• 基本信息
    导师姓名： 徐晨明 学科代码： 100211
    性别： 女 学科名称： 妇产科学
    培养单位： 附属国际和平妇幼保健院 三级学科
    导师类型： 博士生导师 专业领域名称：
    联系方式： 上海市徐汇区衡山路910号 专业领域代码：
    邮编： 200030 邮箱地址： xuchenm@163.com
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    上海市遗传学会第一届遗传与分子诊断专业委员会委员
    上海市医学会第二届分子诊断专科分会副主任委员
    中国优生科学协会理事
    中国医师协会医学遗传学医师分会第一届临床生殖遗传专业委员会委员
    中华医学会医学遗传学分会第八届委员会细胞遗传学组委员
    中国研究型医院学会罕见病分会理事
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    81971344FMR1基因前突变CGG重复序列介导的卵巢功能不全机制国家自然科学基金 2020-01~2023-12 52万元  课题负责人
    81771638PKD1/NPHP4通路参与ADPKD男性患者精子鞭毛结构异常发生的分子机制国家自然科学基金 2018-01~2021-12 56万元  课题负责人
    2016YFC0905103重要罕见病的临床诊疗规范研究国家重点研发计划 2016-07~2020-12 104万元  课题参与人
    15ZH4011基于辅助生殖技术的常见单基因遗传性肾病精准防控新技术交大医学院转化医学创新基金 2015-12~2017-06 100万元  课题负责人
    15411964000基于DNA甲基化的无创产前筛查方法建立及临床评价上海市科委西医引导类 2015-08~2018-08 20万元  课题负责人
    81471506基于NGS技术的遗传性多囊肾病植入前遗传学诊断研究国家自然科学基金 2015-01~2018-12 73万元  课题负责人
    14411965100新一代全基因组低覆盖度测序技术应用于植入前胚胎筛查的临床研究上海市科委西医引导类项目 2015-01~2017-12 20万元  课题负责人
    2012CB944900辅助生殖诱发胚胎源性疾病的风险评估和机制研究国家重大研究计划 2012-01~2016-12 100万元  课题参与人
    81170620胚胎体外培养致辅助生殖子代表观遗传修饰的影响及机制研究国家自然科学基金 2012-01~2015-12 58万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Li S, Han X, Wang Y, Chen S, Niu J, Qian Z, Li P, Jin L,  Chromosomal microarray analysis in fetuses with congenital anomalies of the kidney and urinary tract: A prospective cohort study and meta-analysis.  Prenat Diagn  2019  39(3):165-174 
    Fei HJ, Chen SC, Zhang JY, Li SY, Zhang LL, Chen YY, Chang CX,  Identification of significant biomarkers and pathways associated with gastric carcinogenesis by whole genome-wide expression profiling analysis.  Int J Oncol  2018  52(3):955-966. 
    Chen S, Li S, Zhang J, Zhang L, Chen Y, Wang L, Jin L, Hu Y, Qi X, Huang H,  Preimplantation Genetic Diagnosis of Multiple Endocrine Neoplasia Type 2A Using Informative Markers Identified by Targeted Sequencing.  Thyroid  2018  28(3):281-287. 
    Zhang JY, Chen SC, Chen YY, Li SY, Zhang LL, Shen YH, Chang CX, Xiang YQ, Huang HF,  Targeted sequencing identifies a novel SH2D1A pathogenic variant in a Chinese family: Carrier screening and prenatal genetic testing  PLoS One  2017  12(2):e0172173 
    施炜慧,李淑元,,黄荷凤. .   产前诊断技术在临床中的应用  中国临床医生杂志  2017  (06) :1-4 
    刘凯,林仙华,李蓉,谈雅静,王勇,  正念减压疗法对试管婴儿患者知觉压力及心理状态的影响  现代生物医学进展  2017  24:4668-4671 
    Tian S, Lin XH, Xiong YM, Liu ME, Yu TT, Lv M, Zhao W, Xu GF, Ding GL,, Jin M, Feng C, Wu YT, Tan YJ, Gao Q, Zhang J, Li C, Ren J, Jin LY, Chen B, Zhu H, Zhang XY, Chen SC, Liu XM, Liu Y, Zhang JY, Wang L, Zhang P, Chen XJ, Jin L, Chen X, Meng YC, Wu DD, Lin H, Yang Q, Zhou CL, Li XZ, Wang YY, Xiang YQ, Liu ZW, Gao L, Chen LT, Pan HJ, Li R, Zhang FH, Xing LF, Zhu YM, Klausen C, Leung PCK, Li JX, Sun F, Sheng JZ, Huang HF.   Prevalence of Prediabetes Risk in Offspring Born to Mothers with Hyperandrogenism.  EBioMedicine  2017  16:275-283. 
    高佳琪,王彦林,张海鸥,  胎儿分数在预测子痫前期和早产中的临床意义  中国临床医生杂志  2017  (05) :103-106 
    Chen S, Liu D, Zhang J, Li S, Zhang L, Fan J, Luo Y, Qian Y, Huang H, Liu C, Zhu H, Jiang Z,  A copy number variation genotyping method for aneuploidy detection in spontaneous abortion specimens  Prenat Diagn.  2017  37(2):176-183 
    Sun YX, Zhang YX, Zhang D,, Chen SC, Zhang JY, Ruan YC, Chen F, Zhang RJ, Qian YQ, Liu YF, Jin LY, Yu TT, Xu HY, Luo YQ, Liu XM, Sun F, Sheng JZ, Huang HF.  XCI-escaping gene KDM5C contributes to ovarian development via downregulating miR-320a.  Hum Genet  2017  136(2):227-239. 
    , Wang T, Liu C, Li H, Chen X, Zhu H, Chen S, Xin Q, Tao J, Huang L, Jiang Z  Noninvasive Prenatal Screening of Fetal Aneuploidy without Massively Parallel Sequencing  Clin Chem  2017  63(4):861-869 
    Chen SC, Xu XL, Zhang JY, Ding GL, Jin L, Liu B, Sun DM, Mei CL, Yang XN, Huang HF,  Identification of PKD2 mutations in human preimplantation embryos in vitro using a combination of targeted next-generation sequencing and targeted haplotyping.  Sci Rep.  2016  6:25488. 
    Hou N, Chen S, Chen F, Jiang M, Zhang J, Yang Y, Zhu B, Bai X, Hu Y, Huang H,  Association between premature ovarian failure, polymorphisms in MTHFR and MTRR genes and serum homocysteine concentration  Reprod Biomed Online.  2016  32(4):407-13.  
    Wu YT, Wu Y, Chen SC, Zhou F, Yang CB, Xie ZW,, Jin HM.   A Novel Molecular Cytogenetic Finding of Leiomyomatosis Peritonealis Disseminata.  Gynecol Obstet Invest.  2015  2015 Apr 23. [Epub ahead of print 
    Liu B, Chen SC, Yang YM, Yan K, Qian YQ, Zhang JY, Hu YT, Dong MY, Jin F, Huang HF,  Identification of novel PKD1 and PKD2 mutations in a Chinese population with autosomal dominant polycystic kidney disease.  Sci Rep.  2015  5:17468. 
    李淑元,  高龄生育子代出生缺陷的风险  中国临床医生杂志  2015  8：14-17 
    胡玉婷,陈松长,罗玉琴,  罕见G6PD缺乏症合并21-三体综合征的分子遗传学研究  中国优生与遗传杂志  2014  7 :9-10 
    Luo Y,, Sun Y, Wang L, Chen S, Jin F.   Different segregation patterns in five carriers due to a pericentric inversion of chromosome 1.  Syst Biol Reprod Med.  2014  60(6):367-72. 
    Qiyin Zhou, Ling Pan, Songchang Chen, Fang Chen, Rosa Hwang, Xiaonan Yang, Wei Wang, Jingyi Jiang, Jian Xu, Hefeng Huang,  Clinical application of noninvasive prenatal testing for the detection of trisomies 21, 18, and 13: a hospital experience  Prenatal Diagnosis  2014  34():1-5 
    Ke HP, Jiang HL, Lv YS, Huang YZ, Liu RR, Chen XL, Du ZF, Luo YQ,, Fan QH, Zhang XN.   KRT9 gene mutation as a reliable indicator in the prenatal molecular diagnosis of epidermolytic palmoplantar keratoderma.  Gene.  2014  546(1):124-8. 
    Ling Pan, Yali Sun, Songchang Chen, Jing He,  SNP Microarray Characterization and Genotype-Phenotype Analysis in a Patient with a Ring Chromosome 22  International Journal of Human Genetics  2014  14(1):23-26 
    Chen S, Lau TK, Zhang C,, Xu Z, Hu P, Xu J, Huang H, Pan L, Jiang F, Chen F, Pan X, Xie W, Liu P, Li X, Zhang L, Li S, Li Y, Xu X, Wang W, Wang J, Jiang H, Zhang X.  A method for noninvasive detection of fetal large deletions/duplications by low coverage massively parallel sequencing.   Prenat Diagn  2013  33(6):584-90 
    Zheng J,, Guo J, Wei Y, Ge H, Li X, Zhang C, Jiang H, Pan L, Tang W, Xie W, Zhang H, Zhao Y, Jiang F, Chen S, Wang W, Xu X, Chen F, Huang H, Jiang H.  Effective noninvasive zygosity determination by maternal plasma target region sequencing  PLoS One  2013  8(6):- 
      高通量检测技术在植入前胚胎遗传学诊断中的应用  际生殖健康/计划生育杂志   2013  6：427-432 
    Jing Xu, Dong-Ping Chen, Zhi-Guo Mao, He-Feng Huang,, Cong-Rong Wang, Wei-Ping Jia and Chang-Lin Mei.  Autosomal dominant polycystic kidney disease with ectopic unilateral multicystic dysplastic kidney.   BMC Nephrology.   2013  14():38- 
    Du ZF,, Zhao Y, Liu WT, Chen XL, Chen CY, Fang H, Ke HP, Zhang XN.  Two novel de novo mutations of KRT6A and KRT16 genes in two Chinese pachyonychia congenita pedigrees with fissured tongue or diffuse plantar keratoderma.  Eur J Dermatol  2012  22(4):476-80 
    Ye Y, Qian Y,, Jin F.   Meiotic segregation analysis of embryos from reciprocal translocation carriers in PGD cycles.  Reprod Biomed Online  2012  24(1):83-90 
    Li HG,, Chen WY, Shi QX, Ni Y.  Cystic fibrosis transmembrane conductance regulator protein expression rate in healthy spermatozoa is not correlated with ovum fertilisation rate.  Andrologia  2012  44():231-8 
    Wu R,, Jin F, Tan Z, Gu B, Chen L, Yao X, Zhang M.  Derivation, characterization and differentiation of a new human embryonic stem cell line from a Chinese hatched blastocyst assisted by a non-contact laser system.  Hum Cell  2010  23(3):89-102 
    Chen XL,, Cai SR, Chen CY, Zhang XN.  Prenatal diagnosis of epidermolytic palmoplantar keratoderma caused by c.T470C (p.M157T) of the keratin 9 gene in a Chinese kindred.  Prenat Diagn. 2009,29(9):911-3  2009  29(9):911-3 
    Wang LY, Wang DH, Zou XY,  Mitochondrial functions on oocytes and preimplantation embryos.  J Zhejiang Univ Sci B.   2009  10(7):483-92 
    , Xu Binseng, Huang Hefeng, Huang Xuefeng, Jin Fan.  Preimplantation genetic diagnosis for X-linked agammaglobulinemia: a case report.   Fertil Steril.  2009  91(5):1958- 
    , Xu Jian, Gao Huijuan, Huang Hefeng.  Triplet pregnancy and successful twin delivery in a patient with congenital cervical atresia who underwent transmyometrial embryo transfer and multifetal pregnancy reduction.  Fertil Steril.  2009  91(5):- 
    , Chen XL, Chen CY, Zhang XN.  Missense mutation of keratin 9 (c.487C>T (p.R163W) in southern Chinese patients with epidermolytic palmoplantar keratoderma.  Eur J Dermatol.  2009  19(3):265-6