- 基本信息
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导师姓名：
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王铸钢
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学科代码：
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100100
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性别：
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男
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学科名称：
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基础医学
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培养单位：
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附属瑞金医院
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三级学科
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导师类型：
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博士生导师
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专业领域名称：
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联系方式：
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上海市黄浦区瑞金二路197号23号楼瑞金医院实验医学研究中心
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专业领域代码：
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邮编：
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200025
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邮箱地址：
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zhugang.wang@163.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
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中国遗传学会理事
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医学基因组学国家重点实验室副主任
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上海南方模式生物研究中心主任
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上海遗传学会副理事长
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瑞金医院实验医学研究中心主任
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- 科研项目
| 81430028 | 三种睾丸特异性丝氨酸蛋白酶家族成员的生理功能研究 | 国家自然科学基金重点项目 |
2015-01~2019-12
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320万元
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- 学术论文
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Cui X, Ma B, Wang Y, Chen Y, Shen C, Kuang Y, Fei J, Lu L,
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Rdh13 deficiency weakens carbon tetrachloride-induced liver injury by regulating Spot14 and Cyp2e1 expression levels
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Front Med.
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2019
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13(1):104-111.
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Xu WY, Shen Y, Zhu H, Gao J, Zhang C, Tang L, Lu SY, Shen CL, Zhang HX, Li Z, Meng P, Wan YH, Fei J,
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2-Aminoadipic acid protects against obesity and diabetes.
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J Endocrinol.
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2019
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Epub
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Liu J, Tang LY, Wang YG, Lu SY, Zhang EN,, Zhang HX
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Identification of MAVS as a Novel Risk Factor for the Development of Osteoarthritis
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Aging Dis.
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2018
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1;9(1):40-50
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Xiyi Wang, Chunling Shen, Xuejiao Chen, Jinjin Wang, Xiaofang Cui, Yicheng Wang, Hongxin Zhang, Lingyun Tang, Shunyuan Lu, Jian Fei,
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Tafa-2 plays an essential role in neuronal survival and neurobiological function in mice.
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Acta Biochim Biophys Sin
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2018
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50(10):984-995.
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Xuan Shang, Chunling Shen, Jianbing Liu, Lingyun Tang, Hongxin Zhang, Yicheng Wang, Wenting Wu, Jun Chi, Hua Zhuang, Jian Fei,
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Serine protease PRSS55 is crucial for male mouse fertility via affecting sperm migration and sperm-egg binding
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Cell Mol Life Sci
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2018
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75(23):4371-4384.
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Wang-Yang Xu, Houbao Zhu, Yan Shen, Ying-Han Wan, Xiao-Die Tu, Wen-Ting Wu, Lingyun Tang, Hong-Xin Zhang, Shun-Yuan Lu, Xiao-Long Jin, Ying Kuang, Jian Fei,
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DHTKD1 deficiency causes Charcot-Marie-Tooth disease in mice
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Molecular and Cellular Biology
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2018
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14;38(13). pii: e00085-18
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Mao YL, Shen CL, Zhou T, Ma BT, Tang LY, Wu WT, Zhang HX, Lu HL, Xu WX,
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Ablation of Tacr2 in mice leads to gastric emptying disturbance.
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Neurogastroenterol Motil.
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2017
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29(11): e13117
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Cui X, Dang S, Wang Y, Chen Y, Zhou J, Shen C, Kuang Y, Fei J, Lu L,
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Retinol dehydrogenase 13 deficiency diminishes carbon tetrachloride-induced liver fibrosis in mice.
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Toxicol Lett.
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2017
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265:17-22.
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Tang L, Wu X, Zhang H, Lu S, Wu M, Shen C, Chen X, Wang Y, Wang W, Shen Y, Gu M, Ding X, Jin X, Fei J,
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A point mutation in Fgf9 impedes joint interzone formation leading to Multiple Synostoses Syndrome
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Hum Mol Genet.
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2017
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26(7):1280-1293.
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Ma B, Zhu J, Tan J, Mao Y, Tang L, Shen C, Zhang H, Kuang Y, Fei J, Yang X,
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Gpr110 deficiency decelerates carcinogen-induced hepatocarcinogenesis via activation of the IL-6/STAT3 pathway.
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Am J Cancer Res.
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2017
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7(3):433-447.
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Chen XJ, Wang XY, Tang LY, Wang JJ, Shen CL, Liu JB, Lu SY, Zhang HX, Kuang Y, Fei J,
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Nhe5 deficiency enhances learning and memory via upregulating Bdnf/TrkB signaling in mic
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Am J Med Genet B Neuropsychiatr Gene
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2017
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174(8):828-838
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Tan J, Chen XJ, Shen CL, Zhang HX, Tang LY, Lu SY, Wu WT, Kuang Y, Fei J,
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Lacking of palladin leads to multiple cellular events changes which contribute to NTD
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Neural Dev
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2017
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12(1):4
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Zhu H, Xu WY, Hu Z, Zhang H, Shen Y, Lu S, Wei C,
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RNA virus receptor Rig-I monitors gut microbiota and inhibits colitis-associated colorectal cancer.
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J Exp Clin Cancer Res.
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2017
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36(1):2.
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Cui XF, Dang SY, Wang Y, Chen Y, Zhou J, Shen CL, Kuang Y, Fei J, Lu LG,
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Retinol dehydrogenase 13 deficiency diminishes carbon tetrachloride-induced liver fibrosis in mice
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Toxicol Lett
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2017
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4;265:17-22
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Chen X, Fan X, Tan J, Shi P, Wang X, Wang J, Kuang Y, Fei J, Liu J, Dang S,
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Palladin is involved in platelet activation and arterial thrombosis.
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Thromb Res.
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2017
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149:1-8.
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Liu J, Shen C, Fan W, Chen Y, Zhang A, Feng Y, Li Z, Kuang Y,
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Low levels of PRSS37 protein in sperm are associated with many cases of unexplained male infertility.
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Acta Biochim Biophys Sin (Shanghai)
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2016
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48(11):1058-1065.
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Shen C, Wang J, Zhuang H, Liu J, Wang X, Chen X, Wu Z, Wu W, Wu Y, Sun Y, Yan H, Fei J, Kuang Y,
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Establishment, characterization, and application of pAcr-SP-NTP-EGFP transgenic mice in visualizing the oviduct-migrating ability of sperm from Prss37-null mice.
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Acta Biochim Biophys Sin (Shanghai).
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2015
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47(6):466-73.
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Ni YY, Chen Y, Lu SY, Sun BY, Wang F, Wu XL, Dang SY, Zhang GH, Zhang HX, Kuang Y, Fei J, Gu MM, Rong WF,
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Deletion of Gpr128 results in weight loss and increased intestinal contraction frequency.
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World J Gastroenterol.
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2014
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20(2):498-508
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Xu W, Zhu H, Gu M, Luo Q, Ding J, Yao Y, Chen F,
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DHTKD1 is essential for mitochondrial biogenesis and function maintenance.
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FEBS Letters
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2013
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587(21):3587-3592
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Shen C, Kuang Y, Liu J, Feng J, Chen X, Wu W, Chi J, Tang L, Wang Y, Fei J,
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Prss37 is required for male fertility in the mouse.
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Biol Reprod.
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2013
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88(5):123
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Wang JJ, Zhang LL, Zhang HX, Shen CL, Lu SY, Kuang Y, Wan YH, Wang WG, Yan HM, Dang SY, Fei J, Jin XL,
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Gpr97 is essential for the follicular versus marginal zone B-lymphocyte fate decision.
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Cell Death Dis.
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2013
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4:e853
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Zhu H, Xu W, Zhang HX, Liu J, Xu H, Lu S, Dang S, Kuang Y, Jin X,
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Targeted deletion of Kif18a protects from colitis-associated colorectal (CAC) tumors in mice through impairing Akt phosphorylation.
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Biochem Biophys Res Commun.
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2013
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438(1):97-102
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Chen Y, Ni YY, Liu J, Lu JW, Wang F, Wu XL, Gu MM, Lu ZY,, Ren ZH.
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Dopamine receptor 3 might be an essential molecule in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity.
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BMC Neurosci
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2013
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14:76
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Wang JJ, Kuang Y, Zhang LL, Shen CL, Wang L, Lu SY, Lu XB, Fei J, Gu MM,
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Phenotypic correction and stable expression of factor VIII in hemophilia A mice by embryonic stem cell therapy.
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Genet Mol Res
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2013
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12(2):1511-1521
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Zhang HX, Liu ZX, Sun YP, Zhu J, Lu SY, Liu XS, Huang QH, Xie YY, Zhu HB, Dang SY, Chen HF, Zheng GY, Li YX, Kuang Y, Fei J, Chen SJ, Chen Z,
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Rig-I regulates NF-κB activity through binding to Nf-κb1 3'-UTR mRNA.
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Proc Natl Acad Sci USA.
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2013
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110(16), 6459-6464
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Wangyang Xu, Mingmin Gu, Lianhua Sun, Wenting Guo, Houbao Zhu, Jianfang Ma, Wentao Yuan, Ying Kuang, Baojun Ji, Xiaolin Wu, Yan Chen, Hongxin Zhang, Futing Sun, Wei Huang, Lei Huang, Shengdi Chen,
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A nonsense mutation in DHTKD1 causes Charcot-Marie-Tooth disease type 2 in a large Chinese pedigree.
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AJHG
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2012
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91(6):1-7
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Zhang LL, Wang JJ, Liu Y, Lu XB, Kuang Y, Wan YH, Chen Y, Yan HM, Fei J,
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GPR26-deficient mice display increased anxiety- and depression-like behaviors accompanied by reduced phosphorylated cyclic AMP responsive element-binding protein level in central amygdala.
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Neuroscience
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2011
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196:203-214
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Ye Q, Yan Z, Liao X, Li Y, Yang J, Sun J, Kawano T, Wang X, Cao Z,, Huang L.
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MUC1 induces metastasis in esophageal squamous cell carcinoma by upregulating matrix metalloproteinase 13.
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Laboratory Investigation
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2011
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91(5):778-787
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Yuan Li, Haiying Yi, Yixin Yao, Xiaodong Liao, Yiqun Xie, Jie Yang, Zheng Yan, Long Wang, Shunyuan Lu, Ying Kuang, Mingmin Gu, Jian Fei,, Lei Huang.
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The Cytoplasmic Domain of MUC1 Induces Hyperplasia in the Mammary Gland and Correlates with Nuclear Accumulation of β-catenin.
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PLOS ONE
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2011
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6(4):e19102
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Xue-song Liu, Xu-dong Zhao, Xiao-xing Wang, Yi-xin Yao, Liang-liang Zhang, Run-zhe Shu, Wei-hua Ren, Ying Huang, Lei Huang, Ming-min Gu, Ying Kuang, Long Wang, Shun-yuan Lu, Jun Chi, Jing-sheng Fen, Yi-fei Wang, Jian Fei, Wei Dai,
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Germinal cell aplasia in Kif18a mutant male mice due to impaired chromosome congression and dysregulated BubR1 and CENP-E.
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Gene & Cancer
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2010
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1(1): 26-39
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Run-Zhe Shu, Feng Zhang, Fang Wang , De-Chun Feng, Xi-Hua Li, Wei-Hua Ren, Xiao-Lin Wu, Xue Yang, Xiao-Dong Liao, Lei Huang,
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Adiponectin deficiency impairs liver regeneration through attenuating STAT3 phosphorylation in mice.
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Laboratory Investigation
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2009
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89(9):1043-52
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Feng Zhang, Run-zhe Shu, Xiao-lin Wu, Xiao-ping Zhao, De-chun Feng, Long Wang, Shun-yuan Lu, Qiao-ling Liu, You-gui Xiang, Jian Fei, Lei Huang,
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Delayed liver injury and impaired hepatocyte proliferation after carbon tetrachloride exposure in BPOZ2-deficient mice.
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Toxicology Letters
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2009
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188(3):201-207
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Xiao-lin Wu, Ming-min Gu, Lei Huang, Xue-song Liu, Hong-xin Zhang, Xiao-yi Ding, Jian-qiang Xu, Bin Cui, Long Wang, Shun-yuan Lu, Xiao-yi Chen, Hai-guo Zhang, Wei Huang, Wen-tao Yuan, Jiang-ming Yang, Qun Gu, Jian Fei, Zhu Chen, Zhi-min Yuan,
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Multiple synostoses syndrome is due to a missense mutation in exon 2 of FGF9 gene.
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AJHG
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2009
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85(1):53-63
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Ling Kong, Lei Sun, Hong-xin Zhang, Qin Liu, Ye Liu, Lin-hua Qin, Guo-jun Shi, Jun-Hao Hu, A-jing Xu, Yue-Ping Sun, Dang-sheng Li, Yu-Fang Shi, Jing-Wu Zang, Jiang Zhu, Zhu Chen,, Bao-Xue Ge.
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An Essential Role for RIG-I in Toll-like Receptor-Stimulated Phagocytosis.
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CELL HOST & MICROBE
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2009
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6(2):150-161
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Jin Hou,Pin Wang,Li Lin, Xing-guang Liu, Feng Ma, Hua-zhang An,, and Xue-tao Cao.
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MicroRNA-146a Feedback Inhibits RIG-I-Dependent Type I IFN Production in Macrophages by Targeting TRAF6, IRAK1, and IRAK2.
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Journal of Immunology
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2009
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183(3):2150-2158
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Run-Zhe Shu, Feng Zhang, Xue-Song Liu, Chun-Liang Li, Long Wang, Yi-Lin Tai, Xiao-Lin Wu, Xue Yang, Xiao-Dong Liao, Ying Jin, Ming-Min Gu, Lei Huang, Xiao-Fen Pang,
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Target deletion of the cytoskeleton-associated protein palladin does not impair neurite outgrowth in mice.
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PLoS ONE
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2009
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4(9):e6916
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Nan-Nan Zhang, Shu-Hong Shen, Lin-Jia Jiang, Wu Zhang, Hong-Xin Zhang, Yue-Ping Sun, Xian-Yang Li, Qiu-Hua Huang, Bao-Xue Ge, Sai-Juan Chen,, Zhu Chen, and Jiang Zhu.
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RIG-I plays a critical role in negatively regulating
granulocytic proliferation.
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PNAS
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2008
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105(30):10553-10558
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Gan Y, Zhao X, Hu J,, Zhao XT.
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HCCS1 overexpression induces apoptosis via cathepsin D and intracellular calcium, and HCCS1 disruption in mice causes placental abnormality.
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CELL DEATH AND DIFFERENTIATION
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2008
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15(9):1481-1490
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