• 基本信息
    导师姓名： 刘颖斌 学科代码： 100210
    性别： 男 学科名称： 外科学
    培养单位： 附属仁济医院 三级学科 普外
    导师类型： 博士生导师 专业领域名称： 外科学 专业学位
    联系方式： 上海交通大学医学院附属仁济医院胆胰外科 专业领域代码： 105111
    邮编： 200127 邮箱地址： laoniulyb@163.com
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    肝胆胰外科杂志、浙江临床医学杂志特约编委
    中华医学会肝脏学组委员
    上海医师协会普外科专业委员会副会长
    中华医学会肿瘤分会胰腺学组、胃肠学组委员
    中华外科杂志通讯编委
    中国实用外科杂志、外科理论与实践杂志、世界胃肠病学杂志、实用肿瘤杂志、华人消化外科杂志编委
    中国抗癌协会胆道癌、胰腺癌专业委员会委员
    上海市医学会普外科专业委员会副主任委员
    上海医学会（普外）委员兼秘书
    上海市医学会普外科专业委员会胆道学组组长
    中华医学杂志、中华外科学杂志、中华普通外科杂志、中华实验外科杂志特约编委
    中国医师学会普外科专业委员会委员
    国家自然科学基金、教育部科技奖励评审专家
    上海外科学会普外科分会胰腺学组副组长
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    3213000192基于组学的胆道恶性肿瘤分子免疫全景解析国家自然科学基金重点项目 2022-01~2026-12 308.1万元  课题负责人
    20JC1419101胆道肿瘤分子特征谱及系统功能组学研究上海市科委 2020-10~2023-09 220万元  子课题负责人
    2019XH004 非编码RNA在癌细胞及其微环境共进化中的功能机制国家自然科学基金集成项目 2020-01~2022-12 150万元  课题负责人
    YDZX20193100004049 长三角区域胆石症与胆道肿瘤相关性研究以及胆道肿瘤个体化诊治方案制定上海市科委项目 2019-09~2022-08 150万元  课题负责人
    2019ZX09301-158多激酶抑制剂TT-00420的临床前与多中心篮式临床研究科技部新药创制项目 2019-01~2020-12 677万元  课题负责人
    81874181外泌体介导的LncRNA-LINC00239在胆囊癌侵袭转移中的作用机制研究国家自然科学基金面上项目 2019-01~2022-12 58万元  课题负责人
    SHDC12018107 Afatinib联合Nivolumab治疗ERBB2/3突变型胆囊癌有效性、安全性的多中心、随机对照研究上海市级医院新兴前沿项目 2018-11~2021-11 150万元  课题负责人
    31620103910LINC01605 调控胆囊癌干细胞自我更新的功能和机制研究国家自然科学基金国际合作项目 2017-01~2020-12 256万元  课题负责人
    16JC1400200基于hiHep细胞的生物人工肝支持系统的临床应用研究上海市科委重大基础研究项目 2016-07~2019-06 780万元  课题负责人
    16411952501兼具胆管癌早期影像诊断及基因治疗功能的靶向纳米材料研发上海市科委生药处重点项目 2016-07~2019-09 38万元  课题负责人
    DLY201507胆囊癌恶性靶向治疗多中心临床研究上海交通大学医学院多中心临床研究项目 2015-12~2017-12 200万元  课题负责人
    15ZH4003胆囊癌靶向治疗多中心临床研究上海交通大学医学院转化医学创新基金（第二期）——精准医学研究项目 2015-09~2017-08 100万元  课题负责人
    91440203LncRNA-LINC01133作用机制以及在胆囊癌中功能研究国家自然基金重大项目 2015-01~2018-12 300万元  课题负责人
    SHDC12014109胰头癌全系膜切除技术的解剖和临床应用研究申康 2014-10~2017-09 120万元  课题负责人
    20130073130014基于vimentin构建胆囊癌术后复发转移早期识别的靶向性纳米磁共振造影剂的研发高等学校博士学科点专项科研基金(优先发展领域) 2014-01~2016-12 40万元  课题负责人
    12JC1406700miR-203在胃癌发生和转移过程中的机制研究上海市科委基础重点项目（连续资助项目） 2013-01~2015-12 40万元  课题负责人
    81272402ceRNA调控分子群在胆囊癌细胞转移可塑性中的分子机制研究国家自然科学基金面上项目 2013-01~2016-12 75万元  课题负责人
    SS2012AA023706胆囊癌复发转移识别的高敏分子超声影像技术研发863国家科技重大专项 2012-11~2015-12 420万元  课题负责人
    12410705900FN介导的胆囊癌细胞转移和耐药现象的机制研究2012年上海市科委政府间国际合作项目 2012-10~2014-09 50万元  课题负责人
    81172029ZFX基因调控胆囊癌EMT的功能研究国家自然科学基金面上项目 2012-01~2014-12 55万元  课题负责人
    20110073110086Vimentin与胆囊癌侵袭转移的相关性研究高等学校博士学科点专项科研基金资助课题名单（博导类） 2012-01~2013-12 12万元  课题负责人
    11XD1403800胆囊癌侵袭转移相关优势亚功能单位的筛选上海市科委 2012-01~2014-12 40万元  课题负责人
    C160402胆囊癌细胞亚群的克隆分选及异质性分析国家自然基金面上项目 2010-01~2012-12 32万元  课题负责人
    30972918胆囊癌细胞亚群的克隆分选及异质型分析国家自然科学基金面上项目 2010-01~2012-12 32万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Yijian Zhang , Chunman Zuo, Liguo Liu , Yunping Hu , Bo Yang, Shimei Qiu, Yang Li, Dongyan Cao, Zheng Ju, Jing Ge , Qiu Wang, Ting Wang, Lu Bai, Yang Yang , Guoqiang Li, Ziyu Shao, Yuan Gao, Yongsheng Li, Rui Bian, Huijie Miao, Lin Li, Xuechuan Li, Chengkai Jiang, Siyuan Yan , Ziyi Wang, Zeyu Wang, Xuya Cui, Wen Huang, Dongxi Xiang , Congjun Wang, Qiyun Li, Xiangsong Wu, Wei Gong, Yun Liu , Rong Shao, Fatao Liu , Maolan Li, Luonan Chen,  Single-cell RNA-sequencing atlas reveals an MDK-dependent immunosuppressive environment in ErbB pathway-mutated gallbladder cancer  Journal of Hepatology  2021  Online ahead of print 
    Fatao Liu,Yongsheng Li,Dongjian Ying,Shimei Qiu,Yong He,Maolan Li,Yun Liu, Yijian Zhang, Qin Zhu,Yunping Hu,Liguo Liu,Guoqiang Li,Weihua Pan,Wei Jin,Jiasheng Mu,Yang Cao,  Whole-exome mutational landscape of neuroendocrine carcinomas of the gallbladder  Signal transduction and targeted therapy  2021  6: 55 
    Yijian Zhang, Pengcheng Du, Yang Li, Qin Zhu, Xiaoling Song, Shibo Liu, Jiaqi Hao, Liguo Liu, Fatao Liu, Yunping Hu, Lin Jiang, Qiang Ma, Wei Lu,  TASP1 Promotes Gallbladder Cancer Cell Proliferation and Metastasis by Up-regulating FAM49B via PI3K/AKT Pathway  International Journal of Biological Sciences  2020  16(5): 739-751 
    Xiaoling Song,Yunping Hu,Yongsheng Li,Rong Shao, Fatao Liu,  Overview of current targeted therapy in gallbladder   Signal transduction and targeted therapy  2020  5(1): 1-19 
    Xiaoling Song, Xu'an Wang, Yunping Hu, Huaifeng Li, Tai Ren, Yongsheng Li, Liguo Liu, Lin Li, Xuechuan Li, Ziyi Wang, Wen Huang, Runfa Bao, Yijian Zhang, Maolan Li, Xuefeng Wang, Feng Liu, Jun Gu, Linhui Zheng, Wenguang Wu,  A metagenomic study of biliary microbiome change along the cholecystitis-carcinoma sequence  Clin Transl Med  2020  10.1002 
    ? YunPing Hu, YunPeng Jin, XiangSong Wu, Yang Yang, YongSheng Li, HuaiFeng Li, ShanShan Xiang, XiaoLing Song, Lin Jiang, YiJian Zhang, Wen Huang, ShiLi Chen, FaTao Liu, Chen Chen, Qin Zhu, HongZhuan Chen, Rong Shao,  LncRNA-HGBC stabilized by HuR promotes gallbladder cancer progression by regulating miR-502-3p/SET/AKT axis  Molecular Cancer  2019  18(1) 
    Maolan Li, Fatao Liu, Fei Zhang, Weiping Zhou, Xiaoqing Jiang, Yuan Yang, Kai Qu, Yueqi Wang, Qiang Ma, Ting Wang, Lu Bai, Zheng Wang, Xiaoling Song, Yidi Zhu, Ruiyan Yuan, Yuan Gao, Yongchen Liu, Yunpeng Jin, Huaifeng Li, Shanshan Xiang, Yuanyuan Ye, Yijian Zhang, Lin Jiang, Yunping Hu, Yajuan Hao, Wei Lu, Shili Chen, Jun Gu, Jian Zhou, Wei Gong, Yong Zhang, Xuefeng Wang, Xiyong Liu, Chang Liu, Houbao Liu, Yun Liu & Yingbin Liu.  Genomic ERBB2/ERBB3 mutations promote PD-L1-mediated immune escape in gallbladder cancer: a whole-exome sequencing analysis.  Gut  2019  68(6):1024-1033 
    Shanshan Xiang, Zheng Wang, Yuanyuan Ye, Fei Zhang, Huaifeng Li, Yang Yang, Huijie Miao, Haibin Liang, Yijian Zhang, Lin Jiang, Yunping Hu, Lei Zheng, Xiyong Liu,  E2F1 and E2F7 differentially regulate KPNA2 to promote the development of gallbladder cancer.  Oncogenesis  2019  38:1269-1281 
    Yunpeng Jin, Yunping Hu, Xiangsong Wu, Yaoshi Wu, Yuanyuan Ye, Huaifeng Li, Yongchen Liu, Lin Jiang, Fatao Liu, Yijian Zhang, Yajuan Hao,  miR-143-3p targeting of ITGA6 suppresses tumour growth and angiogenesis by downregulating PLGF expression via the PI3K/AKT pathway in gallbladder carcinoma.  Cell Death & Disease  2018  9, 182 
    Yuanyuan Ye, Jiawei Mei, Shanshan Xiang, Huaifeng Li, Qiang Ma, Xiaoling Song, Zheng Wang, Yichi Zhang, Yongchen Liu, Yunpeng Jin, Yunping Hu, Lin Jiang, Fatao Liu, Yijian Zhang, Yajuan Hao & Yingbin Liu  MicroRNA-30a-5p inhibits gallbladder cancer cell proliferation, migration and metastasis by targeting E2F7.   Cell Death & Disease   2018  9, 410 
    Li M, Liu F, Zhang F, Zhou W, Jiang X, Yang Y, Qu K, Wang Y, Ma Q, Wang T, Bai L, Wang Z, Song X, Zhu Y, Yuan R, Gao Y, Liu Y, Jin Y, Li H, Xiang S, Ye Y, Zhang Y, Jiang L, Hu Y, Hao Y, Lu W, Chen S, Gu J, Zhou J, Gong W, Zhang Y, Wang X, Liu X, Liu C, Liu H, Liu Y,  Genomic ERBB2/ERBB3 mutations promote PD-L1-mediated immune escape in gallbladder cancer: a whole-exome sequencing analysis.  Gut  2018  doi: 10.1136/gutjnl-2018-316039 
    Yuanyuan Ye, Jiawei Mei, Shanshan Xiang, Huaifeng Li, Qiang Ma, Xiaoling Song, Zheng Wang, Yichi Zhang, Yongchen Liu, Yunpeng Jin, Yunping Hu, Lin Jiang, Fatao Liu, Yijian Zhang, Yajuan Hao & Yingbin Liu.  MicroRNA-30a-5p inhibits gallbladder cancer cell proliferation, migration and metastasis by targeting E2F7  Cell Death & Disease  2018  9, 410. 
    Zhang F, Xiang S, Cao Y, Li M, Ma Q, Liang H, Li H, Ye Y, Zhang Y, Jiang L, Hu Y, Zhou J, Wang X, Zhang Y, Nie L, Liang X, Gong W,  EIF3D promotes gallbladder cancer development by stabilizing GRK2 kinase and activating PI3K-AKT signaling pathway.  Cell Death & Disease  2017  8(6):e2868 
    Xiangsong Wu, Fang Wang, Huaifeng Li, Yunping Hu, Lin Jiang, Fei Zhang, Maolan Li, Xu’an Wang, Yunpeng Jin, Yijian Zhang, Wei Lu, Wenguang Wu, Yijun Shu, Hao Weng, Yang Cao, Runfa Bao, Haibin Liang, Zheng Wang, Yichi Zhang, Wei Gong, Lei Zheng, Shuhan Sun & Yingbin Liu  LncRNA-PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis.  EMBO Rep  2017  18(10), 1837-1853 
    Yijun Shu, Runfa Bao, Lin Jiang, Zheng Wang, Xu-An Wang, Fei Zhang, Hanbin Liang, Huaifeng Li, Yuanyuan Ye, Shanshan Xiang, Hao Weng, Xiangsong Wu, Maolan Li, Yunping Hu, Wei Lu, Yijian Zhang, Jian Zhu, Ping Dong and Ying-Bin Liu  MicroRNA-29c-5p Suppresses Gallbladder Carcinoma Progression by Directly Targeting CPEB4 and Inhibiting the MAPK Pathway  Cell Death and Differentiation  2017  doi: 10.1038/cdd.2016.146 
    Maolan Li, Fatao Liu, Yijian Zhang, Xiangsong Wu, Wenguang Wu, Xu-An Wang, Shuai Zhao, Shibo Liu, Haibin Liang, Fei Zhang, Qiang Ma, Shanshan Xiang, Huaifeng Li, Lin Jiang, Yunping Hu, Wei Gong, Yun Zhang, Tieliang Ma, Kai Zhang, Yun Liu,  Whole-genome sequencing reveals the mutational landscape of metastatic small-cell gallbladder neuroendocrine carcinoma (GB-SCNEC)  Cancer letters  2017  391: 20–27 
    Zhang F, Ma Q, Xu Z, Liang H, Li H, Ye Y, Xiang S, Zhang Y, Jiang L, Hu Y, Wang Z, Wang X, Zhang Y, Gong W,  Dihydroartemisinin inhibits TCTP-dependent metastasis in gallbladder cancer  J Exp Clin Cancer Res  2017  36(1):68 
    Yang Cao, Haibin Liang, Fei Zhang, Zhou Luan, Shuai Zhao, Xu-an Wang, Shibo Liu, Runfa Bao, Yijun Shu, Qiang Ma, Jian Zhu,  Prohibitin overexpression predicts poor prognosis and promotes cell proliferation and invasion through ERK pathway activation in gallbladder cancer  Journal of Experimental & Clinical Cancer Research  2016  35:68 
    Shuai Zhao, Yang Cao, Shibo Liu, Xu-an Wang, Runfa Bao, Yijun Shu, Yunping Hu, Yijian Zhang, Lin Jiang, Fei Zhang, Haibin Liang, Huaifeng Li, Qiang Ma, Yi Xu, Zheng Wang, Yichi Zhang, Lei Chen, Jian Zhou,  The E545K mutation of PIK3CA promotes gallbladder carcinoma progression through enhanced binding to EGFR  Journal of Experimental & Clinical Cancer Research  2016  35:97  
    Cao Y, Liu X, Lu W, Chen Y, Wu X, Li M, Wang X-a, Zhang F, Jiang L, Zhang Y, Hu Y, Xiang S, Shu Y, Bao R, Li H, Wu W, Weng H, Yen Y,  Fibronectin promotes cell proliferation and invasion through mTOR signaling pathway activation in gallbladder cancer  Cancer letters  2015  360(2):141-150 
    Shu Y, Weng H, Ye Y, Hu Y, Bao R, Cao Y, Wang X, Zhang F, Xiang S, Li H, Wu X, Li M, Jiang L, Lu W, Han B, Jie Z,  SPOCK1 as a potential cancer prognostic marker promotes the proliferation and metastasis of gallbladder cancer cells by activating the PI3K/AKT pathway  Molecular cancer  2015  14(1):1-14 
    Li M, Zhang Z, Li X, Ye J, Wu X, Tan Z, Liu C, Shen B, Wang XA, Wu W, Zhou D, Zhang D, Wang T, Liu B, Qu K, Ding Q, Weng H, Ding Q, Mu J, Shu Y, Bao R, Cao Y, Chen P, Liu T, Jiang L, Hu Y, Dong P, Gu J, Lu W, Shi W, Lu J, Gong W, Tang Z, Zhang Y, Wang X, Chin YE, Weng X, Zhang H, Tang W, Zheng Y, He L, Wang H, Liu Y,  Whole-exome and targeted gene sequencing of gallbladder carcinoma identifies recurrent mutations in the ErbB pathway.  Nature Genetics  2014  2014(46):872-876 
    ? Maolan Li, Jianhua Lu, Fei Zhang, Huaifeng Li, Bingtai Zhang, Xiangsong Wu, Zhujun Tan, Lin Zhang, Guofeng Gao, Jiasheng Mu, Yijun Shu, Runfa Bao, Qichen Ding, Wenguang Wu, Ping Dong, Jun Gu & Yingbin Liu.  Yes-associated protein 1 (YAP1) promotes human gallbladder tumor growth via activation of the AXL/MAPK pathway  Cancer letters  2014  355, 201-209 
    Quan Z, Gu J, Dong P, Lu J, Wu X, Wu W, Fei X, Li S, Wang Y, Wang J,  Reactive oxygen species-mediated endoplasmic reticulum stress and mitochondrial dysfunction contribute to cirsimaritin-induced apoptosis in human gallbladder carcinoma GBC-SD cells  Cancer Lett  2010  295(2):252-9 
    Li S, Dong P, Wang J, Zhang J, Gu J, Wu X, Wu W, Fei X, Zhang Z, Wang Y, Quan Z,  Icariin, a natural flavonol glycoside, induces apoptosis in human hepatoma SMMC-7721 cells via a ROS/JNK-dependent mitochondrial pathway.  Cancer Lett.  2010  298(2):222-30