- 基本信息
导师姓名:
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李斌
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学科代码:
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100100
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性别:
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男
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学科名称:
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基础医学
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培养单位:
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基础医学院
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三级学科
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导师类型:
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博士生导师
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专业领域名称:
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联系方式:
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binli@shsmu.edu.cn
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专业领域代码:
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邮编:
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20025
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邮箱地址:
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binli@sibs.ac.cn
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- 研究方向 (点击浏览详细信息)
- 社会任职
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中华预防医学会生物安全与防护装备分会青年委员会副主任委员
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中国细胞生物学学会免疫细胞生物学分会副会长
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中华医学会微免分会移植免疫学组常务委员
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中国细胞生物学学会细胞生物学科普工作委员会主任委员
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中国医药生物技术协会精准医疗分会常务委员
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上海市生物化学与分子生物学学会会员
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中华医学生物免疫学会基础免疫学分会副主任委员
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中国免疫学会移植免疫学分会常务委员
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中国医促会结核病防治分会常务委员
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上海市细胞生物学学会副理事长
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- 科研项目
16XD1403800 | 调节性T细胞功能稳定性及其应用 | 上海市科学技术委员会-优秀学术带头人(A类) |
2016-05~2019-04
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40万元
| 课题负责人 |
31525008 | 分子免疫学 | 国家自然科学基金-杰青项目 |
2016-01~2020-12
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400万元
| 课题负责人 |
14JC1406100 | 肿瘤微环境FOXP3蛋白复合体调节的机制研究 | 上海市科学技术委员会基础研究重大重点项目项目 |
2014-09~2017-08
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50万元
| 课题负责人 |
31370863 | FOXP3蛋白泛素化与去泛素化修饰调控Treg细胞功能的机理研究 | 国家自然科学基金-面上项目 |
2014-01~2017-12
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80万元
| 课题负责人 |
2014CB541803 | 遗传变异调控AS自身免疫紊乱的分子机制研究 | 国家重点基础研究计划(973计划) |
2014-01~2018-12
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260万元
| 课题负责人 |
81330072 | 炎症因子对FOXP3+调节性T细胞分化与功能的动态影响及其机理研究 | 国家自然科学基金-重点项目 |
2014-01~2018-12
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290万元
| 课题负责人 |
31170825 | 转录因子IRF4蛋白甲基化修饰及其转录调节功能的分子机理研究 | 国家自然科学基金-面上项目 |
2012-01~2015-12
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65万元
| 课题负责人 |
- 学术论文
Fang S, Huang Y, Liu X, Zhong S, Wang N, Zhao B, Li Y, Sun J, Wang Y, Zhang S, Gu P, Zjpi H,, Fan X.
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.Interaction Between CCR6+ Th17 Cells and CD34+ Fibrocytes Promotes Inflammation: Implications in Graves' Orbitopathy in Chinese Population
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Invest Ophthalmol Vis Sci
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2018
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59 (6):2604-14
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Ni Y, Hao J, Hou X, Du W, Yu Y, Chen T, Wei Z, Li Y, Zhu F, Wang S, Liang R, Li D, Lu Y, Liao K,, Shi G
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Dephosphorylated Polymerase I and Transcript Release Factor Prevents Allergic Asthma Exacerbations by Limiting IL-33 Release.
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Front. Immunol,
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2018
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9:1422
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Yi G, Guo S, Liu W, Wang H, Liu R, Tsun A, Jin G,
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Identification and functional analysis of heterogeneous FOXP3+ Treg cell subpopulations in human pancreatic ductal adenocarcinoma
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Science Bulletin
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2018
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63(15):972-81
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Wang S, Li Y, Zhu F, Lin F, Luo X, Zhao B, Zhang P, Li D, Gao Y, Liang R, Liu L, Tsun A, Yuan X, Wu K,
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DNMT1 cooperates with MBD4 to inhibit the expression of Glucocorticoid-induced TNFR-related protein in human T cells
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FEBS Lett
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2017
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2017,Jul;591(13):1929-1939. doi: 10.1002/1873-3468.12690
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Lin R, Nie J, Ren J, Liang R, Li D, Wang P, Gao C, Zhuo C, Yang C,
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USP4 interacts and positively regulates IRF8 function via K48-linked deubiquitination in regulatory T cells
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FEBS Lett
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2017
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Jun;591(12):1677-1686. doi: 10.1002/1873-3468.12668
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Li YY, Lu Y, Wang SW, Han ZJ, Zhu FX, Ni YM, Liang R, Zhang Y, Leng Q, Wei G, Shi G, Zhu R, Li D, Wang HQ, Zheng SG, Xu HX, Tsun A & Li B
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USP21 Prevents the Generation of T-helper-1-like Treg Cells
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Nature Communications
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2016
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7:13559. doi: 10.1038/ncomms13559
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Fang S, Huang Y, Wang S, Zhang Y, Luo X, Liu L, Zhong S, Liu X, Li D, Liang R, Miranda P, Gu P, Zhou H, Fan X,
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IL-17A exacerbates fibrosis by promoting the proinflammatory and profibrotic function of orbital fibroblasts in TAO
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J Clin Endocrinol Metab
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2016
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doi: 10.1210/jc.2016-1882
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Li YY and Li B*
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A Translational Perspective of a Deubiquitinase Inhibitor in Antitumor Immunity
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EBioMedicine
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2016
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13:7-8. doi: 10.1016
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Lu Y, Cai S, Nie J, Li Y, Shi G, Hao J, Fu W, Tan H, Chen S,, Xu H
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The natural compound nujiangexanthone A suppresses mast cell activation and allergic asthma
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Biochem Pharmacol.
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2016
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100:61-72. doi:10.1016
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Luo X, Nie J, Wang S, Chen Z, Chen W, Li D, Hu H,
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Poly(ADP-ribosyl)ation of FOXP3 Protein Mediated by PARP-1 Protein Regulates the Function of Regulatory T Cells
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J Biol Chem.
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2015
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290(48):28675-82. doi:10.1074
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Gao Y, Tang J, Chen W, Li Q, Nie J, Lin F, Wu Q, Chen Z, Gao Z, Fan H, Tsun A, Shen J, Chen G, Liu Z, Lou Z, Olsen NJ, Zheng SG,
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Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1
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Proc Natl Acad Sci U S A.
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2015
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112(25):E3246-54
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Li Z, Li D, Tsun A,
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FOXP3+ regulatory T cells and their functional regulation
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Cell Mol Immunol.
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2015
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12(5):558-65. doi: 10.1038
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Zhuo C, Xu Y, Ying M, Li Q, Huang L, Li D, Cai S,
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FOXP3+ Tregs: heterogeneous phenotypes and conflicting impacts on survival outcomes in patients with colorectal cancer
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Immunol Res.
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2015
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61(3):338-47. doi: 10.1007
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Ni Y, Tao L, Chen C, Song H, Li Z, Gao Y, Nie J, Piccioni M, Shi G,
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The Deubiquitinase USP17 Regulates the Stability and Nuclear Function of IL-33
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Int J Mol Sci.
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2015
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16(11):27956-66.
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Zhou X, Tang J, Cao H, Fan H,
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Tissue resident regulatory T cells: novel therapeutic targets for human disease
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Cell Mol Immunol.
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2015
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12(5):543-52. doi: 10.1038
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Nie J, Li YY, Zheng SG, Tsun A,
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FOXP3(+) Treg Cells and Gender Bias in Autoimmune Diseases
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Front Immunol.
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2015
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6:493. doi:10.3389
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Xie M, Xuan B, Shan J, Pan D, Sun Y, Shan Z, Zhang J, Yu D,, Qian Z
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Human cytomegalovirus exploits interferon-induced transmembrane proteins to facilitate morphogenesis of the virion assembly compartment
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J Virol.
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2015
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89(6):3049-61. doi: 10.1128
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Wu Y, Yang L, Zhao J, Li C, Nie J, Liu F, Zhuo C, Zheng Y,, Wang Z, Xu Y.
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Nuclear-enriched abundant transcript 1 as a diagnostic and prognostic biomarker in colorectal cancer.
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Mol Cancer
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2015
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14(1):191. doi: 10.1186
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Yang J, Xu P, Han L, Guo Z, Wang X, Chen Z, Nie J, Yin S, Piccioni M, Tsun A, Lv L, Ge S,
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Ubiquitin-specific protease 4 promotes Th17 cell function under inflammation by deubiquitinating and stabilizing RORγt
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J Immunol. Cutting edge
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2015
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194(9):4094-7. doi:10.4049
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Li D, Kong C, Tsun A, Chen C, Song H, Shi G, Pan W, Dai D, Shen N,
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MiR-125a-5p Decreases the Sensitivity of Treg cells Toward IL-6-Mediated Conversion by Inhibiting IL-6R and STAT3 Expression
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Sci Rep.
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2015
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5:14615. doi: 10.1038
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Wang X, Yang J, Han L, Zhao K, Wu Q, Bao L, Li Z, Lv L,
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TRAF5-mediated Lys-63-linked Polyubiquitination Plays an Essential Role in Positive Regulation of RORγt in Promoting IL-17A Expression
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J Biol Chem.
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2015
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290(48):29086-94. doi: 10.1074
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, Zheng SG
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How regulatory T cells sense and adapt to inflammation
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Cell Mol Immunol.
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2015
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12(5):519-20. doi: 10.1038
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Song H, Tao L, Chen C, Pan L, Hao J, Ni Y, Li D,, Shi G
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USP17-mediated deubiquitination and stabilization of HDAC2 in cigarette smoke extract-induced inflammation
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Int J Clin Exp Pathol.
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2015
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8(9):10707-15
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Lin F, Luo X, Tsun A, Li Z, Li D,
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Kaempferol enhances the suppressive function of Treg cells by inhibiting FOXP3 phosphorylation
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Int Immunopharmacol.
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2015
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(2):859-65. doi:10.1016
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Wu Q, Nie J, Gao Y, Xu P, Sun Q, Yang J, Han L, Chen Z, Wang X, Lv L, Tsun A, Shen J,
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Reciprocal regulation of RORγt acetylation and function by p300 and HDAC1
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Sci Rep.
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2015
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5:16355. doi: 10.1038
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Han L, Yang J, Wang X, Li D, Lv L,
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Th17 cells in autoimmune diseases
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Front Med.
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2015
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9(1):10-9. doi: 10.1007
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Han L, Yang J, Wang X, Wu Q, Yin S, Li Z, Zhang J, Xing Y, Chen Z, Tsun A, Li D, Piccioni M, Zhang Y, Guo Q, Jiang L, Bao L, Lv L,
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The E3 deubiquitinase USP17 is a positive regulator of retinoic acid-related orphan nuclear receptor γt (RORγt) in Th17 cells
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J Biol Chem.
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2014
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289(37):25546-55. doi: 10.1074
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Li Z, Lin F, Zhuo C, Deng G, Chen Z, Yin S, Gao Z, Piccioni M, Tsun A, Cai S, Zheng SG, Zhang Y,
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PIM1 kinase phosphorylates the human transcription factor FOXP3 at serine 422 to negatively regulate its activity under inflammation
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J Biol Chem.
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2014
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289(39):26872-81. doi: 10.1074
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Tao L, Chen C, Song H, Piccioni M, Shi G,
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Deubiquitination and stabilization of IL-33 by USP21
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Int J Clin Exp Pathol.
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2014
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7(8):4930-7
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Gao Y, Lin F, Xu P, Nie J, Chen Z, Su J, Tang J, Wu Q, Li Y, Guo Z, Gao Z, Li D, Shen J, Ge S, Tsun A,
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USP22 is a positive regulator of NFATc2 on promoting IL2 expression
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FEBS Lett.
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2014
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588(6):878-83. doi: 10.1016
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Chen Z, Luo X, Lu Y, Zhu T, Wang J, Tsun A,
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Ubiquitination signals critical to regulatory T cell development and function
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Int Immunopharmacol.
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2013
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16(3):348-52. doi: 10.1016
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Zhang J, Chen C, Hou X, Gao Y, Lin F, Yang J, Gao Z, Pan L, Tao L, Wen C, Yao Z, Tsun A, Shi G,
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Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3
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J Biol Chem.
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2013
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288(13):9373-82. doi: 10.1074
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Shan Z, Han Q, Nie J, Cao X, Chen Z, Yin S, Gao Y, Lin F, Zhou X, Xu K, Fan H, Qian Z, Sun B, Zhong J,, Tsun A
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Negative regulation of interferon-induced transmembrane protein 3 by SET7-mediated lysine monomethylation
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J Biol Chem.
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2013
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288(49):35093-103. doi: 10.1074
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Li Y, Tsun A, Gao Z, Han Z, Gao Y, Li Z, Lin F, Wang Y, Wei G, Yao Z,
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60-kDa Tat-interactive protein (TIP60) positively regulates Th-inducing POK (ThPOK)-mediated repression of eomesodermin in human CD4+ T cells
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J Biol Chem.
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2013
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288(22):15537-46. doi: 10.1074
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Chen Z, Barbi J, Bu S, Yang HY, Li Z, Gao Y, Jinasena D, Fu J, Lin F, Chen C, Zhang J, Yu N, Li X, Shan Z, Nie J, Gao Z, Tian H, Li Y, Yao Z, Zheng Y, Park BV, Pan Z, Zhang J, Dang E, Li Z, Wang H, Luo W, Li L, Semenza GL, Zheng SG, Loser K, Tsun A, Greene MI, Pardoll DM, Pan F,
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The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3
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Immunity.
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2013
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39(2):272-85. doi: 10.1016
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Gao Z, Gao Y, Li Z, Chen Z, Lu D, Tsun A,
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Synergy between IL-6 and TGF-β signaling promotes FOXP3 degradation
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Int J Clin Exp Pathol.
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2012
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5(7):626-33
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