- 基本信息
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导师姓名：
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王颖
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学科代码：
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100100
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性别：
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女
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学科名称：
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基础医学
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培养单位：
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基础医学院
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三级学科
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导师类型：
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博士生导师
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专业领域名称：
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联系方式：
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地址：重庆南路280号5号楼1208
电话：63846590-776319
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专业领域代码：
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邮编：
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200025
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邮箱地址：
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ywang@sibs.ac.cn
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- 研究方向 (点击浏览详细信息)
- 社会任职
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上海医学会结核病学专科分会委员
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上海市免疫学会第十届理事会肿瘤免疫专业委员会委员
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上海市免疫学学会第十二届理事会 副理事长
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中国免疫学会第八届理事会理事
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- 科研项目
| 82241228 | EGFR突变型肺癌免疫检查点抑制剂的耐药机制及干预策略 | 国家自然科学基金委专项项目 |
2023-01~2025-12
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200万元
| 课题负责人 |
| 2022LJ016 | 基于嘌呤代谢的肿瘤局部“冷-热”转换调控机制及其免疫增效策略 | 上海市卫健委卫生健康领军人才 |
2023-01~2025-12
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45万元
| 课题负责人 |
| SQ2021YFC2300024 | 重要病原体复杂和多变免疫原的设计和优化研究 | 国家重点研发计划项目 |
2021-11~2024-12
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483万元
| 课题负责人 |
| 20JC1417500 | NLRP4介导的I型干扰素应答参与肺癌肿瘤局部免疫微环境重塑和和免疫检查点治疗的影响机制 | 上海市科学技术委员会基础重点项目 |
2020-10~2023-09
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80万元
| 课题负责人 |
| 81930051 | 可注射水凝胶微球治疗卒中的免疫兼容性机制研究 | 国家自然科学基金委重点项目 |
2020-01~2024-12
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97万元
| 课题参与人 |
| 19411950500 | 标志物指导下的肺癌免疫治疗人群选择策略的前瞻性研究 | 上海市科学技术委员会临床重点项目 |
2019-09~2022-06
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50万元
| 子课题负责人 |
| 81873868 | 结核抗原特异性免疫记忆T细胞功能的代谢调控机制及其临床意义 | 国家自然科学基金面上项目 |
2019-01~2022-12
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56万元
| 课题负责人 |
| 18XD1403300 | 抗结核免疫记忆应答调控新机制与新型疫苗设计策略 | 上海市科委优秀学术带头人计划 |
2018-05~2021-05
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40万元
| 课题负责人 |
| 2016YFC1303300 | 基于组学特征的肺癌免疫治疗疗效预测指标的构建和验证 | 科技部“重大慢性非传染性疾病防控研究”重点专项 |
2017-09~2020-12
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127万元
| 课题参与人 |
| 2017ZX10301301-001-004 | 结核新疫苗的免疫学特征研究 | “艾滋病和病毒性肝炎等重大传染病防治”科技重大专项 |
2017-09~2020-12
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121万元
| 子课题负责人 |
- 学术论文
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Yao CC, Sun RM, Yang Y, Zhou HY, Meng ZW, Chi R, Xia LL, Ji P, Chen YY, Zhang GQ, Sun HP, Lu S*, Yang C*,
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Accumulation of branched-chain amino acids reprograms glucose metabolism in CD8+ T cells with enhanced effector function and anti-tumor response
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Cell Reports
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2023
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42(3):112186
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Meng Z, Niu X, Xia L, Chen Y, Wang Z, Wang H, Ji P, Cui W*,, Lu S*
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A 3D Ex Vivo Tumor-Immune Coculture System Mimicking In Vivo Tumor Environmental Stress on CD8+ T Cells Exhaustion.
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Adv Biol (Weinh)
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2023
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19:e2200264.
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Bao Y, He L, Miao B, Zhong Z, Lu G, Bai Y, Liang Q, Ling Y, Ji P, Su B, Zhao GP, Wu H, Zhang W,, Chen Y*, Xu J*
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BBIBP-CorV vaccination accelerates anti-viral antibody responses in heterologous Omicron infection: A retrospective observation study in Shanghai.
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Vaccine
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2023
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;41(20):3258-3265.
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Gao B, He L, Bao Y, Chen Y, Lu G, Zhang Y, Xu Y, Su B, Xu J,, Yeap LS*
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Repeated vaccination of inactivated SARS-CoV-2 vaccine dampens neutralizing antibodies against Omicron variants in breakthrough infection
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Cell Res
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2023
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33(3):258-261
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Gao S, Chen T, Wang Z, Ji P, Xu L*, Cui W*,
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Immuno-activated mesenchymal stem cell living electrospun nanofibers for promoting diabetic wound repair
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J Nanobiotechnology
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2022
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20(1):294
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Khanniche A, Zhou L, Jiang B, Song J, Jin Y, Yin J, Wang S, Ji P, Shen H,, Xu H*.
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Restored and enhanced memory T cell immunity in Rheumatoid Arthritis after TNFa blocker treatment.
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Front Immunol
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2019
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10:887
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Xia LL#, Liu YY#,
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PD-1/PD-L1 Blockade Therapy in Advanced Non-Small-Cell Lung Cancer: Current Status and Future Directions.
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The Oncologist
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2019
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24(Specical Issue):S31-S41
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Jin Y*, Dong H*, Xia LL, Yang Y, Zhu Y, Shen Y, Zheng H, Yao C,, Lu S*.
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The Diversity of Gut Microbiome is Associated With Favorable Responses to Anti-Programmed Death 1 Immunotherapy in Chinese Patients With NSCLC.
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J Thorac Oncol
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2019
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14(8):1378-1389.
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Chen YY#, Xiao JN#, Li Y#, Xiao YJ#, Xiong YQ, Liu Y, Wang SJ, Ji P, Zhao GP, Shen H, Lu SH, Fan XY*,
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Mycobacterial lipoprotein Z triggers efficient innate and adaptive immunity for protection against Mycobacterium tuberculosis infection
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Front Immunol
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2019
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9:3190
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Zhang MY#, Yao CC#, Cai J#, Liu S, Liu XN, Chen YY, Wang SJ, Ji P, Pan M, Kang ZJ*,
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LRRK2 is involved in the pathogenesis of system lupus erythematosus through promoting pathogenic antibody production
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Journal of Translational Medicine
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2019
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17(1):37
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Liu YY#, Sha W#, Xu SQ, Gui XW, Xia LL, Ji P, Wang SJ, Zhao GP, Zhang X*, Chen YY*,
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Identification of HLA-A2-restricted mycobacterial lipoprotein Z peptides recognized by T Cells from patients with active tuberculosis infection.
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Front Microbiol
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2018
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9:3131
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Li W#, Zhang X#, Yang Y, Yin Q, Wang Y, Li Y, Wang C, Wong SM,, Goldfine H, Akerley BJ, Shen H.
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Recognition of conserved antigens by Th17 cells provides broad protection against pulmonary Haemophilus influenzae infection.
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Proc Natl Acad Sci U S A.
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2018
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115(30):E7149-E7157
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Xiao JN#, XiongYQ#, Chen YY#, Xiao YJ, Ji P, Li Y, Wang SJ, Zhao GP, Cheng QJ, Lu SH*,
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Determination of Lipoprotein Z-specific IgA in tuberculosis and latent tuberculosis infection.
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Front Cell Infect Mcrobiol
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2017
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7:495
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Yang XY#, Wu JB#, Liu Y, Xiong Y, Ji P, Wang SJ, Chen YY, Zhao GP, Lu SH,
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Identification of mycobacterial bacterioferritin B for immune screening of tuberculosis and latent tuberculosis infection.
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Tuberculosis (Edinb)
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2017
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107:119-125
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Yang C#, Khanniche A#, DiSpirito JR, Ji P, Wang S,, Shen H*
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Transcriptome Signatures Reveal Rapid Induction of Immune-Responsive Genes in Human Memory CD8(+) T Cells.
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Sci Rep.
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2016
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6:27005
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Xiao YJ#, Sha W#, Tian ZF#, Chen YY, Ji P, Sun Q, Wang HY, Wang SJ, Fang Y, Wen HL, Zhao HM, Lu J, Xiao HP, Fan XY*, Shen H*,
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Adenylate kinase: a novel antigen for immunodiagnosis and subunit vaccine against tuberculosis.
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J Mol Med
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2016
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94(7):823-34
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Ni C#, Chen YH#, Zeng MS#, Pei RJ, Du Y, Tang LQ, Wang MY, Hu YJ, Zhu HY, He MF, Wei XW, Wang S, Ning XK, Wang MN, Wang JF, Ma L,Chen XW, Sun Q, Tang H,, Wang XN*.
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In-cell infection: a novel pathway for Epstein-Barr virus infection mediated by cell-in-cell structures
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Cell Research
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2015
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25(7):785-800
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