• 基本信息
    导师姓名： 许大康 学科代码： 100208
    性别： 男 学科名称： 临床检验诊断学
    培养单位： 附属瑞金医院 三级学科
    导师类型： 博士生导师 专业领域名称：
    联系方式： 专业领域代码：
    邮编： 邮箱地址： dakang_xu@163.com
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    许大康，医学博士，研究员，博士生导师，曾获得澳大利亚国家卫生研究项目及健康研究基金的项目资助(NHMRC grant)多项。国家自然科学基金面上项目五项（12，14，16，18，20年）。担任国际著名期刊: Frontiers in Oncology, Clinical and Experimental Pharmacology and Physiology (CEPP) 的副主编。已发表SCI论文70余篇，其中第一及通讯作者占20篇以上，多篇论文发表在国际重要核心刊物如 Immunity, EMBO J和Nature Immunology , Nature communication , Proc. NatI. Acad. Sci（PNAS）, Cancer Res等学术期刊上。作为主编，于2017年在Springer Nature 出版社出版了免疫学专著《Regulation of Inflammatory Signaling in Health and Disease》。
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    82071811PLZF调控ASC炎症小体参与类风湿性关节炎发病的分子机制及其靶点干预国家自然科学基金面上项目 2021-01~2024-12 55万元  课题负责人
    81871274探讨锌指家族转录因子对系统性红斑狼疮患者I型干扰素基因特征的调控和疾病的影响国家自然科学基金面上项目 2019-01~2022-12 57万元  课题负责人
    31670905感染性疾病中炎症信号通路的选择性调控国家自然科学基金面上项目 2017-01~2020-12 60万元  课题负责人
    81472655ATF3负向调控炎症和肿瘤进展的机制及其抗肿瘤治疗作用研究国家自然科学基金面上项目 2015-01~2018-12 72万元  课题负责人
    81273247转录因子PLZF在干扰素IFN调控抗病毒感染中的作用国家自然科学基金面上项目 2013-01~2016-12 70万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Guan Y, Du Y, Wang G, Gou H, Xue Y, Xu J, Li E, Chan DW, Wu D, Xu P, Ni P,, Hu Y*  Overexpression of PLXDC2 in Stromal Cell-Associated M2 Macrophages Is Related to EMT and the Progression of Gastric Cancer  Front Cell Dev Biol  2021  Front Cell Dev Biol 
    Liu C, Deng L, Lin J, Zhang J, Huang S, Zhao J, Jin P, Xu P, Ni P,, Ying L*, Hu Y*.   Zinc Finger Protein CTCF Regulates Extracellular Matrix (ECM)-Related Gene Expression Associated With the Wnt Signaling Pathway in Gastric Cancer  Front Oncol.  2021  16;10:625633 
    Li E, Yang X, Du Y, Wang G, Chan DW, Wu D, Xu P, Ni P,, Hu Y*  CXCL8 Associated Dendritic Cell Activation Marker Expression and Recruitment as Indicators of Favorable Outcomes in Colorectal Cancer  Front Immunol  2021  7;12:667177. 
    Wu K, Lin K, Li X, Yuan X, Xu P, Ni P,  Redefining tumor-associated macrophage subpopulations and functions in the tumor microenvironment  Frontiers in Immunology  2020  4;11:1731 
    Ying L, Yan F, Meng Q, Yu L, Yuan X, Gantier MP, Williams BRG, Chan DW, Shi L,Tu Y, Ni P, Wang X, Chen W, Zang X,  PD-L1 expression is a prognostic factor in subgroups of gastric cancer patients stratified according to their levels of CD8 and FOXP3 immune markers.  Oncoimmunology.   2018  20;7(6):e1433520 
    Vasanthakumar A#,, Lun AT, Kueh AJ, van Gisbergen KP, Iannarella N, Li X, Yu L, Wang D, Williams BR, Lee SC, Majewski IJ, Godfrey DI, Smyth GK, Alexander WS, Herold MJ, Kallies A, Nutt SL, Allan RS.  A non-canonical function of Ezh2 preserves immune homeostasis.  EMBO Rep.   2017  18(4):619-631. 
    Ying L, Yan F, Meng Q, Yuan X, Yu L, Williams BRG, Chan DW, Shi L, Tu Y, Ni P,Wang X,  Understanding immune phenotypes in human gastric disease tissues by multiplexed immunohistochemistry.  J Transl Med   2017  12;15(1):206. 
      Regulation of Inflammatory Signalling in Health and Disease  Advances in Experimental Medicine and Biology  2017  Book series  
    Sadler AJ, Rossello FJ, Yu L, Deane JA, Yuan X, Wang D, Irving AT, Kaparakis-Liaskos M, Gantier MP, Ying H, Yim HC, Hartland EL, Notini AJ, de Boer S, White SJ, Mansell A, Liu JP, Watkins DN, Gerondakis S, Williams BR,  BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs  Proc Natl Acad Sci U S A  2015  112(5):1535-40 
    Sadler AJ, Suliman BA, Yu L, Yuan X, Wang D, Irving AT, Sarvestani ST,Banerjee A, Mansell AS, Liu JP, Gerondakis S, Williams BR,  The acetyltransferase HAT1 moderates the NF-κB response by regulating the transcription factor PLZF  Nat Commun.  2015  Apr 13;6:6795. doi:10.1038/ncomms7795.  
    De Nardo D, Labzin LI, Kono H, Seki R, Schmidt SV, Beyer M,, Zimmer S,Lahrmann C, Schildberg FA, Vogelhuber J, Kraut M, Ulas T, Kerksiek A, Krebs W,Bode N, Grebe A, Fitzgerald ML, Hernandez NJ, Williams BR, Knolle P, Kneilling M, R?cken M, Lütjohann D, Wright SD, Schultze JL, Latz E.  High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3.   Nat Immunol  2014  15(2):152-60 
    Li Y, Song W, Wu J, Zhang Q, He J, Li A, Qian J, Zhai A, Hu Y, Kao W, Wei L, Zhang F*,  MAVS-mediated host cell defense is inhibited by Borna disease virus.  Int J Biochem Cell Biol   2013  45:1546-55. 
    Yuan X, Yu L, Li J, Xie G, Rong T, Zhang L, Chen J, Meng Q, Irving A, Wang D, Williams ED, Liu JP, Sadler AJ, Williams BR, Shen L*,  ATF3 suppresses metastasis of bladder cancer by regulating gelsolin-mediated remodelling of the actin cytoskeleton.  Cancer Res.  2013  73:3625-37 
    Yuan X, Zhou Y, Wang W, Li J, Xie G, ZhaoY,, and Shen L*   Activation of TLR4 signaling promotes gastric cancer progression by inducing mitochondrial ROS production   Cell Death & Disease  2013  12;4:e794 
    Ma Y, Yuan X, Deng L, Xu W, Zheng Y, Yue C, Zhang G, Xie F, Yang YH, Gantier MP, Liu J,  Imbalanced Frequencies of Th17 and Treg cells in Acute Coronary Syndromes Are Mediated by IL-6-STAT3 Signaling   PLoS One.  2013  26;8(8):e72804. 
    Zheng Y, Wang Z, Deng L, Yuan X, Ma Y, Zhang G, Gantier MP, Liu JP, Shen L* ,  Osteopontin promotes inflammation in patients with acute coronary syndrome through its activity on IL-17 producing cells.  Eur J Immunol.  2012  42:2803-14 
    Irving AT, Wang D, Vasilevski O, Latchoumanin O, Kozer N, Clayton AH, Szczepny A, Morimoto H,, Williams BR, Sadler AJ.   Regulation of actin dynamics by protein kinase R control of gelsolin enforces basal innate immune defense.  Immunity   2012  25;36(5):795-806 
    Pan X, Yuan X, Zheng Y, Wang W, Shan J, Lin F, Jiang G, Yang Y, Liu JP,  Increased CD45RA+ FoxP3(low) regulatory T cells with impaired suppressive function in patients with systemic lupus erythematosus  PLoS ONE   2012  7(4):e34662. 
    Yuan X, Chen L, Li M., Dong P, Xue J, Wang J., Zhang T, Wang X., Zhang F, Ge H, Shen L* and Xu,  Elevated expression of Foxp3 in tumor-infiltrating Treg cells suppresses T-cell proliferation and contributes to gastric cancer progression in a COX-2-dependent manner  Clin Immunol   2010  134(3), 277-88 
    Shen L,Wang J,Shen D,Yuan X,Dong P,Li M,Xue J,Zhang F,Ge H*,  CD4(+)CD25(+)CD127(low/-) regulatory T cells express Foxp3 and suppress effector T cell proliferation and contribute to gastric cancers progression  Clin Immunol  2009  131(1):109-18 
    , Holko M, Sadler AJ, Scott B, Higashiyama S, Berkofsky-Fessler W, McConnell MJ, Pandolfi PP, Licht JD and Williams BR  Promyelocytic leukemia zincfinger protein regulates interferon-mediated innate immunity.  Immunity  2009  19;30(6):802-16. 
    , Dwyer J, Li H, Duan W and Liu JP*.  Ets2 maintains hTERT gene expression and breast cancer cell proliferation by interacting with c-Myc.   J Biol Chem.   2008  29;283(35):23567-80. 
    Li H#,, Li J, Berndt MC, Liu JP.   Transforming growth factor beta suppresses human telomerase reverse transcriptase (hTERT) by Smad3 interactions with c-Myc and the hTERT gene.  J Biol Chem.   2006  1;281(35):25588-600 
    , Wilson TJ, Chan D, De Luca E, Zhou J, Hertzog PJ and Kola I.  Ets1 is required for p53 transcriptional activity in UV-induced apoptosis in embryonic stem cells  EMBO J  2002  1;21(15):4081-93