- 基本信息
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导师姓名：
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沈键锋
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专业代码：
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100212
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性别：
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男
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专业名称：
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眼科学
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培养单位：
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附属第九人民医院
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三级学科/
专业领域：
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导师类型：
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博士生导师
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专业学位导师：
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联系方式：
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上海市眼眶病眼肿瘤重点实验室，
黄浦区制造局路833弄12号楼3楼309室，
电子邮件： jfshen@shsmu.edu.cn
实验室网页（建设中）：www.shenlab.org.cn
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邮编：
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200011
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邮箱地址：
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darkingfeng@hotmail.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
- 科研项目
| 001 | DNA损伤修复与肿瘤免疫调控 | 国家高层次人才计划 |
2020-01~2022-12
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300万元
| 课题负责人 |
| 81972667 | 聚ADP核糖聚合酶1调控STING信号通路影响肿瘤免疫的机理研究 | 国家自然科学基金面上项目 |
2020-01~2023-12
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55万元
| 课题负责人 |
| 20191817 | "双百人”-临床专职科研队伍 | 上海交通大学医学院 |
2019-10~2022-09
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100万元
| 课题负责人 |
| 002 | 上海交通大学医学院基金 | 引进人才启动经费 |
2019-04~2024-03
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300万元
| 课题负责人 |
- 学术论文
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, Wei Zhao, Zhenlin Ju, Lulu Wang, Yang Peng, Marilyne Labrie, Timothy A. Yap, Gordon B. Mills,Guang Peng
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PARPi Triggers the STING-Dependent Immune Response and Enhances the Therapeutic Efficacy of Immune Checkpoint Blockade Independent of BRCAness
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Cancer Research
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2019
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79(2) January 15
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, Zhenlin Ju, Wei Zhao, Lulu Wang, Yang Peng, Zhongqi Ge, Zachary D. Nagel, Jun Zou, Chen Wang, Prabodh Kapoor, Xiangyi Ma, Ding Ma, Jiyong Liang, Jingsong Liu, Leona D. Samson, Guo-Min Li, Han Liang, Xuetong Shen, Gordon B. Mills, Guang Peng
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ARID1A deficiency promotes mutability and potentiates anti-tumor immunity unleashed by immune checkpoint blockade
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Nature Medicine
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2018
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Vol 24, 556-562
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Xiaojuan Lin,, Dan Peng, Janos L Tanyi, Kathleen Montone, Qihong Huang, Yi Fan, Lin Zhang, Xiaomin Zhong
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RNA-binding protein LIN28B inhibits apoptosis through regulating the AKT2/FOXO3A/Bim axis in ovarian cancer cells
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Signal Transduction and Targeted Therapy
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2018
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3:23
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Hui-Ju Hsieh, Wei Zhang, Shu-Hong Lin, Wen-Hao Yang, Jun-Zhong Wang,, Yiran Zhang, Yiling Lu, Hua Wang, Jane Yu, Gordon B. Mills,Guang Peng
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Systems biology approach reveals that mTORC1 regulates G2/M DNA damage checkpoint recovery, creating a therapeutic vulnerability in mTOR-hyperactivated tumors
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Nature Communications
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2018
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9:3982
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Kumar S, Peng X, Daley J, Yang L,, Nguyen N, Bae G, Niu H, Peng Y, Hsieh HJ, Wang L, Rao C, Stephan CC, Sung P, Ira G, Peng G
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Inhibition of DNA2 nuclease as a therapeutic strategy targeting replication stress in cancer cells
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Oncogenesis
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2017
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6(4):e319
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Lihong Zhang, Yang Peng, Ivan P.Uray,, Lulu Wang, Xiangdong Peng, Powel H.Brown, Wei Tu, Guang Peng
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Natural product beta-thujaplicin inhibits homologous recombination repair and sensitizes cancer cells to radiation therapy
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DNA Repair
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2017
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60:89-101
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Zhang L,, Yin Y, Peng Y, Wang L, Hsieh HJ, Shen Q, Brown PH, Tao K, Uray IP, Peng G
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Identifying Cell Cycle Modulators That Selectively Target ARID1A Deficiency Using High-Throughput Image-Based Screening
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SLAS Discov
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2017
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22(7):813-826
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Zhong X, Zheng L,, Zhang D, Xiong M, Zhang Y, He X, Tanyi JL, Yang F, Montone KT, Chen X, Xu C, Xiang AP, Huang Q, Xu X, Zhang L
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Suppression of MicroRNA 200 Family Expression by Oncogenic KRAS Activation Promotes Cell Survival and Epithelial-Mesenchymal Transition in KRAS-Driven Cancer
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Mol Cell Biol
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2016
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36(21):2742-2754
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Kapoor P, Bao Y, Xiao J, Luo J,, Persinger J, Peng G, Ranish J, Bartholomew B, Shen X
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Regulation of Mec1 kinase activity by the SWI/SNF chromatin remodeling complex
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Genes Dev
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2015
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29(6):591-602
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, Peng Y, Wei L, Zhang W, Yang L, Lan L, Kapoor P, Ju Z, Mo Q, Shih IeM, Uray IP, Wu X, Brown PH, Shen X, Mills GB, Peng G
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ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors
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Cancer Discovery
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2015
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5(7):752-67
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Jiang Y, Qian X,, Wang Y, Li X, Liu R, Xia Y, Chen Q, Peng G, Lin SY, Lu Z
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Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation
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Nat Cell Biol
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2015
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17(9):1158-68
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Zhang B, Wang E, Dai H,, Hsieh HJ, Lu X, Peng G
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Phosphorylation of the BRCA1 C terminus (BRCT) repeat inhibitor of hTERT (BRIT1) protein coordinates TopBP1 protein recruitment and amplifies ataxia telangiectasia-mutated and Rad3-related (ATR) Signaling
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J Biol Chem
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2014
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289(49):34284-95
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