• 基本信息
    导师姓名: 孙皎 学科代码: 100301
    性别: 学科名称: 口腔基础医学
    培养单位: 口腔医学院 三级学科
    导师类型: 博士生导师 专业领域名称:
    联系方式: jiaosun59@126.com 专业领域代码:
    邮编: 邮箱地址: jiaosun59@yahoo.com
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    中国生物医学工程学会生物材料分会 副主任委员
    《口腔材枓学》 (全国高等学校教材) 副主编
    中国生物材料学会生物材料生物学评价分会 副主任委员
    中国生物材料学会海洋生物材料分会 副主任委员
    上海市口腔医学会口腔材料专业委员会 主任委员
    上海市生物医学工程学会生物材料专业委员会 高级顾问
    全国计划生育器械标准化技术委员会 主任委员
    中华口腔医学会口腔材料专业委员会 副主任委员
    国家自然基金项目 二审专家
    《口腔材料器械杂志》 主 编
    《口腔生物材料学》(全国高等学校研究生教材) 主编
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    2018YFC1105202有机材料与组织工程制品的免疫特性的调控及对干细胞分化的影响中华人民共和国科学技术部 2018-08~2021-07 304万元  课题负责人
    18DZ2290300上海市生物医用材料测试专业技术服务平台上海市科学技术委员会 2018-04~2021-03 150万元  课题负责人
    18DZ2201500医用镁基骨植入材料体内降解、成骨与安全性评价技术规范的研究上海市科学技术委员会 2018-04~2021-03 30万元  课题负责人
    31771086仿生介孔生物玻璃纳米球的研制及对乳腺癌骨转移瘤的抑制效应和机制探讨国家自然科学基金 2018-01~2021-12 60万元  课题负责人
    15DZ2290100上海市生物医用材料测试专业技术服务平台市科委 2015-07~2017-07 200万元  课题负责人
    31470917静电纺鱼胶原纳米纤维皮肤创面修复材料的研制、生物学效应及其机制探讨国家自然科学基金 2015-01~2018-12 90万元  课题负责人
    13441902300新型高氮无镍不锈钢骨植入医疗器械用材料的研制及临床前评价研究上海市科委 2013-09~2016-09 50万元  课题负责人
    13DZ2291100上海市生物医用材料测试专业技术服务平台上海市科委 2013-07~2015-07 200万元  课题负责人
    81271700药物载体纳米颗粒激活补体介导的免疫学效应及其机制探讨国家自然科学基金 2013-01~2016-12 80万元  课题负责人
    81190132硬组织生物活性材料与宿主局部微环境的相互作用以及在组织再生中的转归国家自然科学基金重大项目 2012-01~2016-12 84万元  子课题负责人
    2012BAI22B01新型及高风险医疗器械检测与安全性评价技术研究国家科技部十二五支撑计划 2012-01~2014-12 54万元  子课题负责人
    1111DZ2291700生物医用材料测试专业技术服务平台能力建设上海市科委科研项目 2011-11~2013-10 230万元  课题负责人
    11dz0503300含铜宫内节育器用铜技术规范的研究上海市科委科研项目 2011-10~2014-09 30万元  课题负责人
    31070843无机纳米颗粒体内分布、排泄和对肝脏代谢功能的影响及其分子机制国家自然基金项目 2011-01~2013-12 33万元  课题负责人
    09JC1409200β-磷酸钙/硅酸钙复合生物陶瓷的设计及其生物学效应的相关机制上海市科委项目 2009-09~2011-08 35万元  课题负责人
    09JC1409200β-磷酸钙/硅酸钙复合生物陶瓷的设计及其生物学效应的相关机制上海市科委"创新行动计划"基础研究重点项目 2009-09~2011-08 35万元  课题负责人
    30870680纳米颗粒对中枢神经元的潜在毒性及分子机制研究国家自然基金委,面上项目 2009-01~2011-12 32万元  课题负责人
    08DZ2291600无机纳米颗粒的生物学效医疗器械生物学评价体系建设及服务能力提升上海市科委项目 2008-10~2010-10 90万元  课题负责人
    08dz2291600医疗器械生物学评价体系建设及服务能力的提升上海市科委,基地平台 2008-09~2010-09 90万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Sui Baiyan, Liu Xin,  Dual-Functional Dendritic Mesoporous Bioactive Glass Nanospheres for Calcium Influx-Mediated Specific Tumor Suppression and Controlled Drug Delivery in Vivo.  ACS applied materials & interfaces  2018  10(28), 23548-23559 
    Dai Meilu, Liu Xin, Wang Nanping,  Squid type ii collagen as a novel biomaterial: Isolation, characterization, immunogenicity and relieving effect on degenerative osteoarthritis via inhibiting stat1 signaling in pro-inflammatory macrophages.  Materials Science and Engineering: C  2018  89, 283-294 
    Dai Meilu, Sui Baiyan, Xue Yang, Liu Xin,  Cartilage repair in degenerative osteoarthritis mediated by squid type II collagen via immunomodulating activation of M2 macrophages, inhibiting apoptosis and hypertrophy of chondrocytes.  Biomaterials  2018  180, 91-103 
    Yu Yiqiang, Lu Hua,  Long-term in vivo evolution of high-purity Mg screw degradation-Local and systemic effects of Mg degradation products.  Acta biomaterialia  2018  71, 215-224 
    Yiqiang Yu, Guodong Jin, Yang Xue, Donghui Wang, Xuanyong Liu,  Multifunctions of dual Zn/Mg ion co-implanted titanium on osteogenesis, angiogenesis and bacteria inhibition for dental implants.  Acta Biomater  2017  49:590-603 
    Liu Xin, Sui Baiyan,  Size-and shape-dependent effects of titanium dioxide nanoparticles on the permeabilization of the blood–brain barrier.  Journal of Materials Chemistry B  2017  5(48), 9558-9570 
    Xin Liu, Baiyan Sui and Jiao Sun  Blood-Brain Barrier Dysfunction induced by silica nanoparticles in vitro and in vivo: Involvement of oxidative stress and Rho-Kinase /JNK signaling pathways  Biomaterials  2017  Vol 121:64-82 
    Zhou Tian, Liu Xin, Sui Baiyan, Liu Chao, Mo Xiumei,  Development of fish collagen/bioactive glass/chitosan composite nanofibers as a GTR/GBR membrane for inducing periodontal tissue regeneration.  Biomedical Materials  2017  12(5), 055004 
    Tian Zhou,Baiyan sui,Xiumei Mo,  Multifunctional and biomimetic fish collagen/ bioactive glass nanofibers: fabrication, antibacterial activity and inducing skin regeneration in vitro and in vivo  Inter J Nanomed  2017  12 3495–3507  
    Yang Xue, Qingqing Chen,  HAP Nanoparticle-Induced Mitochondrial Energy Metabolism Impairment in Liver Cells in Vitro and in Vivo Studies  Journal of Applied Toxicology  2017  37(8):1004-1016 
    Yiqiang Yu, Tingting Ding, Yang Xue,  Osteoinduction and long-term osseointegration promoted by combined effects of nitrogen and manganese elements in high nitrogen nickel-free stainless steel.  Journal of Materials Chemistry B  2016  4: 801-812 
    Tian Zhou, Nanping Wang, Yang Xue, Tingting Ding, Xin Liu, Xiumei Mo,  Electrospun tilapia collagen nano?bers accelerating wound healing via inducing keratinocytes proliferation and differentiation  Colloids and Surfaces B: Biointerfaces  2016  143 (2016): 415–422 
    Baiyan Sui, Gaoren Zhong,  Drug-loadable Mesoporous Bioactive Glass Nanospheres: Biodistribution, Clearance, BRL Cellular Location and Systemic Risk Assessment via 45Ca Labelling and Histological Analysis  Scientific Reports  2016  6:33443.doi:10.1038/srep33443 
    Chao Liu, Xin Liu, Yang Xue, Tingting Ding,  Hydrolyzed tilapia fish collagen modulates the biological behavior of macrophages under inflammatory conditions  RSC Advances  2015  5(39): 30727-30736 
    Xiaomeng Zhang, Chengtie Wu, Jiang Chang,  Odontogenic differentiation of human dental pulp cells induced by silicate-based bioceramics via activation of P38/MEPE pathway.  RSC Advances  2015  5:72536-72543. 
    Liu C,  Potential application of hydrolyzed fish collagen for inducing the multi-directional differentiation of rat bone marrow mesenchymal stem cells.  Biomacromolecules  2014  15(1):436-443 
    Wang C, Lin K, Chang J,  The stimulation of osteogenic differentiation of mesenchymal stem cells and vascular endothelial growth factor secretion of endothelial cells by β-CaSiO3 /β-Ca3 (PO4)2 scaffolds  J Biomed Mater Res A  2014  102(7):2096-104 
    Xin Liu; Jiao Sun  Potential proinflammatory effects of hydroxyapatite nanoparticles on endothelial cells in a monocyte-endothelial cell coculture model.  INT J NANOMED  2014  9():1261-1273 
    Yang Xue, Qingqing Chen, Tingting Ding,  SiO2 nanoparticle-induced impairment of mitochondrial energy metabolism in hepatocytes directly and through a Kupffer cell-mediated pathway in vitro  INT J NANOMED  2014  9():2891-2903 
    Xiaomeng Zhang, Chengtie Wu, Jiang Changb ,  Stimulation of osteogenic protein expression for rat bone marrow stromal cells involving in ERK signalling pathway by the ions released from Ca7Si2P2O16 bioceramics  J. Mater. Chem. B  2014  2():885-891 
    Sui B, Zhong G,  Evolution of mesoporous bioactive glass scaffold implanted in rat femur based on 45Ca labelling, tracing and histological analysis.  ACS APPL MATER INTER  2014  6(5):3528-3535 
    ChenQ, Xue Y,  Hepatotoxicity and liver injury induced by hydroxyapatite nanoparticles  J Appl Toxicol  2014  34(11):1256-1264 
    Chen Q, Xue Y,  Kupffer cell-mediated hepatic injury induced by silica nanoparticles in vitro and in vivo  INT J NANOMED  2013  8():1129-1140 
    Liu Xin; Sun,  Time-Course Effects of Intravenously Administrated Silica Nanoparticles on Blood Coagulation and Endothelial Function in Rats.  J nanosci nanotechno  2013  13(1):222-228 
    Chen Wang,  Osteogenesis and angiogenesis induced by porous β- CaSiO3/PDLGA composite scaffold via activation of AMPK / ERK1/2 and PI3K/ Akt pathways  Biomaterials  2013  34(1):64-77 
    Wu J, Ding T,  Neurotoxic Potential of Iron Oxide Nanoparticles in the Rat Brain Striatum and Hippocampus  Neurotoxicology  2013  34():243-253 
    Lisha Fei, Yang Xue, Kaili Lin, Jiang Chang,  Osteogenic differentiation of osteoblasts induced by calcium silicate and calcium silicate/β-tricalcium phosphate composite bioceramics.  J Biomed Mater Res B Appl Biomater.  2012  100(5):1237-44 
    Guangping Xie,  Tissular Localization and Excretion of Intravenously Administered Silica Nanoparticles of Different Sizes.  J Nanopart Res  2012  14(1):671-680 
    Xu Z, Chou L,  Effects of SiO2 nanoparticles on HFL-I activating ROS -mediated apoptosis via p53 pathway nanomedicine.  J Appl Toxicol  2012  32(5):358-64 
    Tingting Ding, Yang Xue, Hua Lu, Zhewei Huang,  Effect of Particle Size of Hydroxyapatite Nanoparticles on its Biocompatibility.  Ieee t nanobiosci  2012  11(4): 336-340 
    Xu Z, Liu C, Wei J,  Effects of four types of hydroxyapatite nanoparticles with different nanocrystal morphologies and sizes on apoptosis in rat osteoblasts.  J Appl Toxicol  2012  32(6):429-35 
    Yang Xue, Jie Wu,  Four types of inorganic nanoparticles stimulate the inflammatory reaction in brain microglia and damage neurons in vitro.  Toxicol Lett  2012  214(2):91-8. 
    Zheng Y, Li J, Liu X,  Antimicrobial and osteogenic effect of Ag-implanted titanium with a nanostructured surface.  INT J NANOMED  2012  7:875-84. 
    Liu x, Xue y, Ding t,  Enhancement of proinflammatory and procoagulant responses to silica particles by monocyte-endothelial cell interactions.  PART FIBRE TOXICOL  2012  18;9(1):36-65 
    Chen Wang, Yang Xue, Kaili Lin, Jianxi Lu, Jiang Chang,  The enhancement of bone regeneration by the combination of osteoconductivity and osteostimulation using β-CaSiO3/β-Ca3 (PO4)2 composite bioceramics.  Acta biomater  2012  8(1):350-60. 
    , GuangPing Xie.  Tissue Distribution of Intravenously Administrated Hydroxyapatite Nanoparticles Labeled with 125I.  J nanosci nanotechno  2011  11(12):10996-1000. 
    Wu J, Wang C,, Xue Y.  Neurotoxicity of Silica Nanoparticles:Brain Localization and Dopaminergic Neurons Damage Path ways.  ACS Nano  2011  28;5(6):4476-89 
    Jie Wu,  Effect of Iron Oxide Nanoparticles on PC12 Cells by MTS and P53. J nanosci nanotechno.  J nanosci nanotechno  2011  11(12):11079-11083 
    Xie GP, Wang C,, Zhong G.  Tissue distribution and excretion of intravenously administered titanium dioxide nanoparticles.  Toxicol Lett  2011  10;205(1):55-61 
    Xue Y, Liu X,  PU/PTFE-stimulated monocyte-derived soluble factors induced inflammatory activation in endothelial cells  Toxicol in Vitro  2010  24(2):404-10. 
    Liu X, Xue Y,  Indirect Induction of Endothelial Cell Injury by PU- or PTFE-Mediated Activation of Monocytes.   J BIOMAT SCI-POLYM E  2010  21(13)1783-1797 
    Xie G,, Zhong G, Shi L, Zhang D  Biodistribution and toxicity of intravenously administered silica nanoparticles in mice  ARCH TOXICOL  2010  84(3):183-190 
    Xie G,, Zhong G, Liu C, Wei J  An In Vitro Investigation of the Mechanical-Chemical and Biological Properties of Calcium Hydroxyapatite nanoparticles as a controlled-release carrier of BMP-2: Absorption and release kinetics in vitro.  J Mater Sci: Mater Med  2010  21(6):1875-80 
    Liu X,  Endothelial cells dysfunction induced by silica nanoparticles through oxidative stress via JNK/P53 and NF-kB pathway  Biomaterials  2010  31(32):8198-209 
    Jie Wu,, Yang Xue.  Involvement of JNK and P53 Activation in G2/M Cell Cycle Arrest and Apoptosis induced by Titanium Dioxide Nanoparticles in neuron cells.  Toxicol Lett  2010  199(3):269–276. 
    Shen Q,, Wu J, Liu C, Chen F  An In Vitro Investigation of the Mechanical-Chemical and Biological Properties of Calcium Phosphate/Calcium Silicate/Bismutite Cement for Dental Pulp Capping.  J BIOMED MATER RES B  2010  94(1):141-8.