- 基本信息
导师姓名:
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赖东梅
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学科代码:
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100211
|
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性别:
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女
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学科名称:
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妇产科学
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培养单位:
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附属国际和平妇幼保健院
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三级学科
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导师类型:
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博士生导师
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专业领域名称:
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妇产科学 专业学位
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联系方式:
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laidongmei@hotmail.com
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专业领域代码:
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105115
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邮编:
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200030
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邮箱地址:
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laidongmei@hotmail.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
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《human reproduction》《stem cell &development》杂志, 《stem cell research and therapy》等多种国际期刊同行评议审稿人
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上海市科委专家库专家,市科委科技奖评审专家
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国家科技部重点专项评审专家
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湖南大学学报(医学版)编委
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中国女医师协会干细胞与免疫细胞专委会委员
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国家自然科学基金评审专家
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上海交通大学“医工交叉基金”顾问组专家
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中国生物技术协会临床专委会委员
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中国临床医学专家组成员
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中国细胞生物学学会会员
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美国干细胞协会ISSCR会员
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中华医学会上海分会青年学组成员
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- 科研项目
82271664 | 慢性应激通过去甲肾上腺素调节IDH1的表达促进颗粒细胞衰老的研究 | 国家自然科学基金面上项目 |
2023-01~2026-12
|
52万元
| 课题负责人 |
YG2022ZD028 | 抗缪勒氏管激素超敏检测方法的建立及其在年轻乳腺癌患者卵巢功能和生育力评估中的应用 | 上海交通大学医工交叉重点项目 |
2022-01~2024-12
|
100万元
| 课题负责人 |
20JC1412100 | SPECT/MRI复合纳米荧光探针用于干细胞在卵巢早衰中的示踪及修复机理研究 | 上海市科委基础研究项目 |
2020-10~2023-09
|
60万元
| 课题负责人 |
81971334 | PLGA微球缓释人羊膜上皮细胞分泌因子修复化疗损伤卵巢功能的作用 研究 | 国家自然科学基金 |
2020-01~2023-12
|
55万元
| 课题负责人 |
18410721200 | 人胚胎干细胞向子宫内膜上皮分化的构建研究 | 市科委国际合作项目 |
2019-01~2021-12
|
100万元
| 课题负责人 |
2018YFC1004802 | 卵巢生育力保护与再生修复的新技术及关键机制研究 | 国家重点研发计划 |
2019-01~2021-08
|
219万元
| 课题负责人 |
81741013 | 18-三体多能干细胞三体染色体丢失后细胞分化功能是否正常? | 国家自然科学基金 |
2018-01~2018-12
|
20万元
| 课题负责人 |
YG2015ZD11 | 基于新型纳米多指标编码技术的宫颈高危型HPV多型别检测方法的研究 | 上海交大医工交叉重点课题 |
2015-11~2018-11
|
60万元
| 课题负责人 |
20152236 | 人羊膜上皮细胞移植治疗卵巢早衰的临床研究 | 上海市教委高峰高原计划研究型医师项目 |
2015-11~2018-11
|
100万元
| 课题负责人 |
14411961500 | 靶向肿瘤干细胞的DC-CIK细胞自体移植治疗卵巢癌的基础与临床研究 | 上海市科委 |
2014-09~2017-09
|
30万元
| 课题负责人 |
81370678 | 人羊膜上皮细胞移植修复卵巢早衰的机理研究 | 国家自然科学基金面上项目 |
2014-01~2017-12
|
70万元
| 课题负责人 |
12431902201 | 宫内膜干细胞移植治疗卵巢早衰的应用研究 | 上海市科委2012年度成果转化与应用生物医药领域项目 |
2012-10~2016-10
|
100万元
| 课题负责人 |
2010011 | 表达α-gal表位的卵巢癌干细胞疫苗研制及临床前研究 | 上海市卫生局重点课题 |
2011-01~-2013-12
|
20万元
| 主要责任人 |
81070533 | 人羊膜上皮细胞对胚胎干细胞增殖和分化的影响 | 国家自然科学基金面上项目 |
2011-01~-2013-12
|
32万元
| 主要责任人 |
XBR2011069 | 上海市卫生局优秀学科带头人基金 | 上海市卫生局 |
2011-01~2016-10
|
100万元
| 课题负责人 |
07pj14090 | 优化培养系统进行人胚胎干细胞的建系及其鉴定 | 上海市科委浦江人才计划 |
2007-09~2009-09
|
20万元
| 课题负责人 |
- 学术论文
Sun J, Fan Y, Guo Y, Pan H, Zhang C, Mao G, Huang Y, Li B, Gu T, Wang L, Zhang Q, Wang Q, Zhou Q, Li B,
|
Chronic and Cumulative Adverse Life Events in Women with Primary Ovarian Insufficiency: An Exploratory Qualitative Study.
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Front Endocrinol (Lausanne).
|
2022
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13:856044.
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Huang Y, Huang Q, Liu J, Guo M, Liu Y,
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Concurrent Ovarian and Tubal Ectopic Pregnancy After IVF-ET: Case Report and Literature Review
|
Front Physiol. 2022 ;
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2022
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13:850180
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Kuang X, Tang Y, Xu H, Ji M,
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The Evaluation of Ovarian Function Recovery Following Treatment of Primary Ovarian Insufficiency: A Systematic Review.
|
Front Endocrinol (Lausanne).
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2022
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13:855992.
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Wang L, Zhou C, Sun J, Zhang Q,
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Glutamine and norepinephrine in follicular fluid synergistically enhance the antioxidant capacity of human granulosa cells and the outcome of IVF-ET.
|
Sci Rep.
|
2022
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12(1):9936.
|
Mao G, Xin D, Wang Q,
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Sodium molybdate inhibits the growth of ovarian cancer cells via inducing both ferroptosis and apoptosis.
|
Free Radic Biol Med.
|
2022
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182:79-92.
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Huang Y, Ma Z, Kuang X, Zhang Q, Li H,
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Sodium alginate-bioglass-encapsulated hAECs restore ovarian function in premature ovarian failure by stimulating angiogenic factor secretion
|
Stem Cell Res Ther
|
2021
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12(1):223
|
Wang Q, Gu T, Ma L, Bu S, Zhou W, Mao G, Wang LL, Guo Y,
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Efficient iron utilization compensates for loss of extracellular matrix of ovarian cancer spheroids
|
Free Radic Biol Med
|
2021
|
164:369-380
|
Fan Y, Sun J, Zhang Q,
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Transplantation of human amniotic epithelial cells promotes morphological and functional regeneration in a rat uterine scar model
|
Stem Cell Res Ther
|
2021
|
12(1):207
|
Sun J, Guo Y, Fan Y, Wang Q, Zhang Q,
|
Decreased expression of IDH1 by chronic unpredictable stress suppresses proliferation and accelerates senescence of granulosa cells through ROS activated MAPK signaling pathways
|
Free Radic Biol Med
|
2021
|
12(1):223
|
Zhang Q,
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Application of human amniotic epithelial cells in regenerative medicine: a systematic review
|
Stem Cell Res Ther
|
2020
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11(1):439
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Guo Y, Sun J, Bu S, Li B, Zhang Q, Wang Q,
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Melatonin protects against chronic stress-induced oxidative meiotic defects in mice MII oocytes by regulating SIRT1
|
Cell Cycle
|
2020
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19(13):1677-1695
|
Yu Z, Lyu W, Yu M, Wang Q, Qu H, Ismagilov RF, Han X,, Shen F
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Self-partitioning SlipChip for slip-induced droplet formation and human papillomavirus viral load quantification with digital LAMP
|
Biosens Bioelectron
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2020
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155:112107
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Bu S, Wang Q, Sun J, Li X, Gu T,
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Melatonin suppresses chronic restraint stress-mediated metastasis of epithelial ovarian cancer via NE/AKT/β-catenin/SLUG axis
|
Cell Death Dis
|
2020
|
11(8):644
|
Liu X, Fang Z, Wen J, Tang F, Liao B, Jing N,, Jin Y
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SOX1 Is Required for the Specification of Rostral Hindbrain Neural Progenitor Cells from Human Embryonic Stem Cells
|
iScience
|
2020
|
23(9):101475
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Zhang Q, Sun J, Huang Y, Bu S, Guo Y, Gu T, Li B, Wang C,
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Human Amniotic Epithelial Cell-Derived Exosomes Restore Ovarian Function by Transferring MicroRNAs against Apoptosis.
|
Mol Ther Nucleic Acids
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2019
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16:407-418
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Zhang Q, Huang Y, Sun J, Gu T, Shao X,
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Immunomodulatory effect of human amniotic epithelial cells on restoration of ovarian function in mice with autoimmune ovarian disease.
|
Acta Biochim Biophys Sin (Shanghai).
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2019
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51(8):845-855.
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Sun J, Guo Y, Ma L, Qian Z,
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An unusual cause of postmenopausal vaginal haemorrhage: a case report.
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BMC Womens Health.
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2019
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19(1):31
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Bu S, Li B, Wang Q, Gu T, Dong Q, Miao X,
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Epithelial ovarian cancer stem?like cells are resistant to the cellular lysis of cytokine?induced killer cells via HIF1A?mediated downregulation of ICAM?1.
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Int J Oncol.
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2019
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55(1):179-190
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Li B, Zhang Q, Sun J,
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Human amniotic epithelial cells improve fertility in an intrauterine adhesion mouse model.
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Stem Cell Res Ther.
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2019
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10(1):257.
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Li B, Bu S, Sun J, Guo Y,
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Artemisinin derivatives inhibit epithelial ovarian cancer cells via autophagy-mediated cell cycle arrest.
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Acta Biochim Biophys Sin (Shanghai).
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2018
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50(12):1227-1235
|
Wang Q, Bu S, Xin D, Li B, Wang L,
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Autophagy Is Indispensable for the Self-Renewal and Quiescence of Ovarian Cancer Spheroid Cells with Stem Cell-Like Properties.
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Oxid Med Cell Longev.
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2018
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2018:7010472
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Sun J, Guo Y, Zhang Q, Bu S, Li B, Wang Q,
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Chronic restraint stress disturbs meiotic resumption through APC/C-mediated cyclin B1 excessive degradation in mouse oocytes
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Cell Cycle
|
2018
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doi: 10.1080/15384101.2018.1471316
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Xu M, Sun J, Wang Q, Zhang Q, Wei C,
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Chronic restraint stress induces excessive activation of primordial follicles in mice ovaries
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PLoS One
|
2018
|
2018,13(3):e0194894
|
Guo Y, Sun J,
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Role of microRNAs in premature ovarian insufficiency
|
Reprod Biol Endocrinol. .
|
2017
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2017, 15(1):38
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Wang Q, Xue L, Zhang X, Bu S, Zhu X,
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Autophagy protects ovarian cancer-associated fibroblasts against oxidative stress.
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Cell Cycle.
|
2016
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2016, 15(10):1376-85.
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Chen Y, Wang S, Bu S, Xu M,
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Low-dose cisplatin-induced CXCR4 expression promotes proliferation of ovarian cancer stem-like cells.
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Acta Biochim Biophys Sin (Shanghai).
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2016
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2016, 48(3):282-9.
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Yao X, Guo Y, Wang Q, Xu M, Zhang Q, Li T,
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The Paracrine Effect of Transplanted Human Amniotic Epithelial Cells on Ovarian Function Improvement in a Mouse Model of Chemotherapy-Induced Primary Ovarian Insufficiency
|
Stem Cells Int
|
2016
|
2016:4148923
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Bu S, Wang Q, Zhang Q, Sun J, He B, Xiang C, Liu Z,
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Human endometrial mesenchymal stem cells exhibit intrinsic anti-tumor properties on human epithelial ovarian cancer cells.
|
Sci Rep
|
2016
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2016;6:37019.
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, Bu S.
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Comparison of the Ultrastructures of Primed and Na?ve Mouse Embryonic Stem Cells.
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Cell Reprogram.
|
2016
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2016, 18(1):48-53.
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, Guo Y, Zhang Q, Chen Y, Xiang C.
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Differentiation of human menstrual blood-derived endometrial mesenchymal stem cells into oocyte-like cells.
|
.Acta Biochim Biophys Sin (Shanghai).
|
2016
|
2016,48(11):998-1005
|
, Xu M, Zhang Q, Chen Y, Li T, Wang Q, Gao Y, Wei C
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Identification and characterization of epithelial cells derived from human ovarian follicular fluid
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Stem Cell Res Ther
|
2015
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6(1):13
|
, Wang F, Yao X, Zhang Q, Wu X, Xiang C
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Human endometrial mesenchymal stem cells restore ovarian function through improving the renewal of germline stem cells in a mouse model of premature ovarian failure
|
J Transl Med
|
2015
|
13(1):155
|
Yao X, Dong Z, Zhang Q, Wang Q,
|
Epithelial ovarian cancer stem-like cells expressing α-gal epitopes increase the immunogenicity of tumor associated antigens
|
BMC Cancer
|
2015
|
15(1):956.
|
, Wang Y, Sun J, Chen Y, Li T, Wu Y, Guo L, Wei C
|
Derivation and characterization of human embryonic stem cells on human amnion epithelial cells
|
Sci Rep
|
2015
|
2015, 5:10014
|
Zhang Q, Xu M, Yao X, Li T, Wang Q,
|
Human amniotic epithelial cells inhibit granulosa cell apoptosis induced by chemotherapy and restore the fertility
|
Stem Cell Res Ther
|
2015
|
6(1):152
|
Yifei Chen,
|
Pluripotent States of Human Embryonic Stem Cells.
|
Cell Reprogram
|
2015
|
17(1):1-6
|
Zhang J, Wang W, Qian L, Zhang Q,,Qi C
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Ursolic acid inhibits the proliferation of human ovarian cancer stem-like cells through epithelial-mesenchymal transition
|
Oncol Rep
|
2015
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34(5):2375-84
|
Huang P, Zhang L, Gao Y, He Z, Yao D, Wu Z, Cen J, Chen X, Liu C, Hu Y,, Hu Z, Chen L, Zhang Y, Cheng X, Ma X, Pan G, Wang X, Hui L.
|
Direct Reprogramming of Human Fibroblasts to Functional and Expandable Hepatocytes
|
Cell Stem Cell
|
2014
|
14(3):370-84
|
, Fangyuan Wang, Zhangli Dong, Qiuwan Zhang
|
Skin-derived mesenchymal stem cells help restore function to ovaries in a premature ovarian failure mouse model.
|
PLoS One
|
2014
|
9(5):-9874
|
Chen YF, Wang SY, Shen H, Yao XF, Zhang FL,
|
The marine-derived fungal metabolite, terrein, inhibits cell proliferation and induces cell cycle arrest in human ovarian cancer cells
|
Int J Mol Med
|
2014
|
34(6):1591-8
|
Chen YF, Dong Z, Xia Y, Tang J, Peng L, Wang S,
|
A nucleoside analog inhibits microRNA-214 through targeting heat-shock factor 1 in human epithelial ovarian cancer
|
Cancer Sci
|
2013
|
104(12):1683-9
|
, Wang F, Chen Y, Wang L, Wang Y, Cheng W.
|
Human amniotic fluid stem cells have a potential to recover ovarian function in mice with chemotherapy-induced sterility
|
BMC Dev Biol
|
2013
|
13(1):34-
|
Yang H, Liu Z, Ma Y, Zhong C, Yin Q, Zhou C, Shi L, Cai Y, Zhao H, Wang H, Tang F, Wang Y, Zhang C, Liu XY,, Jin Y, Sun Q, Li J.
|
Generation of haploid embryonic stem cells from Macaca fascicularis monkey parthenotes
|
Cell Res
|
2013
|
9(3):1-1
|
Fangyuan Wang F, Li Wang, Xiaofen Yao ,
|
Human amniotic epithelial cells can differentiate into granulosa cells and restore folliculogenesis in a mouse model of chemotherapy-induced premature ovarian failure
|
Stem Cell Res Ther
|
2013
|
4(5):12-4
|
XinLuo,Zhangli Dong,Yifei Chen,Lijuan Yang,
|
Enrichment of ovarian cancer stem-like cells is associated with epithelial to mesenchymal transition through an miRNA-activated AKT pathway.
|
Cell Prolif
|
2013
|
46():436-446
|
Yang L, Ma L,
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Over-expression of fibroblast activation protein alpha increases tumor growth in xenografts of ovarian cancer cells.
|
Acta Biochim Biophys Sin (Shanghai)
|
2013
|
45(11):928-37
|
Zhangli Dong,Lijuan Yang,
|
KLF5 strengthens drug resistance of ovarian cancer stem-like cells by regulating survivin expression
|
Cell Prolif
|
2013
|
4(6):425-435
|
Yang L,
|
Ovarian cancer stem cells enrichment
|
Methods Mol Biol
|
2013
|
1049(1):337-45
|
, Li Ma, Fangyuan Wang41(2):541-550
|
Fibroblast activation protein regulates tumor-associated fibroblasts and epithelial ovarian cancer cells
|
Int J oncol
|
2013
|
41(2):541-550
|
Yifei Chen, Zhangli Dong, Lizhen Jiang,, Lihe Guo
|
Mouse Primed Embryonic Stem Cells Could Be Maintained and Reprogrammed on Human Amnion Epithelial Cells
|
Stem Cells Dev
|
2013
|
22(2):320-329
|
杨丽娟,
|
卵巢癌干细胞及新的治疗策略
|
现代妇产科进展
|
2012
|
21(2): 142-144
|
, Li Ma, Fangyuan Wang.
|
Fibroblast activation protein regulates tumor-associated fibroblasts and epithelial ovarian cancer cells
|
Int J oncol
|
2012
|
41(2):541-550
|
, Fangyuan Wang, Yifei chen, Chunhui Wang, Sha Liu, Bufeng Lu, Girui Ge, Lihe Guo
|
Human ovarian cancer stem-like cells can be efficiently killed by γδ T lymphocytes
|
Cancer Immunol Immunother
|
2012
|
61(7): 979-989
|
, Yifei Chen, Fangyuan Wang, Lizhen Jiang, and Chunsheng Wei
|
LKB1 Controls the Pluripotent State of Human Embryonic Stem Cells
|
Cellular Reprogramming
|
2012
|
14 (2):164-170
|
陈一飞,
|
人类及小鼠胚胎干细胞的不同多能性状态
|
中国细胞生物学学报
|
2011
|
33(10): 1166–1172
|
董张丽,杨丽娟,
|
免疫对肿瘤的负向调控
|
现代免疫学
|
2011
|
31(5): 428-431
|
,郭礼和
|
炎性单核细胞促进乳腺癌转移的分子机制
|
中国细胞生物学学报
|
2011
|
33(8): 948–949
|
王方圆,谢超,程蔚蔚,韩伟,
|
环磷酰胺化疗导致小鼠卵巢功能损伤模型的建立
|
上海交通大学学报
|
2011
|
10:1398-1405
|
Te Liu,Weiwei Cheng,Tianjin Liu,Lihe Guo,Qin Huang,Lizhen Jiang,Xiling Du,Fuhui Xu,Zhixue Liu,
|
Human amniotic epithelial cell feeder layers maintain mouse embryonic spermatogonial stem cell pluripotency via epigenetic regulation of the c-Myc promote
|
Acta Biochimica et Biophysica Sinica
|
2010
|
42(2):-
|
, Weiwei Cheng, Te liu,Lizheng Jiang, Tianjin Liu, Qin Huang, Lihe Guo
|
Optimization of culture conditions to support undifferentiated growth of human embryonic stem cells.
|
Cellular Reprogramming.
|
2010
|
12(3)
|
,刘特
|
叶酸对卵巢癌细胞株SKOV3的增殖抑制作用.
|
上海交通大学学报(医学版).
|
2010
|
30 (4): 386-389
|
Te Liu, Weiwei Cheng,,Yong Huang,Lihe Guo
|
Characterization of primary ovarian cancer cells in different culture system
|
Oncology reports
|
2010
|
23 (5): 1277-1284
|
,刘特,黄勇,王丽华,张健,程蔚蔚.
|
原代卵巢癌干细胞样细胞的分离,培养及鉴定.
|
中华妇产科杂志.
|
2009
|
12(44):936-940
|
, Weiwei Cheng, Tianjin Liu, Lizhen Jiang, Te Liu
|
Human Amnion Epithelial Cell Feeder Layers Support Undifferentiated Growth of Murine Embryonic Stem Cells.
|
Cloning and stem cell.
|
2009
|
11(2): 331-340
|
,Denny Sakkas,Yingqun Huang
|
The fragile X mental retardation protein interacts with a distinct mRNA nuclear export factor, NXF2.
|
RNA.
|
2006
|
12():-
|
, Guanzhen Zhu, Jianping Zhou, Youji Feng
|
The effect of estrogen and antiestrogen on chemotherapeutic sensitivity of endometrial carcinoma cell line.
|
The Chinese-German Journal of Clinical Oncology, 2003
|
2003
|
2(4):-
|
,朱关珍.
|
子宫内膜癌MDR基因的表达与临床意义.
|
肿瘤
|
2002
|
22(1):-
|
,朱关珍
|
子宫内膜癌细胞凋亡及其相关基因研究进展
|
中国临床医学.
|
2001
|
6():-
|
,朱关珍,周剑萍.
|
子宫内膜癌C-myc癌基因的表达及临床意义
|
实用妇产科杂志.
|
2000
|
16(1):-
|
,朱关珍,周剑萍,丰有吉
|
雌激素与抗雌激素制剂对子宫内膜癌细胞化疗效应的影响.
|
中华肿瘤杂志.
|
2000
|
22(5):-
|
,朱关珍,周剑萍,刘银坤,丰有吉.
|
雌激素与三苯氧胺对子宫内膜癌细胞bcl-2 mRNA水平的调节
|
中华妇产科杂志.
|
1999
|
34(10):-
|
|