• 基本信息
    导师姓名: 李斌 专业代码: 100100
    性别: 专业名称: 基础医学
    培养单位: 基础医学院 三级学科/
    专业领域:
    导师类型: 博士生导师 专业学位导师:
    联系方式: binli@shsmu.edu.cn
    邮箱地址: binli@sibs.ac.cn 邮编: 20025
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    中华预防医学会生物安全与防护装备分会青年委员会副主任委员
    中国细胞生物学学会免疫细胞生物学分会副会长
    中华医学会微免分会移植免疫学组常务委员
    中国细胞生物学学会细胞生物学科普工作委员会主任委员
    中国医药生物技术协会精准医疗分会常务委员
    上海市生物化学与分子生物学学会会员
    中华医学生物免疫学会基础免疫学分会副主任委员
    中国免疫学会移植免疫学分会常务委员
    中国医促会结核病防治分会常务委员
    上海市细胞生物学学会副理事长
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    16XD1403800调节性T细胞功能稳定性及其应用上海市科学技术委员会-优秀学术带头人(A类) 2016-05~2019-04 40万元  课题负责人
    31525008分子免疫学国家自然科学基金-杰青项目 2016-01~2020-12 400万元  课题负责人
    14JC1406100肿瘤微环境FOXP3蛋白复合体调节的机制研究上海市科学技术委员会基础研究重大重点项目项目 2014-09~2017-08 50万元  课题负责人
    31370863FOXP3蛋白泛素化与去泛素化修饰调控Treg细胞功能的机理研究国家自然科学基金-面上项目 2014-01~2017-12 80万元  课题负责人
    2014CB541803遗传变异调控AS自身免疫紊乱的分子机制研究国家重点基础研究计划(973计划) 2014-01~2018-12 260万元  课题负责人
    81330072炎症因子对FOXP3+调节性T细胞分化与功能的动态影响及其机理研究国家自然科学基金-重点项目 2014-01~2018-12 290万元  课题负责人
    31170825转录因子IRF4蛋白甲基化修饰及其转录调节功能的分子机理研究国家自然科学基金-面上项目 2012-01~2015-12 65万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Fang S, Huang Y, Liu X, Zhong S, Wang N, Zhao B, Li Y, Sun J, Wang Y, Zhang S, Gu P, Zjpi H,, Fan X.  .Interaction Between CCR6+ Th17 Cells and CD34+ Fibrocytes Promotes Inflammation: Implications in Graves' Orbitopathy in Chinese Population  Invest Ophthalmol Vis Sci  2018  59 (6):2604-14 
    Ni Y, Hao J, Hou X, Du W, Yu Y, Chen T, Wei Z, Li Y, Zhu F, Wang S, Liang R, Li D, Lu Y, Liao K,, Shi G  Dephosphorylated Polymerase I and Transcript Release Factor Prevents Allergic Asthma Exacerbations by Limiting IL-33 Release.  Front. Immunol,  2018  9:1422 
    Yi G, Guo S, Liu W, Wang H, Liu R, Tsun A, Jin G,  Identification and functional analysis of heterogeneous FOXP3+ Treg cell subpopulations in human pancreatic ductal adenocarcinoma  Science Bulletin  2018  63(15):972-81 
    Wang S, Li Y, Zhu F, Lin F, Luo X, Zhao B, Zhang P, Li D, Gao Y, Liang R, Liu L, Tsun A, Yuan X, Wu K,  DNMT1 cooperates with MBD4 to inhibit the expression of Glucocorticoid-induced TNFR-related protein in human T cells  FEBS Lett  2017  2017,Jul;591(13):1929-1939. doi: 10.1002/1873-3468.12690 
    Lin R, Nie J, Ren J, Liang R, Li D, Wang P, Gao C, Zhuo C, Yang C,  USP4 interacts and positively regulates IRF8 function via K48-linked deubiquitination in regulatory T cells  FEBS Lett  2017  Jun;591(12):1677-1686. doi: 10.1002/1873-3468.12668 
    Li YY, Lu Y, Wang SW, Han ZJ, Zhu FX, Ni YM, Liang R, Zhang Y, Leng Q, Wei G, Shi G, Zhu R, Li D, Wang HQ, Zheng SG, Xu HX, Tsun A & Li B  USP21 Prevents the Generation of T-helper-1-like Treg Cells  Nature Communications  2016  7:13559. doi: 10.1038/ncomms13559 
    Fang S, Huang Y, Wang S, Zhang Y, Luo X, Liu L, Zhong S, Liu X, Li D, Liang R, Miranda P, Gu P, Zhou H, Fan X,  IL-17A exacerbates fibrosis by promoting the proinflammatory and profibrotic function of orbital fibroblasts in TAO  J Clin Endocrinol Metab  2016  doi: 10.1210/jc.2016-1882 
    Li YY and Li B*  A Translational Perspective of a Deubiquitinase Inhibitor in Antitumor Immunity  EBioMedicine  2016  13:7-8. doi: 10.1016 
    Lu Y, Cai S, Nie J, Li Y, Shi G, Hao J, Fu W, Tan H, Chen S,, Xu H  The natural compound nujiangexanthone A suppresses mast cell activation and allergic asthma  Biochem Pharmacol.  2016  100:61-72. doi:10.1016 
    Luo X, Nie J, Wang S, Chen Z, Chen W, Li D, Hu H,  Poly(ADP-ribosyl)ation of FOXP3 Protein Mediated by PARP-1 Protein Regulates the Function of Regulatory T Cells  J Biol Chem.  2015  290(48):28675-82. doi:10.1074 
    Gao Y, Tang J, Chen W, Li Q, Nie J, Lin F, Wu Q, Chen Z, Gao Z, Fan H, Tsun A, Shen J, Chen G, Liu Z, Lou Z, Olsen NJ, Zheng SG,  Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1  Proc Natl Acad Sci U S A.  2015  112(25):E3246-54 
    Li Z, Li D, Tsun A,  FOXP3+ regulatory T cells and their functional regulation  Cell Mol Immunol.   2015  12(5):558-65. doi: 10.1038 
    Zhuo C, Xu Y, Ying M, Li Q, Huang L, Li D, Cai S,  FOXP3+ Tregs: heterogeneous phenotypes and conflicting impacts on survival outcomes in patients with colorectal cancer  Immunol Res.  2015  61(3):338-47. doi: 10.1007 
    Ni Y, Tao L, Chen C, Song H, Li Z, Gao Y, Nie J, Piccioni M, Shi G,  The Deubiquitinase USP17 Regulates the Stability and Nuclear Function of IL-33  Int J Mol Sci.  2015  16(11):27956-66. 
    Zhou X, Tang J, Cao H, Fan H,  Tissue resident regulatory T cells: novel therapeutic targets for human disease  Cell Mol Immunol.  2015  12(5):543-52. doi: 10.1038 
    Nie J, Li YY, Zheng SG, Tsun A,  FOXP3(+) Treg Cells and Gender Bias in Autoimmune Diseases  Front Immunol.  2015  6:493. doi:10.3389 
    Xie M, Xuan B, Shan J, Pan D, Sun Y, Shan Z, Zhang J, Yu D,, Qian Z  Human cytomegalovirus exploits interferon-induced transmembrane proteins to facilitate morphogenesis of the virion assembly compartment  J Virol.  2015  89(6):3049-61. doi: 10.1128 
    Wu Y, Yang L, Zhao J, Li C, Nie J, Liu F, Zhuo C, Zheng Y,, Wang Z, Xu Y.  Nuclear-enriched abundant transcript 1 as a diagnostic and prognostic biomarker in colorectal cancer.  Mol Cancer  2015  14(1):191. doi: 10.1186 
    Yang J, Xu P, Han L, Guo Z, Wang X, Chen Z, Nie J, Yin S, Piccioni M, Tsun A, Lv L, Ge S,  Ubiquitin-specific protease 4 promotes Th17 cell function under inflammation by deubiquitinating and stabilizing RORγt  J Immunol. Cutting edge  2015  194(9):4094-7. doi:10.4049 
    Li D, Kong C, Tsun A, Chen C, Song H, Shi G, Pan W, Dai D, Shen N,  MiR-125a-5p Decreases the Sensitivity of Treg cells Toward IL-6-Mediated Conversion by Inhibiting IL-6R and STAT3 Expression  Sci Rep.  2015  5:14615. doi: 10.1038 
    Wang X, Yang J, Han L, Zhao K, Wu Q, Bao L, Li Z, Lv L,  TRAF5-mediated Lys-63-linked Polyubiquitination Plays an Essential Role in Positive Regulation of RORγt in Promoting IL-17A Expression  J Biol Chem.  2015  290(48):29086-94. doi: 10.1074 
    , Zheng SG  How regulatory T cells sense and adapt to inflammation  Cell Mol Immunol.  2015  12(5):519-20. doi: 10.1038 
    Song H, Tao L, Chen C, Pan L, Hao J, Ni Y, Li D,, Shi G  USP17-mediated deubiquitination and stabilization of HDAC2 in cigarette smoke extract-induced inflammation  Int J Clin Exp Pathol.  2015  8(9):10707-15 
    Lin F, Luo X, Tsun A, Li Z, Li D,  Kaempferol enhances the suppressive function of Treg cells by inhibiting FOXP3 phosphorylation  Int Immunopharmacol.  2015  (2):859-65. doi:10.1016 
    Wu Q, Nie J, Gao Y, Xu P, Sun Q, Yang J, Han L, Chen Z, Wang X, Lv L, Tsun A, Shen J,  Reciprocal regulation of RORγt acetylation and function by p300 and HDAC1  Sci Rep.  2015  5:16355. doi: 10.1038 
    Han L, Yang J, Wang X, Li D, Lv L,  Th17 cells in autoimmune diseases  Front Med.  2015  9(1):10-9. doi: 10.1007 
    Han L, Yang J, Wang X, Wu Q, Yin S, Li Z, Zhang J, Xing Y, Chen Z, Tsun A, Li D, Piccioni M, Zhang Y, Guo Q, Jiang L, Bao L, Lv L,  The E3 deubiquitinase USP17 is a positive regulator of retinoic acid-related orphan nuclear receptor γt (RORγt) in Th17 cells  J Biol Chem.  2014  289(37):25546-55. doi: 10.1074 
    Li Z, Lin F, Zhuo C, Deng G, Chen Z, Yin S, Gao Z, Piccioni M, Tsun A, Cai S, Zheng SG, Zhang Y,  PIM1 kinase phosphorylates the human transcription factor FOXP3 at serine 422 to negatively regulate its activity under inflammation  J Biol Chem.  2014  289(39):26872-81. doi: 10.1074 
    Tao L, Chen C, Song H, Piccioni M, Shi G,  Deubiquitination and stabilization of IL-33 by USP21  Int J Clin Exp Pathol.  2014  7(8):4930-7 
    Gao Y, Lin F, Xu P, Nie J, Chen Z, Su J, Tang J, Wu Q, Li Y, Guo Z, Gao Z, Li D, Shen J, Ge S, Tsun A,  USP22 is a positive regulator of NFATc2 on promoting IL2 expression  FEBS Lett.   2014  588(6):878-83. doi: 10.1016 
    Chen Z, Luo X, Lu Y, Zhu T, Wang J, Tsun A,  Ubiquitination signals critical to regulatory T cell development and function  Int Immunopharmacol.  2013  16(3):348-52. doi: 10.1016 
    Zhang J, Chen C, Hou X, Gao Y, Lin F, Yang J, Gao Z, Pan L, Tao L, Wen C, Yao Z, Tsun A, Shi G,  Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3  J Biol Chem.  2013  288(13):9373-82. doi: 10.1074 
    Shan Z, Han Q, Nie J, Cao X, Chen Z, Yin S, Gao Y, Lin F, Zhou X, Xu K, Fan H, Qian Z, Sun B, Zhong J,, Tsun A  Negative regulation of interferon-induced transmembrane protein 3 by SET7-mediated lysine monomethylation  J Biol Chem.  2013  288(49):35093-103. doi: 10.1074 
    Li Y, Tsun A, Gao Z, Han Z, Gao Y, Li Z, Lin F, Wang Y, Wei G, Yao Z,  60-kDa Tat-interactive protein (TIP60) positively regulates Th-inducing POK (ThPOK)-mediated repression of eomesodermin in human CD4+ T cells  J Biol Chem.  2013  288(22):15537-46. doi: 10.1074 
    Chen Z, Barbi J, Bu S, Yang HY, Li Z, Gao Y, Jinasena D, Fu J, Lin F, Chen C, Zhang J, Yu N, Li X, Shan Z, Nie J, Gao Z, Tian H, Li Y, Yao Z, Zheng Y, Park BV, Pan Z, Zhang J, Dang E, Li Z, Wang H, Luo W, Li L, Semenza GL, Zheng SG, Loser K, Tsun A, Greene MI, Pardoll DM, Pan F,  The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3  Immunity.   2013  39(2):272-85. doi: 10.1016 
    Gao Z, Gao Y, Li Z, Chen Z, Lu D, Tsun A,  Synergy between IL-6 and TGF-β signaling promotes FOXP3 degradation  Int J Clin Exp Pathol.  2012  5(7):626-33