- 基本信息
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导师姓名：
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徐璐
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学科代码：
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100700
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性别：
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女
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学科名称：
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药学
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培养单位：
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基础医学院
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三级学科
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导师类型：
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硕士生导师
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专业领域名称：
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联系方式：
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luxupharm@163.com
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专业领域代码：
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邮编：
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邮箱地址：
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luxuluxu@yahoo.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
- 科研项目
| 81773747 | miR-483-3p调控上皮间质转化在非小细胞肺癌EGFR TKI获得性耐药和转移中的作用及机制 | 国家自然基金 |
2018-01~2021-12
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55万元
| 课题负责人 |
| 81372522 | IGF1R信号通路在非小细胞肺癌EGFR TKI 耐药性产生中的作用及调控机制 | 国家自然基金 |
2014-01~2017-12
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70万元
| 课题负责人 |
| 12140901400 | 肺癌动物模型的建立和应用 | 上海市科委 |
2012-11~2014-09
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40万元
| 课题负责人 |
| 12ZR1416000 | IGF1R信号通路在肺腺癌和肺腺癌干细胞对EGFR TKI靶向治疗耐药中的作用及机制 | 上海市科委 |
2012-07~2015-06
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10万元
| 课题负责人 |
- 学术论文
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Ling Li, Mengdi Hu,Tao Wang, Hongzhuan Chen*,
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Repositioning aspirin to treat lung and breast cancers and overcome acquired resistance to targeted therapy
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Frontiers in Oncology
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2020
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14;9:1503
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Caiyun Wang, Tao Wang, Dacheng Lv, Ling Li, Jinnan Yue, Hongzhuan Chen*,
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Acquired resistance to EGFR TKIs mediated by TGF-b1/integrinb 3 signaling in EGFR-mutant lung cancer
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Molecular Cancer Therapeutics
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2019
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18(12):2357-2367
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Yue J,Lv D,Wang C,Li L,Zhao Q, Chen H*,
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Epigenetic silencing of miR-483-3p promotes acquired gefitinib resistance and EMT in EGFR-mutant NSCLC by targeting integrin b3
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Oncogene
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2018
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37(31):4300-4312
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Li L, Gu X, Yue J, Zhao Q, Lv D, Chen HZ*,
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Acquisition of EGFR TKI resistance and EMT phenotype is linked with activation of IGF1R/NF-κB pathway in EGFR-mutant NSCLC
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Oncotarget
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2017
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8(54): 92240-53
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Zhang C, Ding XP, Zhao QN, Yang XJ, An SM, Wang H,, Zhu L*, Chen HZ*
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Role of a7-nicotinic acetylcholine receptor in nicotine-induced invasion and epithelial-to-mesenchymal transition in human non-small cell lung cancer cells.
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Oncotarget
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2016
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7(37): 59199-208
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Zhao Q, Yue J, Zhang C, Gu X, Chen H*,
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Inactivation of M2 AChR/NF-κB signaling axis reverses epithelial-mesenchymal transition (EMT) and suppresses migration and invasion in non-small cell lung cancer (NSCLC)
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Oncotarget
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2015
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6(30):29335-46
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Zhao Q,Gu X,Zhang C,Lu Q,Chen H*,
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Blocking M2 muscarinic receptor signaling inhibits tumor growth and reverses epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC)
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Cancer Bio Ther
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2015
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16(4): 634-43
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,Kikuchi E,Xu C,Ebi H,Ercan D,Cheng KA,Padera R, Engelman JA,J?nne PA,Shapiro GI,Shimamura T,Wong KK.
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Combined EGFR/MET or EGFR/HSP90 Inhibition Is Effective in the Treatment of Lung Cancers Codriven by Mutant EGFR Containing T790M and MET.
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Cancer Res
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2012
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72(13):3302-331
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, Sterling CR, Tank AW
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cAMP-mediated stimulation of tyrosine hydroxylase mRNA translation is mediated by polypyrimidine-rich sequences within its 3’ untranslated region and poly(C)-binding protein 2.
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Mol Pharmacol
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2009
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76(4):872-883
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Chen X*,, Radcliffe P, Sun B, Tank AW.
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Activation of tyrosine hydroxylase mRNA translation by cAMP in midbrain dopaminergic neurons. 73(6): 1816-1828.
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Mol Pharmacol
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2008
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73(6):1816-1828
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, Chen X, Sun B, Sterling C, Tank AW.
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Evidence for regulation of tyrosine hydroxylase mRNA translation by stress in rat adrenal medulla.
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Brain Res
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2007
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1158():1-10
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Sun B, Chen X,, Sterling C, Tank AW.
66(4): 1011-1021.
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Chronic nicotine treatment leads to induction of tyrosine hydroxylase in locus ceruleus neurons: the role of transcriptional activation.
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Mol Pharmacol
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2004
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66(4):1011-1021
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