• 基本信息
    导师姓名: 张雁云 专业代码: 100100
    性别: 专业名称: 基础医学
    培养单位: 基础医学院 三级学科/
    专业领域:
    导师类型: 博士生导师 专业学位导师:
    联系方式: 上海市黄浦区重庆南路225号健康科学研究所1号楼306室
    邮箱地址: yyzhang@sibs.ac.cn 邮编: 200025
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    美国血液学学会会员
    美国免疫学学会会员
    《现代免疫学》期刊主编
    中国免疫学学会理事
    美国免疫学学会会员
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    81373164组蛋白乙酰化/去乙酰化表观调控效应型记忆CD8+T细胞及其防治GVHD的研究国家自然科学基金 2014-01~2017-12 70万元  课题负责人
    81130057间充质干细胞治疗肝衰竭的细胞与分子机制研究国家自然科学基金重点项目 2012-01~2016-12 240万元  课题负责人
    11JC1411400诱导抑制性树突状细胞干预多发性硬化的机制及新策略上海市科委基础研究重点项目 2012-01~2014-12 50万元  课题负责人
    11431920900利尿钠肽等心衰治疗药物的研究上海市科委重点科技攻关 2011-11~2014-09 80万元  课题负责人
    81071748肿瘤干细胞自噬性死亡中趋化因子受体CXCR4调控及干预机制研究国家自然基金委,面上项目 2011-01~2013-12 38万元  课题负责人
    2011CB966200组织干细胞在器官衰老与再生中的作用及调控机制研究973项目重大科学研究计划 2011-01~2015-12 2500万元  课题负责人
    09431901000长效重组人胰高血糖素样多肽-1药物的临床前研究上海市科委,重点科技攻关 2009-11~2012-10 50万元  课题负责人
    30873045IDO/TTS平衡格局与肿瘤干细胞免疫逃逸调控机制关系研究国家自然基金委,面上项目 2009-01~2011-12 30万元  课题负责人
    074319102胚胎肝造血干细胞分离纯化新策略和实验性治疗应用的研究上海市科委,重点科技攻关 2007-11~2009-10 70万元  课题负责人
    30670911趋化因子及其受体介导异体效应型记忆CD8+ T细胞致移植物抗宿主病作用及靶向干预研究国家自然基金委,面上项目 2007-01~2009-12 27万元  课题负责人
    08JC1413300类风湿性关节炎遗传相关性、免疫病理机制及新型免疫调节剂实验性治疗策略研究上海市科委,基础重点项目 ~2010-09 25万元   
    09431901000长效重组人胰高血糖素样多肽-1药物的临床前研究上海市科委,生物医药重点重大项目资助 ~ 0万元   
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Dang S, Xu H, Xu C, Cai W, Li Q, Cheng Y, Jin M, Wang RX, Peng Y, Zhang Y, Wu C, He X, Wan B,  Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis  Autophagy  2014  10(7):1301-1315 
    Zhang Y, Cai W, Huang Q, Gu Y, Shi Y, Huang J, Zhao F, Liu Q, Wei X, Jin M, Wu C, Xie Q, Zhang Y, Wan B,  Mesenchymal Stem Cells Alleviate Bacteria-Induced Liver Injury in Mice by Inducing Regulatory Dendritic Cells  Hepatology  2014  59(2):671-682 
    Tan W, Meng Y, Li H, Chen Y, Han S, Zeng J, Huang A, Li B,, Guo Y  A bispecific antibody against two different epitopes on hepatitis B surface antigen has potent hepatitis B virus neutralizing activity  mAbs  2013  6():945-953 
    Wu Q, Wang H, Zhao X, Shi Y, Jin M, Wan B, Xu H, Cheng Y, Ge H,  Identification of G-protein-coupled receptor 120 as a tumor-promoting receptor that induces angiogenesis and migration in human colorectal carcinoma  Oncogene  2013  32():5541-5550 
    Xu J, Zhang Y, Xiao Y, Ma S, Liu Q, Dang S, Jin M, Shi Y, Wan B,  Inhibition of 12/15-lipoxygenase by baicalein induces microglia PPARβ/δ: a potential therapeutic role for CNS autoimmune disease  Cell Death & Disease  2013  2013(86):- 
    Gu Q, Wu Q, Jin M, Xiao Y, Xu J, Mao C, Zhao F, Zhang Y,  Heme oxygenase-1 alleviates mouse hepatic failure through suppression of adaptive immune responses  J Pharmacol Exp Ther  2012  340(1):2-10 
    Mao C , Wang S , Xiao Y , Xu J , Jiang Q , Jin M , Jiang X , Guo H , Ning G ,  Impairment of Regulatory Capacity of CD4+CD25+ Regulatory T Cells Mediated by Dendritic Cell Polarization and Hyperthyroidism in Graves’ Disease  The Journal of Immunology  2011  186(8): 4734-43 
    Zhao F, Zhang Y, Wang H, Jin M, S, He S, Shi Y, Guo Y,  Elevated IGFIR expression regulating VEGF and VEGF-C predicts lymph node Blockade of osteopontin reduces alloreactive CD8+ T cell-mediated graft-versus-host disease  Blood  2011  1179(5):1723-33 
    Xu H, Wu Q, Dang S, Jin M, Xu J, Cheng Y, Pan M, Wu Y, Zhang C,  Alteration of CXCR7 expression mediated by TLR4 promotes tumor cell proliferation and migration in human colorectal carcinoma  PLoS One  2011  6(12):27398-e27399 
    Cao Q, Jin Y, Jin M, He S, Gu Q, He S, Qiu Y, Ge H, Yoneyama H,  Therapeutic effect of MIP-1alpha-recruited dendritic cells on preestablished solid and metastatic tumors  Cancer Letters  2010  295(1):17-26 
    Xiao Y, Xu J, Wang S, Mao C, Jin M, Ning G, Xu J,  Genetic ablation of steroid receptor coactivator-3 promotes PPAR-beta-mediated alternative activation of microglia in experimental autoimmune encephalomyelitis  Glia  2010  58(8):932-42 
    Zhang C, Hao L, Wang L, Xiao Y, Ge H, Zhu Z, Luo Y, Zhang Y,  Elevated IGFIR expression regulating VEGF and VEGF-C predicts lymph node etastasis in human colorectal cancer  BMC Cancer  2010  10:184-95 
    Xiao Y, Xu J, Mao C, Jin M, Wu Q, Zou J, Gu Q, Zhang Y,  18β-glycyrrhetinic acid ameliorated Propionibacterium acnes-induced acute liver injury through inhibition of MIP-1α  The Journal of Biological Chemistry  2010  285(2):1128-37 
    Xiao Y,  Suppressor of cytokine signaling-1, a possible cause for regulatory T cells in hepatitis  Hepatology  2008  48(4):1353-53 
    He S, Cao Q, Qiu Y, Mi J, Zhang J Z, Matsushima K, Jin M, Ge H, Emerson S, Zhang Y,  A new approach of blocking alloreactive T cell-mediated GVHD by in vivo administration of anti-CXCR3 neutralizing antibody  The Journal of Immunology  2008  181(11):7581-92 
    Xu J, Zhou T,  Role of dendritic cells and chemokines in acute graft-versus-host disease  Frontiers in bioscience  2008  13:2065-74 
    He S, Cao Q, Yoneyama H, Ge H,  MIP-3(alpha) and MIP-1(alpha) rapidly mobilize dendritic cell precursors into the peripheral blood  Journal of Leukocyte Biology  2008  84(6):1549-56 
    Hao L, Zhang C, Qiu Y, Wang L, Luo Y, Jin M, Zhang Y, Guo B, Matsushima K,  Recombination of CXCR4, VEGF, and MMP-9 predicting lymph node metastasis in human breast cancer  Cancer Letters  2007  253(1):34-42 
    Zhu L, Ji F, Wang Y, Zhang Y, Liu Q, Zhang J Z, Matsushima K, Zhang D,  Synovial autoreactive T cells in rheumatoid arthritis resist indoleamine IDO-mediated inhibition  The Journal of Immunology  2006  177(11):8226-33 
    , Yoneyama H, Wang Y, Onai N, Ishikawa S  Mobilization of dendritic cell precursors into the circulation by administration of MIP-1alpha in mice  Journal of the National Cancer Institute  2004  96(3):201-9 
    Yoneyama H, Matsuno K,, Nishiwaki T, Kitabatake M  Evidence for recruitment of plasmacytoid dendritic cell precursors to inflamed lymph nodes through high endothelial venules  International Immunology  2004  16(7):915-28 
    Yoneyama H, Narumi S,, Murai M, Baggiolini M  Pivotal role of dendritic cell-derived CXCL 10 in the retention of T helper cell 1 lymphocytes in the secondary lymph nodes  Journal of Experimental Medicine  2002  195(10):1257-66 
    Onai N, Kitabatake M,, Kitamura T, Ishikawa H  Pivotal role of CCL25 (TECK)/CCR9 in the formation of gut cryptopatches and consequent appearance of intestinal intraepithelial T lymphocytes  International Immunology  2002  14(7):687-694 
    Wang Y,, Onai N, Yoneyama H, Hashimoto S  Pivotal role of dendritic cell-derived CXCL 10 in the retention of T helper cell 1 lymphocytes in the secondary lymph nodes  Blood  2002  96(3):201-9 
    Yoneyama H, Matsuno K,, Murai M, Itakura M  Regulation by chemokines of circulating dendritic cell precursors, and the formation of portal tract-associated lymphoid tissue in a granulomatous liver disease  Journal of Experimental Medicine  2001  193(1):35-49 
    , Wang Y, Ogata M, Hashimoto S  Development of dendritic cells in vitro from murine fetal liver-derived lineage phenotype-negative c-kit+ hematopoietic progenitor cells  Blood  2000  95(1):138-46 
    Onai N,, Yoneyama H, Kitamura T and Matsushima K  Impairment of Lymphopoiesis and myelopoiesis in mice reconstituted with bone marrow-hematopoietic progenitor cells expressing SDF-1-Intrakine  Blood  2000  96(6):2074-80 
    Ogata M, Zhang Y, Wang Y, Itakura M,  Chemotactic response toward chemokines and its regulation by transforming growth factor-β1 of bone marrow hematopoietic progenitor cell-derived different subset of dendritic cells  Blood  1999  93(10):3225-32 
    Zhang Y,, Ogata M, Chen P, Harada A  Transforming growth factor-polarizes murine hematopoietic progenitor cells to generate Langerhans cell-like dendritic cells through monocyte/macrophage differentiation pathway  Blood  1999  93(4):1208-20 
    Zhang Y, Harada A, Wang J-B,, Hashimoto S  Bifurcated dendritic cell differentiation in vitro from murine lineage phenotype-negative c-kit+ bone marrow hematopoietic progenitor cells  Blood  1998  92(1):118-28