- 基本信息
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导师姓名：
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武志祥
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学科代码：
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100202
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性别：
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男
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学科名称：
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儿科学
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培养单位：
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附属新华医院
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三级学科
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导师类型：
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博士生导师
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专业领域名称：
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儿外科学 专业学位
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联系方式：
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wuzhixiang@xinhuamed.com.cn
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专业领域代码：
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105112
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邮编：
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邮箱地址：
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wuzhixiang@xinhuamed.com.cn
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- 研究方向 (点击浏览详细信息)
- 社会任职
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中华医学会小儿外科分会青年委员
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中国抗癌协会小儿肿瘤专业委员会外科学组委员
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上海医学会小儿外科分会青委副主任委员
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- 科研项目
| 81874234 | 基于TH-MYCN小鼠的MYCN扩增型神经母细胞瘤新致病机制研究 | 国家自然基金委 |
2019-01~2022-12
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57万元
| 课题负责人 |
| XH2698 | 上海市“医苑新星”青年医学人才培养资助计划 | 上海市卫健委 |
2019-01~2021-12
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20万元
| 课题负责人 |
| 16QA1402900 | 儿童神经母细胞瘤自然转归机制研究 | 上海市科委 |
2016-04~2019-03
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40万元
| 课题负责人 |
| 81402478 | ALK异常型神经母细胞瘤原发性耐药机制的磷酸化蛋白组学研究 | 国家自然基金委 |
2015-01~2017-12
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23万元
| 课题负责人 |
- 学术论文
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Xiaowei Liu, Yuanxia Cai, Cheng Cheng, Yaoyao Gu, Xiaoxiao Hu, Kai Chen, Yeming Wu,
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PCLAF promotes neuroblastoma G1/S cell cycle progression via the E2F1/PTTG1 axis
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Cell death & disease
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2022
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13(2):1-12
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Xiaowei Liu, Cheng Cheng, Yuanxia Cai, Yaoyao Gu, Yangkun Wu, Kai Chen,
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Pan?cancer analyses reveal the regulation and clinical outcome association of PCLAF in human tumors
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International journal of oncology
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2022
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60(6):1-13
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Lijia Pan, Cheng Cheng, Peiwen Duan, Kai Chen, Yeming Wu,
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XPO1/CRM1 is a promising prognostic indicator for neuroblastoma and represented a therapeutic target by selective inhibitor verdinexor
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Journal of Experimental & Clinical Cancer Research
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2021
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40（1）：1-16
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Yaoyao Gu, Xiaoxiao Hu, Xiaowei Liu, Cheng Cheng, Kai Chen, Yeming Wu,
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MCM6 indicates adverse tumor features and poor outcomes and promotes G1/S cell cycle progression in neuroblastoma
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BMC cancer
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2021
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21（1）：1-14
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Chen H, Lin H, Xu M, Xu G, Fang X, He L, Chen Z,, Geng H
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Quantitative Urinary Proteome Reveals Potential Biomarkers for Ureteropelvic Junction Obstruction
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Proteomics Clin Appl
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2019
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13(4):e1800101
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Cheng C, Wu Y, Pan W, Wang J,, Lv F.
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Follow-Up Report of Laparoscopic Fundoplication in Different Types of Esophageal Hiatal Hernia in Children
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J Laparoendosc Adv Surg Tech A
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2019
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29(10):1320-1324
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Y Cai, F Lv, N Kaldybayeva, A Zhamilya,, Y Wu
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15, 16-Dihydrotanshinone I Inhibits Hemangiomas through Inducing Pro-apoptotic and Anti-angiogenic Mechanisms in Vitro and in Vivo
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Frontiers in pharmacology
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2018
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9,25
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K Chen, Y Cai, M Zhang,, Y Wu
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Both serum and tissue Galectin‐1 levels are associated with adverse clinical features in neuroblastoma
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Pediatric Blood & Cancer
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2018
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e27229
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金惠明,
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先天性哑铃形神经母细胞瘤3例疗效分析
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临床儿科杂志
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2018
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36(12)
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Gu Y, Lv F, Xue M, Chen K, Cheng C, Ding X, Jin M, Xu G, Zhang Y,, Zheng L, Wu Y
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The deubiquitinating enzyme UCHL1 is a favorable prognostic marker in neuroblastoma as it promotes neuronal differentiation
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J Exp Clin Cancer Res
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2018
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Oct 25;37(1):258
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Chen H, Lin H, Xu M, Xu G, Fang X, He L, Chen Z,, Geng H
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Quantitative Urinary Proteome Reveals Potential Biomarkers for Ureteropelvic Junction Obstruction
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Proteomics Clin Appl
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2018
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Nov 24:e1800101
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Nagel MK, Kalinowska K, Vogel K, Reynolds GD,, Anzenberger F, Ichikawa M, Tsutsumi C, Sato MH, Kuster B, Bednarek SY, Isono E.
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Arabidopsis SH3P2 is an ubiquitin-binding protein that functions together with ESCRT-I and the deubiquitylating enzyme AMSH3
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Proc Natl Acad Sci U S A
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2017
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2017 Aug 7. pii: 201710866
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B Liu, H Lu, D Li, X Xiong, L Gao, Z Wu,
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Aberrant Expression of FBXO2 Disrupts Glucose Homeostasis Through Ubiquitin-Mediated Degradation of Insulin Receptor in Obese Mice
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Diabetes
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2017
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db161104
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Gu S, Chen K, Yin M,, Wu Y
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Proteomic profiling of isogenic primary and metastatic medulloblastoma cell lines reveals differential expression of key metastatic factors.
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J Proteomics
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2017
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2017 May 8;160:55-63
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Y Wang, K Chen, Y Cai, Y Cai, X Yuan, L Wang,, Y Wu
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Annexin A2 could enhance multidrug resistance by regulating NF-κB signaling pathway in pediatric neuroblastoma
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Journal of Experimental & Clinical Cancer Research
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2017
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36 (1), 111
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Susan Klaeger, Stephanie Heinzlmeir, Mathias Wilhelm, Harald Polzer, Binje Vick, Paul-Albert Koenig, Maria Reinecke, Benjamin Ruprecht, Svenja Petzoldt, Chen Meng, Jana Zecha, Katrin Reiter, Huichao Qiao, Dominic Helm, Heiner Koch, Melanie Schoof, Giulia Canevari, Elena Casale, Stefania Re Depaolini, Annette Feuchtinger,, Tobias Schmidt, Lars Rueckert, Wilhelm Becker, Jan Huenges, Anne-Kathrin Garz, Bjoern-Oliver Gohlke, Daniel Paul Zolg, Gian Kayser, Tonu Vooder, Robert Preissner, Hannes Hahne, Neeme T?nisson, Karl Kramer, Katharina G?tze, Florian Bassermann, Judith Schlegl, Hans-Christian Ehrlich, Stephan Aiche, Axel Walch, Philipp A Greif, Sabine Schneider, Eduard Rudolf Felder, Juergen Ruland, Guillaume Médard, Irmela Jeremias, Karsten Spiekermann, Bernhard Kuster
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The target landscape of clinical kinase drugs
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Science
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2017
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358 (6367), eaan4368
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K Chen, F Lv, G Xu, M Zhang, Y Wu,
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Phosphoproteomics reveals ALK promote cell progress via RAS/JNK pathway in neuroblastoma
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Oncotarget
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2016
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7 (46), 75968
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J Shi, WJ Wu, G Hu, X Yu, GS Yu, H Lu, ML Yang, B Liu,
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Regulation of β-catenin transcription activity by leupaxin in hepatocellular carcinoma
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Tumor Biology
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2016
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37 (2), 2313-2320
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WJ Wu, J Shi, G Hu, X Yu, H Lu, ML Yang, B Liu,
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Wnt/β-catenin signaling inhibits FBXW7 expression by upregulation of microRNA-770 in hepatocellular carcinoma
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Tumor Biology
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2016
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37 (5), 6045-6051
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Medard G, Pachl F, Ruprecht B, Klaeger S, Heinzlmeir S, Helm D, Qiao H, Ku X, Wilhelm M, Kuehne T ,, Dittmann A, Hopf C, Kramer K, Kuster, B
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Optimized Chemical Proteomics Assay for Kinase Inhibitor Profiling
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Journal of proteome research
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2015
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14 (3), 1574-1586
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, Cheng Z, Sun M, Wan X, Liu P, He T, Tan M, Zhao Y
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A chemical proteomics approach for global analysis of lysine monomethylome profiling
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Mol Cell Proteomics
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2015
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14(2):329-39
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G Xu, J Wang,, L Qian, L Dai, X Wan, M Tan, Y Zhao, Y Wu
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SAHA regulates histone acetylation, butyrylation, and protein expression in neuroblastoma
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Journal of proteome research
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2014
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13 (10), 4211-4219
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AM Gholami, H Hahne,, FJ Auer, C Meng, M Wilhelm, B Kuster
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Global proteome analysis of the NCI-60 cell line panel
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Cell reports
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2013
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4 (3), 609-620
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, AM Gholami, B Kuster
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Systematic identification of the HSP90 regulated proteome
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Molecular & cellular proteomics
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2012
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M111. 016675
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, Jessica B Doondeea, Amin Moghaddas Gholami, Melanie C Janning, Simone Lemeer, Karl Kramer, Suzanne A Eccles, Susanne M Gollin, Reidar Grenman, Axel Walch, Stephan M Feller, Bernhard Kuster
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Quantitative chemical proteomics reveals new potential drug targets in head and neck cancer
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Molecular & Cellular Proteomics
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2011
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mcp. M111. 011635
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, Junfeng Luo, Qinyu Ge, Zuhong Lu
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Microarray-based Ms-SNuPE: near-quantitative analysis for a high-throughput DNA methylation
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Biosensors and Bioelectronics
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2008
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23 (9), 1333-1339
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, J Luo, Q Ge, D Zhang, Y Wang, C Jia, Z Lu
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Allele-specific extension on microarray for DNA methylation analysis
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Analytica chimica acta
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2007
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603 (2), 199-204
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