- 基本信息
导师姓名:
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蒙国宇
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学科代码:
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100201
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性别:
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男
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学科名称:
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内科学
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培养单位:
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附属瑞金医院
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三级学科
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血液病
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导师类型:
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博士生导师
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专业领域名称:
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联系方式:
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guoyu.meng@icloud.com, guoyumeng@shsmu.edu.cn
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专业领域代码:
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邮编:
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200025
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邮箱地址:
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guoyu.meng@gmail.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
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上海生物物理学会第十一届理事会理事
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上海市生物物理学会专业委员会委员
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中华医学奖(第一完成人)
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瑞金医院先进研究生导师团队(团队负责人)
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华夏医学奖(第一完成人)
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瑞金医院卓越员工荣誉称号
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上海医学奖(第一完成人)(2次)
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中亚重大疾病防治国际合作联合实验室学术委员会副主任委员
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中国生物物理学会分子生物物理分会委员
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中国抗癌协会青年副主委
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- 科研项目
20JC1410600 | 以PML核体亚细胞器为核心的抗肿瘤新策略研究 | 上海市科学技术委员会 |
2021-01~2023-12
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70万元
| 课题负责人 |
81970132 | 急性B淋巴细胞白血病致癌蛋白MEF2D-fusion的发病机制研究 | 国家自然科学基金 |
2020-01~2023-01
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55万元
| 课题负责人 |
20152504-2 | 上海市教委高峰高原计划 (第二期) | 上海市教委 |
2019-01~2021-12
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50万元
| 课题负责人 |
81770142 | DUX4-IGH融合蛋白诱导急性B淋巴细胞白血病的发病机制研究 | 国家自然科学基金 |
2018-01~2021-12
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55万元
| 课题负责人 |
81570120 | 白血病靶点蛋白PML-RARa等的结构和功能研究 | 国家自然科学基金 |
2016-01~2017-12
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25万元
| 课题负责人 |
20152504 | 上海市教委高峰高原计划 | 上海市教委 |
2015-10~2018-10
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50万元
| 课题负责人 |
81370620 | 整合素激活c-Src的机制及其在血栓中的应用研究 | 国家自然科学基金 |
2014-01~2017-12
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70万元
| 课题负责人 |
31070645 | 流感嗜血杆菌病理和感染的结构生物学基础 | 国家自然科学基金 |
2011-01~2013-12
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34万元
| 课题负责人 |
- 学术论文
Zhihui Li, Minghao Jiang, Junfei Wang, Zhiyi Zhuo, Shiyan Zhang, Yangxia Tan, Weiguo Hu, Hao Zhang,
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Transcription factor 12 mediated self-feedback regulatory mechanism is required in DUX4 fusion leukemia
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Clinical and Translational Medicine (IF=10.6, Q1)
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2024
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DOI: 10.1002/ctm2.1514
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Minghao Jiang, Shiyan Zhang, Hongxin Yin, Zhiyi Zhuo,
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A comprehensive benchmarking of differential splicing tools for RNA-seq analysis at the event level
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Briefings in Bioinformatics (IF=13.9,Q1)
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2023
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10.1093/bib/bbad121
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Wu W, Tan Y, Yin H, Jiang M, Jiang Y, Ma X, Yin T, Li Y, Zhang H, Cai X,
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Phase separation is required for PML nuclear body biogenesis and function.
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FASEB J. (IF=6,Q1)
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2023
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37(6):e22986.
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Gang Lu, Yun Ling, Minghao Jiang, Yun Tan,Dong Wei, Lu Jiang, Shuting Yu, Fangying Jiang, Shuai Wang, Yao Dai, Jinzeng Wang, Geng Wu, Xinxin Zhang,,Shengyue Wang, Feng Liu, Xiaohong Fan, Saijuan Chen
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Primary assessment of the diversity of Omicron sublineages and the epidemiologic features of autumn/winter 2022 COVID-19 wave in Chinese mainland
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Frontiers of Medicine (IF=9.9,Q1)
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2023
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https://doi.org/10.1007/s11684-022-0981-7
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Hongxin Yin, Junfei Wang , Yangxia Tan , Minghao Jiang , Hao Zhang ,
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Transcription factor abnormalities in B-ALL leukemogenesis and treatment
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Trends in Cancer (IF=18,Q1)
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2023
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S2405-8033(23)00105-X.
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Jiang M, Yin H, Zhang S,, Wu G
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Mathematical appraisal of SARS-CoV-2 Omicron epidemic outbreak in unprecedented Shanghai lockdown
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Frontiers in Medicine (IF=5.0)
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2022
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9:1021560.
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Minghao Jiang,, Geng Wu
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The Dawn is Coming —— the Description and Prediction of Omicron SARSCoV-2 Epidemic Outbreak in Shanghai by Mathematical Modeling
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medRxiv preprint
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2022
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doi.org/10.1101/2022.04.13.22273788
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Zhang M, Zhang H, Li Z, Bai L, Wang Q, Li J, Jiang M, Xue Q, Cheng N, Zhang W, Mao D, Chen Z, Huang J,, Chen Z, Chen SJ.
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Functional, structural and molecular characterizations of leukemogenic driver MEF2D-HNRNPUL1 fusion.
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Blood (IF=25.7,Q1)
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2022
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doi: 10.1182/blood.2022016241
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Hao Zhang,
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A typical bedside-to-bench investigation of leukemogenic driver MEF2D fusion reveals new targeted therapy in B-cell acute lymphoblastic leukemia
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Blood Science
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2022
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doi: 10.1097/BS9.0000000000000126
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Zhang H, Cheng N, Li Z, Bai L, Fang C, Li Y, Zhang W, Dong X, Jiang M, Liang Y, Zhang S, Mi J, Zhu J, Zhang Y, Chen SJ, Zhao Y, Weng XQ, Hu W, Chen Z, Huang J,
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DNA crosslinking and recombination-activating genes 1/2 (RAG1/2) are required for oncogenic splicing in acute lymphoblastic leukemia.
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Cancer Commun (IF=15.3, Q1)
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2021
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41(11):1116-1136.
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Nuo Cheng, Hao Zhang, Shiyan Zhang, Xiaodan Ma,
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Crystal structure of GTP-binding protein-like domain of AGAP1
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Acta Crystallographica Section F
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2021
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77(Pt 4):105-112
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Chen Z, Wang Q, Zhang H, Ma X, Wu W, Cheng N, Zhang J, Zhou A, Li Y,
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Purification, crystallization, and X-ray diffraction analysis of myocyte enhancer factor 2D and DNA complex
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Protein Expr Purif.
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2021
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179:105788
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Li Yuwen, Ma Xiaodan,
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PML nuclear body biogenesis and oligomerization-driven leukemogenesis
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Blood Science
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2020
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2(1):7-10
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Yuwen Li, Xiaodan Ma, Wenyu Wu, Zhu Chen,
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PML nuclear body biogenesis, carcinogenesis and targeted therapy
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Trends in Cancer (IF=19.2, Q1)
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2020
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S2405-8033(20)30160-6
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Ma X, Wang Q, Li Y, Tan P, Wu H, Wang P, Dong X, Hong L,
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How BamA recruits OMP substrates via poly-POTRAs domain
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FASEB J.
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2019
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doi: 10.1096/fj.201900681RR
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Xue Dong, Hao Zhang, Nuo Cheng, Kening Li,
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DUX4(HD2)-DNA(ERG) structure reveals new insight into DUX4-Responsive-Element
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Leukemia (IF=12.9, Q1)
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2019
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33(2):550-553
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Li Y, Ma X, Chen Z, Wu H, Wang P, Wu W, Cheng N, Zeng L, Zhang H, Cai X, Chen
SJ, Chen Z,
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B1 oligomerization regulates PML nuclear body biogenesis and leukemogenesis.
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Nat Commun. (IF=17.7, Q1)
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2019
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10(1):3789
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P. Wang, S. Benhenda, H. Wu, V. Lallemand-Breitenbach, T. Zhen, F. Jollivet, L. Peres, Y. Li, S. Chen, Z. Chen, H. de The,
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RING tetramerization is required for nuclear body biogenesis and PML sumoylation
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Nat Commun. (IF=17.7, Q1)
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2018
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9(1):1841
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Xue Dong, Weina Zhang, Haiyan Wu, Jinyan Huang, Ming Zhang, Pengran Wang, Hao Zhang, Zhu Chen, Sai-Juan Chen,
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Structural basis of DUX4/IGH-driven transactivation
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Leukemia (IF=12.9, Q1)
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2018
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32(6):1466-1476
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L. Zeng, L. Zhang, P. Wang,
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Structural basis of host recognition and biofilm formation by Salmonella Saf pili
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eLife (IF=8, Q1)
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2017
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6. pii: e28619
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Lei J, Cai X, Ma X, Zhang L, Li Y, Dong X, St Geme J 3rd,
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Recombinant expression, purification, crystallization and preliminary X-ray diffraction analysis of Haemophilus influenzae BamD and BamCD complex.
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Acta Crystallogr F Struct Biol Commun.
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2015
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71(Pt 2):234-8.
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R. Xiao, X.D. Xi, Z. Chen, S.J. Chen,
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Structural framework of c-Src activation by integrin β3
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Blood (IF=25.7, Q1)
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2013
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121(4):700-706
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Cai X, Wang R, Filloux A, Waksman G,
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Structural and functional characterization of Pseudomonas aeruginosa CupB chaperones.
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PLoS One.
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2011
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6(1):e16583.
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, N. Spahich, R. Kenjale, G. Waksman, J. St Geme
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Crystal structure of the Haemophilus influenzae Hap adhesin reveals an intercellular oligomerization mechanism for bacterial aggregation
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EMBO J. (IF=13.8, Q1)
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2011
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30: 3864-3874.
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