- 基本信息
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导师姓名：
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陈源文
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学科代码：
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100201
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性别：
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男
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学科名称：
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内科学
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培养单位：
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附属新华医院
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三级学科
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消化系病
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导师类型：
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博士生导师
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专业领域名称：
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内科学 专业学位
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联系方式：
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上海市杨浦区控江路1665号新华医院消化内科
shsmus@263.net
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专业领域代码：
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105101
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邮编：
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200092
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邮箱地址：
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shsmus@263.net
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- 研究方向 (点击浏览详细信息)
- 社会任职
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中华医学会肝病学分会青年委员会委员
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《实用肝脏病杂志》编委
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上海市医学会肝病专科分会委员兼秘书
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《胃肠病学和肝病学杂志》编委
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- 科研项目
| 81970511 | 甘丙肽调控脂肪组织CD11c+巨噬细胞促炎功能改善小鼠肝内细胞免疫失衡和NASH的作用及机制研究 | 国家自然科学基金面上项目 |
2020-01~2023-12
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53万元
| 课题负责人 |
| 81770575 | 脯氨酰内肽酶介导肝细胞脂肪变及中性粒细胞诱导的肝内炎症微环境在小鼠NASH发病中的作用 | 国家自然科学基金面上项目 |
2018-01~2021-12
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56万元
| 课题负责人 |
| 211233146-10 | 甘丙肽及其受体调控肝星状细胞生物学行为研究 | 新疆维吾尔自治区自然科学基金 |
2012-01~2014-12
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10万元
| 课题负责人 |
| XYQ2011010 | 脯氨酰寡肽酶调控肝损伤修复功能研究 | 上海市卫生局，新优秀青年医学人才计划 |
2012-01~2014-12
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60万元
| 课题负责人 |
| 81170410 | 脯氨酰寡肽酶对慢性肝损伤时局部微环境的调节和双重与协同调控损伤修复的作用研究 | 国家自然科学基金面上项目 |
2012-01~2015-12
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60万元
| 课题负责人 |
| 10PJ1407600 | 肝内源性AcSDKP的调控及其肝内生理功能研究 | 上海市科委，浦江人才计划 |
2010-07~2013-09
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20万元
| 课题负责人 |
- 学术论文
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Jiang DX, Zhang JB, Li MT, Lin SZ, Wang YQ,,Fan JG
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Prolyl endopeptidase gene disruption attenuates high fat diet-induced nonalcoholic fatty liver disease in mice by improving hepatic steatosis and inflammation
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. Annals of translational medicine
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2020
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8(5):218
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Zhang J, Lin S, Jiang D, Li M,, Li J, Fan J
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Chronic hepatitis B and non-alcoholic fatty liver disease: Conspirators or competitors?
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Liver Int
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2020
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40(3):496-508
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Zhou D,, Zhao ZH, Yang RX, Xin FZ, Liu XL, Pan Q, Zhou H, Fan JG
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Sodium butyrate reduces high-fat diet-induced non-alcoholic steatohepatitis through upregulation of hepatic GLP-1R expression
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Exp Mol Med
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2018
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50(12): 157
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Li BH, He FP, Yang X,, Fan JG
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Steatosis induced CCL5 contributes to early-stage liver fibrosis in nonalcoholic fatty liver disease progress
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Transl Res
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2017
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180:103-117
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Huang YH, Ye TT, Liu CX, Wang L,, Dong Y
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Maternal high-fat diet impairs glucose metabolism, β-cell function and proliferation in the second generation of offspring rats
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Nutr Metab (Lond)
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2017
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2;14:67
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Zhou D, Pan Q, Shen F, Cao HX, Ding WJ,, Fan JG
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Total fecal microbiota transplantation alleviates high-fat diet-induced steatohepatitis in mice via beneficial regulation of gut microbiota
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Sci Rep
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2017
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7(1):1529
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Zhou D, Wang J, Li BH, He LN, Ding YN,, Fan JG
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Prolyl oligopeptidase attenuates hepatic stellate cell activation through induction of Smad7 and PPAR?γ
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Exp Ther Med
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2017
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13(2):780-786
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Zhou D, Pan Q, Xin FZ, Zhang RN, He CX, Chen GY, Liu C,, Fan JG
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Sodium butyrate attenuates high-fat diet-induced steatohepatitis in mice by improving gut microbiota and gastrointestinal barrier
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World J Gastroenterol
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2017
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23(1):60-75
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Zhou D, Pan Q, Liu XL, Yang RX,, Liu C, Fan JG
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Clostridium butyricum B1 alleviates high-fat diet-induced steatohepatitis in mice via enterohepatic immunoregulation
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J Gastroenterol Hepatol
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2017
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32(9):1640-1648
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He LN, Li ZH, Zhou D, Ding YN, Xu LM,, Fan JG
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Galanin receptor 2 mediates antifibrogenic effects of galanin on hepatic stellate cells
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Exp Ther Med
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2016
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12(5):3375-3380
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Zhou D, Li BH, Wang J, Ding YN, Dong Y,, Fan JG
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Prolyl Oligopeptidase Inhibition Attenuates Steatosis in the L02 Human Liver Cell Line
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PLoS One
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2016
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11(10):e0165224
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Ulasova E, Gladden JD,, Zheng J, Pat B, Bradley W, Powell P, Zmijewski JW, Zelickson BR, Ballinger SW, Darley-Usmar V, Dell'italia LJ
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Loss of interstitial collagen causes structural and functional alterations of cardiomyocyte subsarcolemmal mitochondria in acute volume overload
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J Mol Cell Cardiol
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2011
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50(1):147-156
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, Pat B, Gladden JD, Zheng J, Powell P, Wei CC, Cui X, Husain A, Dell'italia LJ
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Dynamic molecular and histopathological changes in the extracellular matrix and inflammation in the transition to heart failure in isolated volume overload
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Am J Physiol Heart Circ Physiol
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2011
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300(6):H2251-60
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Pat B,, Killingsworth C, Gladden JD, Shi K, Zheng J, Powell PC, Walcott G, Ahmed MI, Gupta H, Desai R, Wei CC, Hase N, Kobayashi T, Sabri A, Granzier H, Denney T, Tillson M, Dillon AR, Husain A, Dell'italia LJ
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Chymase inhibition prevents fibronectin and myofibrillar loss and improves cardiomyocyte function and LV torsion angle in dogs with isolated mitral regurgitation
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Circulation
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2010
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122(15):1488-1495
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, Pat B, Zheng J, Cain L, Powell P, Shi K, Sabri A, Husain A, Dell'italia LJ
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Tumor necrosis factor-alpha produced in cardiomyocytes mediates a predominant myocardial inflammatory response to stretch in early volume overload
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J Mol Cell Cardiol
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2010
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49(1):70-78
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Pat B, Killingsworth C,, Gladden JD, Walcott G, Powell PC, Denney T, Gupta H, Desai R, Tillson M, Dillon AR, Dell'italia LJ
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Mast cell stabilization decreases cardiomyocyte and LV function in dogs with isolated mitral regurgitation
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J Card Fail
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2010
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16(9):769-776
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, Liu BW, Zhang YJ, Chen YW, Dong GF, Ding XD, Xu LM, Fan JG, Li DG
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Preservation of basal AcSDKP attenuates carbon tetrachloride-induced fibrosis in the rat liver
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J Hepatol
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2010
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53(3):528-536
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Zheng J,, Pat B, Dell'italia LA, Tillson M, Dillon AR, Powell PC, Shi K, Shah N, Denney T, Husain A, Dell'Italia LJ
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Microarray identifies extensive downregulation of noncollagen extracellular matrix and profibrotic growth factor genes in chronic isolated mitral regurgitation in the dog
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Circulation
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2009
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119(15):2086-2095
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