yu XM, Bai J, Zhu HY, Wang YY, Zhao H, Mei Q, Nie J, Ma J, Wang JF, Wen Q, Ma L,, Wang XN*.
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Rapid reuptake of granzyme B leads to emperitosis: an apoptotic cell-in-cell death of immune killer cells inside tumor cells
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Cell Death &Disease
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2013
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4:e856
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Ouyang S, Gong B, Li JZ, Zhao LX, Wu W, Zhang FS, Sun L, Wang SJ, Pan M, Li C, Liang W, Shaw N, Zheng J, Zhao GP,, Liu ZJ, Liang M
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Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus
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J Mol Med (Berl)
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2012
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90(7):837-46
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He M,, Shi WJ, Wang SJ, Sha HF, Feng JX, Wang J
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Immunomodulation of inducible co-stimulator (ICOS) in human cytokine-induced killer cells against cholangiocarcinoma through ICOS/ICOS ligand interaction
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J Dig Dis
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2011
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12(5):393-400
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Mingueneau M, Roncagalli R, Gregoire C, Kissenpfennig A, Miazek A, Archambaud C,, Perrin P, Bertosio E, Sansoni A, Richelme S, Locksley RM, Aguado E, Malissen M, Malissen B
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Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor.
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Immunity
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2009
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31(2):197-208
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Jin S,, Zhang Y, Zhang HZ, Wang SJ, Tang JQ, Chen HJ, Ge HL
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Humoral immune responses against tumor-associated antigen OVA66 originally defined by serological analysis of recombinant cDNA expression libraries and its potentiality in cellular immunity
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Cancer Sci
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2008
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99(8):1670-8
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, Kissenpfennig A, Mingueneau M, Richelme S, Perrin P, Chevrier S, Genton C, Lucas B, DiSanto JP, Acha-Orbea H, Malissen B, Malissen M
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Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells
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J Immunol
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2008
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180(3):1565-75
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Gregoire C, Simova S,, Sansoni A, Richelme S, Schmidt-Giese A, Simeoni L, Angelisova P, Reinhold D, Schraven B, Horejsi V, Malissen B, Malissen M
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Deletion of the LIME adaptor protein minimally affects T and B cell development and function
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Eur J Immunol
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2007
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37(11):3259-69
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