- 基本信息
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导师姓名：
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吴皓
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学科代码：
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100213
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性别：
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男
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学科名称：
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耳鼻咽喉科学
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培养单位：
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附属第九人民医院
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三级学科
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导师类型：
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博士生导师
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专业领域名称：
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耳鼻咽喉科学 专业学位
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联系方式：
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021-63288830
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专业领域代码：
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105117
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邮编：
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210000
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邮箱地址：
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wuhao@sh9hospital.org.cn
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- 研究方向 (点击浏览详细信息)
- 社会任职
| |
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上海医学会耳鼻咽喉头颈外科分会前任主任委员
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中华医学会耳鼻咽喉头颈外科分会主任委员
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上海市耳鼻咽喉科临床质控中心主任
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卫生部新生儿听力筛查专家组组长
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- 科研项目
| TM202011 | 国产人工听觉脑干植入装置的研发及优化研究 | 医学院 |
2020-12~2022-11
|
20万元
| 课题负责人 |
| SHDC2020CR1044B | 老年性聋队列的建立及防控策略研究 | 申康 |
2020-10~2022-09
|
715万元
| 课题负责人 |
| shslczdzk00802 | 上海市临床重点专科建设项目 | 临床重点专科 |
2020-01~2024-12
|
1942.28万元
| 课题负责人 |
| 81970872 | 听神经瘤细胞NF2基因状态差异对肿瘤发生发展的作用研究 | 国家自然科学基金面上项目 |
2020-01~2023-12
|
55万元
| 课题负责人 |
| XK2019015 | 用于人工耳蜗抱轴电极微创植入的智能手术机器人及核心组件的研发 | 上海交通大学医疗机器人项目 |
2020-01~2022-12
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100万元
| 课题负责人 |
| 2018SHZDZX05 | 脑疾病模型克隆猴制作 | 基础研究重大 |
2018-07~2023-06
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442.43万元
| 课题负责人 |
| 81730028 | 遗传和环境因素对GJB2基因p.V37I突变所致迟发型耳聋表型修饰作用的机制研究 | 国家自然科学基金重点项目 |
2018-01~2022-12
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299万元
| 课题负责人 |
| 2017YFC1001800 | 出生缺陷一级预防孕前检测技术设备及应用平台的研发 | 科技部重点研发计划 |
2017-07~2020-12
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1918万元
| 课题负责人 |
| 2014BAI04B01 | 听神经瘤规范化手术治疗策略研究 | 科技部 |
2017-05~2017-12
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80万元
| 课题负责人 |
| 16CR1005A | 先天性耳聋早期双侧人工耳蜗植入的多中心临床研究 | 申康重大疾病 |
2016-12~2019-06
|
200万元
| 课题负责人 |
| 81570906 | merlin/p53协同信号的核质穿梭对前庭神经鞘膜瘤生长的影响 | 国家自然科学基金面上项目 |
2016-01~2019-12
|
57万元
| 课题负责人 |
| 81330023 | 儿童迟发性耳聋的分子致病机制及基因治疗研究 | 国自然重点 |
2014-01~2019-12
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290万元
| 主要责任人 |
| 201202005 | 耳鼻重大疾病的早期发现、规范诊治和防控体系研究及推广应用 | 卫生行业科研专项基金 |
2012-01~2014-12
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2313万元
| 主要责任人 |
| 2012BAI109B02 | 遗传性耳聋的预防和干预 | “国家十二五”科技支撑计划 |
2012-01~2015-12
|
50万元
| 子课题负责人 |
| 81170924 | 迟发型儿童听力障碍的分子病因及基因型－表型关联研究 | 国家自然科学基金面上项目 |
2012-01~2015-12
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57万元
| 课题负责人 |
| 2011CB504501 | 遗传性聋相关新基因识别及其功能的研究 | 国家973计划 |
2011-01~2015-08
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517万元
| 子课题负责人 |
| 201002026 | 我国耳鼻重大疾病的早期发现、规范诊治和防控 | 卫生部科研专项经费 |
2010-07~2013-06
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2800万元
| 课题负责人 |
| C170703 | 不同生长特性的听神经瘤细胞对听神经瘤生物学行为的影响 | 国家自然基金，面上项目 |
2010-01~2012-12
|
32万元
| |
| 8411954500 | 遗传性耳聋常见基因产前筛查体系的研究 | 上海市科委，生药项目 |
~
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300万元
| |
| 2008B089 | 耳科学、耳神经科学及侧颅底外科讲学 | 上海市科委，白玉兰 |
~
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30万元
| |
- 学术论文
|
Minfei Qian* ,Qixuan Wang*,Zhongying Wang ,Qingping Ma,Xueling Wang,Kun Han ,,Zhiwu Huang#
|
Dose-dependent Pattern of Cochlear Synaptic Degeneration in C57BL/6J Mice Induced by Repeated Noise Exposure
|
Neural plasitity
|
2021
|
2021:9919977
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|
Zhuoer Sun* ,Zhenzhe Cheng ,Neng Gong,Zhen Xu ,Chenxi Jin ,,Yong Tao#
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Neural presbycusis at ultra-high frequency in aged common marmosets and rhesus monkeys
|
Aging (Albany NY)
|
2021
|
13(9):12587-12606
|
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Tan Haoyue*, Yao Junji*, Li Yun, Zhang Zhihua, Chen Ying, Huang Meiping, Sterkers, Olivier,, Wu Hao#
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Radiological and Audiological Outcomes of the LISTENT LCI-20PI Cochlear Implant Device
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OTOLOGY & NEUROTOLOGY
|
2021
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42(4):524-531
|
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Chen Jianqing*,Chai Yongchuan* ,Zhang Zhihua,Jia Huan ,Wang Zhaoyan# ,
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A Microscope-assisted Endoscopic Transcanal Transpromontorial Approach for Vestibular Schwannoma resection: a preliminary report
|
Eur Arch Otorhinolaryngol
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2021
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doi: 10.1007/s00405-021-06612-z
|
|
Hua Y*#, Ding X*, Wang H*, Wang F*, Lu Y, Neef J, Gao Y, Moser T#,
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Electron Microscopic Reconstruction of Neural Circuitry in the Cochlea
|
Cell Reports
|
2021
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34(1):108551
|
|
Qixuan Wang*,Minfei Qian* ,Lu Yang,Junbo Shi,Yingying Hong ,Kun Han ,Chen Li,James Lin ,Zhiwu Huang# ,
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Audiometric Phenotypes of Noise-induced Hearing Loss by Data- driven Cluster Analysis and Their Relevant Characteristics
|
Frontiers of Medicine
|
2021
|
8:662045
|
|
Ying Chen* ,Jianqing Chen* ,Haoyue Tan ,Mengda Jiang ,Yingwei Wu,Zhihua Zhang ,Yun Li ,Huan Jia# ,
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Cochlear duct length calculation : comparison between using Otoplan and curved multiplanar reconstruction in non-malformed cochlea
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OTOLOGY & NEUROTOLOGY
|
2021
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42(7):e875-e880
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Hongchao Liu* ,Hu Peng* ,Longhao Wang,Pengcheng Xu ,Zhaoyan Wang# ,Huihui Liu# ,
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Differences in Calcium Clearance at Inner Hair Cell Active Zones May Underlie the Difference in Susceptibility to Noise-induced Cochlea Synaptopathy of B6 and CBA Mice
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Frontiers in Cell and Developmental Biology
|
2021
|
8:635201
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|
Haibin Sheng*,Qian Zhou* ,Qixuan Wang,Yun Yu ,Lihua Liu ,Meie Liang ,Xueyan Zhou,,Xiangrong Tang#,Zhiwu Huang#
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Comparison of Two-Step Transient Evoked Otoacoustic Emissions and One-Step Automated Auditory Brainstem Response for Universal Newborn Hearing Screening Programs in Remote Areas of China
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Frontiers in Surgery
|
2021
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9:655625. doi: 10.3389/fped.2021.655625
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|
Zhigang Wang* ,Hongsai Chen* ,Lu Xue* ,Weiwei He ,Wenying Shu ,,Zhaoyan Wang#
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High throughput proteomic and metabolic profiling identified target correction of metabolic abnormalities as a novel therapeutic approach in head and neck paraganglioma
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Translational oncology
|
2021
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14(8):101146
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Qixuan Wang* ,Lu Yang* ,Minfei Qian* ,Yingying Hong ,Xueling Wang ,Zhiwu Huang#,
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Acute Recreational Noise-Induced Cochlear Synaptic Dysfunction in Humans With Normal Hearing: A Prospective Cohort Study
|
Frontiers in neuroscience
|
2021
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15:659011.doi: 10.3389/fnins.2021.659011
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|
Qixuan Wang* ,Xueling Wang* ,Lu Yang ,Kun Han ,Zhiwu Huang#,
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Sex differences in noise-induced hearing loss: a cross-sectional study in China
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Biology of Sex Differences
|
2021
|
12(1):24
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Jinxi Pan*,Haoyue Tan* ,Jun Shi* ,Zhaoyan Wang ,Olivier Sterkers,Huan Jia# ,
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Thermal Safety of Endoscopic Usage in Robot-Assisted Middle Ear Surgery: An Experimental Study
|
Frontiers in Surgery
|
2021
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doi: 10.3389/fsurg.2021.659688
|
|
Haoyu Wang* ,Shengxiong Wang* ,Yan Lu* ,Ying Chen ,Wenqing Huang,Miaoxin Qiu ,,Yunfeng Hua#
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Cytoarchitecture and Innervation of the Mouse Cochlear Amplifier Revealed by Large-scale Volume Electron Microscopy
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JOURNAL OF COMPARATIVE NEUROLOGY
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2021
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doi: 10.1002/cne.25137
|
|
Huan Jia* ,Jinxi Pan* ,Wenxi Gu*,Haoyue Tan ,Ying Chen ,Zhihua Zhang ,Mengda Jiang ,Yun Li,Olivier Sterkers ,
|
Robot-assisted electrode array insertion becomes available in pediatric cochlear implant recipients: first report and an intra-individual study”
|
Frontiers in Surgery
|
2021
|
8:695728
|
|
Longhao Wang*,Lin Zhao*,Hu Peng* ,Jun Xu,Yun Lin ,Tao Yang# ,
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Targeted Next-Generation Sequencing Identified Compound Heterozygous Mutations in MYO15A as the Probable Cause of Nonsyndromic Deafness in a Chinese Han Family
|
Neural Plasticity
|
2020
|
2020:6350479
|
|
Luping Zhang*,Yu Gao*,Ru Zhang*,Feifei Sun,Cheng Cheng,Fuping Qian,Xuchu Duan,Guanyun Wei,Cheng Sun,Xiuhong Pang,Penghui Chen,Renjie Chai,Tao Yang#,,Dong Liu#
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THOC1 deficiency leads to late-onset nonsyndromic hearing loss through p53-mediated hair cell apoptosis
|
PLoS Genet
|
2020
|
16 (8), e1008953
|
|
Ying Chen*,Meiping Huang*,Bei Li,Zhaoyan Wang,Zhihua Zhang,Huan Jia,Lingxiang Hu,Yun Cai,Yun Li#,Zhiwu Huang#,
|
Bimodal Stimulation in Children With Bilateral Profound Sensorineural Hearing Loss: A Suitable Intervention Model for Children at the Early Developmental Stage
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Otology & Neurotology
|
2020
|
41(10):1357-1362
|
|
Wen Kang*,Xingle Zhao*,Zhuoer Sun,Tingting Dong,Chenxi Jin,Ling Tong,Weidong Zhu,Yong Tao#,
|
Adeno-associated virus vector enables safe and efficient Cas9 activation in neonatal and adult Cas9 knockin murine cochleae
|
Gene Ther
|
2020
|
27(7-8):392-405
|
|
Xingle Zhao*, Chenxi Jin*, Tingting Dong*, Zhuoer Sun,Xiaofei Zheng, Baoyi Feng, Zhenzhe Cheng, Xiang Li, Yong Tao#,
|
Characterization Promoters for Adeno-associated Virus Mediated 1 Efficient Cas9 Activation 2 in Adult Cas9 Knock-In Murine Cochleae
|
Hearing research
|
2020
|
394:107999
|
|
Wang Zhigang*, Chen Hongsai*, Xue Lu,He Weiwei,Jiang Lianying,Wang Zhaoyan#,, Hao#
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Proteomic screening identifies PML/p53 axis as a potential treatment target of facial nerve schwannomas
|
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
|
2020
|
12(8):4237
|
|
Yu Dehong*,Gu Jiayi,Chen Yuming,Kang Wen,Wang Xueling#,
|
Current Strategies to Combat Cisplatin-Induced Ototoxicity
|
FRONTIERS IN PHARMACOLOGY
|
2020
|
11
|
|
Xiaoyu Yu*,Yun Lin*,Jun Xu*,Tuanjie Che,Lin Li,Tao Yang#,
|
Molecular epidemiology of Chinese Han deaf patients with bi-allelic and mono-allelic GJB2 mutations
|
Orphanet J Rare Dis
|
2020
|
15(1):29
|
|
Jiayi Gu*,Yuming Chen*,Ling Tong,Xueling Wang#,Dehong Yu#,
|
Astaxanthin-loaded polymer-lipid hybrid nanoparticles (ATX-LPN): assessment of potential otoprotective effects
|
J Nanobiotechnology
|
2020
|
18(1):53
|
|
You Zhou*,Chenchen Xia,Manli Yin,Xueling Wang,,Yonghua Ji#
|
Distribution and Functional Characteristics of Voltage-Gated Sodium Channels in Immature Cochlear Hair Cells
|
Neurosci Bull
|
2020
|
36(1):49-65
|
|
Xiaoyu Yu* ,Yun Lin*,Jun Xu* ,Tuanjie Che ,Lin Li ,Tao Yang# ,
|
Molecular epidemiology of Chinese Han deaf patients with bi-allelic and mono-allelic GJB2mutations
|
Orphanet Journal of Rare Diseases
|
2020
|
15(1):29
|
|
Huan Jia*,Yann Nguyen ,Baptiste Hochet ,Mustapha Smail,Isabelle Mosnier,,Olivier Sterkers #,Michel Kalamarides,Daniele Bernardeschi
|
NF2-Related Intravestibular Schwannomas: Long-Term Outcomes of Cochlear Implantation
|
Otol Neurotol
|
2020
|
41(1):94-99
|
|
Jiawen Lu *,Huihui Liu *,Shanshan Lin,Chao Li,
|
Electrophysiological characterization of acutely isolated spiral ganglion neurons in neonatal and mature sonic hedgehog knock-in mice
|
Neuroscience Letters
|
2020
|
714: 0-134536
|
|
Yu Xiaoyu*,Lin Yun,
|
Targeted Next-Generation Sequencing Identifies Separate Causes of Hearing Loss in One Deaf Family and Variable Clinical Manifestations for the p.R161C Mutation in SOX10
|
NEURAL PLASTICITY
|
2020
|
2020:8860837
|
|
Feng Baoyi*,Jin Chenxi,Cheng Zhenzhe,Zhao Xingle,Sun Zhuoer,Zheng Xiaofei,Li Xiang,Dong Tingting,Tao Yong#,
|
Mitochondrial Dysfunction and Therapeutic Targets in Auditory Neuropathy
|
NEURAL PLASTICITY
|
2020
|
2020:8843485
|
|
Wang Zhongying*,Qian Minfei,Wang Qixuan,Liu Huihui,,Huang Zhiwu#
|
An In Vitro Study on Prestin Analog Gene in the Bullfrog Hearing Organs
|
NEURAL PLASTICITY
|
2020
|
3570732
|
|
Dehog Yu*, Jiayi Gu, Yuming Chen, Wen Kang, Xueling Wang#,
|
Current strategies to reduce cisplatin-induced ototoxicity
|
Frontiers in Pharmacology
|
2020
|
11:999
|
|
Bei Li*,Kun Han*,Lu Yang,Meiping Huang,Zhiwu Huang,Yun Li#,
|
The characteristics of social maturity in infants and children with cochlear implants in China
|
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
|
2020
|
131:109887
|
|
Zhao Xingle*,Jin Chenxi*,Dong Tingting,Sun Zhuoer,Zheng Xiaofei,Feng Baoyi,Cheng Zhenzhe,Li Xiang,Tao Yong#,
|
Characterization of promoters for adeno-associated virus mediated efficient Cas9 activation in adult Cas9 knock-in murine cochleae
|
HEARING RESEARCH
|
2020
|
394
|
|
Jingjing Zhao*,Gen Li*,Xuan Zhao,Xin Lin,Yunge Gao,Nuno Raimundo,Geng-Lin Li,Wei Shang,,Lei Song#
|
Down-regulation of AMPK signaling pathway rescues hearing loss in TFB1 transgenic mice and delays age-related hearing loss
|
Aging (Albany NY)
|
2020
|
12(7):5590-5611
|
|
Huang He*,Chen Hongsai*, Wang Xueling*, Qiu Fangxia, Liu Huihui, Lu Jiawen, Tong Ling, Yang Yuming, Wang Xiansong#,, Hao#.
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Degradable and bioadhesive alginate-based composites: An effective hemostatic agent
|
ACS Biomaterials Science & Engineering
|
2019
|
5, 10, 5498-5505
|
|
Zirong Huo*,Jianqing Chen*,Zhaoyan Wang,Zhihua Zhang#,
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Prognostic Factors of Long-Term Hearing Preservation in Small and Medium-Sized Vestibular Schwannomas After Microsurgery.
|
Otol Neurotol.
|
2019
|
40(7):957-964
|
|
Chen, Hongsai* ;Huang, He* ;Zhao, Jingjing * ;Wang, Zhigang *;Chang, Mengling ;Xue, Lu ;Zhu, Weidong ;Chai, Yongchuan ;Li, Gen ;Wang,, Hao#
|
Age-dependent copy number variations of TP53 tumour suppressor gene associated with altered phosphorylation status of p53 protein in sporadic schwannomas
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J Neurooncol.
|
2019
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143(3):369-379.
|
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Chen, J-Q*;Tan, H-Y *;Wang, Z-Y* ;Zhu, W-D ;Chai, Y-C ;Jia,, H.#
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Strategy for facial nerve management during surgical removal of benign jugular foramen tumors: Outcomes and indications
|
Eur Ann Otorhinolaryngol Head Neck Dis
|
2019
|
136(3S),S21-S25
|
|
Huihui Liu*,Jiawen Lu*,Zhongying Wang,Lei Song,Xueling Wang#,Geng-Lin Li#,
|
Functional alteration of ribbon synapses in inner hair cells by noise exposure causing hidden hearing loss
|
Neuroscience Letters
|
2019
|
707:134268
|
|
Chen, Yuming* ;Gu, Jiayi;Liu, Jian ;Tong, Ling;Shi, Fuxin;Wang, Xiaoqin ;Wang, Xueling# ;Yu,, Hao#
|
Dexamethasone-loaded injectable silk-polyethylene glycol hydrogel alleviates cisplatin-induced ototoxicity
|
International Journal of Nanomedicine
|
2019
|
14, 4211–4227
|
|
Liu H*, Li G, Lu J, Gao YG, Song L, Li GL#,
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Cellular Differences in the Cochlea of CBA and B6 Mice May Underlie Their Difference in Susceptibility to Hearing Loss.
|
Front Cell Neurosci
|
2019
|
13, 60
|
|
Chen, Jianqing * ;Wu, Yingwei ;Shi, Jun ;Jia, Huan ;Wang, Zhaoyan ;Zhang,, Hao#7
|
Predictors of round window membrane visibility in pediatric cochlear implant surgery using temporal bone HRCT: A retrospective study.
|
Int J Pediatr Otorhinolaryngol.
|
2019
|
121:150-153.
|
|
Shuang Yan*, Quan Wang*,Zirong Huo, Tao Yang, Xiaoling Yin,Zhaoyan Wang,Zhihua Zhang#,
|
Gene expression profiles between cystic and solid vestibular schwannoma indicate susceptible molecules and pathways in the cystic formation of vestibular schwannoma.
|
Functional and Integrative Genomics.
|
2019
|
19(4):673-684.
|
|
Jiawen Lu*, Wenxiao Wang*, Hongchao Liu, Huihui Liu,
|
Cisplatin induces calcium ion accumulation and hearing loss by causing functional alterations in calcium channels and exocytosis.
|
American Journal of Translational Research
|
2019
|
11(11): 6877-6889
|
|
Chen, Ying*;Li, Yun;Ren, Yan ;Li, Haifeng;Huang, Meiping ;Jia, Huan;Yang, Tao ;Wang, Zhaoyan ;Huang,, Hao#
|
Identification of a novel CDH23 gene variant associated with non-syndromic progressive hearing loss in a Chinese family: Individualized hearing rehabilitation guided by genetic diagnosis
|
International Journal of Pediatric Otorhinolaryngology
|
2019
|
127 (2019) 109649
|
|
Peng, Hu * ;Deng, Yue ;Wang, Longhao;Cheng, Yin;Xu, Yaping ;Liao,, Hao#
|
Identification of Potential Biomarkers with Diagnostic Value in Pituitary Adenomas Using Prediction Analysis for Microarrays Method
|
J Mol Neurosci
|
2019
|
69(3):399-410
|
|
Bin Ye*,Quan Wang*,Haixia Hu*,Yilin Shen,Cui Fan,Penghui Chen,Yan Ma,,Mingliang Xiang#
|
Restoring autophagic flux attenuates cochlear spiral ganglion neuron degeneration by promoting TFEB nuclear translocation via inhibiting MTOR.
|
Autophagy
|
2019
|
15(6): 998–1016.
|
|
Wen Kang*,Zhuoer Sun,Xingle Zhao,Xueling Wang#,Yong Tao#,
|
Gene editing based hearing impairment research and therapeutics
|
Neuroscience Letters
|
2019
|
709:134326
|
|
Jingrong Lu* ,Lingxiang Hu*,Bin Ye,Haixia Hu,Yong Tao,?Yilai Shu ,Hao Chiang,Vikrant Borse ,?Mingliang Xiang,,Albert S B Edge,Fuxin Shi #
|
Increased type I and decreased type II hair cells after deletion of Sox2 in the developing mouse utricle
|
Neuroscience
|
2019
|
1;422:146-160
|
|
You Zhou, Manli Yin, Chenchen Xia, Xueling Wang,, Yonghua Ji#
|
Visual deprivation modifies glutamate receptor expression in visual and auditory centers
|
Am J Tra
|
2019
|
11(12):7523-7537
|
|
Chen, Penghui*; Liu, Haijin*;Lin, Yun;Xu, Jun;Zhu, Weidong ;Wu,, Tao#
|
EYA1 mutations leads to Branchio-Oto syndrome in two Chinese Han deaf families
|
Int J Pediatr Otorhinolaryngol
|
2019
|
123:141-145
|
|
Tan H(#),Yang J, Wang Z Y, Zhu W D, Chai Y C, Jia H(*),
|
Simultaneous supervision by microscope of endoscope-assisted microsurgery via presigmoid retrolabyrinthine approach: A pilot study.Dis.
|
Eur Ann Otorhinolaryngol Head Neck Dis
|
2018
|
135(5): S103~S106
|
|
Wang Xueling(#), Chen Yuming, Tao Yong, Gao Yunge, Yu Dehong(*),
|
A666-conjugated nanoparticles target prestin of outer hair cells preventing cisplatin-induced hearing loss
|
International Journal of Nanomedicine
|
2018
|
13: 7517~7531
|
|
Chen Penghui(#), Chai Yongchuan, Liu Haijin, Li Gen, Wang Longhao, Yang Tao(*),
|
Postnatal Development of Microglia-Like Cells in Mouse Cochlea
|
Neural Plasticity
|
2018
|
2018: 1970150
|
|
He L(#), Pang X, Liu H, Chai Y,, Yang T(*)
|
Targeted next-generation sequencing and parental genotyping in sporadic Chinese Han deaf patients
|
Clinical Genetics,
|
2018
|
93(4): 899~904
|
|
Tan Haoyue(#),Jia Huan(#)(*), Li Yun, Zhang Zhihua, Zhu Weidong, Cai Yun, Wang Zhaoyan(*),
|
Impact of cochlear implantation on the management strategy of patients with neurofibromatosis type 2.
|
European Archives of Oto-Rhino-Laryngology
|
2018
|
275(11): 2667~2674
|
|
Hongsai Chen#, Lu Xue#, He Huang#, Hantao Wang#, Xiaoman Zhang, Weidong Zhu, Zhigang Wang, Zhaoyan Wang*,
|
Synergistic effect of Nutlin-3 combined with MG-132 on schwannoma cells through restoration of merlin and p53 tumour suppressors
|
EBioMedicine
|
2018
|
36: 252~265
|
|
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