- 基本信息
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导师姓名：
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胡国勇
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学科代码：
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100201
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性别：
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男
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学科名称：
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内科学
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培养单位：
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附属第一人民医院
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三级学科
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消化系病
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导师类型：
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博士生导师
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专业领域名称：
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内科学 专业学位
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联系方式：
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huguoyongsh@163.com
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专业领域代码：
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105101
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邮编：
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邮箱地址：
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huguoyongyz@yahoo.com.cn
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- 研究方向 (点击浏览详细信息)
- 社会任职
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中华医学会消化病分会胰腺病学组委员
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上海市消化病学会青年委员
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上海市肠内肠外营养学会青年委员
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上海市胰腺疾病重点实验室执行主任
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中华医学会消化病分会青年委员
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中国医师协会胰腺病分会急性胰腺炎学组委员
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上海市消化病学会胰腺病学组副组长
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中华医学会消化病分会营养协作组委员
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中国研究性医院学会胰腺病专业委员会急性胰腺炎学组委员
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- 科研项目
| 8217031247 | IDH2调控的胰腺腺泡细胞铁死亡在急性胰腺炎中的作用及机制研究 | 国家自然科学基金 |
2022-01~2025-12
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55万元
| 课题负责人 |
| SHDC2020CR5013 | 急性胰腺炎队列数据库及生物样本全息库平台建设 | 申康医院发展中心重大专病队列数据库与生物样本全息库建设项目 |
2020-12~2022-09
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715.5万元
| 课题负责人 |
| 81970556 | 慢性高甘油三酯血症诱导的srebp1c/miR-153信号通路失调在急性胰腺炎中的作用及其机制研究 | 国家自然科学基金 |
2020-01~2023-12
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55万元
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| 18PJD041 | 多巴胺D2受体信号通路调控急性胰腺炎中巨噬细胞的极化状态及其分子机制研究 | 上海市浦江人才计划 |
2018-09~2020-08
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20万元
| 课题负责人 |
| 81670584 | 胰腺内源性多巴胺系统调控急性胰腺炎诱导的炎症反应及 其分子机制研究 | 国家自然科学基金 |
2017-01~2020-12
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58万元
| 课题负责人 |
| 81370568 | JAM-C调控中性粒细胞转内皮迁移在急性胰腺炎的作用及其机制研究 | 国家自然科学基金 |
2014-01~2017-12
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70万元
| 课题负责人 |
| 81100317 | RIP1/RIP3激酶依赖的程序性坏死促进急性胰腺炎重症演变及其调控机理研究 | 国家自然科学基金 |
2012-01~2014-12
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23万元
| 课题负责人 |
- 学术论文
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Han X, Li B, Bao J, Wu Z, Chen C, Ni J, Shen J, Song P, Peng Q, Wan R,
Wang X, Wu J and Hu G
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Endoplasmic reticulum stress promoted acinar cell necroptosis in acute pancreatitis through cathepsinBmediated AP-1 activation.
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Front. Immunol.
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2022
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13:968639.
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Wu Z, Han X, Bao J, Li B, Shen J, Song P, Peng Q, Wang X,
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Dopamine D2 Receptor Signaling Attenuates Acinar Cell Necroptosis in Acute Pancreatitis through the Cathepsin B/TFAM/ROS Pathway.
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Oxid Med Cell Longev.
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2022
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2022:4499219
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Bao J, Zhang X, Li B, Niu M, Wu Z, Song P, Guo X, Husain SZ,, Li L, Wen L.
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AXL and MERTK receptor tyrosine kinases inhibition protects against pancreatic necrosis via selectively limiting CXCL2-related neutrophil infiltration.
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Biochim Biophys Acta Mol Basis Dis.
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2022
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1868(12):166490.
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Dai J, Jiang M, Hu Y, Xiao J, Hu B, Xu J, Han X, Shen S, Li B, Wu Z, He Y, Ren Y, Wen L, Wang X,
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Dysregulated SREBP1c/miR-153 signaling induced by hypertriglyceridemia worsens acute pancreatitis and delays tissue repair
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JCI Insight
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2021
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6(2):e138584
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Dai J, He Y, Jiang M, Niu M, Li B, Wu Z, Bao J, Wen L, Wang X,
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Reg4 regulates pancreatic regeneration following pancreatitis via modulating the Notch signaling
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J Cell Physiol
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2021
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doi: 10.1002/jcp.30397.
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He Y, Dai J, Niu M, Li B, Chen C, Jiang M, Wu Z, Bao J, Zhang X, Li L,Husain SZ,, Wen L.
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Inhibition of nicotinamide phosphoribosyltransferase protects against acute pancreatitis via modulating macrophage polarization and its related metabolites
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Pancreatology
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2021
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21(5):870-883
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Han X, Ni J, Wu Z, Wu J, Li B, Ye X, Dai J, Chen C, Xue J, Wan R, Wen L, Wang X,
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Myeloid-specific dopamine D2 receptor signalling controls inflammation in acute pancreatitis via inhibiting M1 macrophage
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Br J Pharmacol
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2020
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177(13):2991-3008
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Ye X, Han X, Li B, Dai J, Wu Z, He Y, Wen L,
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Dopamine D2 receptor activator quinpirole protects against trypsinogen activation during acute pancreatitis via upregulating HSP70
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Am J Physiol Gastrointest Liver Physiol
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2020
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318(6):G1000-G1012
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Wu Z, Mulatibieke T, Niu M, Li B, Dai J, Ye X, He Y, Chen C, Wen L,
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Inhibition of Matrix Metalloproteinase with BB-94 Protects against Caerulein-Induced Pancreatitis via Modulating Neutrophil and Macrophage Activation
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Gastroenterol Res Pract
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2020
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28;2020:8903610
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Shen S, Li B, Dai J, Wu Z, He Y, Wen L, Wang X,
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BRD4 Inhibition Protects Against Acute Pancreatitis Through Restoring Impaired Autophagic Flux
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Front Pharmacol
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2020
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11:618
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Bao J, Zhang X, Li B, Niu M, Wu Z, Song P, Guo X, Husain SZ,, Li L, Wen L.
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AXL and MERTK receptor tyrosine kinases inhibition protects against pancreatic necrosis via selectively limiting CXCL2-related neutrophil infiltration
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Biochim Biophys Acta Mol Basis Dis
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2020
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1868(12):166490.
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Li B, Wu J, Bao J, Han X, Shen S, Ye X, Dai J, Wu Z, Niu M, He Y, Ni J, Wen L, Wang X,
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Activation of α7nACh receptor protects against acute pancreatitis through enhancing TFEB-regulated autophagy
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Biochim Biophys Acta Mol Basis Dis
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2020
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1866(12):165971
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Ren YC, Zhao Q, He Y, Li B, Wu Z, Dai J, Wen L, Wang X,
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Legumain promotes fibrogenesis in chronic pancreatitis via activation of transforming growth factor β1
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J Mol Med (Berl)
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2020
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98(6):863-874
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Huang L, Chen C, Yang L, Wan R,
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Neutrophil-to-lymphocyte ratio can specifically predict the severity of hypertriglyceridemia-induced acute pancreatitis compared with white blood cell
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J Clin Lab Anal
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2019
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33(4):e22839
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Zhang R, Shi J, Zhang R, Ni J, Habtezion A, Wang X,, Xue J.
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Expanded CD14(hi)CD16(-) Immunosuppressive Monocytes Predict Disease Severity in Patients with Acute Pancreatitis
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J Immunol
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2019
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202(9):2578-2584
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Li B, Han X, Ye X, Ni J, Wu J, Dai J, Wu Z, Chen C, Wan R, Wang X,
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Substance P-regulated leukotriene B4 production promotes acute pancreatitis-associated lung injury through neutrophil reverse migration.
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Int Immunopharmacol
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2018
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57:147-156
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Wu J, Zhang R,, Zhu HH, Gao WQ, Xue J.
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Carbon Monoxide Impairs CD11b(+)Ly-6C(hi) Monocyte Migration from the Blood to Inflamed Pancreas via Inhibition of the CCL2/CCR2 Axis
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J Immunol
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2018
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200(6):2104-2114
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Chen C, Xiao W, Huang L, Yu G, Ni J, Yang L, Wan R,
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Shikonin induces apoptosis and necroptosis in pancreatic cancer via regulating the expression of RIP1/RIP3 and synergizes the activity of gemcitabine.
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Am J Transl Res
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2017
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9(12):5507-5517
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Chen C, Yu G, Xiao W, Xing M, Ni J, Wan R,
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Thalidomide inhibits proliferation and epithelial-mesenchymal transition by modulating CD133 expression in pancreatic cancer cells
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Oncol Lett
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2017
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14(6):8206-8212
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Wu J, Mulatibieke T, Ni J, Han X, Li B, Zeng Y, Wan R, Wang X,
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Dichotomy between Receptor-Interacting Protein 1- and Receptor-Interacting Protein 3-Mediated Necroptosis in Experimental Pancreatitis
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Am J Pathol
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2017
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187(5):1035-1048
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Han X, Li B, Ye X, Mulatibieke T, Wu J, Dai J, Wu D, Ni J, Zhang R, Xue J, Wan R,, Hu G
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Dopamine D(2) receptor signalling controls inflammation in acute pancreatitis via a PP2A-dependent Akt/NF-κB signalling pathway.
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Br J Pharmacol
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2017
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174(24):4751-4770
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Wu D, Zeng Y, Fan Y, Wu J, Mulatibieke T, Ni J, Yu G, Wan R, Wang X,
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Reverse-migrated neutrophils regulated by JAM-C are involved in acute pancreatitis-associated lung injury
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Sci Rep
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2016
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6:20545
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Hu B, Zhang K, Li S, Li H, Yan Z, Huang L, Wu J, Han X, Jiang W, Mulatibieke T, Zheng L, Wan R, Wang X,
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HIC1 attenuates invasion and metastasis by inhibiting the IL-6/STAT3 signalling pathway in human pancreatic cancer
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Cancer Lett
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2016
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376(2):387-98
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Yin G,, Wan R, Yu G, Cang X, Ni J, Xiong J, Hu Y, Xing M, Fan Y, Xiao W, Qiu L, Wang S, Wang X.
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Role of bone marrow mesenchymal stem cells in L-arg-induced acute pancreatitis: effects and possible mechanisms
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Int J Clin Exp Pathol
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2015
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8(5):4457-68
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Fan YT, Yin GJ, Xiao WQ, Qiu L, Yu G, Hu YL, Xing M, Wu DQ, Cang XF, Wan R,
Wang XP,
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Rosmarinic Acid Attenuates Sodium Taurocholate-Induced Acute Pancreatitis in Rats by Inhibiting Nuclear Factor-κB Activation
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Am J Chin Med
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2015
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43(6):1117-35
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Xing M, Ni J, Wan R, Tang M, Hu Y, Yu G, Yin G, Chen C, Fan Y, Xiao W, Zhao Y, Wang X,
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The tetraspanin CD9 is involved in pancreatic damage during caerulein-induced acute pancreatitis in mice
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J Dig Dis
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2015
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16(1):43-51
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Yu G, Li S, Wan R, Wang X,
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Nafamostat Mesilate for Prevention of Post-ERCP Pancreatitis: A Meta-analysis of Prospective, Randomized, Controlled Trials.
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Pancreas
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2015
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44(4):561-9
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Yu G, Wan R, Yin G, Xiong J, Hu Y, Xing M, Cang X, Fan Y, Xiao W, Qiu L, Wang X,
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Diosmetin ameliorates the severity of cerulein-induced acute pancreatitis in mice by inhibiting the activation of the nuclear factor-κB
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Int J Clin Exp Pathol
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2014
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7(5):2133-42
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Hu Y, Wan R, Yu G, Shen J, Ni J, Yin G, Xing M, Chen C, Fan Y, Xiao W, Xu G, Wang X,
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Imbalance of Wnt/Dkk negative feedback promotes persistent activation of pancreatic stellate cells in chronic pancreatitis.
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PLoS One
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2014
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9(4):e95145
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Yu G, Wan R, Hu Y, Ni J, Yin G, Xing M, Shen J, Tang M, Chen C, Fan Y, Xiao W, Zhao Y, Wang X,
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Pancreatic acinar cells-derived cyclophilin A promotes pancreatic damage by activating NF-κB pathway in
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Biochem Biophys Res Commun.
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2014
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444(1):75-80
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Ni J,, Xiong J, Shen J, Shen J, Yang L, Tang M, Zhao Y, Ying G, Yu G, Hu Y, Xing M, Wan R, Wang X.
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Involvement of interleukin-17A in pancreatic damage in rat experimental acute necrotizing pancreatitis.
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Inflammation
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2013
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36(1):53-65
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, Zhao Y, Tang Y, Wang Y, Shen J, Liu L, Li H, Liu Y, Cui X, Yu Y, Guo C, Wang X, Liu G.
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Development of a novel model of hypertriglyceridemic acute pancreatitis in hamsters: protective effects of probucol.
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Pancreas
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2012
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41(6):845-8
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, Shen J, Cheng L, Guo C, Xu X, Wang F, Huang L, Yang L, He M, Xiang D, Zhu S, Wu M, Yu Y, Han W, Wang X.
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Reg4 protects against acinar cell necrosis in experimental pancreatitis
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Gut
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2011
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60(6):820-8
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, Shen J, Cheng L, Xiang D, Zhang Z, He M, Lu H, Zhu S, Wu M, Yu Y, Wang X, Han W.
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Purification of a bioactive recombinant human Reg IV expressed in Escherichia coli
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Protein Expr Purif
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2010
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69(2):186-90
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