• 基本信息
    导师姓名： 邓侠兴 学科代码：
    性别： 男 学科名称：
    培养单位： 附属瑞金医院 三级学科 普外
    导师类型： 博士生导师 专业领域名称： 外科学 专业学位
    联系方式： 专业领域代码： 105111
    邮编： 邮箱地址： kejiadxx@hotmail.com
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    中国医师协会外科学分会机器人外科工作组成员
    上海抗癌协会胆道肿瘤分会副主任委员
    上海医学会普外科学会副主任委员
    中国抗癌协会胰腺癌专业委员会微创学组委员
    上海市医师协会普外科医师分会肝胆胰外科工作组副组长
    中国抗癌协会胰腺癌专业委员会神经内分泌肿瘤学组委员
    上海市医学会胰腺外科学组组长
    中国医师协会外科医师分会腹膜后肿瘤工作组成员
    中国医师协会外科医师分会胆道外科工作组成员
    国际肝胆胰协会中国分会胆道肿瘤专委会委员
    中国医疗保健国际交流促进会外科分会委员
    中华医学会外科学分会胆道外科专委会委员
    中国医师协会外科医师分会手术质控专家工作组成员
    中国抗癌协会胆道肿瘤专委会常委
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    82372865MYC扩增联合PTEN缺失型胰腺癌中靶向FBXO3通过诱导合成致死激活抗肿 瘤免疫的机制研究国家自然科学基金 2024-01~2027-12 60万元  课题负责人
    22ZR1438900缺氧诱导的外泌体环状RNA hsa_circRNA_102854激活糖 酵解代 谢促进胰腺癌化疗耐药的机制研究上海市科学技术委员会 2022-04~2025-03 20万元  课题负责人
    214307119000胰腺导管腺癌基质干细胞在肿瘤微环境中的免疫抑制作用及对肿瘤发生发展的影响上海市2021年度“科技创新行动计划”国际科技合作项目 2021-07~2024-06 45万元  课题负责人
    TMSK-2021-502不同临床分期胰腺癌患者，结合转录组测序，ctDNA状态以及肿瘤浸润淋巴细胞情况的评价及临床转化探索转化医学国家重大科技基础设施（上海）开放课题项目 2021-06~2023-06 40万元  课题负责人
    SHDC12020121胰腺切除联合胰岛自体移植技术的多中心实践与推广上海市申康新兴前沿项目 2020-01~2023-11 100万元  课题负责人
    17ZR1417800基于胆固醇代谢通路探讨蜂毒素诱导的LncRNA NONHSAT105177抑制胰腺癌的机制研究上海市自然科学基金 2017-05~2020-04 20万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Chen D, Cao Y, Tang H, Zang L, Yao N, Zhu Y, Jiang Y, Zhai S, Liu Y, Shi M, Zhao S, Wang W, Wen C, Peng C, Chen H,, Jiang L, Shen B.  Comprehensive machine learning-generated classifier identifies pro-metastatic characteristics and predicts individual treatment in pancreatic cancer: A multicenter cohort study based on super-enhancer profiling  Theranostics .   2023  13(10):3290-3309.  
    Wang L, Liu Y, Dai Y, Tang X, Yin T, Wang C, Wang T, Dong L, Shi M, Qin J, Xue M, Cao Y, Liu J, Liu P, Huang J, Wen C, Zhang J, Xu Z, Bai F,, Peng C, Chen H, Jiang L, Chen S, Shen B.  Single-cell RNA-seq analysis reveals BHLHE40-driven pro-tumour neutrophils with hyperactivated glycolysis in pancreatic tumour microenvironment  Gut .  2023  72(5):958-971 
    Chen H, Wang C, Shen Z, Wang W, Weng Y, Ying X,, Shen B.  Postpancreatectomy Acute Pancreatitis After Pancreaticoduodenectomy: A Distinct Clinical Entity  Ann Surg .  2023  278(2):e278-e283 
    Cao Y, Wang X, Liu Y, Liu P, Qin J, Zhu Y, Zhai S, Jiang Y, Liu Y, Han L, Luo J, Zhang R, Shi M, Wang L, Tang X, Xue M, Liu J, Wang W, Wen C,, Peng C, Chen H, Cheng D, Jiang L, Shen B.  BHLHE40 Inhibits Ferroptosis in Pancreatic Cancer Cells via Upregulating SREBF1  Adv Sci (Weinh) .   2023  e2306298 
    Weng Y, Qian H, Hong L, Zhao S,, Shen B.  Identification of EMT-related alternative splicing event of TMC7 to promote invasion and migration of pancreatic cancer  Front Immunol .  2023  13:1089008 
    Zhai S, Lin J, Ji Y, Zhang R, Zhang Z, Cao Y, Liu Y, Tang X, Liu J, Liu P, Lin J, Li F, Li H, Shi Y, Fu D,, Shen B.  A microprotein N1DARP encoded by LINC00261 promotes Notch1 intracellular domain (N1ICD) degradation via disrupting USP10-N1ICD interaction to inhibit chemoresistance in Notch1-hyperactivated pancreatic cancer  Cell Discov .  2023  9(1):95 
    Xue M, Zhu Y, Jiang Y, Han L, Shi M, Su R, Wang L, Xiong C, Wang C, Wang T, Deng S, Wu D, Cao Y, Dong L, Bai F, Zhao S,, Peng C, Li H, Chen J, Shen B, Jiang L, Chen H.  Schwann cells regulate tumor cells and cancer-associated fibroblasts in the pancreatic ductal adenocarcinoma microenvironment  Nat Commun .   2023  14(1):4600 
    Chen H, Xu Z, Shen Z, Weng Y, Wang W, Ying X, Wang X,, Shen B.  Clinical characteristics and surgical outcomes of resectable acinar cell carcinoma of the pancreas-propensity score matching analysis with pancreatic ductal adenocarcinoma  Eur J Surg Oncol .   2022  48(5):1062-1067 
    Zhang B, Lin J, Zhang J, Wang X,  Integrated Chromatin Accessibility and Transcriptome Landscapes of 5-Fluorouracil-Resistant Colon Cancer Cells  Front Cell Dev Biol .   2022  10:838332 
    Weng Y, Jiang Y, Fu N, Jin J, Shi Y, Huo Z,, Peng C, Shen B.  Oncological outcomes of robotic-assisted versus open pancreatoduodenectomy for pancreatic ductal adenocarcinoma: a propensity score-matched analysis  Surg Endosc .  2021  35(7):3437-3448 
    Qian H, Li H, Xie J, Lu X, Li F, Wang W, Tang X, Shi M, Jiang L, Li H, Chen H, Peng C, Xu Z,, Shen B.  Immunity-Related Gene Signature Identifies Subtypes Benefitting From Adjuvant Chemotherapy or Potentially Responding to PD1/PD-L1 Blockage in Pancreatic Cancer  Front Cell Dev Biol .  2021  9:682261. 
    Weng Y, Jin J, Huo Z, Shi Y, Jiang Y,, Peng C, Shen B.  Robotic-assisted versus open distal pancreatectomy for benign and low-grade malignant pancreatic tumors: a propensity score-matched study  Surg Endosc .  2021  35(5):2255-2264. 
    Zhai S, Xu Z, Xie J, Zhang J, Wang X, Peng C, Li H, Chen H, Shen B,  Epigenetic silencing of LncRNA LINC00261 promotes c-myc-mediated aerobic glycolysis by regulating miR-222-3p/HIPK2/ERK axis and sequestering IGF2BP1  Oncogene .  2021  40(2):277-291 
    Shi Y, Wang W, Qiu W, Zhao S, Wang J, Weng Y, Huo Z, Jin J, Wang Y,, Shen B, Peng C.  Learning Curve From 450 Cases of Robot-Assisted Pancreaticoduocectomy in a High-Volume Pancreatic Center: Optimization of Operative Procedure and a Retrospective Study  Ann Surg .   2021  274(6):e1277-e1283 
    Shi Y, Wang Y, Wang J, Ma Y, Huo Z, Jin J, Weng Y, Zhao S,, Shen B, Peng C.  Learning curve of robot-assisted middle pancreatectomy (RMP): experience of the first 100 cases from a high-volume pancreatic center in China  Surg Endosc  2020  34(8):3513-3520 
    Wang X, Li H, Lu X, Wen C, Huo Z, Shi M, Tang X, Chen H, Peng C, Fang Y,, Shen B.  Melittin-induced long non-coding RNA NONHSAT105177 inhibits proliferation and migration of pancreatic ductal adenocarcinoma  Cell Death Dis  2018  09 20;9(10) 
    Wang X, Xie J, Lu X, Li H, Wen C, Huo Z, Xie J, Shi M, Tang X, Chen H, Peng C, Fang Y,, Shen B.  Melittin inhibits tumor growth and decreases resistance to gemcitabine by downregulating cholesterol pathway gene CLU in pancreatic ductal adenocarcinoma  Cancer Lett.  2017  07 28;399 
    Jiang H, Li H, Li A, Tang E, Xu D, Chen Y, Zhang Y, Tang M, Zhang Z,, Lin M.  Preoperative combined hemoglobin, albumin, lymphocyte and platelet levels predict survival in patients with locally advanced colorectal cancer  Oncotarget   2016  Nov 01;7(44) 
    Lu X, Wang X, Fang Y, Chen H, Peng C, Li H,, Shen B.  Systematic Review and Meta-Analysis of Pancreatic Amylase Value on Postoperative Day 1 After Pancreatic Resection to Predict Postoperative Pancreatic Fistula.  Medicine  2016  95(5):e2569. 
    Zhang T, Wang X, Zhao L, Liu F, Chen H,, Peng C, Shen B.   Transperitoneal robotic resection of benign primary retroperitoneal tumors: can it be widely used?  Int J Med Robot.  2016  doi: 10.1002/rcs.1689. 
    Wang X, Lu X, Zhang T, Wen C, Shi M, Tang X, Chen H, Peng C, Li H, Fang Y,, Shen B.  mir-329 restricts tumor growth by targeting grb2 in pancreatic cancer.  Oncotarget.   2016  7(16):21441-53.  
    Zhang T, Wang X, Huo Z, Shi Y, Jin J, Zhan Q, Chen H,, Shen B.  Shen's Whole-Layer Tightly Appressed Anastomosis Technique for Duct-to-Mucosa Pancreaticojejunostomy in Pancreaticoduodenectomy.  Med Sci Monit.  2016  22:540-8 
    Xinjing Wang, Yang Dong,Jiabin Jin, Qin Liu, Qian Zhan, Hao Chen, Baiyong Shen,, Chenghong Peng, Hongwei Li  Efficacy of modified Appleby surgery: a benefit for elderly patients?   Journal of Surgical Research  2015  194(1):83-90. 
    Zhang T, Wang X, Huo Z, Wen C, Wu Z, Jin J, Cheng D, Chen H,, Shen B, Peng C.   Robot-Assisted Middle Pancreatectomy for Elderly Patients: Our Initial Experience.   Med Sci Monit.  2015  21:2851-60. 
    QIN LIU, XINJING WANG, BAIYONG SHEN, LIANGCHAO ZHAO, QIAN ZHAN, SHULIN ZHAO, CHENLEI WEN,, CHENGHONG PENG, HONGWEI LI  Preliminary experience of the robot?assisted laparoscopic excision of a retroperitoneal mass: A case report.   Oncology Letters  2014  8():2399-2402 
    Xinjing Wang,Xiongxiong Lu,Yuan Fang,Hao Chen,,Chenghong Peng,Hongwei Li,Baiyong Shen  Association between miR34b/c Polymorphism rs4938723 and Cancer Risk: A Meta-Analysis of 11 Studies including 6169 Cases and 6337 Controls   Med Sci Monit  2014  20():1977-1982 
    Lei Cheng, Qing Zhang, Sheng Yang, Yanqing Yang, Wen Zhang, Hengjun Gao,,Qinghua Zhang  A 4-gene panel as a marker at chromosome 8q in Asian gastric cancer patients  Genomics  2013  102():323-330 
    Yuan Shi,, Qian Zhan, Baiyong Shen, Xiaolong Jin, Zhecheng Zhu, Hao Chen, Hongwei Li, Chenghong Peng  A Prospective Proteomic-Based Study for Identifying Potential Biomarkers for the Diagnosis of Cholangiocarcinoma  Journal of Gastrointestinal Surgery  2013  17(9):1584-1591 
    董阳,王以巧,,詹茜,沈柏用,彭承宏,李宏为  胆管细胞癌ROS酪氨酸激酶基因融合的初步研究  外科理论与实践  2012  17(6):645-648 
    Lei Cheng,Sheng Yang,Yanqing Yang, Wen Zhang, Huasheng Xiao, Hengjun Gao,, Qinghua Zhang  Global gene expression and functional network analysis of gastric canceridentify extended pathway maps and GPRC5A as a potential biomarker  Cancer Letters  2012  326():- 
    韩波,,梁赘,沈柏用,詹茜,程东峰,祝哲诚,彭承宏,李宏为  机器人外科手术系统辅助下治疗胰腺疾病的临床疗效  上海医学  2011  32（1）:12-14 
    Ting-Lei Gu1,, Feizhou Huang, Meghan Tucker, Katherine Crosby, Victoria Rimkunas, Yi Wang, Gang Deng, Lei Zhu, Zhiping Tan, Yerong Hu, Chunlin Wu, Julie Nardone, Joan MacNeil, Jianmin Ren, Cynthia Reeves, Gregory Innocenti, Brett Norris, Jin   Survey of Tyrosine Kinase Signaling Reveals ROS Kinase Fusions in Human Cholangiocarcinoma  plos one  2011  6(1):e15640 
    ,詹茜,王以巧,施源,沈柏用,彭承宏  胆管细胞癌酪氨酸激酶激活及其磷酸化酶分布  外科理论与实践  2011  16(6)：548-552 
    ,沈柏用,彭承宏  胰腺肿瘤的微创治疗  上海医学  2010  33（11）:989-991 
      原发性腹膜后肿瘤临床诊治与复发因素分析  中国实用外科杂志  2009  29 增刊（1）：92-94 
      The relationship between recipient cytokine TNF-αand IL-10 gene polymorphysim and acute biological rejection after liver transplantation  Transplantation International  2009  22 suppl 2:253 
    彭承宏 邓侠兴 金佳斌  胰头癌胰十二指肠切除难点与争议  中华普外科手术学杂志  2009  3（1）：13-14 
      受体细胞因子TGF-β1和TNF-α的基因多态性与肝移植急性生物学排斥的关系  外科理论与实践  2008  13(4)：334-337