- 基本信息
导师姓名:
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赵维莅
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学科代码:
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100201
|
|
性别:
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女
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学科名称:
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内科学
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培养单位:
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附属瑞金医院
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三级学科
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血液病
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导师类型:
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博士生导师
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专业领域名称:
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内科学 专业学位
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联系方式:
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专业领域代码:
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105101
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邮编:
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200020
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邮箱地址:
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Zhao.weili@yahoo.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
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Biomarker Res编委
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中国病理生理学会理事
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美国血液学会外籍委员
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中国病理生理学会理事
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临床血液学杂志编委
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Pathobiology编委
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中国病理生理学会中国实验血液学分会常委
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白血病淋巴瘤杂志编委
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中华医学会血液学分会副主任委员
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中华医学会血液学分会淋巴细胞疾病学组副组长
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药学进展 副主编
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中华血液学杂志编委
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中国临床肿瘤协会抗淋巴瘤联盟副主席
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中国病理生理学会中国实验血液学分会秘书长
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上海市医学会血液学专科分会候任主任委员
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- 科研项目
2022YFC2502600 | T细胞淋巴瘤/白血病进展演变机制及个体化精准诊疗体系 | 国家科技部重点研发计划 |
2022-11~2025-12
|
1490万元
| 课题负责人 |
82130004 | 谷氨酰胺代谢异常导致NK/T细胞淋巴瘤免疫微环境失衡的分子机制和靶向干预 | 国家自然科学基金重点项目
|
2022-01~2026-12
|
290万元
| 课题负责人 |
SHDC2020CR1032B | R-DA-EDOCH对比R-CEOP90方案联合ASCT治疗年轻高危弥漫大B细胞淋巴瘤安全性及有效性的多中心、观察性临床研究 | 上海申康重大临床研究项目 |
2020-10~2022-09
|
715万元
| 课题负责人 |
81830007 | 组蛋白修饰异常导致B淋巴细胞恶变的分子机制和靶向干预 | 国家自然科学基金/重点项目 |
2019-01~2023-12
|
294万元
| 课题负责人 |
YFC0902801 | 白血病分子分型精细图谱构建及新型分子标志发现 ,国家重点研发计划项目 | 国家重点研发计划 |
2016-07~2018-10
|
100万元
| 课题负责人 |
81520108003 | 微小RNA/Ras信号通路在肿瘤血管介导淋巴瘤细胞免疫 | 国家自然科学基金 |
2016-01~2020-12
|
235万元
| 课题负责人 |
81325003 | 淋巴细胞疾病 | 国家杰出青年科学基金 |
2014-01~2016-12
|
200万元
| 课题负责人 |
13XD1402700 | AMPK/mTOR通路调控恶性淋巴细胞自噬的机制研究和靶向干预 | 上海市科委优秀学术带头人 |
2013-05~2015-12
|
40万元
| 课题负责人 |
11JC1407300 | 运用代谢组学方法研究淋巴瘤疾病进展的分子标志 | 上海市科委重点项目 |
2012-01~2014-12
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30万元
| 课题负责人 |
81172254 | T细胞淋巴瘤NF-kappaB信号通路组蛋白乙酰化修饰的研究 | 国家自然科学基金面上项目 |
2012-01~2015-12
|
60万元
| 课题负责人 |
09SG21 | 毛萼乙素抗淋巴瘤作用及其机制研究 | 上海市教委曙光计划 |
2010-01~2012-12
|
15万元
| 课题负责人 |
09QH1401700 | 血管内皮细胞促T细胞淋巴瘤生长的调控机制及干预治疗的研究 | 上海市科委青年科技启明星跟踪资助项目 |
2009-07~2011-06
|
20万元
| 课题负责人 |
08410708800 | 凋亡相关基因在恶性淋巴瘤中的表达调控机制及其生物学作用 | 上海市科委国际合作项目 |
2008-09~2010-09
|
30万元
| 课题负责人 |
30700335 | PRDM1基因beta异构型在弥漫大B细胞性淋巴瘤中的表达及其生物学作用 | 国家自然基金委青年科学基金项目 |
2008-01~2010-12
|
17万元
| 课题负责人 |
NCET-07-0556 | 弥漫大B细胞淋巴瘤分子分型 | 国家教育部“新世纪优秀人才支持计划” |
2007-10~2010-12
|
50万元
| 课题负责人 |
2006aa02a301 | 癌症的基因组重排研究 | 国家科技部“863”计划重大项目 |
2007-01~2009-12
|
756万元
| 课题负责人 |
05QMX1429 | T细胞淋巴瘤血管内皮生长因子A表达和抗血管治疗的研究 | 上海市科委启明星 |
2005-09~2008-09
|
10万元
| 课题负责人 |
- 学术论文
Shen R, Fu D, Dong L, Zhang MC, Shi Q, Shi ZY, Cheng S, Wang L, Xu PP, Zhao WL
|
Simplified algorithm for genetic subtyping in diffuse large B-cell lymphoma
|
Signal Transduct Target Ther
|
2024
|
8(1):145.
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Zhong H, Cheng S, Zhang X, Xu B, Chen J, Jiang X, Xiong J, Hu Y, Cui G, Wei J, Qian W, Huang X, Hou M, Yan F, Wang X, Song Y, Hu J, Liu Y, Ma X, Li F, Wu C, Chen J, Yu L, Bai O, Xu J, Zhu Z, Liu L, Zhou X, Huang L, Tong Y, Niu T, Wu D, Zhang H, Wang C, Ouyang B, Yi H, Song Q, Cai G, Li B, Liu J, Li Z, Xiao R, Wang L, Jiang Y, Liu Y, Zheng X, Xu P, Huang H, Wang L, Chen S,
|
Etoposide, dexamethasone, and pegaspargase with sandwiched radiotherapy in early-stage natural killer/T-cell lymphoma: A randomized phase III study
|
Innovation (Camb).
|
2023
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4(3):100426
|
Qin W, Wang N, Shi Q, Sun R, Zheng Z, Fu D, Dong L, Li C, Zhang Y, Xu P, Cheng S, Qian Y, Feng Y, Wang L,
|
Genomic and transcriptomic characterization reveals B-cell hyperactivation and immune evasion in hepatitis B virus-associated diffuse large B-cell lymphoma
|
Clin Transl Med
|
2023
|
13(6):e1293.
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Shi Q, He Y, Yi HM, Mu RJ, Jiang XF, Fu D, Dong L, Qin W, Xu PP, Cheng S, Song Q, Chen SJ, Wang L,
|
Positron emission tomography-adapted therapy in low-risk diffuse large B-cell lymphoma: results of a randomized, phase III, non-inferiority trial.
|
Cancer Commun (Lond).
|
2023
|
43(8):896-908.
|
XU PP,Huo YJ,
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All roads lead to targeted diffuse large B-cell lymphoma approaches
|
Cancer Cell
|
2022
|
40(2):131-133
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Lu H, Xu X, Fu D, Gu Y, Fan R, Yi H, He X, Wang C, Ouyang B, Zhao P, Wang L, Xu P, Cheng S, Wang Z, Zou D, Han L,
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Butyrate-Producing Eubacterium rectale Suppress Lymphomagenesis by alleviating the TNF-induced TLR4/MYD88/NF-κB Axis
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Cell Host & Microbe
|
2022
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30(8):1139-1150
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Wang N, Qin W, Zheng Z, Zhao M, Xiong J, Fang H, Sun R, Wang Y, Li C, Dong L, Sun X, Wang L, Xu P, Cheng S, Xu H, Zhang F,
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Hepatitis B virus-associated follicular lymphoma presents T-cell inflamed phenotype and response to lenalidomide.
|
Cancer Commun (Lond)
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2022
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42(2):170-174
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Huo YJ, Xu PP, Fu D, Yi HM, Huang YH, Wang L, Wang N, Ji MM, Liu QX, Shi Q, Wang S, Cheng S, Feng Y, Zhao WL.
|
Molecular heterogeneity of CD30+ diffuse large B-cell lymphoma with prognostic significance and therapeutic implication
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Blood Cancer J
|
2022
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12(3):48
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Sun R, Zhang PP, Weng XQ, Gao XD, Huang CX, Li W, Hu XX, Xu PP, Cheng L, Jiang L, Fu D, Qu B, Zhao Y, Feng Y, Dou HJ, Zheng Z,
|
Therapeutic targeting miR130b counteracts diffuse large B-cell lymphoma progression via OX40/OX40L-mediated interaction with Th17 cells.
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Signal Transduct Target Ther
|
2022
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7(1):80
|
Huo YJ, Xu PP, Fu D, Yi HM, Huang YH, Wang L, Wang N, Ji MM, Liu QX, Shi Q, Wang S, Cheng S, Feng Y, Zhao WL.
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Molecular heterogeneity of CD30+ diffuse large B-cell lymphoma with prognostic significance and therapeutic implication
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Blood Cancer J
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2022
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12(3):48
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Xu PP, Shi ZY, Qian Y, Cheng S, Zhu Y, Jiang L, Li JF, Fang H, Huang HY, Yi HM, Ouyang BS, Wang L, Zhao WL.
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Ibrutinib, rituximab, and lenalidomide in unfit or frail patients aged 75 years or older with de novo diffuse large B-cell lymphoma: a phase 2, single-arm study.
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Lancet Healthy Longev.
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2022
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3(7):e481-e490
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Fang Y, Zhang MC, Xu PP, Zhang SJ, Wang L, Cheng S, Fu D, Chang CK, Sun XJ, Zhao Y, Tang YJ, Tian X, Yi HM, Liu F,
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Integrative genome-wide chromatin accessibility and transcriptome profiling of diffuse large B-cell lymphoma.
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Clin Transl Med
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2022
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12(7):e975
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Huo YJ, Xu PP, Wang L, Zhong HJ, Fu D, Shi Q, Cheng S, Wang S, Zhang MC,
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Dynamic change of soluble interleukin-2 receptor distinguished molecular heterogeneity and microenvironment alterations in diffuse large B-cell lymphoma.
|
Biomark Res
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2022
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10(1):51
|
Huang YH, Cai K, Xu PP, Wang L, Huang CX, Fang Y, Cheng S, Sun XJ, Liu F, Huang JY, Ji MM,
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CREBBP/EP300 mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-associated macrophage polarization via FBXW7-NOTCH-CCL2/CSF1 axis
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Signal Transduct Target Ther
|
2021
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6(1):10
|
Wang S, Wang L, Hu J, Qian W, Zhang X, Hu Y, Zhu Q, Chen B, Wu D, Chang CH, Xu P, Zheng X, Wei J, Liu Y, Cui G, Tang Y, Ma Y, Huang H, Yi H,
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Outcomes in refractory diffuse large B-cell lymphoma: results from a multicenter real-world study in China
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Cancer Commun
|
2021
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41(3):229-239
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Xiong J, Cui BW, Wang N, Dai YT, Zhang H, Wang CF, Zhong HJ, Cheng S, Ou-Yang BS, Hu Y, Zhang X, Xu B, Qian WB, Tao R, Yan F, Hu JD, Hou M, Ma XJ, Wang X, Liu YH, Zhu ZM, Huang XB, Liu L, Wu CY, Huang L, Shen YF, Huang RB, Xu JY, Wang C, Wu DP, Yu L, Li JF, Xu PP, Wang L, Huang JY, Chen SJ,
|
Genomic and transcriptomic characterization of natural-killer T-cell lymphoma
|
Cancer Cell
|
2020
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37(3):403-419
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Cai MC, Cheng S, Wang X, Hu JD, Song YP, Huang YH, Yan ZX , Jiang YJ, Fang XS, Zheng XY, Dong LH, Ji MM, Wang L ,Xu PP,
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CEOP/IVE/GDP alternating regimen compared with CEOP as the first-line therapy for newly diagnosed patients with peripheral T cell lymphoma: results from a phase 2, multicenter, randomized, controlled clinical trial
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Genome Medicine
|
2020
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12 (1) : 41
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Shen R, Xu PP, Wang N, Yi HM, Dong L, Fu D, Huang JY, Janin A,Cheng S,Wang L,
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Influence of oncogenic mutations and tumor microenvironment alterations on extranodal invasion in diffuse large B-cell lymphoma
|
Clin Transl Med
|
2020
|
10(7):221
|
Wang L, Qin W, Huo YJ, Li X, Shi Q,Rasko John E J ,Janin A,
|
Advances in targeted therapy for malignant lymphoma
|
Signal Transduct Target Ther
|
2020
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5(1):15
|
Cao YW, Liu Z, Wu W, Qian Y, Shi Q, Shen R, Ouyang B, Xu P, Cheng S, Ye J, Lu Y, Wang C, Yang C, Wang L,
|
Presence of multiple abnormal immunologic markers is an independent prognostic factor of diffuse large B-cell lymphoma
|
Front Med
|
2019
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13(1):94-103
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Xu PP, Fu D, Li JY, Hu JD, Wang X, Zhou JF, Yu H, Zhao X, Huang YH, Jiang L, Liu F, Su LP, Chen ZW, Zeng QS, Chen JP, Fang MY, Ma J, Liu T, Song YP, Yu K, Li Y, Qiu LG, Chen XQ, Gu J, Yan JS, Hou M, Huang HY, Wang L, Cheng S, Shen Y, Xiong H, Chen SJ,
|
Anthracycline dose optimisation in patients with diffuse large B-cell lymphoma: a multicentre, phase 3, randomised, controlled trial
|
Lancet Haematol
|
2019
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6(6):328-337
|
Yan ZX, Li L, Wang W, OuYang BS, Cheng S, Wang L, Wu W, Xu PP, Muftuoglu M, Hao M, Yang S, Zhang MC, Zheng Z, Li J,
|
Clinical Efficacy and Tumor Microenvironment Influence in a Dose-Escalation Study of Anti-CD19 Chimeric Antigen Receptor T Cells in Refractory B-Cell Non-Hodgkin's Lymphoma
|
Clin Cancer Res
|
2019
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25(23):6995-7003
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Zheng Z, Sun R, Zhao HJ, Fu D, Zhong HJ, Weng XQ, Qu B, Zhao Y, Wang L,
|
MiR155 sensitized B-lymphoma cells to anti-PD-L1 antibody via PD-1/PD-L1-mediated lymphoma cell interaction with CD8+T cells
|
Mol Cancer
|
2019
|
18(1):54
|
Xiong J,
|
Targetable Metabolic Vulnerability in Diffuse Large B-Cell Lymphoma
|
EBioMedicine
|
2018
|
28;5–6
|
Ji MM, Huang YH, Huang JY, Wang ZF, Fu D, Liu H, Liu F, Leboeuf C, Wang L, Ye J, Lu YM, Janin A, Cheng S,
|
Histone modifier gene mutations in peripheral T-cell lymphoma not otherwise specified
|
Haematologica
|
2018
|
103(4):679-687
|
Fang Y,Wang H,Dou HJ,Fan X,Fei XC, Cheng S,Janin A,Wang L,
|
Doxorubicin-loaded dextran-based nano-carriers for highly efficient inhibition of lymphoma cell growth and synchronous reduction of cardiac toxicity
|
Int J Nanomedicine
|
2018
|
13;5673–5683
|
Xu PP,Sun C, Cao X, Zhao X, Dai HJ, Lu S, Guo JJ, Fu SJ, Liu YX , Li SC, Chen M, McCord R, Venstromd J, Glusman ES, Punnoose E, Kiermaier A, Cheng G,
|
Immune Characteristics of Chinese Diffuse Large B-Cell Lymphoma Patients: Implications for Cancer Immunotherapies
|
EBioMedicine
|
2018
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33;94-104
|
Zheng Z, Xu PP, Wang L, Zhao HJ, Weng XQ, Zhong HJ, Qu B, Xiong J, Zhao Y, Wang XF, Janin A,
|
MiR21 sensitized B-lymphoma cells to ABT-199 via ICOS/ICOSL-mediated interaction of Treg cells with endothelial cells
|
Journal of Experimental & Clinical Cancer Research
|
2017
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36:82
|
Xiong J, Wang L, Fei XC, Jiang XF, Zheng Z, Zhao Y, Wang CF, Li B, Chen SJ, Janin A, Gale RP,
|
MYC is a positive regulator of choline metabolism and impedes mitophagy-dependent necroptosis in diffuse large B-cell lymphoma
|
Blood Cancer Journal
|
2017
|
7; e582
|
Xu PP, Zhong HJ, Huang YH, Gao XD, Zhao X, Shen Y, Cheng S, Huang JY, Chen SJ, Wang L,
|
B-cell Function Gene Mutations in Diffuse Large B-cell Lymphoma:A Restropective Cohort Study
|
EBioMedicine
|
2017
|
16;106–114
|
Ji MM, Wang L, Zhan Q, Xue W, Zhao Y, Zhao X, Xu PP, Shen Y, Liu H, Janin A, Cheng S,
|
Induction of autophagy by valproic acid enhanced lymphoma cell chemo-sensitivity through an HDAC-independent IP3-mediated PRKAA/AMPK activation
|
Autophagy
|
2015
|
11:10,1-12
|
Xiong J, Bian J, Wang L, Zhou JY, Wang Y, Zhao Y, Wu LL, Hu JJ, Li B, Chen SJ, Yan C,
|
Dysregulated choline metabolism in T-cell lymphoma: role of choline kinase-α and therapeutic targeting
|
Blood Cancer J.
|
2015
|
13;5:287. doi: 10.1038/
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Jiang L, Gu ZH, Yan ZX, Zhao X, Xie YY, Zhang ZG, Pan CM, Hu Y, Cai CP, Dong Y, Huang JY, Wang L, Shen Y, Meng GY, Zhou JF, Hu JD, Wang JF, Liu YH, Yang LH, Zhang F, Wang JM, Wang Z, Peng ZG, Chen FY, Sun ZM, Ding H, Shi JM, Hou J, Yan JS, Shi JY, Xu L, Li Y, Lu J, Zheng Z, Xue W,, Chen Z, Chen SJ
|
Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma
|
Nature Genetics
|
2015
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47(9):1061-6
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Zhang L, Chen QS, Xu PP, Qian Y, Wang AH, Xiao D, Zhao Y, Sheng Y, Wen XQ,
|
Catechins induced acute promyelocytic leukemia cell apoptosis and triggered PML-RARα oncoprotein degradation
|
J Hematol Oncol.
|
2014
|
7(1):75
|
Xu PP, Yu D, Wang L, Shen Y, Shen ZX,
|
Analysis of prognostic factors and comparison of prognostic scores in peripheral T cell lymphoma, not otherwise specified: a single-institution study of 105 Chinese patients
|
Ann Hematol.
|
2014
|
94(2):239-47
|
Yan ZX, Wu LL, Xue K, Zhang QL, Guo Y, Romero M, Leboeuf C, Janin A, Chen SJ, Wang L,
|
MicroRNA187 overexpression is related to tumor progression and determines sensitivity to bortezomib in peripheral T-cell lymphoma
|
LEUKEMIA
|
2014
|
28(4):880-887
|
Zheng Z, Cheng S, Wu W, Wang L, Zhao Y, Shen Y,
|
c-FLIP is involved in tumor progression of peripheral T-cell lymphoma and targeted by histone deacetylase inhibitors
|
J Hematol Oncol.
|
2014
|
7(1):88
|
Yang F, Xiong J, Jia XE, Gu ZH, Shi JY, Zhao Y, Li JM, Chen SJ,
|
GSTT1 deletion is related to polycyclic aromatic hydrocarbons-induced DNA damage and lymphoma progression
|
PLoS One
|
2014
|
9(2):e89302. doi: 10.1371/journal.pone.0089302
|
Dong LH, Cheng S, Zheng Z, Wang L, Shen Y, Shen ZX, Chen SJ,
|
Histone deacetylase inhibitor potentiated the ability of MTOR inhibitor to induce autophagic cell death in Burkitt leukemia/lymphoma
|
J Hematol Oncol.
|
2013
|
6:53. doi: 10.1186/1756-8722-6-53
|
Shi WY, Xiao D, Wang L, Dong LH, Yan ZX, Shen ZX, Chen SJ, Chen Y,
|
Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibitionof mTOR pathway and induction of autophagy
|
Cell Death Dis
|
2012
|
1;3:e275
|
Xu PP, Wang Y, Shen Y, Wang L, Shen ZX,
|
Bevacizumab potentiates chemotherapeutic effect on T-leukemia/lymphoma cells by direct action on tumor endothelial cells. Prognostic factors of Chinese patients with T/NK-cell lymphoma: a single institution study of 170 patients
|
Med Oncol
|
2012
|
29(3):2176-82
|
Wang L, Shi WY, Yang F, Tang W, Gapihan G, Varna M, Shen ZX, Chen SJ, Leboeuf C, Janin A,
|
Bevacizumab potentiates chemotherapeutic effect on T-leukemia/lymphoma cells by direct action on tumor endothelial cells
|
Haematologica.
|
2011
|
96(6):927-31
|
Shi WY, Wang L, Xiao D, Yao Y, Yang F, Jiang XX, Leboeuf C, Janin A, Chen SJ,
|
Proteasome inhibitor bortezomib targeted tumor-endothelial cell interaction in T-cell leukemia/lymphoma
|
Ann Hematol
|
2011
|
90(1): 53-56
|
Tang W, Wang L,, Chen YB, Shen ZX, Hu J
|
Inttravenous busulfan-cyclophosphamide as a preparative regimen before allogeneic hematopoietic stem cell transplantation for adult patients with acute lymphoblastic leukemia
|
Biol Blood Marrow Transplant
|
2011
|
17(10):1555-61
|
Zhang YW, Jiang XX, Chen QS, Shi WY, Wang L, Sun HD, Shen ZX, Chen Z, Chen SJ,
|
Eriocalyxin B induces apoptosis in lymphoma cells through multiple cellular signaling pathways
|
Exp Hematol.
|
2010
|
38(3):191-201
|
|
Targeted therapy in T-cell malignancies: dysregulation of the cellular signaling pathways
|
Leukemia
|
2010
|
24(1):13-21
|
Xia ZG, Xu ZZ,, Zhao SQ, Ding F, Chen Y, Chen QS, Zheng Y, Zhu Q, Hu JP, Shen ZX, Li JM
|
The prognostic value of immunohistochemical subtyping in Chinese patients with de novo diffuse large B-cell lymphoma undergoing CHOP or R-CHOP treatment
|
Ann Hematol.
|
2010
|
89(2):171-7
|
Zhang QL, Wang L, Zhang YW, Jiang XX, Yang F, Wu WL, Janin A, Chen Z, Shen ZX, Chen SJ,
|
The proteasome inhibitor bortezomib interacts synergistically with the histone deacetylase inhibitor suberoylanilide hydroxamic acid to induce T-leukemia/lymphoma cells apoptosis
|
Leukemia
|
2009
|
23(8):1507-1514
|
Shen Y, Yao Y, Li JM, Mi JQ, Chen QS, Chen Y,, You JH, Zhao HJ, Wang Y, Wang L, Cheng S, Shen ZX
|
Reassessment of the prognostic factors of international prognostic index (IPI) in the patients with diffuse large B-cell lymphoma in an era of R-CHOP in Chinese population
|
Ann Hematol.
|
2009
|
88(9):863-869
|
Soltani-Arabshahi R, Leboeuf C, Rivet J, Pisonero H,, Bachelez H,
Ameisen JC, Janin A
|
Bcl-xL gene expression correlated with lower apoptotic cell numbers and shorter progression-free survival in PCFCL
|
J Invest Dermatol.
|
2009
|
129(7):1703-9
|
Fu JF, Shi JY,, Li G, Pan Q, Li JM, Hu J, Shen ZX, Jin J, Chen FY, Chen SJ
|
MassARRAY assay: a more accurate method for JAK2V617F mutation detection in Chinese patients with myeloproliferative disorders
|
Leukemia
|
2008
|
22(3):660-663
|
, Liu YY, Zhang QL, Wang L, Leboeuf C, Zhang YW, Ma J, Garcia JF, Song YP, Li JM, Shen ZX, Chen Z, Janin A, Chen SJ
|
PRDM1 is involved in chemoresistance of T-cell lymphoma and down-regulated by the proteasome inhibitor
|
Blood
|
2008
|
111(7):3867-3871
|
Wang L,, Yan JS, Liu P, Sun HP, Zhou GB, Weng ZY, Wu WL, Weng XQ, Sun XJ, Chen Z, Sun HD, Chen SJ
|
Eriocalyxin B induces apoptosis of t(8;21) leukemia cells through NF-kappaB and MAPK signaling pathways and triggers degradation of AML1-ETO oncoprotein in a caspase-3-dependent manner
|
Cell Death Differ
|
2007
|
14(2): 306-317
|
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