• 基本信息
    导师姓名： 刘辰莹 学科代码： 100210
    性别： 男 学科名称： 外科学
    培养单位： 附属新华医院 三级学科 普外
    导师类型： 博士生导师 专业领域名称：
    联系方式： 专业领域代码：
    邮编： 邮箱地址： liuchenying@xinhuamed.com.cn
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    中国生物化学与分子生物学学会生物技术专业委员会委员
    国际肝胆胰协会中国分会转移性肝癌专业委员会委员
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    82372648转录因子TEAD4通过招募细胞核酸结合蛋白CNBP促进结直肠癌发生发展的作用及机制研究国自然面上项目 2024-01~2027-12 49万元  课题负责人
    23ZR1441400转录因子TEAD4基因转录协同调控新机制及其在肠癌发生中的作用研究上海市科委面上项目 2023-04~2026-03 20万元  课题负责人
    TP2022053上海高校特聘教授(东方学者)上海市教委 2023-01~2025-12 100万元  课题负责人
    82172916转录因子SP1协同YAP/TEAD促进结直肠癌发生进展的生物学功能与机制研究国自然面上项目 2022-01~2025-12 54.7万元  课题负责人
    QD2018018上海高校“青年东方学者”上海市教委 2019-01~2021-12 60万元  课题负责人
    81874177转录因子TEAD4促进结直肠癌淋巴转移的生物学功能与机制研究国自然面上项目 2019-01~2022-12 57万元  课题负责人
    18PJ1407400转录因子TEAD4在结直肠癌发生中的作用与机制研究上海市浦江人才计划（A类） 2018-07~2020-06 20万元  课题负责人
    20171918转录因子TEAD4在结直肠癌发生中的作用与机制研究上海交通大学医学院"高峰高原"项目 2017-07~2020-06 100万元  课题负责人
    81672517前列腺癌中转录共激活子TAZ的基因转录调控机制及其功能研究国自然面上项目 2017-01~2020-12 57万元  课题负责人
    YG2014MS71利用果蝇模型筛选先天性巨结肠相关基因及功能研究上海交通大学医工交叉面上项目 2015-01~2017-12 15万元  课题负责人
    ZZjdyx13074结直肠癌发病中Hippo抑癌信号通路的失活机制及靶向治疗研究上海高校优秀青年教师培养资助计划 2014-01~2015-12 5万元  课题负责人
    81302089TEAD4高表达：一种结直肠癌Hippo抑癌信号通路失活的新分子机制研究国自然青年项目 2014-01~2016-12 23万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Xu W, Hua Z, Wang Y, Tang W, Ou W, Liu F, Yang Y, Ding W, Wang Z, Cui L, Ge W, Gu Y, Wang X, Chen Y,, Du P.  AMBRA1 promotes intestinal inflammation by antagonizing PP4R1/PP4c mediated IKK dephosphorylation in an autophagy-independent manner  Cell Death & Differentiation  2024  online 
    Zhu Z, Guo Y, Liu Y, Ding R, Huang Z, Yu W, Cui L, Du P, Goel A,  ELK4 Promotes Colorectal Cancer Progression by Activating the Neoangiogenic Factor LRG1 in a Noncanonical SP1/3-Dependent Manner.   Advanced Science  2023  Oct 2:e2303378 
    Xia Shen,Xiang Peng,Yuegui Guo,Zhujiang Dai,Long Cui,Wei Yu,Yun Liu,  YAP/TAZ enhance P-body formation to promote tumorigenesis  eLife  2023  12:RP88573 
    Song J, Dang X, Shen X, Liu Y, Gu J, Peng X, Huang Z, Hong W, Cui L,  The YAP/TEAD4 complex promotes tumor lymphangiogenesis by transcriptionally upregulating CCBE1 in colorectal cancer.  J Biol Chem.  2023  299(4):103012. 
    Yuji Huang, Zhehui Zhu, Weize Li, Yiqin Ge, Yanning Li, Juan Wang, Xia Peng, Lihui Lin, Jia Li,, Li Li  ELK4 exerts opposite roles in cytokine/chemokine production and degranulation in activated mast cells  Front. Immunol.  2023  14:1171380 
    Jie Zhong,Yuegui Guo,Shaoyong Lu,Kun Song,Ying Wang,Li Feng,Zhen Zheng,Qiufen Zhang,Jiacheng Wei,Peng Sang,Yan Shi,Jianfeng Cai,Guoqiang Chen,,Xiuyan Yang,Jian Zhang   Rational design of a sensitivity-enhanced tracer for discovering efficient APC–Asef inhibitors  Nature Communications  2022  13, 4961 
    Yuegui Guo,Zhehui Zhu,Zhenyu Huang,Long Cui,Wei Yu,Wanjin Hong,Zhaocai Zhou,Peng Du,  CK2-induced cooperation of HHEX with the YAP-TEAD4 complex promotes colorectal tumorigenesis  Nature Communications  2022  13, 4995 
    Weijun Ou,Weimin Xu,Fangyuan Liu,Yuegui Guo,Zhenyu Huang,Tienan Feng,,Peng Du  Increased expression of yes-associated protein/YAP and transcriptional coactivator with PDZ-binding motif/TAZ activates intestinal fibroblasts to promote intestinal obstruction in Crohn's disease  EBioMedicine  2021  69:103452. 
    Chao Wang,Xingyou Wan,Tong Yu,Zhenyu Huang,Chao Shen,Qian Qi,Sheng Xiang,Xinyuan Chen,Eyal Arbely,Zhi-Qiang Ling,,Wei Yu  Acetylation Stabilizes Phosphoglycerate Dehydrogenase by Disrupting the Interaction of E3 Ligase RNF5 to Promote Breast Tumorigenesis  Cell Reports  2020  32(6):108021 
    Song J, Chen W, Cui X, Huang Z, Wen D, Yang Y, Yu W, Cui L,  CCBE1 promotes tumor lymphangiogenesis and is negatively regulated by TGFβ signaling in colorectal cancer   Theranostics   2020  10(5):2327-2341.  
    Zhehui Zhu, Jinglue Song, Yuegui Guo, Zhenyu Huang, Xiaojian Chen, Xuening Dang, Yuji Huang, Yuhan Wang, Weijun Ou, Yili Yang, Wei Yu,, Long Cui  LAMB3 promotes tumour progression through the AKT–FOXO3/4 axis and is transcriptionally regulated by the BRD2/acetylated ELK4 complex in colorectal cancer  Oncogene  2020  39(24):4666-4680. 
    Jialin Shang, Zhehui Zhu, Yingyi Chen, Jinglue Song, Yuji Huang, Kun Song, Jie Zhong, Xinyuan Xu, Jiacheng Wei, Chengxiang Wang, Long Cui,, and Jian Zhang  Small-molecule activating SIRT6 elicits therapeutic effects and synergistically promotes anti-tumor activity of vitamin D3 in colorectal cancer  Theranostics  2020  10(13):5845-5864.  
    Song J, Shen X, Huang Z, Liu Y, Cui L, Cui X,  Clostridium difficile toxin A and toxin B inhibit YAP in the colonic epithelial cells   J Biochem Mol Toxicol.   2020  Nov 30:e22652.  
    Dongpeng Wen, Yuhan Wang, Zhehui Zhu, Zhenyu Huang, Long Cui, Tingyu Wu,  Bromodomain and Extraterminal (BET) protein inhibition suppresses tumor progression and inhibits HGF-MET signaling through targeting cancer-associated fibroblasts in colorectal cancer  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease  2020  1866(12):165923 
    Wei Z, Song J, Wang G, Cui X, Zheng J, Tang Y, Chen X, Li J, Cui L,, Yu W.  Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis.  Nat Commun.   2018  9(1):4468.  
    Zhu Z, Mei Z, Guo Y, Wang G, Wu T, Cui X, Huang Z, Zhu Y, Wen D, Song J, He H, Xu W, Cui L,  Reduced Risk of Inflammatory Bowel Disease-associated Colorectal Neoplasia with Use of Thiopurines: a Systematic Review and Meta-analysis.  J Crohns Colitis.  2018  12(5):546-558.  
    Wu T, Wang G, Chen W, Zhu Z, Liu Y, Huang Z, Huang Y, Du P, Yang Y,, Cui L.  Co-inhibition of BET proteins and NF-κB as a potential therapy for colorectal cancer through synergistic inhibiting MYC and FOXM1 expressions.  Cell Death Dis.   2018  9(3):315 
    , Pobbati AV, Huang Z, Cui L, Hong W  Transglutaminase 2 Is a Direct Target Gene of YAP/TAZ-Letter.  Cancer Research  2017  77(17):4734-4735. 
    , Yu T, Huang Y, Cui L, Hong W.  ETS (E26 transformation-specific) up-regulation of the transcriptional co-activator TAZ promotes cell migration and metastasis in prostate cancer.  J Biol Chem.  2017  292(22):9420-9430.  
    , Chan SW, Guo F, Toloczko A, Cui L, Hong W.  MRTF/SRF dependent transcriptional regulation of TAZ in breast cancer cells.  Oncotarget  2016  7(12):13706-16. 
    Huang Y, Wang G, Liang Z, Yang Y, Cui L,  Loss of nuclear localization of TET2 in colorectal cancer.  Clinical Epigenetics   2016  8:9.  
    Liu Y, Wang G, Yang Y, Mei Z, Liang Z, Cui A, Wu T,, Cui L.  Increased TEAD4 expression and nuclear localization in colorectal cancer promote epithelial-mesenchymal transition and metastasis in a YAP-independent manner.  Oncogene  2016  35(21):2789-800.  
    Lv XB,, Wang Z, Sun YP, Xiong Y, Lei QY, Guan KL.  PARD3 induces TAZ activation and cell growth by promoting LATS1 and PP1 interaction.  EMBO Reports  2015  16(8):975-85.  
    Wu T, Wang Z, Liu Y, Mei Z, Wang G, Liang Z, Cui A, Hu X, Cui L, Yang Y,  Interleukin 22 protects colorectal cancer cells from chemotherapy by activating the STAT3 pathway and inducing autocrine expression of interleukin 8.  Clinical Immunology   2014  154(2):116-26.  
    Zhao B, Li L, Lu Q, Wang LH,, Lei Q, Guan KL.  Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein.  Genes & Development   2011  25(1):51-63.  
    , Lv X, Li T, Xu Y, Zhou X, Zhao S, Xiong Y, Lei QY, Guan KL.  PP1 cooperates with ASPP2 to dephosphorylate and activate TAZ.  J Biol Chem.  2011  286(7):5558-66.  
    , Zha ZY, Zhou X, Zhang H, Huang W, Zhao D, Li T, Chan SW, Lim CJ, Hong W, Zhao S, Xiong Y, Lei QY, Guan KL.  The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF{beta}-TrCP E3 ligase.  J Biol Chem.  2010  285(48):37159-69. 
    Zhang H,, Zha ZY, Zhao B, Yao J, Zhao S, Xiong Y, Lei QY, Guan KL.  TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition.  J Biol Chem.   2009  284(20):13355-62.