• 基本信息
    导师姓名： 蒙国宇 学科代码： 100201
    性别： 男 学科名称： 内科学
    培养单位： 附属瑞金医院 三级学科 血液病
    导师类型： 博士生导师 专业领域名称：
    联系方式： guoyu.meng@icloud.com, guoyumeng@shsmu.edu.cn 专业领域代码：
    邮编： 200025 邮箱地址： guoyu.meng@gmail.com
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    上海生物物理学会第十一届理事会理事
    上海市生物物理学会专业委员会委员
    中华医学奖（第一完成人）
    瑞金医院先进研究生导师团队（团队负责人）
    华夏医学奖（第一完成人）
    瑞金医院卓越员工荣誉称号
    上海医学奖（第一完成人）（2次）
    中亚重大疾病防治国际合作联合实验室学术委员会副主任委员
    中国生物物理学会分子生物物理分会委员
    中国抗癌协会青年副主委
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    20JC1410600以PML核体亚细胞器为核心的抗肿瘤新策略研究上海市科学技术委员会 2021-01~2023-12 70万元  课题负责人
    81970132急性B淋巴细胞白血病致癌蛋白MEF2D-fusion的发病机制研究国家自然科学基金 2020-01~2023-01 55万元  课题负责人
    20152504-2上海市教委高峰高原计划 (第二期）上海市教委 2019-01~2024-12 50万元  课题负责人
    81770142DUX4-IGH融合蛋白诱导急性B淋巴细胞白血病的发病机制研究国家自然科学基金 2018-01~2021-12 55万元  课题负责人
    81570120白血病靶点蛋白PML-RARa等的结构和功能研究国家自然科学基金 2016-01~2017-12 25万元  课题负责人
    20152504上海市教委高峰高原计划上海市教委 2015-10~2018-10 50万元  课题负责人
    81370620整合素激活c-Src的机制及其在血栓中的应用研究国家自然科学基金 2014-01~2017-12 70万元  课题负责人
    31070645流感嗜血杆菌病理和感染的结构生物学基础国家自然科学基金 2011-01~2013-12 34万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Zhihui Li, Minghao Jiang, Junfei Wang, Zhiyi Zhuo, Shiyan Zhang, Yangxia Tan, Weiguo Hu, Hao Zhang,  Transcription factor 12 mediated self-feedback regulatory mechanism is required in DUX4 fusion leukemia  Clinical and Translational Medicine (IF=10.6, Q1)  2024  DOI: 10.1002/ctm2.1514 
    Minghao Jiang, Shiyan Zhang, Hongxin Yin, Zhiyi Zhuo,  A comprehensive benchmarking of differential splicing tools for RNA-seq analysis at the event level   Briefings in Bioinformatics (IF=13.9，Q1)  2023  10.1093/bib/bbad121 
    Wu W, Tan Y, Yin H, Jiang M, Jiang Y, Ma X, Yin T, Li Y, Zhang H, Cai X,  Phase separation is required for PML nuclear body biogenesis and function.  FASEB J. （IF=6，Q1）  2023  37(6):e22986. 
    Gang Lu, Yun Ling, Minghao Jiang, Yun Tan,Dong Wei, Lu Jiang, Shuting Yu, Fangying Jiang, Shuai Wang, Yao Dai, Jinzeng Wang, Geng Wu, Xinxin Zhang,,Shengyue Wang, Feng Liu, Xiaohong Fan, Saijuan Chen  Primary assessment of the diversity of Omicron sublineages and the epidemiologic features of autumn/winter 2022 COVID-19 wave in Chinese mainland  Frontiers of Medicine (IF=9.9，Q1)  2023  https://doi.org/10.1007/s11684-022-0981-7 
    Hongxin Yin, Junfei Wang , Yangxia Tan , Minghao Jiang , Hao Zhang ,  Transcription factor abnormalities in B-ALL leukemogenesis and treatment  Trends in Cancer （IF=18,Q1）  2023  S2405-8033(23)00105-X. 
    Jiang M, Yin H, Zhang S,, Wu G  Mathematical appraisal of SARS-CoV-2 Omicron epidemic outbreak in unprecedented Shanghai lockdown  Frontiers in Medicine (IF=5.0)  2022  9:1021560. 
    Minghao Jiang,, Geng Wu  The Dawn is Coming —— the Description and Prediction of Omicron SARSCoV-2 Epidemic Outbreak in Shanghai by Mathematical Modeling  medRxiv preprint  2022  doi.org/10.1101/2022.04.13.22273788 
    Zhang M, Zhang H, Li Z, Bai L, Wang Q, Li J, Jiang M, Xue Q, Cheng N, Zhang W, Mao D, Chen Z, Huang J,, Chen Z, Chen SJ.  Functional, structural and molecular characterizations of leukemogenic driver MEF2D-HNRNPUL1 fusion.  Blood (IF=25.7，Q1)  2022  doi: 10.1182/blood.2022016241 
    Hao Zhang,  A typical bedside-to-bench investigation of leukemogenic driver MEF2D fusion reveals new targeted therapy in B-cell acute lymphoblastic leukemia  Blood Science  2022  doi: 10.1097/BS9.0000000000000126 
    Zhang H, Cheng N, Li Z, Bai L, Fang C, Li Y, Zhang W, Dong X, Jiang M, Liang Y, Zhang S, Mi J, Zhu J, Zhang Y, Chen SJ, Zhao Y, Weng XQ, Hu W, Chen Z, Huang J,  DNA crosslinking and recombination-activating genes 1/2 (RAG1/2) are required for oncogenic splicing in acute lymphoblastic leukemia.  Cancer Commun (IF=15.3, Q1)  2021  41(11):1116-1136.  
    Nuo Cheng, Hao Zhang, Shiyan Zhang, Xiaodan Ma,  Crystal structure of GTP-binding protein-like domain of AGAP1  Acta Crystallographica Section F  2021  77(Pt 4):105-112 
    Chen Z, Wang Q, Zhang H, Ma X, Wu W, Cheng N, Zhang J, Zhou A, Li Y,  Purification, crystallization, and X-ray diffraction analysis of myocyte enhancer factor 2D and DNA complex  Protein Expr Purif.  2021  179:105788 
    Li Yuwen, Ma Xiaodan,  PML nuclear body biogenesis and oligomerization-driven leukemogenesis  Blood Science  2020  2(1):7-10 
    Yuwen Li, Xiaodan Ma, Wenyu Wu, Zhu Chen,  PML nuclear body biogenesis, carcinogenesis and targeted therapy   Trends in Cancer (IF=19.2, Q1)  2020  S2405-8033(20)30160-6 
    Ma X, Wang Q, Li Y, Tan P, Wu H, Wang P, Dong X, Hong L,  How BamA recruits OMP substrates via poly-POTRAs domain  FASEB J.  2019  doi: 10.1096/fj.201900681RR 
    Xue Dong, Hao Zhang, Nuo Cheng, Kening Li,  DUX4(HD2)-DNA(ERG) structure reveals new insight into DUX4-Responsive-Element  Leukemia (IF=12.9, Q1)  2019  33(2):550-553 
    Li Y, Ma X, Chen Z, Wu H, Wang P, Wu W, Cheng N, Zeng L, Zhang H, Cai X, Chen SJ, Chen Z,  B1 oligomerization regulates PML nuclear body biogenesis and leukemogenesis.   Nat Commun. (IF=17.7, Q1)  2019  10(1):3789 
    P. Wang, S. Benhenda, H. Wu, V. Lallemand-Breitenbach, T. Zhen, F. Jollivet, L. Peres, Y. Li, S. Chen, Z. Chen, H. de The,  RING tetramerization is required for nuclear body biogenesis and PML sumoylation  Nat Commun. (IF=17.7, Q1)  2018  9(1):1841 
    Xue Dong, Weina Zhang, Haiyan Wu, Jinyan Huang, Ming Zhang, Pengran Wang, Hao Zhang, Zhu Chen, Sai-Juan Chen,  Structural basis of DUX4/IGH-driven transactivation  Leukemia (IF=12.9, Q1)  2018  32(6):1466-1476 
    L. Zeng, L. Zhang, P. Wang,  Structural basis of host recognition and biofilm formation by Salmonella Saf pili  eLife (IF=8, Q1)  2017  6. pii: e28619 
    Lei J, Cai X, Ma X, Zhang L, Li Y, Dong X, St Geme J 3rd,  Recombinant expression, purification, crystallization and preliminary X-ray diffraction analysis of Haemophilus influenzae BamD and BamCD complex.  Acta Crystallogr F Struct Biol Commun.  2015  71(Pt 2):234-8. 
    R. Xiao, X.D. Xi, Z. Chen, S.J. Chen,  Structural framework of c-Src activation by integrin β3  Blood (IF=25.7, Q1)  2013  121(4):700-706 
    Cai X, Wang R, Filloux A, Waksman G,  Structural and functional characterization of Pseudomonas aeruginosa CupB chaperones.  PLoS One.  2011  6(1):e16583. 
    , N. Spahich, R. Kenjale, G. Waksman, J. St Geme  Crystal structure of the Haemophilus influenzae Hap adhesin reveals an intercellular oligomerization mechanism for bacterial aggregation  EMBO J. (IF=13.8, Q1)  2011  30: 3864-3874.