- 基本信息
导师姓名:
|
沈键锋
|
学科代码:
|
100212
|
|
性别:
|
男
|
学科名称:
|
眼科学
|
培养单位:
|
附属第九人民医院
|
三级学科
|
|
导师类型:
|
博士生导师
|
专业领域名称:
|
|
联系方式:
|
上海市眼眶病眼肿瘤重点实验室,
黄浦区制造局路833弄12号楼3楼309室,
电子邮件: jfshen@shsmu.edu.cn
|
专业领域代码:
|
|
邮编:
|
200011
|
邮箱地址:
|
darkingfeng@hotmail.com
|
- 研究方向 (点击浏览详细信息)
- 社会任职
|
Journal of Molecular Cell Biology青年编委
|
中国医药生物技术协会组织生物样本库分会类器官学组委员
|
上海市医学会眼科专科分会视觉研究学组委员
|
中初保肿瘤临床转化研究委员会常委
|
- 科研项目
GKZK6260002/001/009 | 可变剪切调控肿瘤免疫的机制与转化研究 | 转化医学国家重大科技基础设施(上海)开放课题项目 |
2021-01~2022-12
|
50万元
| 课题负责人 |
001 | DNA损伤修复与肿瘤免疫调控 | 国家高层次人才计划 |
2020-01~2022-12
|
300万元
| 课题负责人 |
81972667 | 聚ADP核糖聚合酶1调控STING信号通路影响肿瘤免疫的机理研究 | 国家自然科学基金面上项目 |
2020-01~2023-12
|
55万元
| 课题负责人 |
20191817 | "双百人”-临床专职科研队伍 | 上海交通大学医学院 |
2019-10~2022-09
|
100万元
| 课题负责人 |
002 | 上海交通大学医学院基金 | 引进人才启动经费 |
2019-04~2024-03
|
300万元
| 课题负责人 |
- 学术论文
Zhe Zhang, Chen Li, Qian Li, Xiaoming Su, Jiayi Li, Lili Zhu, Xinhua James Lin,
|
Structure prediction of novel isoforms from uveal melanoma by AlphaFold
|
Sci Data .
|
2023
|
Aug 4;10(1):513
|
Tengteng Yao, Chingchoon Foo, Guopei Zheng, Rui Huang, Qian Li,, Zhaoyang Wang
|
Insight into the mechanisms of coronaviruses evading host innate immunity
|
Biochim Biophys Acta Mol Basis Dis .
|
2023
|
Jun;1869(5):166671
|
Feiyang Shen, Yan Fang, Yijia Wu, Min Zhou,, Xianqun Fan
|
Metal ions and nanometallic materials in antitumor immunity: Function, application, and perspective
|
J Nanobiotechnology
|
2023
|
Jan 19;21(1):20
|
Chunyan Zong, Zhe Zhang, Li Gao, Jie He, Yiran Wang, Qian Li, Xiaoting Liu, Jie Yang, Di Chen, Rui Huang, Guopei Zheng, Xiaoliang Jin, Wu Wei, Renbing Jia,
|
APOBEC3B coordinates R-loop to promote replication stress and sensitize cancer cells to ATR/Chk1 inhibitors
|
Cell Death Dis .
|
2023
|
Jun 3;14(6):348
|
Jie He, Jili Chen,
|
Selamectin increases cisplatin sensitivity by inhibiting cisplatin-resistant genes expression and autophagy in uveal melanoma
|
Biochem Biophys Res Commun .
|
2023
|
Jun 18;661:75-81
|
Zong C, Zhu T, He J, Huang R, Jia R,
|
PARP mediated DNA damage response, genomic stability and immune responses
|
Int J Cancer.
|
2022
|
Epub
|
Jiahao Shi, Xiaoliang Jin, Yihao Wang, Tianyu Zhu, Dongmei Zhang, Qian Li, Xiaomin Zhong, Yaqi Deng,, Xianqun Fan
|
LIN28B inhibition sensitizes cells to p53-restoring PPI therapy through unleashed translational suppression
|
Oncogenesis
|
2022
|
Jul 2;11(1):37
|
Yihao Wang,Rui Huang,Guopei Zheng,
|
Small ring has?big potential: insights into?extrachromosomal DNA in?cancer
|
Cancer Cell International
|
2021
|
(2021) 21:236
|
Min Zhou,Jianlong Yuan,Yaqi Deng,Xianqun Fan,
|
Emerging role of SWI/SNF complex de?ciency as a target of immune checkpoint blockade in human cancers
|
Oncogenesis
|
2021
|
(2021) 10:3
|
, Wei Zhao, Zhenlin Ju, Lulu Wang, Yang Peng, Marilyne Labrie, Timothy A. Yap, Gordon B. Mills,Guang Peng
|
PARPi Triggers the STING-Dependent Immune Response and Enhances the Therapeutic Efficacy of Immune Checkpoint Blockade Independent of BRCAness
|
Cancer Research
|
2019
|
79(2) January 15
|
, Zhenlin Ju, Wei Zhao, Lulu Wang, Yang Peng, Zhongqi Ge, Zachary D. Nagel, Jun Zou, Chen Wang, Prabodh Kapoor, Xiangyi Ma, Ding Ma, Jiyong Liang, Jingsong Liu, Leona D. Samson, Guo-Min Li, Han Liang, Xuetong Shen, Gordon B. Mills, Guang Peng
|
ARID1A deficiency promotes mutability and potentiates anti-tumor immunity unleashed by immune checkpoint blockade
|
Nature Medicine
|
2018
|
Vol 24, 556-562
|
Xiaojuan Lin,, Dan Peng, Janos L Tanyi, Kathleen Montone, Qihong Huang, Yi Fan, Lin Zhang, Xiaomin Zhong
|
RNA-binding protein LIN28B inhibits apoptosis through regulating the AKT2/FOXO3A/Bim axis in ovarian cancer cells
|
Signal Transduction and Targeted Therapy
|
2018
|
3:23
|
Hui-Ju Hsieh, Wei Zhang, Shu-Hong Lin, Wen-Hao Yang, Jun-Zhong Wang,, Yiran Zhang, Yiling Lu, Hua Wang, Jane Yu, Gordon B. Mills,Guang Peng
|
Systems biology approach reveals that mTORC1 regulates G2/M DNA damage checkpoint recovery, creating a therapeutic vulnerability in mTOR-hyperactivated tumors
|
Nature Communications
|
2018
|
9:3982
|
Kumar S, Peng X, Daley J, Yang L,, Nguyen N, Bae G, Niu H, Peng Y, Hsieh HJ, Wang L, Rao C, Stephan CC, Sung P, Ira G, Peng G
|
Inhibition of DNA2 nuclease as a therapeutic strategy targeting replication stress in cancer cells
|
Oncogenesis
|
2017
|
6(4):e319
|
Lihong Zhang, Yang Peng, Ivan P.Uray,, Lulu Wang, Xiangdong Peng, Powel H.Brown, Wei Tu, Guang Peng
|
Natural product beta-thujaplicin inhibits homologous recombination repair and sensitizes cancer cells to radiation therapy
|
DNA Repair
|
2017
|
60:89-101
|
Zhang L,, Yin Y, Peng Y, Wang L, Hsieh HJ, Shen Q, Brown PH, Tao K, Uray IP, Peng G
|
Identifying Cell Cycle Modulators That Selectively Target ARID1A Deficiency Using High-Throughput Image-Based Screening
|
SLAS Discov
|
2017
|
22(7):813-826
|
Zhong X, Zheng L,, Zhang D, Xiong M, Zhang Y, He X, Tanyi JL, Yang F, Montone KT, Chen X, Xu C, Xiang AP, Huang Q, Xu X, Zhang L
|
Suppression of MicroRNA 200 Family Expression by Oncogenic KRAS Activation Promotes Cell Survival and Epithelial-Mesenchymal Transition in KRAS-Driven Cancer
|
Mol Cell Biol
|
2016
|
36(21):2742-2754
|
Kapoor P, Bao Y, Xiao J, Luo J,, Persinger J, Peng G, Ranish J, Bartholomew B, Shen X
|
Regulation of Mec1 kinase activity by the SWI/SNF chromatin remodeling complex
|
Genes Dev
|
2015
|
29(6):591-602
|
, Peng Y, Wei L, Zhang W, Yang L, Lan L, Kapoor P, Ju Z, Mo Q, Shih IeM, Uray IP, Wu X, Brown PH, Shen X, Mills GB, Peng G
|
ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors
|
Cancer Discovery
|
2015
|
5(7):752-67
|
Jiang Y, Qian X,, Wang Y, Li X, Liu R, Xia Y, Chen Q, Peng G, Lin SY, Lu Z
|
Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation
|
Nat Cell Biol
|
2015
|
17(9):1158-68
|
Zhang B, Wang E, Dai H,, Hsieh HJ, Lu X, Peng G
|
Phosphorylation of the BRCA1 C terminus (BRCT) repeat inhibitor of hTERT (BRIT1) protein coordinates TopBP1 protein recruitment and amplifies ataxia telangiectasia-mutated and Rad3-related (ATR) Signaling
|
J Biol Chem
|
2014
|
289(49):34284-95
|
|