- 基本信息
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导师姓名：
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陈晟
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学科代码：
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100204
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性别：
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男
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学科名称：
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神经病学
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培养单位：
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附属瑞金医院
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三级学科
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导师类型：
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博士生导师
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专业领域名称：
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神经病学 专业学位
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联系方式：
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专业领域代码：
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105104
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邮编：
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邮箱地址：
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mztcs@163.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
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中国医师协会杰出青年神经科医师
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Frontiers in Molecular Neuroscience客座主编;The Lancet, Nature Medicine 杂志审稿人;Brain中文版青年编委 ;中国现代神经疾病杂志编委
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上海市医学会神经内科分会青年委员
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Member of American Academy of Neurology; Member of The Movement Disorder Society (MDS)
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中国医师协会神经内科医师分会神经免疫疾病专业委员会委员
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上海交通大学医学院附属瑞金医院神经科副主任 主任医师 博士后合作导师
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上海市免疫学会神经内免疫业委员会副主任委员
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美国ECFMG注册医师
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上海市医师协会罕见病分会委员
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中国卒中学会神经免疫专委会委员
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上海市医学会神经内科分会免疫遗传学组成员
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上海高校特聘教授 东方学者
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上海交通大学晨星学者、上海交通大学医学院上药杏林育才奖获得者
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Lancet主刊, Nature Medicine审稿人
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Aging and neurodegenerative disease杂志编委
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中华医学会神经内科分会神经免疫学组成员
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上海市曙光学者
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中国罕见病联盟自身免疫性脑炎专委会 常委
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- 科研项目
| 无 | DPA714 PET/M RI在抗体阴性的自身免疫性小脑炎诊断和预后评估中的应用 | 生命绿洲神经系统免疫性疾病合作课题 |
2024-01~2026-02
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10万元
| 课题负责人 |
| 上海东方学者特聘教授 | 自身免疫性脑炎创新影像诊断方法研究 | 上海东方学者特聘教授 |
2023-10~2026-10
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100万元
| 课题负责人 |
| 82271383 | IgLON5抗体介导中枢神经系统损伤表型探索及机制研究 | 国家自然科学基金面上项目 |
2023-01~2026-12
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52万元
| 课题负责人 |
| 2019044 | 自身免疫性脑炎发病机制的研究 | 上海市人才发展基金 |
2019-10~2021-10
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30万元
| 课题负责人 |
| 上海市青年拔尖人才 | 自身免疫性脑炎分子机制研究 | 上海市青年拔尖人才 |
2019-01~2022-01
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15万元
| 课题负责人 |
| 18SG15 | 自噬激活剂在肌萎缩侧索硬化自噬靶向治疗中的转化研究 | 上海教委曙光学者计划 |
2019-01~2021-01
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15万元
| 课题负责人 |
| 20181802 | 上海交通大学医学院高原学科研究型医师 | 上海交通大学 |
2018-11~2021-11
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100万元
| 课题负责人 |
| 上海交通大学医学院优青推进 | 运动神经元疾病表观遗传相关机制的研究 | 上海交通大学医学院优青推进 |
2018-01~2018-12
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5万元
| 课题负责人 |
| 81671241 | 线粒体自噬在肌萎缩侧索硬化发病中的作用及其表观遗传学机制研究 | 国家自然科学基金面上项目 |
2017-01~2020-01
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58万元
| 课题负责人 |
| 15QA1403000 | ALS新型药物筛选平台的建立及其 在ALS相关自噬激活剂筛选中的应用和验证 | 上海市青年科技启明星 |
2015-03~2018-06
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20万元
| 课题负责人 |
| YG2014MS54 | 帕金森病运动障碍的量化诊断与康复治疗新技术 | 上海交通大学医工交叉项目 |
2014-03~2017-03
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20万元
| 课题负责人 |
| 81200977 | 肌萎缩侧索硬化中自噬通量异常的发生机制及HDAC6靶向治疗研究 | 国家自然科学基金青年项目 |
2013-01~2015-12
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26万元
| 课题负责人 |
| BXJ201218 | 过表达VCP通过促进自噬对肌萎缩侧索硬化模型小鼠的神经保护作用研究 | 上海交通大学博士点创新基金 |
2012-01~2013-01
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3万元
| 课题负责人 |
| 教育部新教师基金项目 | D2/D3受体激动剂对蛋白酶体抑制剂介导多巴胺能细胞损伤保护作用的研究 | 教育部新教师基金项目 |
2009-06~2011-06
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3万元
| 课题负责人 |
- 学术论文
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Zhang M, Meng HY, Zhou QM, ChunYu HX, He L, Meng HP, Wang HZ, Wang Y, Sun CW, Xi Y, Hai WX, Huang Q, Li B,
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Translocator protein radioligand 18F-DPA714 PET for detecting autoimmune encephalitis in patients from East Asia
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Radiology
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2024
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310(3):e230397
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He L,Zhou QM,Xiu CY,Shao YP,Shen DD,Meng HY,Le WD,
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Circulating proteomic biomarkers for diagnosing sporadic amyotrophic lateral sclerosis: a cross-sectional study
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Neural Regeneration Research
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2024
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2024 Aug 1;19(8):1842-1848
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Yining Gao, Yizongheng Zhang, Hangxing Chunyu,Yongfeng Xu, Ying Wang, Suzhi Liu, Jie Chang, Bo Tang, Congying Xu,Yi Lu, Jian Zhou, Xiangyong Kong, Xiaoying Zhu,Qinming Zhou, Huanyu Meng,
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Expanding the clinical spectrum of anti-DPPX encephalitis: a multicenter retrospective study.
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Front. Neurosci.
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2024
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18:1379933.
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Zhang-Yi ZH, Ni Y, Gao YN, Yin D, Meng HY, Zhou QM, Hu J,
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Perspective of anti-IgLON5 disease from clinic practice to basic research: a novel topic beyond neuroimmunology Neural Regeneration Research
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Neural Regeneration Research
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2023
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18(5):1017-1022.
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Zhou QM, Yin D, Ma JF,
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The therapeutic effect of Ofatumumab in autoimmune encephalitis: a case series
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Journal of Neuroimmunology
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2023
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JNI_578062 in press
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SCREAM Study Investigators
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A multicentre, prospective, double-blind study comparing the accuracy of autoantibody diagnostic assays in myasthenia gravis: the SCREAM study
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The Lancet Regional Health -Western Pacific
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2023
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2023;38: 100846
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Hai-rong Peng,Jia-Qian Qiu, Qin-ming Zhou, Yu-kai Zhang, Qiao-yu Chen, Yan-qing Yin, Wen Su, Shui Yu, Ya-ting Wang, Yu-ping Cai, Ming-na Gu, Hao-hao Zhang, Qing-qing Sun, Gang Hu, Yi-wen Wu, Jun Liu,, Zheng-Jiang Zhu*, Xin-yang Song*,Jia-wei Zhou*
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An intestinal epithelium-dependent gut-brain axis confers risk for CNS autoimmune diseases
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Immunity
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2023
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56,1-17; https://doi.org/10.1016/j.immuni.2023.10.016
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Shen DD, Zhou QM, Meng HY, Zhang M, Peng LS,
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Image Features of Anti-SEZ6L2 Encephalitis, a Rare Cause of Ataxia and Parkinsonism
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Journal of Neurology
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2023
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https://doi.org/10.1007/s00415-023-11756-5
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Huanyu Meng, Qinming Zhou,
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Neurological complications of COVID-19 and SARS-CoV-2 vaccination: an update
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Ageing and Neurodegenerative Diseases
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2023
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In press
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Zhang YZH, Zhou QM, Peng LS,
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Increased cerebellum 18F-DPA-714 uptake in anti-Gluk2-autoimmune encephalitis
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Annals of Neurology
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2023
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93, 635-36
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张仪纵横,
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从IgLON5抗体看神经免疫与神经变性间的联系
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诊断学理论与实践
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2023
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21（6）
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Sijia Du, Cheng Yuan, Qinming Zhou, Xinyun Huang, Hongping Meng, Meidi Chen, Hanzhong Wang, Qiu Huang, Suncheng Xiang, Dahong Qian, Biao Li,, Ming Zhang
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Deep Learning-based PET/MR radiomics for the prediction of annualized relapse rate in multiple sclerosis
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Multiple Sclerosis and Related Disorders
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2023
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104750
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Yining Gao, Hongxia Li, Huoqing Luo, You Ni, Yifan Feng, Lu He,
Qinming Zhou, Ji Hu,
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Anti-IgLON5 antibodies cause long-term movement disorders with impaired dopaminergic pathways
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Biomedicines
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2023
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11, 2483
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Yining Gao, Jie Pan, Dingding Shen, Lisheng Peng, Zhifeng Mao,
Chunxia Wang, Huanyu Meng, Qinming Zhou,
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Immune checkpoint inhibitor associated autoimmune encephalitis, rare and novel topic of neuroimmunology: a case report and review of the literature
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Brain sciences
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2022
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12:773
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Ruinan Shen, Dingding Shen, Qinming Zhou, Min Zhang,
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Antibody-mediated autoimmune encephalitis evaluated by 18 F-DPA714 PET/MRI
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Brain, Behavior, & Immunity - Health
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2022
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26,100535
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Ni Y,Yang Z,Zhou QM,Meng HY,Liu J,Zhou HY,
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The clinical and neuroimaging features of sporadic neuronal intranuclear inclusion disease
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Canadian Journal of Neurological Sciences
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2022
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Published online by Cambridge University Press: 07 February 2022
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Meng H, Zheng S, Zhou Q, Gao Y, Zhang M,
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Hybrid 18F-florbetapir PET/MRI for assessing myelin recovery in GFAP-A
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Translational Neuroscience
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2022
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13: 120–124
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YOU NI,Yifan Feng,Dingding Shen,Ming Chen,Xiaona Zhu,Qinming Zhou, Yining Gao, Jun Liu, Qi Zhang, Yuntian Shen, Lisheng Peng, Zike Zeng, Dou Yin, Ji Hu,
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Anti-IgLON5 antibodies cause progressive behavioral and neuropathological changes in mice
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Journal of Neuroinflammation
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2022
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19:140
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Guo WT, Zou ZY, Leng Y, Sheng D,
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Editorial: Current Concept and Translational Study in ALS–FTD Spectrum: from Genetics, Neuroinflammation to Neurodegeneration
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Frontiers in Molecualr Neuroscience
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2022
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935115
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Qinming Zhou, Tianxiao Zhang, Huanyu Meng, Dingding Shen, Yao Li, Lu He, Yining Gao, Yizongheng Zhang, Xinyun Huang, Hongping Meng, Biao Li, Min Zhang*,
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Characteristics of cerebral blood flow in an Eastern sample of multiple sclerosis patients: a potential quantitative imaging marker associated with disease severity
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Frontiers in immunology
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2022
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2022, 1025908
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,张仪纵横,沈丁玎,周勤明
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论自身免疫性脑炎责任抗体的致病性
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中国现代神经疾病杂志
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2022
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22: 1-7
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Zhao Yang, Lu He, Manli Ren, Yizhou Lu, Huanyu Meng, Dou Yin,, Qinming Zhou *
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Paraneoplastic amyotrophic lateral sclerosis: case series and literature reviews
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Brain sciences
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2022
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12, 1053
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You Ni, Dingding Shen, Ying Zhang, Yaying Song, Yining Gao, Qinming Zhou, Dou Yin, Ying Wang, Fan Song, Meiyuan Chen, Yajun Lian, Yuan Chen, Xing Zhao, Xiang Zhang, Xiangjun Chen, Zhifeng Mao, Lisheng Peng,
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Expanding the clinical spectrum of anti-IgLON5 disease: A multicenter retrospective study
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European Journal of Neurology
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2022
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29(1), pp. 267–276
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Qinming Zhou, Lu He, Jin Hu, Yining Gao, Dingding Shen, You Ni, Yuening Qin, Huafeng Liang, Jun Liu, Weidong Le,
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Elevated expression of Coronin-1a in ALS: a potential diagnostic biomarker and therapeutic target
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Frontiers of Medicine
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2022
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Published: 01 June 2022
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|
Min Zhang1*, You Ni2*, Qinming Zhou2*, Lu He2, Huanyu Meng2, Yining Gao2, Xinyun Huang1, Hongping Meng1, Peihan Li3, Meidi Chen3, Danni Wang4, Jingyi Hu4, Qiu Huang1,3, Yao Li1,4, Fabien Chauveau5, Biao Li1#,
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18F-florbetapir PET/MRI for quantitatively monitoring myelin loss and recovery in patients with multiple sclerosis：A longitudinal study
|
EclinicalMedicine（Lancet子刊）
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2021
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37, 100982
|
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Huanyu Meng,Shuyu Zheng,Qinmin Zhou,Yining Gao,You Ni,Huafeng Liang,
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FoxP3- Tr1 cell in generalized myasthenia gravis and its relationship with the anti-AChR antibody and immunomodulatory cytokines
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Frontiers in Neurology
|
2021
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755356
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卢逸舟,
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自身免疫性脑炎的诊断进展（约稿，述评）
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重庆医科大学学报
|
2021
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已接受
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Xiaojiao Xu,Dingding Shen,Yining Gao,Qinming Zhou,You Ni,Huanyu Meng, Hongqin Shi, Weidong Le, Shengdi Chen,
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A perspective on therapies for amyotrophic lateral sclerosis: can disease progression be curbed?
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Translational Neurodegeneration
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2021
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10(1), 29
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陈向军,李海峰,邱伟,徐雁,
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神经免疫疾病与责任抗体
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中国神经免疫学和神经病学杂志
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2021
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2021年7月第28卷第4期
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Yin D,, Liu J
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Sleep disturbances in autoimmune neurologic diseases:manifestation and pathophysiology
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Frontiers in Neuroscience
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2021
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15, 687536
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Zhou QM, Zhu X, Meng H, Zhang M,
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Anti-dipeptidyl-peptidase-like protein 6 encephalitis, a rare cause of reversible rapid progressive dementia and insomnia
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J. Neuroimmunol
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2020
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Feb 15;339-345
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Zhou LC, Luan XH,
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Encephalitic episodes followed by leukoencephalopathy: A novel indication for neuronal intranuclear inclusion body disease
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Journal of Clinical Neurology
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2020
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16(3), pp. 494–496
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Meng HY, Zhou QM, Ni Y,
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Anti-Ma encephalitis masquerading as Wernicke encephalopathy
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Journal of clinical neuroscience
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2020
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79, pp. 160–162
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, 周勤明, 倪优
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开启神经免疫领域新征程（述评）
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中国现代神经疾病杂志
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2020
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20 (9): 757-759
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, Xiaojie Zhang, Yining Gao, and Weidong Le
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Parkinsonian Drugs in China
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NeuroPsychopharmacotherapy,Springer Nature Switzerland AG 2020
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2020
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待出版
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,周勤明,倪优,刘军
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自身免疫性脑炎的昨天，今天和明天（述评）
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中国现代神经疾病杂志
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2020
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2020年1月第20卷第1期
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周勤明,
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抗DPPX脑炎临床特征分析
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中国现代神经疾病杂志
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2020
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20(10)：862-867
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, Zhou QM, Ni Y, Le W
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Autophagy
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Adv. Exp. Med. Biol.
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2020
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1207
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Jia C, Qi H, Cheng C, Wu X, Yang Z, Cai H,, Le W,
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α-Synuclein Negatively Regulates Nurr1 Expression Through NF-κB-Related Mechanism.
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Front Mol Neurosci
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2020
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13:1-9
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石红琴, 孟环宇, 梁华峰,
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免疫相关运动障碍临床研究进展
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中国现代神经疾病杂志
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2020
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20 (9): 766-772
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Sheng DD, Zhou HY,
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Spasms and Myoclonus in a Young Woman With Hashimoto Thyroiditis
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JAMA Neurology
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2020
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77(5), pp. 650–651
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Hua Zhao, Dingding Shen,Haiyan Zhou, Jun Liu,
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Guillain-Barré syndrome associated with SARS-CoV-2 infection: causality or coincidence?
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Lancet Neurology
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2020
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April 1 online
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陆翠, 蔡勇, 赵迎春, 张鹏, 薛冬梅, 周水阳,
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慢性进展型神经白塞综合征临床特点分析
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中国现代神经疾病杂志
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2019
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19 (6): 437-442
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Yao MS,, Liu J
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Cowden syndrome, presenting with autoimmune encephalitis
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Neurology
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2019
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93:813-816
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倪优,
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抗N-甲基-D-天冬氨酸受体脑炎发病机制及临床研究进展
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上海交通大学学报（医学版）
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2019
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39：1095-1099
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Zhang M, Liu J, Li B,
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18F-florbetapir PET/MRI for quantitatively monitoring demyelination and remyelination in acute disseminated encephalomyelitis.
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EJNMMI Research
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2019
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Nov 12;9(1): 96-99
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Shang HY, Zhang JJ, Fu ZF, Liu YF, Li S,, Le WD
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Therapeutic effects of hirsutella sinensis on the disease onset and progression of amyotrophic lateral sclerosis in SOD1G93A transgenic mouse model.
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CNS Neurosci Ther
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2019
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18: 1-12
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Zhang XJ,, Le W, Zhao YW
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Verapamil Ameliorates Motor Neuron Degeneration and Improves Lifespan in the SOD1 Mouse Model of ALS by Enhancing Autophagic Flux.
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Aging and Disease
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2019
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10(6): 1159-1173
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Zhang JJ, Liu YF, Liu XY, Li S,
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Dynamic changes of CX3CL1/CX3CR1 axis during microglial activation and motor neuron loss in the spinal cord of ALS mouse model
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Translational Neurodegeneration
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2018
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7:35-55
|
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Zhang JJ, Zhou QM,, Le WD.
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Repurposing carbamazepine for the treatment of amyotrophic lateral sclerosis in SOD1-G93A mouse model.
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CNS Neurosci Ther
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2018
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24(12): 1163-1174
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, Yao M and Yuan F
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A 66-year-old woman with progressive dementia.
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Brain Pathology
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2018
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2018 Sep;28(5):779-781
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高丹宇 陈晟（通讯作者）
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双侧延髓内侧梗死的临床特征(附1例报道及国内文献分析)
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卒中与神经疾病杂志
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2018
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2018（1）
|
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高丹宇 赵迎春 袁菲 陈晟（通讯作者）
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大脑胶质瘤病临床分析(1例报告并文献复习)
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中风与神经疾病杂志
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2017
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34(6): 548-550
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|
Lin Y, Yuan F,
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Leptomeningeal carcinomatosis 9 years after nodule resection for pulmonary carcinoma in situ: MRS and pathological studies.
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J Neurooncol.
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2017
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134(2):469-471
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Zhou QM, Zhang JJ, Li S,, Le WD
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n-butylidenephthalide treatment prolongs life span and attenuates motor neuron loss in SOD1G93A mouse model of amyotrophic lateral sclerosis.
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CNS Neurosci Ther
|
2017
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23(5):375-385
|
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,Yao MS, Liu J, Jia CF
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Anti-N-methyl-d-aspartate receptor autoimmune encephalitis with sensory attack. Is limbic encephalitis only “limbic”?
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Neuroimmunol Neuroinflammation
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2017
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4:78-81
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, Zhang XJ, Xie WJ, Qiu HY, Liu H, Le WD
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A New VMAT-2 Inhibitor NBI-641449 in the Treatment of Huntington Disease.
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CNS Neurosci Ther.
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2015
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21(8):662-71
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, Zhang XJ, Li LX, Wang Y, Zhong RJ, Le W
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Histone deacetylase 6 delays motor neuron degeneration by ameliorating the autophagic flux defect in a transgenic mouse model of amyotrophic lateral sclerosis.
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Neurosci Bull.
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2015
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31(4):459-68;
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Zhang X,, Song L, Tang Y, Shen Y, Jia L, Le W
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MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis
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Autophagy
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2014
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10(4):588-60
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, Luo GR, Li T, Liu TX, Le W.
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Correlation of Nr4a2 expression with the neuron progenitors in adult zebrafish brain.
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J Mol Neurosci
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2013
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51(3):719-23
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, Sayana P, Zhang X, Le W.
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Genetics of amyotrophic lateral sclerosis: an update.
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Mol Neurodegener.
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2013
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8(1):28
|
|
, Zhang X, Song L and Le w
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Autophagy dysregulation in amyotrophic lateral sclerosis.
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Brain Pathology
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2012
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22(1):110-6
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Zhang XJ,, Yang DH, Wang Y, Zhang X, Wang Z, Le WD
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Rapamycin treatment augments motor neuron degeneration in SOD1G93A mouse model of amyotrophic lateral sclerosis.
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Autophagy
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2011
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7(4):1-14.
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Zhang XJ,, Li L, Wang Q, Le WD.
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Decreased level of 5-methyltetrahydrofolate: a potential biomarker for pre-symptomatic amyotrophic lateral sclerosis.
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Journal of the Neurological Sciences.
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2010
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293(1-2):102-105
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