- 基本信息
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导师姓名：
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李佩盈
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学科代码：
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100217
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性别：
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女
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学科名称：
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麻醉学
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培养单位：
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附属仁济医院
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三级学科
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导师类型：
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博士生导师
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专业领域名称：
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麻醉学 专业学位
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联系方式：
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peiying.li@qq.com
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专业领域代码：
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105118
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邮编：
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200127
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邮箱地址：
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peiying.li@qq.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
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中华医学会麻醉学分会神经外科学组委员
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中华医学会麻醉学分会青年学组副组长
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上海医师协会麻醉学分会委员
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《CNS Neuroscience & Therapeutics》副主编
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《Stroke》杂志编委
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《Journal of Cerebral Blood Flow & Metabolism》杂志副主编
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国际脑血流与代谢协会（ISCBFM）2019年Brain大会项目委员
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美国神经科学协会（SfN）会员
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美国心脏协会（AHA）会员
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- 科研项目
| U22A20295 | Ccrl2+CX3CR1+小胶质细胞细胞亚型在缺血性脑卒中后认知障碍中的作用及机制 | 国家自然科学基金联合重点 |
2023-01~2026-12
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255万元
| 课题负责人 |
| M-0671 | SUCNR1介导缺血性脑卒中后脑内调节性T细胞脂质代谢重塑及表型转化 | 国家自然科学基金中德合作交流项目 |
2022-11~2025-10
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147万元
| 课题负责人 |
| kjbqb221144 | 2021科技部QB项目 | 科技部青年拔尖项目 |
2021-12~2026-11
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160万元
| 课题负责人 |
| 20181805 | 上海交大医学院高峰高原计划 | 研究型医师滚动资助项目 |
2021-11~2024-10
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100万元
| 课题负责人 |
| 20181805 | 围术期管理对缺血性脑卒中患者的影响 | 上海市教育委员会高峰高原学科建设计划 |
2021-10~2024-09
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100万元
| 课题负责人 |
| PYII20-03 | 计算机深度学习脑小血管病多模态MRI预测术后患者认知功能 障碍的前瞻性队列研究 | 仁济医院临床研究培育项目 |
2020-12~2023-11
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20万元
| 课题负责人 |
| 20SG17 | 调控Th17/Treg平衡减轻围术期患者血脑屏障损伤及术后认知功能障碍 | 上海市教育发展基金会和上海市教育委员会“曙光计划” |
2020-11~2023-12
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15万元
| 课题负责人 |
| 20XD1422400 | 缺血性脑卒中的免疫机制与治疗新靶点 | 上海市科委青年学术带头人 |
2020-10~2023-09
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40万元
| 课题负责人 |
| 82061130224 | 间歇性禁食对脑卒中后T细胞免疫的代谢重塑对脑白质损伤的保护作用 | 国际(地区)合作与交流项目
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2020-07~2023-06
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50万元
| 课题负责人 |
| NAF\R11\1010 | Intermittent fasting mediated metabolic reprogramming reshapes the T cell immunity and preserves white matter integrity after stroke | 牛顿高级学者项目，英国医学科学会 |
2020-07~2023-06
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100万元
| 课题负责人 |
| 91957111 | 卡路里限制的T细胞糖脂代谢重塑机制及网络调控 | 国家自然科学基金重大研发计划培育项目 |
2020-01~2022-12
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80万元
| 课题负责人 |
| 81971096 | RAGE调控CD4+T细胞ACC1酶在加重脑缺血再灌注损伤中的作用与机制 | 国自然面上项目 |
2020-01~2023-12
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55万元
| 课题负责人 |
| SHDC12019102 | 围术期患者脑小血管病MRI多模态成像与术后隐匿型脑卒中的多中心前瞻性队列研究 | 上海申康临床科技创新项目 |
2019-11~2022-11
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180万元
| 课题负责人 |
| 20181805 | 上海市教育委员会 | 高峰高原学科建设计划 |
2019-01~2021-12
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100万元
| 课题负责人 |
| 81722017 | 缺血性脑卒中后血脑屏障损伤 | 国自然优青项目 |
2018-01~2020-12
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130万元
| 课题负责人 |
| 16QA1402600 | 调控T细胞的脂肪酸合成对缺血性脑损伤的保护作用 | 上海市科委启明星 |
2016-07~2019-06
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40万元
| 课题负责人 |
| 81400956 | 调节性T细胞体外扩增及细胞移植对脑缺血损伤后神经血管单元重建的影响 | 国家自然科学基金 |
2015-01~2017-12
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25万元
| 课题负责人 |
| 13ZR1452200 | 离体扩增调节性T细胞移植促进脑缺血损伤后神经血管单元重建的研究 | 上海市科委 |
2013-10~2016-09
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10万元
| 课题负责人 |
- 学术论文
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Zhang Y, Guo Y, Li R, Huang T, Li Y, Xie W, Chen C, Chen W, Wan J, Yu W,
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Novel CH25H+ and OASL+ microglia subclusters play distinct roles in cerebral ischemic stroke
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J Neuroinflammation
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2023
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20(1）：115
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Li Y, Zou C, Chen C, Li S, Zhu Z, Fan Q, Pang R, Li F, Chen Z, Wang Z, Yu W, Yuan J,
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Li Y, Zou C, Chen C, Li S, Zhu Z, Fan Q, Pang R, Li F, Chen Z, Wang Z, Yu W, Yuan J, Li P.
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Myeloid-derived MIF drives RIPK1-mediated cerebromicrovascular endothelial cell death to exacerbate ischemic brain injury
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2023
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120(5):e2219091129
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Xie W, Simats A, Guo Y, Huang T, Sun X, Chen W, Lin Y, Wang X, Lai Z, Yu W, Liesz A,
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Perspective Review of Myeloid Immune Cell Responses and Poststroke Immunosuppression
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Stroke
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2023
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54(7):1920-1929
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Xie W, Huang T, Guo Y, Zhang Y, Chen W, Li Y, Chen C,
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Neutrophil-derived cathelicidin promotes cerebral angiogenesis after ischemic stroke
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J Cereb Blood Flow Metab
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2023
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43(9):1503-1518
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Guo Y,, Boltze J
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Recent advances in mechanistic, therapeutic, and diagnostic research of cerebrovascular diseases: updates from brain & Brain PET 2022
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J Cereb Blood Flow Metab
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2023
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271678X231183290
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Chen W, Zhang Y, Zhai X, Xie L, Guo Y, Chen C, Li Y, Wang F, Zhu Z, Zheng L, Wan J,
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Microglial phagocytosis and regulatory mechanisms after stroke.
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J Cereb Blood Flow Metab
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2022
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42(9):1579-1596.
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Liu B, Huang D, Guo Y, Sun X, Chen C, Zhai X, Jin X, Zhu H,, Yu W
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Recent advances and perspectives of postoperative neurological disorders in the elderly surgical patients
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CNS Neurosci Ther
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2022
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28(4):470-483.
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Guo Y,
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Recent highlights in periopeative neurological disorders, from bench to bedside.
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CNS Neurosci Ther.
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2022
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28(4):467-469
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Wanqing Xie,
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Visualizing regulatory lymphocytic responses to predict neurological outcome after stroke.
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CNS Neurosci Ther.
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2021
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27(8):867-868
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Zhang Y, Li F, Chen C, Li Y, Xie W, Huang D, Zhai X, Yu W, Wan J,
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RAGE-mediated T cell metabolic reprogramming shapes T cell inflammatory response after stroke.
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J Cereb Blood Flow Metab
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2021
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42(6):952-965
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Chen C, Huang T, Zhai X, Ma Y, Xie L, Lu B, Zhang Y, Li Y, Chen Z, Yin J*,
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Targeting neutrophils as a novel therapeutic strategy after stroke
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J Cereb Blood Flow Metab
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2021
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41(9):2150-2161
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Zhang Y, Liesz A,
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Coming to the Rescue: Regulatory T Cells for Promoting Recovery After Ischemic Stroke
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Stroke
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2021
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52(12):e837-e841
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Xie L, Lu B, Ma Y, Yin J, Zhai X, Chen C, Xie W, Zhang Y, Zheng L*,
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The 100 most-cited articles about the role of neurovascular unit in stroke 2001-2020: A bibliometric analysis.
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CNS Neurosci Ther.
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2021
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27(7):743-752.
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Chen W, Xie L, Yu F, Li Y, Chen C, Xie W, Huang T, Zhang Y, Zhang S*,
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Zebrafish as a Model for In-Depth Mechanistic Study for Stroke.
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Transl Stroke Res.
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2021
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doi: 10.1007/s12975-021-00907-3
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Tingting Huang, Yan Li, Yuxi Zhou, Bingwei Lu, Yueman Zhang, Dan Tang, Yu Gan, Zhengzhou He, Zeng-ai Chen, Weifeng Yu,
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Stroke exacerbates cancer progression by upregulating LCN2 in PMN-MDSCs.
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Frontiers in Immunology
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2020
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21;11:299.
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Shiqiu Yu,
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Cognitive declines after perioperative covert stroke: Recent advances and perspectives
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Curr Opin Anaesthesiol .
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2020
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10.1097/ACO.0000000000000903
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Yan Li, Zi-Yu Zhu, Bing-Wei Lu, Ting-Ting Huang, Yue-Man Zhang, Na-Ying Zhou, Wei Xuan, Zeng-Ai Chen, Da-Xiang Wen, Wei-Feng Yu,
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Rosiglitazone ameliorates tissue plasminogen activator‐induced brain hemorrhage after stroke
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CNS Neurosci Ther.
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2019
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25 (12), 1343-1352
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Li Y#, Xie L#, Huang T, Zhang Y, Zhou J, Qi B, Wang X, Chen Z,
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Aging Neurovascular Unit and Potential Role of DNA Damage and Repair in Combating Vascular and Neurodegenerative Disorders.
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Front Neurosci.
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2019
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8;13:778.
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Zhu Z#, Zheng L#, Li Y, Huang T, Chao YC, Pan L, Zhu H, Zhao Y, Yu W*,
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Potential Immunotherapeutic Targets on Myeloid Cells for Neurovascular Repair After Ischemic Stroke.
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Front Neurosci.
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2019
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9;13:758.
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Wang X#, Zhou Y#, Tang D, Zhu Z, Li Y, Huang T, Müller R, Yu W*,
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ACC1 (Acetyl Coenzyme A Carboxylase 1) Is a Potential Immune Modulatory Target of Cerebral Ischemic Stroke.
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Stroke.
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2019
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50(7):1869-1878.
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Zhou YX#, Wang X#, Tang D, Li Y, Jiao YF, Gan Y, Hu XM, Yang LQ, Yu WF, Stetler RA,, Wen DX*
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IL-2mAb reduces demyelination after focal cerebral ischemia by suppressing CD8+ T cells.
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CNS Neurosci Ther.
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2019
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25(4):532-543
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Wang X#, Xuan W#, Zhu Z, Li Y, Zhu H, Zhu L, Fu D, Yang L,, Yu W*.
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The evolving role of neuro-immune interaction in brain repair after cerebral ischemic stroke.
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CNS Neurosci Ther.
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2018
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24(12):1100-1114
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Li Y#, Zhu Z#, Huang T, Zhou Y, Wang X, Yang L, Chen Z, Yu W*,
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The peripheral immune response after stroke – a double edge sword for blood brain barrier integrity.
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CNS Neurosci Ther.
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2018
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24(12):1115-1128
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, Stetler RA, Leak RK, Shi Y, Li Y, Yu W, Bennett MVL, Chen J*.
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Oxidative stress and DNA damage after cerebral ischemia: Potential therapeutic targets to repair the genome and improve stroke recovery.
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Neuropharmacology.
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2018
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134(Pt B):208-217.
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Wang L#, Zhou Y#, Yin J#, Gan Y, Wang X, Wen D, Thomson AW, Hu X, Yang L, Stetler RA,, Yu W*.
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Cancer Exacerbates Ischemic Brain Injury Via Nrp1 (Neuropilin 1)-Mediated Accumulation of Regulatory T Cells Within the Tumor.
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Stroke
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2018
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49(11):2733-2742
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Mao L,, Zhu W, Cai W, Liu Z, Wang Y, Luo W, Stetler RA, Leak RK, Yu W, Gao Y, Chen J, Chen G, Hu X.
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Regulatory T cells ameliorate tissue plasminogen activator-induced brain haemorrhage after stroke.
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Brain.
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2017
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1;140(7):1914-1931.
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, Wang L, Zhou Y, Gan Y, Zhu W, Xia Y, Jiang X, Watkins S, Vazquez A, Thomson AW, Chen J, Yu W, Hu X.
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C-C Chemokine Receptor Type 5 (CCR5)-Mediated Docking of Transferred Tregs Protects Against Early Blood-Brain Barrier Disruption After Stroke.
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J Am Heart Assoc.
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2017
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2;6(8)
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Leak RK,, Zhang F, Sulaiman HH, Weng Z, Wang G, Stetler RA, Shi Y, Cao G, Gao Y, Chen J
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APE1 upregulation reduces oxidative DNA damage and protects hippocampal neurons from ischemic injury
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Antioxid Redox Signal.
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2015
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22(2):135-48
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, Mao L, Liu X, Gan Y, Zheng J, Thomson AW, Gao Y, Chen J, Hu X.
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Essential role of program death 1-ligand 1 in regulatory T-cell-afforded protection against blood-brain barrier damage after stroke
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Stroke
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2014
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45(3):857-64
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An C, Shi Y,, Hu X, Gan Y, Stetler RA, Leak RK, Gao Y, Sun BL, Zheng P, Chen J.
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Molecular dialogs between the ischemic brain and the peripheral immune system: dualistic roles in injury and repair.
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Prog Neurobiol
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2014
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115:6-24
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, Gan Y, Sun B, Zhang F, Lu B, Gao Y, Liang W, Thomson AW, Chen J, Hu X
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Adoptive regulatory T cell therapy protects against cerebral ischemia.
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Ann Neurol
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2013
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74(3):458-71
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, Mao L, Zhou G, Leak RK, Sun BL, Chen J, Hu X
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Adoptive Regulatory T-Cell Therapy Preserves Systemic Immune Homeostasis After Cerebral Ischemia.
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Stroke
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2013
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44(12):3509-15
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, Hu X, Gan Y, Gao Y, Liang W, Chen J.
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Mechanistic insight into DNA damage and repair in ischemic stroke: exploiting the base excision repair pathway as a model of neuroprotection.
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Antioxid Redox Signal.
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2011
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14(10):1905-18
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