• 基本信息
    导师姓名： 王莹 学科代码： 071000
    性别： 女 学科名称： 生物学
    培养单位： 健康科学研究所 三级学科
    导师类型： 硕士生导师 专业领域名称：
    联系方式： 上海市岳阳楼320号新生科大楼A座1111室 专业领域代码：
    邮编： 200031 邮箱地址： yingwang@sibs.ac.cn
  • 研究方向 (点击浏览详细信息)
  • 社会任职
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    81571612CD11b调控巨噬细胞状态对肥胖及其相关的胰岛素抵抗的影响及机制国家自然基金面上项目 2016-01~2019-12 58万元  课题负责人
    2015CB964400造血干细胞移植的免疫学基础研究国家重点基础研究发展计划 2015-01~2019-08 150万元  课题参与人
    14QA1404200I型干扰素调控间充质干细胞抗肿瘤特性及机制上海市青年科技启明星 2014-07~2016-06 20万元  课题负责人
    81273316间充质干细胞在高脂诱导肥胖发病中的作用及机制国家自然基金面上项目 2013-01~2016-12 70万元  课题负责人
    13YZ029Gamma‐氨基丁酸转运蛋白1调节Th17细胞分化及机制上海市教委科研项目一般项目 2013-01~2015-12 8万元  课题负责人
    12ZR1452600脂肪基质干细胞与单核/巨噬细胞的相互作用对高脂诱导肥胖的影响上海市自然基金青年项目 2012-10~2015-09 10万元  课题负责人
    XDA01040110干细胞免疫原性对其生物学行为和应用的影响中国科学院战略性先导专项 2012-07~2015-12 480万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Song J, Wu C, Korpos E, Zhang X, Agrawal S,, Faber C, Schafers M, Korner H, Opdenakker G, Hallmann R, Sorokin L.  Focal MMP-2 and MMP-9 Activity at the Blood-Brain Barrier Promotes Chemokine-Induced Leukocyte Migration.  Cell Reports.  2015  10:1040-54 
    Cao K, Wang G, Li W, Zhang L, Wang R, Huang Y, Du L, Jiang J, Wu C, He X, Roberts AI,, Shi Y*.  Histone deacetylase inhibitors prevent activation-induced cell death and promote anti-tumor immunity.   Oncogene.   2015  doi: 10.1038/onc.2015.46. 
    Zheng C, Yang Q, Xu C, Shou P, Cao J, Jiang M, Chen Q, Cao G, Han Y, Li F, Cao W, Zhang L, Zhang L,Shi Y,  CD11b regulates obesity-induced insulin resistance via limiting alternative activation and proliferation of adipose tissue macrophages  PNAS  2015  E7239–E7248 
    Su J, Chen X, Huang Y, Li W, Li J, Cao K, Cao G, Zhang L, Li F, Robert A, Kang H, Yu P, Ren G, Ji W,, Shi Y*.  Phylogenetic distinction of iNOS and IDO function in mesenchymal stem cell-mediated immunosuppression in mammalian species.   Cell Death and Differentiation.   2014  21(3):388-96 
    Han X, Yang Q, Lin L, Xu C, Zheng C, Chen X, Han Y, Li M, Cao W, Cao K, Chen Q, Xu G, Zhang Y, Zhang J, Schneider RJ, Qian Y,, Brewer G*, Shi Y*.   Interleukin-17 enhances immunosuppression by mesenchymal stem cells.  Cell Death Differ.  2014  21(11):1758-68 
    Ling W, Zhang J, Yuan Z, Ren G, Zhang L, Chen X, Rabson AB, Roberts AI,, Shi Y.   Mesenchymal stem cells use IDO to regulate immunity in tumor microenvironment.  Cancer Res.   2014  74(5):1576-87. 
    Xu C, Yu P, Han X, Du L,, Shi Y.   Transforming growth factor β promotes immune responses in the presence of mesenchymal stem cells.  J Immunol.   2014  192(1):103-9 
    Chen Q, Shou P, Zhang L, Xu C, Zheng C, Han Y, Li W, Huang Y, Zhang X, Shao C, A. Roberts A, Rabson A, Ren G, Zhang Y,, Denhardt D, Shi Y.  Osteopontin plays a critical role in directing adipogenesis and osteogenesis of mesenchymal stem cells.   Stem Cells.   2014  32(2):327-37 
    Cao G, Yang Q, Zhang S, Xu C, Roberts AI, Wang Y*,  Mesenchymal stem cells prevent restraint stress-induced lymphocyte depletion via interleukin-4.   Brain Behav Immun.   2014  38:125-132. 
    Wu C, Chen Q, Fang Y, Wu J, Han Y,, Yang Y, Chu M, Feng Y, Tan L, Guo X, Hu W, Wang Z.  Schistosoma japonicum egg specific protein SjE16.7 recruits neutrophils and induces inflammatory hepatic granuloma initiation.  PLoS Negl Trop Dis.   2014  8(2):e2703 
    Ma S, Xie N, Li W, Yuan B, Shi Y*,  Immunobiology of mesenchymal stem cells.  Cell Death and Differentiation.   2014  21(2):216-25 
    , Chen X, Cao W, Shi Y.   Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications.  Nature Immunology.  2014  15(11):1009-1016 
    Chen X, Gan Y, Li W, Su J, Zhang Y, Huang Y, Roberts A, Han Y, Li J,, Shi Y*.  The interaction between mesenchymal stem cells and steroids during inflammation.   Cell Death and Disease  2014  23;5:e1009 
    Huang Y, Yu P, Li W, Ren G, Roberts AI, Cao W, Zhang X, Su J, Chen X, Chen Q, Shou P, Xu C, Du L, Lin L, Xie N, Zhang L,, Shi Y*.  p53 regulates mesenchymal stem cell-mediated tumor suppression in a tumor microenvironment through immune modulation.   Oncogene.   2014  33(29):3830-8. 
    Xu C, Lin L, Cao G, Chen Q, Shou P, Huang Y, Han Y,, Shi Y*.   Interferon-α-secreting mesenchymal stem cells exert potent antitumor effect in vivo.  Oncogene.  2014  33(42):5047-52. 
    Yang X, Hou J, Han Z,, Hao C, Wei L, Shi Y.  One cell, multiple roles: contribution of mesenchymal stem cells to tumor development in tumor microenvironment.   Cell Biosci.   2013  3(1):5. 
    Xu C, Ren G, Cao G, Chen Q, Shou P, Zheng C, Du L, Han X, Jiang M, Yang Q, Lin L, Wang G, Yu P, Zhang X, Cao W, Brewer G,, Shi Y*.  miR-155 regulates immune modulatory properties of mesenchymal stem cells by targeting TAK1-binding protein 2  J Biol Chem.   2013  288(16):11074-9 
    Liu B, Chen X,, Shi Y.  Curative effect of hepatic portal venous administration of autologous bone marrow in AIDS patients with decompensated liver cirrhosis.  Cell Death Dis.   2013  4:e739 
    Shi Y, Wei L,, Ren G.  Stem cells deployed for bone repair hijacked by T cells.  Cell Stem Cell.   2012  10(1):6-8. 
    Ren GW, Zhao X,, Zhang X, Chen XD, Xu CL, Yuan ZR, Roberts AI, Zhang LY, Zheng B, Wen T, Han YY, Rabson AB, Tischfield JA, Shao CS and Shi YF.   Tumor resident mesenchymal stromal cells promote tumor development through CCR2-dependent recruitment of monocytes/macrophages.   Cell Stem Cell.   2012  11(6):812-24 
    Wu CY, Feng Y, Qian GC, Wu JH, Luo J,, Chen GJ, Guo XK, Wang ZJ.   α-Galactosylceramide protects mice from lethal Coxsackievirus B3 infection and subsequent myocarditis.  Clin Exp Immunol.   2010  162(1):178-87 
    Feng D,, Mei Y, Xu Y, Xu H, Lu Y, Luo Q, Zhou S, Kong X, Xu L.   Stearoyl-CoA desaturase 1 deficiency protects mice from immune-mediated liver injury.   Lab Invest.  2009  89(2):222-30 
    Xu Y, Xue Y,, Feng D, Lin S, Xu L.  Multiple-modulation effects of Oridonin onmicroglia: anti-inflammation and neuroprotection.   Int Immunopharmacol.   2009  9(3):360-5. 
    Luo Q,, Feng D, Xu Y, Xu L.   Vasoactive intestinal peptide attenuated immune-mediated liver injury via a cAMP-dependent pathway.  Eur J Pharmacol.   2009  607(1-3):226-33 
    Xu Y, Feng D,, Luo QQ, Xu L.  STAT3 mediates protection from liver inflammation after partial hepatectomy.  Cell Physiol Biochem.   2009  23(4-6):379-86 
    Feng D,, Xu Y, Luo Q, Lan B, Xu L.  Interleukin 10 deficiency exacerbates halothane induced liver injury by increasing interleukin 8 expression and neutrophil infiltration.  Biochem Pharmacol.   2009  77(2):277-84. 
    , Luo Q, Xu Y, Feng D, Fei J, Cheng Q, Xu L.  ?-aminobutyric acid transporter 1 negatively regulates T cell activation and survival through protein kinase C-dependent signaling pathways.  J Immunol.   2009  183:3488-95 
    Lin S,, Xue Y, Feng D, Xu Y, Xu L.   Tetrandrine suppresses LPS-induced astrocyte activation via modulating IKKs-IκBα-NF-κB signaling pathway.   Mol Cell Biochem.  2008  315:41-9.  
    , Mei Y, Fend D, Xu L.  Triptolide modulates T cell inflammatory responses and ameliorates experimental autoimmune encephalomyelitis.   J Neurosci Res.   2008  86:2441-9. 
    Feng D,, Wang Y, Zhang B, Wang C, Xu L.   Tetrandrine protects mice from concanavalin A-induced hepatitis through inhibiting NF-κB activation.  Immunol lett.  2008  121(2):127-33. 
    , Feng D, Liu G, Luo Q, Xu Y, Lin S, Fei J, Xu L.  ?-aminobutyric acid transporter 1 negatively regulates T cell mediated immune responses and ameliorates autoimmune inflammation in the central nervous system.   J Immunol.   2008  181:8226-36. 
    Xu Y, Feng D,, Lin S, Xu L.   Tanshinone IIA Sulfonate protects mice from ConA-Induced hepatitis via inhibiting NF-κB and IFN-γ/STAT1 pathways.   J Clin Immunol.   2008  28:512-9. 
    Xue Y,, Feng D, Xiao BG, Xu L.  Tetrandrine suppresses lipopolysaccharide-induced microglial activation by inhibiting the NF-κB pathway.  Acta Pharmacol Sin.   2008  29:245-51. 
    Wang Z, Qiu J, Guo TB, Liu A,, Li Y, Zhang JZ  Anti-inflammatory properties and regulatory mechanism of a novel derivative of artemisinin in experimental autoimmune encephalomyelitis.  J Immunol.   2007  179:5958-65. 
    Mei YH,, Xu L.   Suppression of immune-mediated liver injury after vaccination with attenuated pathogenic cells.  Immunol lett.  2007  110:29-35. 
    , Mei Y, Bao S, Xu L.   Vasoactive intesinal polypeptide enhances oral tolerance by regulating both cellular and humoral immune responses.  Clin Exp Immunol.  2007  148:178-87 
    Li HY, Mei YH,, Xu L.  Vasoactive intestinal polypeptide suppressed experimental autoimmune encephalomyelitis by inhibiting T helper 1 responses.  J Clin Immunol.   2006  26:430-37.  
    , Mei Y, Feng D, Xu L.   (-)-epigallocatechin-3-gallate protects mice from concanavalin A-induced hepatitis through suppressing immune mediated liver injury.  Clin Exp Immunol.   2006  145: 485-92. 
    Li F, Mei YH,, Chen C, Xiao BG, Xu L.  Trichosanthin inhibits antigen-specific T cell expansion through nitric oxide-mediated apoptosis pathway.  Cell. Immunol.   2005  234: 23-30.