- 基本信息
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导师姓名：
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李海
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学科代码：
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100201
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性别：
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男
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学科名称：
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内科学
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培养单位：
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附属仁济医院
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三级学科
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消化系病
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导师类型：
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博士生导师
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专业领域名称：
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内科学 专业学位
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联系方式：
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haili_17@126.com
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专业领域代码：
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105101
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邮编：
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邮箱地址：
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haili_17@126.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
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中华医学会临床流行病学与循证医学上海分会委员会后任主委
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研究型医院重肝学组副主任委员
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中华医学院肝病分会重肝与人工肝学组委员
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中华医学会临床流行病学与循证医学分会常委
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- 科研项目
| 82170629 | FXR在肝坏死损伤修复中调控肝-毛细胆管功能性再生关键转运泵及缝隙连接蛋白表达的机制研究 | 国家自然基金面上项目 |
2022-01~2025-12
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55万元
| 课题负责人 |
| SHDC2020CR1037B | 早期筛选慢性肝病急性加重不良预后患者及精准诊断 pre ACLF 的多中心临床研究 | 上海申康三年第二期重大疾病多中心临床研究项目 |
2020-10~2022-10
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715万元
| 课题负责人 |
| 2018ZX10302206-005 | 新技术在慢加急肝衰竭治疗中的应用及疗效评估 | “艾滋病和病毒性肝炎等重大传染病防治”科技重大专项2018年度公开择优课题 |
2018-02~2020-12
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946万元
| 课题负责人 |
| 81670576 | HNF4a调控慢加急肝衰竭(ACLF)患者祖细胞来源功能性肝再生的机制研究 | 国家自然基金 |
2017-01~2020-12
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58万元
| 课题负责人 |
| GZ1263 | “慢加急性肝衰竭：肝细胞的死亡和再生分子机制”中德合作小组项目 | 国家自然基金委-中德科学中心 |
2016-12~2018-12
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150万元
| 课题负责人 |
| 16CR1024B | 完善慢加急性肝衰竭诊断标准的全国 多中心、前瞻性、大样本临床研究 | 上海市申康中心-促进市级医院临床技能与临床创新能力三年行动计划 |
2016-12~2019-06
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150万元
| 课题负责人 |
| 20152213 | 高原高峰计划-研究型医师 | 上海交通大学医学院 |
2016-01~2017-12
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100万元
| 课题负责人 |
| 81470869 | 亚大块肝坏死在慢加急性肝衰竭发生中的核心作用及相关发病机制假说 | 国家自然基金面上项目 |
2015-01~2018-12
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73万元
| 课题负责人 |
| 12431900705 | Enbrel治疗急性肝衰竭新适应症的临床前研究” | 上海市科委 |
2012-09~2015-08
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50万元
| 课题负责人 |
| 81170421 | 单核细胞分化障碍预测慢加急性肝衰竭患者临床转归的机制研究 | 国家自然基金委，面上项目 |
2012-01~2015-12
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64万元
| 课题负责人 |
| 30971333 | 长效可溶性TNFα p55蛋白持续靶向阻抑急性肝损伤信号通路的疗效与机制研究 | 国家自然基金，面上项目 |
2010-01~2012-12
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32万元
| 课题负责人 |
| 2009ZX09103-660 | 人源化血清白蛋白-Ⅰ型可溶性TNFα受体融合蛋白防治急性肝衰竭的药物代谢及安全性研究 | “十一五”新药创制重大专项 |
2009-01~2011-12
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150万元
| 课题负责人 |
| 30770962 | HBV急性重症肝衰竭免疫效应细胞募集肝脏的发生机制研究 | 国家自然基金委 |
2008-01~2008-12
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8万元
| 课题负责人 |
| 2006AA02A411 | 慢性肝病分子分型及个体化治疗-重症肝衰竭子课题 | 十一五863课题 |
2008-01~2010-12
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60万元
| 子课题负责人 |
| 05PJ14056 | 长效肿瘤坏死因子a抑制剂的研制及其防治急性肝细胞坏死的动物实验研究 | 上海市科委 |
2005-12~2007-09
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20万元
| 课题负责人 |
| 05PJ14056 | TNFα长效抑制剂的研制及抗鼠急性肝细胞坏死的实验研究 | 上海市浦江人才计划 |
2005-09~2007-08
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20万元
| 课题负责人 |
| 044050 | 建立胰岛素抵抗的基因诊断方法 | 上海市卫生局,局级课题 |
2005-01~2007-06
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3万元
| 课题负责人 |
- 学术论文
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Mei X,, Deng G, …, Ren H, Yuan W, Qian Z
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Prevalence and?clinical signifcance of serum sodium variability in patients with acute-on-chronic liver diseases: a prospective multicenter study in China.
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Hepatology International
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2022
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16(1):183-194
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Tongyu Wang, Wenting Tan, Xianbo Wang, Xin Zheng, Yan Huang, Beiling Li, Zhongji Meng, Yanhang Gao, Zhiping Qian, Feng Liu , Xiaobo Lu, Huadong Yan, Yubao Zheng, Weituo Zhang, Shan Yin , Wenyi Gu, Yan Zhang, Fuchen Dong, Jianyi Wei, Guohong Deng , Xiaomei Xiang, Yi Zhou, Yixin Hou, Qun Zhang, Shue Xiong, Jing Liu, Liyuan Long, Ruochan Chen, Jinjun Chen, Xiuhua Jiang, Sen Luo, Yuanyuan Chen, Chang Jiang, Jinming Zhao, Liujuan Ji, Xue Mei, Jing Li, Tao Li, Rongjiong Zheng, Xinyi Zhou, Haotang Ren, Yu Shi,
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Role of precipitants in transition of acute decompensation to acute-on-chronic liver failure in patients with HBV-related cirrhosis
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JHEP Reports
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2022
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4(10):100529
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Li Han, Chenhui Ma, Huige Peng, Zhitao Wu, Huiming Xu, Jianjun Wu, Ning Zhang, Qinghui Jiang, Chen Ma, Ruimin Huang,
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Define mesenchymal stem cell form its fate: Biodisposition of human mesenchymal stem cells in normal and Con-A induced liver injury mice
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Journal of Pharmacology and Experimental Therapeuitcs
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2021
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379(2):125-133
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Jing Liu,, Jie Xia,… Xin Zheng.
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Baseline Neutrophil-to-Lymphocyte Ratio Is Independently Associated With 90-Day Transplant-Free Mortality in Patients With Cirrhosis
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Frontier in Medicine
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2021
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8:726950
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Liang Qiao, Wenting Tan, Xiaobo Wang …Weituo Zhang*, Hai Li *
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Different Effects of Total Bilirubin on 90-Day Mortality in Hospitalized Patients With Cirrhosis and Advanced Fibrosis: A Quantitative Analysis.
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Frontier in Medicine
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2021
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8:704452
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Long L,, Deng G, …, Mei X, Chen R, Huang Y
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Impact of Hepatic Encephalopathy on Clinical Characteristics and Adverse Outcomes in Prospective and Multicenter Cohorts of Patients With Acute-on-Chronic Liver Diseases.
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Frontier in Medicine
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2021
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8:709884
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Chen Y-y,, Xu B-y, Zheng X, Li B,Wang X-b, Huang Y, Gao Y-h,Qian Z-p, Liu F, Lu X-b, Shang J, Li H, Wang S-y, Zhang Y-h, Meng Z-j
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Plasma Exchange-Based Non-bioartificial Liver Support System Improves the Short-Term Outcomes of Patients With Hepatitis B Virus-Associated Acute-on-Chronic Liver Failure: A Multicenter Prospective Cohort Study.
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Frontier in Medicine
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2021
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8:779744
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Zhongji Meng, Tongyu Wang, Li Chen, Xinhe Chen, Longti Li, Xueqin Qin,, Jie Luo
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The effect of recombinant human interferon alpha nasal drops to prevent COVID-19 pneumonia for medical staff in an epidemic area.
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Current Topics in Medical Chemistry
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2021
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21:920-927
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Liang Qiao,Xianbo Wang, Guohong Deng, Yan Huang, Jinjun Chen, Zhongji Meng, Xin Zheng, Yu Shi, Zhiping Qian, Feng Liu, Yanhang Gao, Xiaobo Lu, Junping Liu, Wenyi Gu,Yan Zhang, Tongyu Wang, Dandan Wu, Fuchen Dong, Xin Sun*,
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Cohort profile: a multicentre prospective validation cohort of the Chinese Acute-on-Chronic Liver Failure
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BMJ Open
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2021
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11: e037793
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Ying Wang, Fuchen Dong, Shuning Sun, … Hai Li* and Zhongji Meng*
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Increased INR Values Predict Accelerating Deterioration and High Short-Term Mortality Among Patients Hospitalized With Cirrhosis or Advanced Fibrosis.
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Frontier in Medicine
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2021
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8:762291
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Yan Zhang, Biao-yan Xu,Xian-bo Wang ….Hai Li*, Jing Hua*
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Prevalence and clinical significance of portal vein thrombosis in patients with cirrhosis and acute decompensation
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Clinical Gastroenterology and Hepatology
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2020
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18:2564-2572
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Cao Z, Liu Y, Wang S, Lu X, Yin S, Jiang S, Chen L, Cai M, Zeng B, Yao Y, Tang W, Zhao G, Xiang X, Wang H, Cai W, Zhu C,, Xie Q*
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The impact of HBV flare on the outcome of HBV-related decompensated cirrhosis patients with bacterial infection
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Liver Int.
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2019
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39(10):1943-1953
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Wen-yi Gu, Bao-yan Xu, Xin Zheng, Jinjun Chen, Xian-bo Wang, Yan Huang, Yan-hang Gaog, Zhong-ji Mengh, Zhi-ping Qian, Feng Liu, Xiao-bo Lu, Jia Shang, Hai Li, Shao-yang Wang, Xin Sun, Hai Li*
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Acute-on-chronic liver failure in China: Rationale for developing a patient registry and baseline characteristics.
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American Journal of Epidemiology
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2018
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187(9):1829–1839
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Shan YIN , Shi Jin WANG, Wen Yi GU, Yan ZHANG, Liu Ying CHEN & Hai LI*
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Risk of different precipitating events for progressing to acute-on- chronic liver failure in HBV-related cirrhotic patients.
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Journal of Digestive Diseases
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2017
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18; 292–301
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, Liu-Ying Chen, Nan-nan Zhang, Shu-Ting Li, Bo Zeng, Marco Pavesi, àlex Navarro, Rajeshwar P Mookerjee, Qian Xia, Feng Xue, Xiong Ma, Jing Hua, Li Sheng, De-kai Qiu, Qing Xie, Graham R Foster, Geoffrey Dusheiko, Richard Moreau, Pere Gines, Vicente Arroyo, Rajiv Jalan.
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Characteristics, Diagnosis and Prognosis of Acute-on-Chronic Liver Failure in Cirrhosis Associated to Hepatitis B
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Scientific Reports
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2016
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6:25487
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, Qiang Xia, Bo Zeng, Shu-Ting Li, Heng Liu, Qi Li, Jun Li, Shu-Yin Yang, Xiao-Jun Dong, Ting Gao,Stefan Munker, Yan Liu, Roman Liebe, Feng Xue, Qi-Gen Li, Xiao-Song Chen, Qiang Liu, Hui Zeng, Ji-Yao Wang, Qing Xie, Qin-Hua Meng, Jie-Fei Wang, Peter R. Mertens, Frank Lammert, Manfred V. Singer, Steven Dooley, Matthias P.A. Ebert, De-Kai Qiu, Tai-Ling Wang *, Hong-Lei Weng *.
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Submassive hepatic necrosis distinguishes HBV-associated acute on chronic liver failure from cirrhotic patients with acute decompensation
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Journal of Hepatology
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2015
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63: 50–59
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曾菠, 陈柳莹, 张楠楠, 李淑婷, 杨淑殷 ,尹珊,
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肝脏特异多器官功能衰竭评分预测乙型肝炎肝硬化急性失代偿患者短期死亡的对比研究
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胃肠病学
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2015
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05:261-266
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杨淑殷, 李淑婷, 薛峰, 王蓓蓓, 曾菠, 张楠楠, 陈柳莹, 王泰龄,
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乙型肝炎相关慢加急性肝衰竭合并脓毒症的病理特征
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中国肝脏病杂志
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2014
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2: 6-9
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Yumin Xu, Hui Wang, Shishan Bao, Fazal Tabassam, Wei Cai, Xiaogang Xiang, Gangde Zhao,
Haiqing Wu, Ting Gao,, Qing Xie*.
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Amelioration of Liver Injury by Continuously Targeted intervention against TNFRP55 in rats with ACLF.
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PLOS ONE
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2013
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8(7) :68757-68766
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周婷婷,卫 超,陈晓东,,汪 铮
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无血清培养体系原代培养脐带间充质干细胞.
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中国组织工程研究
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2013
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17(27):4980-4987
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董晓君,陈萦暄,周婷婷,李淑婷,栗雅杰,杨淑殷,薛峰,,王泰龄
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乙型肝炎肝硬化基础上慢加急性肝衰竭及失代偿终末期患者肝内细胆管反应特点对比研究
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中国肝脏病杂志
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2013
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5(2)：1-5.
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2. Gao T, Xia Q, Qiu de K, Feng YY, Chi JC, Wang SY, Xi ZF, Zhang JJ, Xu N, Chen SY, Qiu YL, Shen LW, Zhou TT, Dong XJ, Li QG,
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Comparison of survival and tumor recurrence rates in patients undergoing liver transplantation for hepatitis B-related hepatocellular carcinoma using Milan, Shanghai Fudan and Hangzhou criteria
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J Dig Dis
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2013
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14(10):552-8
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找准慢加急肝衰竭研究的关键点和突破点
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胃肠病学
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2013
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18（12）：705-707
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李淑婷,高婷,杨淑殷,沈黎蔚,周婷婷,董晓君,曾菠,
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乙型肝炎后肝硬化失代偿期患者自然病程进展与血清乙肝病毒复制载量关系的研究
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胃肠病学
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2013
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2013，18（9）：516-520
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1. Dong X, Gong Y, Zeng H, Hao Y, Wang X, Hou J, Wang J, Li J, Zhu Y, Liu H, Han J, Zhou H, Shen L, Gao T, Zhou T, Yang S, Li S, Chen Y, Meng Q,
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Imbalance between circulating CD4+ regulatory T and conventional T lymphocytes in patients with HBV-related acute-on-chronic liver failure.
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Liver International
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2013
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33(10):1517-1526
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Zhan J, Chen Y, Yuan HY,, Lu H*.
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Fusion of HSA influences TNF-α neutralizing activity of shTNFRs
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. Biotechnol Lett.
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2012
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34(3):417-23
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高婷,章鹏,宫钰,沈黎蔚,夏强,
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乙肝后肝硬化失代偿患者肝脏炎症活动性的研究
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胃肠病学
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2012
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17(8):453-456
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沈黎蔚,王介非,董晓君,宫钰,高婷,周婷婷,李淑婷,杨淑殷,
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乙型肝炎慢加急性肝功能衰竭患者免疫失衡状态下单核细胞的研究
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中华消化杂志
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2012
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32(8):25-29
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宫钰,沈黎蔚,王介非,张正国,章鹏,
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乙型肝炎慢加急性肝衰竭患者免疫功能抑制与疾病严重程度的研究
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中华消化杂志
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2011
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31(8):11-16
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Ogyi Park, Hua Wang, Honglei Weng, Lionel Feigenbaum,, Shi Yin, Sung Hwan Ki,Seong Ho Yoo, Steven Dooley, Fu-Sheng Wang, Howard A.Young and Bin Gao
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InVivo Consequences of Liver-Specific Interleukin-22 Expression in Mice: Implications for Human Liver Disease Progression
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HEPATOLOGY,
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2011
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54(1):252-261
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Honglei Weng,, Steven Dooley
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Inflammation Does Not Always Kill Hepatocytes During Liver Damage
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HEPATOLOGY,
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2011
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54(1):366-366
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章鹏,陈婷,宫钰,沈黎蔚,高婷,薛峰,夏强,
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Th1细胞在活动性乙型肝炎肝硬化和慢加急性肝衰竭发病中的作用
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中华肝脏病杂志
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2010
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18(11):958-960
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章鹏, 陈婷, 宫钰, 冯怡燕, 薛峰,
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Th17 细胞及其细胞因子与乙型肝炎后肝硬化肝组织炎症活动度相关性的研究
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胃肠病学
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2010
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15(8):353-356
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周昱,
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急性肝功能衰竭的预后评估模型及进展
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肝脏
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2009
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14(6):490-493
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冯怡燕,
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基因多态性参与胆固醇结石发病机制的研究进展
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国际消化病杂志
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2009
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29(3):157-159
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,王吉耀
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PBC应命名为原发性胆汁性胆管炎（Primary Biliary Cholangitis）
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肝脏
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2009
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14(3):25-25
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冯怡燕,
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线粒体通透性转换与非酒精性脂肪性肝病
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肝脏
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2009
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14(3):256-258
|
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冯怡燕,
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SIRT-1:非酒精性脂肪性肝炎新治疗靶点
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中华肝脏病杂志
|
2008
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16(12):958-960
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陈莹,袁汉英,,吕红
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毕赤酵母YPS1基因的失活对减少重组人血清白蛋白降解的作用
|
复旦学报（自然科学版）
|
2008
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47(3):311-317
|
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,徐军,俞愉,陈婷,冯怡燕,章鹏,邱德凯
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脂质体法转染人肿瘤坏死因子α基因对裸鼠人肝癌移植瘤的抑制效应及机制
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胃肠病学
|
2008
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13(6):345-348
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