• 基本信息
    导师姓名： 王计秋 学科代码： 100201
    性别： 男 学科名称： 内科学
    培养单位： 附属瑞金医院 三级学科 内分泌与代谢病
    导师类型： 博士生导师 专业领域名称：
    联系方式： 上海市瑞金二路197号11号楼922室 专业领域代码：
    邮编： 200025 邮箱地址： jiqiuwang@163.com
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    上海市“银蛇奖”一等奖
    教育部“长江学者奖励计划”青年学者
    国家重点研发计划首席科学家
    国家自然科学基金委“优秀青年”
    上海市优秀学术/技术带头人（上海市学带）
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    2022YFC2505200中国人极端肥胖队列与精细分型研究科技部国家重点研发计划“常见多发病” 2022-12~2025-12 1500万元  课题负责人
    2023-xxx“脑肠轴”对话调控肠道油脂吸收机制及其在肥胖发生中的作用研究上海市自然科学重大项目 2022-11~2027-11 300万元  课题负责人
    20XD1403200青少年肥胖病的发病机制与干预研究2020年度优秀学术技术带头人计划（上海市科委） 2020-08~2022-07 40万元  课题负责人
    91957124性别决定关键基因调控能量平衡与糖脂代谢的机制研 究重大研究计划-培育项目 2020-01~2020-12 92万元  课题负责人
    20191306 R-Spondins/LGR4 通路调控能量平衡与糖脂代谢的机制研究上海交通大学医学院 “临床专职科研队伍”（第二轮） 2020-01~2022-12 100万元  课题负责人
    2019-08Jiangnan Diet Intervention Study上海市医药卫生发展基金会与赛诺菲（中国）联合“糖尿病临床研究项目” 2019-09~2020-08 20万元  课题负责人
    19140904000构建多种动物模型探究经典Wnt信号通路参与肥胖症发生和脂肪棕色化的分子机制上海市科委（科技专项经费） 2019-06~2022-03 40万元  课题负责人
    SQ2018YFC130289肠道与下丘脑在糖尿病发生发展中的作用及干预新方案研究国家重点研发计划“重大慢病防控研究” 2019-01~2021-12 250万元  子课题负责人
    2018BR01Wnt信号通路与肥胖发生上海市优秀学科带头人 2018-07~2021-06 45万元  课题负责人
    20161306LGR4/Wnt/beta-catenin信号通路与肥胖发生上海交通大学医学院高原高峰计划 2016-07~2019-06 100万元  课题负责人
    81522011 肥胖症发病机制国家自然科学基金-优秀青年项目 2016-01~2018-01 150万元  课题负责人
    81570757NPC1促进中国青少年肥胖发生的遗传与机制研究国家自然科学基金-面上项目 2016-01~2019-12 59.6万元  课题负责人
    81370949LGR4调节米色脂肪前体细胞定向分化机制及肥胖治疗应用国家自然科学基金-面上项目 2014-01~2017-12 61万元  课题负责人
    8100634GPR48在昼夜节律异常与能量代谢紊乱中的作用国家自然科学基金-青年科学基金项目 2012-01~2012-12 14万元  课题负责人
    81030011G蛋白偶联受体家族成员GPR48在能量平衡与肥胖发生中的作用研究国家自然科学基金-重点项目 2011-01~2014-12 240万元  课题参与人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Yaogan Luo, Liang Sun, Qingqing Wu, Boyu Song, Yanpu Wu, Xiaowei Yang, Puchen Zhou, Zhenhua Niu, He Zheng, Huaixing Li, Weiqiong Gu,, Guang Ning, Rong Zeng, Xu Lin  Diet-Related Lipidomic Signatures and Changed Type 2 Diabetes Risk in a Randomized Controlled Feeding Study With Mediterranean Diet and Traditional Chinese or Transitional Diets  Diabetes Care  2023  dc230314 
    Na Chen#, Mingyang Yuan#, NingNing Zhang, Maopei Chen, Ruixin Liu,, Peng Lu*  Ctnnb1/β-catenin inactivation in UCP1-positive adipocytes augments the browning of white adipose tissue  iScience  2023  26(5):106552 
    Zhiyin Zhang#, Na Chen#, Nan Yin#, Ruixin Liu#, Yang He#, Danjie Li, Muye Tong, Aibo Gao, Peng Lu, Yuxiao Zhao, Huabing Li, Junfang Zhang, Dan Zhang, Weiqiong Gu, Jie Hong, Weiqing Wang, Lu Qi, Guang Ning,  The rs1421085 variant within FTO promotes brown fat thermogenesis  Nat Metab  2023  doi: 10.1038/s42255-023-00847-2 
    Ran Wei#, Danjie Li#, Sheng Jia, Yuhong Chen,  MC4R in Central and Peripheral Systems  Adv Biol  2023  e2300035 
    Yingkai Sun#, Juan Zhang#, Jie Hong#, Zhongyun Zhang#, Peng Lu#, Aibo Gao, Mengshan Ni, Zhiyin Zhang, Huanjie Yang, Juan Shen, Jieli Lu, Wenzhi Xue, Qianqian Lv, Yufang Bi, Yi Arial Zeng, Weiqiong Gu, Guang Ning, Weiqing Wang*, Ruixin Liu*,  Human RSPO1 Mutation Represses Beige Adipocyte Thermogenesis and Contributes to Diet-Induced Adiposity  Adv Sci  2023  10(12):e2207152 
    Ningning Zhang#, Mingyang Yuan#,  LGR4: A New Receptor Member in Endocrine and Metabolic Diseases  Endocr Rev  2023  44(4):647-667 
    Yaogan Luo#,,#, Liang Sun#, Weiqiong Gu#, Geng Zong, Boyu Song, Chongrong Shen, Puchen Zhou, Yufei Chen, Yanpu Wu, Huibin Lin, He Zheng, Mengshan Ni, Xiaowei Yang, Yanru Chen, Xinming Xu, Juan Zhang, Juan Shi, Ru Zhang, Jinfen Hu, Hong Hou, Ling Lu, Xiaoqiang Xu, Liming Liang, Ruixin Liu, Xiaoran Liu, Huaixing Li, Jie Hong, Weiqing Wang, Xu Lin*, Guang Ning*  Isocaloric-restricted Mediterranean diet and Chinese diets high or low in plants in adults with prediabetes  J Clin Endocrinol Metab  2022  dgac303 
    Yu Li, Dongmei Wang, Xiaodan Ping, Yankang Zhang, Ting Zhang, Li Wang, Li Jin, Wenjun Zhao, Mingwei Guo, Fei Shen, Meiyao Meng, Xin Chen, Ying Zheng,, Dali Li, Qiang Zhang, Cheng Hu, Lingyan Xu, Xinran Ma  Local hyperthermia therapy induces browning of white fat and treats obesity  Cell  2022  185(6):949-966.e19 
    Zhongyun Zhang, Juan Zhang,  Surface charge changes in spike RBD mutations of SARS-CoV-2 and its variant strains alter the virus evasiveness via HSPGs: A review and mechanistic hypothesis  Front Public Health  2022  10:952916 
    Lingfang Zhuang, Kangni Jia, Chen Chen, Zhigang Li, Jiaxin Zhao, Jian Hu, Hang Zhang, Qin Fan, Chunkai Huang, Hongyang Xie, Lin Lu, Weifeng Shen, Guang Ning,, Ruiyan Zhang*, Kang Chen*, Xiaoxiang Yan*  DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by Impairing Mitochondrial Bioenergetics  Circulation  2022  145(11):829-846 
    Wen Liu#, Danjie Li#, Minglan Yang#, Long Wang#, Yu Xu#, Na Chen, Zhiyin Zhang, Juan Shi, Wen Li, Shaoqian Zhao, Aibo Gao, Yufei Chen, Qinyun Ma, Ruizhi Zheng, Shujing Wu, Yifei Zhang, Yuhong Chen, Shuwen Qian, Yufang Bi, Weiqiong Gu, Qiqun Tang, Guang Ning, Ruixin Liu, Weiqing Wang, Jie Hong,  GREM2 is associated with human central obesity and inhibits visceral preadipocyte browning  EBioMedicine  2022  78:103969 
    Jie Hong, Tingting Bo, Liuqing Xi, Xiaoqiang Xu, Naying He, Yafeng Zhan, Wanyu Li, Peiwen Liang, Yufei Chen, Juan Shi, Danjie Li, Fuhua Yan, Weiqiong Gu, Weiqing Wang, Ruixin Liu,, Zheng Wang*, Guang Ning  Reversal of Functional Brain Activity Related to Gut Microbiome and Hormones After VSG Surgery in Patients With Obesity  J Clin Endocrinol Metab  2021  106(9):e3619-e3633 
    Yuying Yang, Yanman Zhou, Jingzun Xu, Lihao Sun, Bei Tao, Weiqing Wang,, Hongyan Zhao*, Jianmin Liu*  Lgr4 promotes aerobic glycolysis and differentiation in osteoblasts via the canonical Wnt/β-catenin pathway  J Bone Miner Res  2021  36(8):1605-1620 
    Zhiyin Zhang, Qihan Wu, Yang He, Peng Lu, Danjie Li, Minglan Yang, Weiqiong Gu, Ruixin Liu, Jie Hong*,  IRX3 Overexpression Enhances Ucp1 Expression In Vivo  Front Endocrinol  2021  12:634191 
    Aibo Gao#, Bin Gu#, Juan Zhang, Chen Fang, Junlei Su, Haorong Li, Rulai Han, Lei Ye, Weiqing Wang, Guang Ning,, Weiqing Gu*  Missense Variants in PAX4 Are Associated with Early-Onset Diabetes in Chinese  Diabetes Ther  2021  12(1):289-300 
    Juan Shi, Guoqing Bao, Jie Hong, Simin Wang, Yufei Chen, Shaoqian Zhao, Aibo Gao, Ru Zhang, Jingfen Hu, Wenjie Yang, Fuhua Yan, Ankang Lyu, Ruixin Liu, Bin Cui, Yuhong Chen, Jiabin Jin, Baiyong Shen, Yifei Zhang, Weiqiong Gu, Dagan Feng, Weiqing Wang,, Xiuying Wang*, Guang Ning*  Deciphering CT texture features of human visceral fat to evaluate metabolic disorders and surgery-induced weight loss effects  EBioMedicine  2021  69:103471 
    Aibo Gao#, Junlei Su#, Ruixin Liu#, Shaoqian Zhao, Wen Li, Xiaoqiang Xu, Danjie Li, Juan Shi, Bin Gu, Juan Zhang, Qi Li, Xiaolin Wang, Yifei Zhang, Yu Xu, Jieli Lu, Guang Ning, Jie Hong, Yufang Bi, Weiqiong Gu*,, Weiqing Wang*  Sexual dimorphism in glucose metabolism is shaped by androgen-driven gut microbiome  Nat Commun  2021  12(1):7080 
    Lingxia Ye, Weiqiong Gu, Yufei Chen, Xuelin Li, Juan Shi, Ankang Lv, Jingfen Hu, Ru Zhang, Ruixin Liu, Jie Hong,, Yifei Zhang*.   The impact of shift work on glycemic characteristics assessed by CGM and its association with metabolic indices in non-diabetic subjects  Acta Diabetol  2020  57(1):53-61 
    Ajun Geng#, Ting Wu#, Cheguo Cai#, Wenqian Song,, Qing Cissy Yu , Yi Arial Zeng*  A novel function of R-spondin1 in regulating estrogen receptor expression independent of Wnt/β-catenin signaling  Elife  2020  doi: 10.7554/eLife.56434 
    Chunkai Huang, Daopeng Dai, Hongyang Xie, Zhenbing Zhu, Jian Hu, Min Su, Mingyao Liu, Lin Lu , Weifeng Shen, Guang Ning,, Ruiyan Zhang*, Xiaoxiang Yan*  Lgr4 Governs a Pro-Inflammatory Program in Macrophages to Antagonize Post-Infarction Cardiac Repair  Cir Res  2020  10.1161/CIRCRESAHA.119.315807 
    , Xu Lin, Zachary T. Bloomgarden, Guang Ning*  The Jiangnan diet, a healthy diet pattern for Chinese  J Diabetes  2020  2020;1–7 
    Maopei Chen, Peng Lu, Qinyun Ma, Yanan Cao, Na Chen, Wen Li, Shaoqian Zhao, Banru Chen, Juan Shi, Yingkai Sun, Hongbin Shen, Liangdan Sun, Juan Shen, Qijun Liao, Yifei Zhang, Jie Hong, Weiqiong Gu, Ruixin Liu*, Guang Ning*, Weiqing Wang*,  CTNNB1/β-catenin dysfunction contributes to adiposity by regulating the cross-talk of mature adipocytes and preadipocytes  Sci Adv  2020  6(2):eaax9605 
    Yang He#, Ruixin Liu#, Mingting Zhu, Wenbin Shen, Jing Xie, Zhiyin Zhang, Na Chen, Chang Shan, Xin zhi Guo, Yide Lu, Bei Tao, Lihao Sun, Hongyan Zhao, Rui Guo, Biao Li, Simin Liu, Guang Ning*,, Jianmin Liu*  The browning of white adipose tissue and body weight loss in primary hyperparathyroidism  EBioMedicine  2019  Feb;40:56-66 
    Xuemin Gong#, Yunfeng Li#, Jie Luo#,, Jian Wei#, Juqiong Wang, Ting Xiao, Chang Xie, Jie Hong, Guang Ning, Xiongjie Shi, Boliang Li, Wei Qi*, Baoliang Song*  Gpnmb secreted from liver promotes lipogenesis in white adipose tissue and aggravates obesity and insulin resistance  Nat Met  2019  doi.org/10.1038/s42255-019-0065-4 
    Zhou M, Jing S, Wu CY, Shu L, Dong W, Liu Y, Chen M, Wynn RM,, Wang J, Gui WJ, Qi X, Lusis AJ, Li Z, Wang W, Ning G, Yang X, Chuang DT, Wang Y, Sun H.  Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance  Diabetes  2019  68(9):1730-1746 
    Pei Liu, Sixia Huang, Shifeng Ling, Shuqin Xu, Fuhua Wang, Wei Zhang, Rujiang Zhou, Lin He, Xuechun Xia, Zhengju Yao, Ying Fan, Niansong Wang, Congxia Hu, Xiaodong Zhao, Haley O. Tucker,, Xizhi Guo*.  Foxp1 controls brown/beige adipocyte differentiation and thermogenesis through regulating β3-AR desensitization.  Nat Commun  2019  10(1):5070 
    Ma X, Feng D, Lu Y, Sun N,, Xu L  Novel Strategies Targeting Obesity and Metabolic Diseases  Front Physiol  2019  29;10:668 
    Lishu Yue#, Wenjun Zhao#, Dongmei Wang#, Meiyao Meng, Ying Zheng, Yu Li, Jin Qiu, Jian Yu, Yang Yan, Peng Lu, Youmin Sun, Jie Fu,, Qiang Zhang, Lingyan Xu*, Xinran Ma*  Silver nanoparticles inhibit beige fat function and promote adiposity  Mol Metab  2019  Apr;22:1-11 
    Tianshi Wang#,*, Ying Cao#, Quan Zheng, Jun Tu, Wei Zhou, Jianli He, Jie Zhong, Yalan Chen,, Rong Cai, Yong Zuo, Bo Wei, Qiuju Fan, Jie Yang, Yicheng Wu, Jing Yi, Dali Li, Mingyao Liu, Chuangui Wang, Aiwu Zhou, Yu Li, Xuefeng Wu, Wen Yang, Y. Eugene Chin, Guoqiang Chen, Jinke Cheng*.  SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism  Mol Cell  2019  75(4):823-834.e5 
    Qianqian Lv#, Yuying Yang, Sheng Jia, Shaoqian Zhao, Bin Gu, Peng Lu, Yang He, Ruixin Liu,, Guang Ning*, Qinyun Ma*  SRC1 Deficiency in Hypothalamic Arcuate Nucleus Increases Appetite and Body Weight  J Mol Endocrinol  2018  doi: 10.1530/JME-18-0075 
    Xuhao Zhi,, Peng Lu, Jue Jia, Hongbin She*, Guang Ning*  AdipoCount: A New Software for Automatic Adipocyte Counting  Front Physiol  2018  20;9:85 
    Na Chen,  Wnt/β-Catenin Signaling and Obesity  Front Physiol  2018  17;9:792 
    Dandan Zhao, Shaoqian Zhao, Xiao Wang, Mingbo Su, Wen Liu, Qinyun Ma, Jie Hong, Weiqiong Gu, Jingya Li, Ruixin Liu, Guang Ning,, Yifei Zhang*  Clinical and Physiological Characterization of Elevated Plasma Glucagon-Like Peptide-1 Levels (Hyperglipemia) in a Dipeptidyl Peptidase IV Mutation Carrier  Front Endocrinol (Lausanne)  2018  5;9:62 
    Yingkai Sun#, Rui Wang#, Shaoqian Zhao, Wen Li, Wen Liu, Linyun Tang, Zhugang Wang, Weiqing Wang, Ruixin Liu, Guang Ning,, Jie Hong*  FGF9 inhibits browning program of white adipocytes and associates with human obesity  J Mol Endocrinol  2018  doi: 10.1530/JME-18-0151 
    Ruixin Liu#, Jie Hong#, Xiaoqiang Xu#, Qiang Feng#, Dongya Zhang#, Yanyun Gu#, Juan Shi, Shaoqian Zhao, Wen Liu, Xiaokai Wang, Huihua Xia, Zhipeng Liu, Bin Cui, Peiwen Liang, Liuqing Xi, Jiabin Jin, Xiayang Ying, Xiaolin Wang, Xinjie Zhao, Wanyu Li, Huijue Jia, Zhou Lan, Fengyu Li, Rui Wang, Yingkai Sun, Minglan Yang, Yuxin Shen, Zhuye Jie, Junhua Li, Xiaomin Chen, Huanzi Zhong, Hailiang Xie, Yifei Zhang, Weiqiong Gu, Xiaxing Deng, Baiyong Shen, Xun Xu, Huanming Yang, Guowang Xu, Yufang Bi, Shenghan Lai, Jian Wang, Lu Qi, Lise Madsen,, Guang Ning*, Karsten Kristiansen*, Weiqing Wang*  Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention  Nature Medicine  2017  doi: 10.1038/nm.4358 
    Ruixin Liu#, Yaoyu Zou#, Jie Hong#, Min Cao#, Bin Cui#, Huiwen Zhang, Maopei Chen, Juan Shi, Tinglu Ning, Shaoqian Zhao, Wen Liu, Hui Xiong, Cuijie Wei, Zhengqing Qiu, Weiqiong Gu, Yifei Zhang, Wanyu Li, Lin Miao, Yingkai Sun, Minglan Yang, Rui Wang, Qinyun Ma, Min Xu, Yu Xu, Tiange Wang, Kei-hang Katie Chan, Xianbo Zuo, Haoyan Chen, Lu Qi, Shenghan Lai, Shumin Duan, Baoliang Song, Yufang Bi, Simin Liu*, Weiqing Wang*, Guang Ning*,  Rare Loss-of-Function Variants in NPC1 Predispose to Human Obesity  Diabetes  2017  66(4):935-947 
    Quan Zheng#, Ying Cao#, Yalan Chen,, Qiuju Fan, Xian Huang, Yiping Wang, Tianshi Wang, Xiuzhi Wang, Jiao Ma, Jinke Cheng*  Senp2 Regulates Adipose Lipid Storage by De-SUMOylation of Setdb1  J Mol Cell Biol  2017  10.1093/jmcb/mjx055 
    Yaoyu Zou#, Peng Lu#, Juan Shi, Wen Liu, Minglan Yang, Shaoqian Zhao, Na Chen, Maopei Chen, Yingkai Sun, Aibo Gao, Qingbo Chen, Zhiguo Zhang, Qinyun Ma, Tinglu Ning, Xiayang Ying, Jiabin Jin, Xiaxing Deng, Baiyong Shen, Yifei Zhang, Bo Yuan, Sophie Kauderer, Simin Liu, Jie Hong, Ruixin Liu, Guang Ning*, Weiqing Wang*, Weiqiong Gu*,  IRX3 Promotes the Browning of White Adipocytes and Its Rare Variants Are Associated with Human Obesity Risk  EBioMedicine  2017  24:64-75 
    Tingting Liu, Dongmei Liu, Yan Xuan, Lin Zhao, Lihao Sun, Diandian Zhao, Xiaofeng Wang, Yang He, XingZhi Guo, Rui Du,, Jianmin Liu, Hongyan Zhao, Bei Tao  The association between the baseline bone resorption marker CTX and incident dysglycemia after 4 years  Bone Research  2017  4(5):17020 
    Rong Wu, Jianguang Sun,, Binhua Li, Qingsong Liu, Guang Ning, Wanzhu Jin*, and Zengqiang Yuan*  c-Abl inhibition mitigates diet-induced obesity through improving insulin sensitivity of subcutaneous fat in mice  Diabetologia  2017  60(5): 900-910 
    Tinglu Ning, Yaoyu Zou, Minglan Yang, Qianqian Lu, Maopei Chen, Wen Liu, Shaoqian Zhao, Yingkai Sun, Juan Shi, Qinyun Ma, Jie Hong, Ruixin Liu,, Guang Ning*  Genetic interaction of DGAT2 and FAAH in the development of human obesity  Endocrine  2017  56(2):366-378 
    Wen Liu#, Shaoqian Zhao#,, Juan Shi, Yingkai Sun, Weiqing Wang, Guang Ning, Jie Hong*, Ruixin Liu*  Grape seed proanthocyanidin extract ameliorates inflammation and adiposity by modulating gut microbiota in high-fat diet mice  Mol Nutr Food Res  2017  10.1002/mnfr.201601082 
    Rong Wu, Xiaomeng Liu Jianguang Sun, Hong Chen, Jun Ma, Meng Dong, Shengyi Peng, Jiqiu Wang,, Donghao Li, John R Speakman, Guang Ning, Wanzhu Jin*, and Zengqiang Yuan*  DJ-1 maintains energy and glucose homeostasis by regulating the function of brown adipose tissue  Cell Discov   2017  3: 16054 
    Shaoqian Zhao#, Wen Liu#,, Juan Shi, Yingkai Sun, Weiqing Wang, Guang Ning, Ruixin Liu*, Jie Hong*  Akkermansia muciniphila improves metabolic profiles by reducing inflammation in chow diet-fed mice  J Mol Endocrinol  2017  58(1):1-14 
    Yaoyu Zou, Tinglu Ning, Juan Shi, Maopei Chen, Lin Ding, Ya Huang, Sophie Kauderer, Min Xu, Bin Cui, Yufang Bi, Simin Liu, Jie Hong, Ruixin Liu, Guang Ning*,  Association of a gain-of-function variant in LGR4 with central obesity  Obesity  2017  25(1):252-260 
    Jian Luo, Zhengfeng Yang, Yu Ma, Zhiying Yue, Hongyu Lin, Guojun Qu, Jinping Huang, Wentao Dai, Chenghai Li, Chunbing Zheng, Leqin Xu, Huaqing Chen,, Dali Li, Stefan Siwko, Josef M Penninger, Guang Ning, Jianru Xiao, Mingyao Liu   LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption  Nature Medicine  2016  22:539-546 
    Qinyun Ma#, Jianxia Fan#,, Shuai Yang, Qing Cong, Rui Wang, Qianqian Lv, Ruixin Liu, Guang Ning*   High levels of CG attenuate insulin sensitivity and promote inflammation in adipocytes  J Mol Endocrinol  2015  54:161-170 
    Feng Wang, Xianfeng Zhang,, Maopei Chen, Nengguang Fan, Qinyun Ma, Ruixin Liu, Rui Wang, Xiaoying Li, Mingyao Liu and Guang Ning*  LGR4 acts as a link between the peripheral circadian clock and lipid metabolism in liver  J Mol Endocrinol  2015  52:133-143 
    Rui Wang#, Jie Hong#, Ruixin Liu#, Maopei Chen, Min Xu, Wiqiong Gu, Yifei Zhang, Qinyun Ma, Feng Wang, Juan Shi,, Weiqing Wang and Guang Ning*  SFRP5 acts as a mature adipocyte marker but not as a regulator in adipogenesis  J Mol Endocrinol  2015  53:405-415 
    Yingkai Sun#, Jie Hong#, Maopei Chen#, Yingying Ke, Shaoqian Zhao, Wen Liu, Qinyun Ma, Juan Shi, Yaoyu Zou, Tinglu Ning, Zhiguo Zhang, Ruixin Liu*,, Guang Ning  Ablation of Lgr4 enhances energy adaptation in skeletal muscle via activation of Ampk/Sirt1/Pgc1α pathway  Biochem Bioph Res Co  2015  464:396-400 
    Zhiguo Zhang, Huizhi Zhang, Bo Li, Xiangjian Meng,, Yifei Zhang, Shuangshuang Yao, Qinyun Ma, Lina Jin, Jian Yang, Weiqing Wang, Guang Ning  Berberine activates thermogenesis in white and brown adipose tissue.  Nat Commun  2014  25:5393 
    Liyu Huang, Yuping Wang, Baofeng Wei, Jian Yang,, Binghao Wu, Zhuangzhuang Zhang, Yingyong Hou, Weiming Sun, Renming Hu, Guang Ning, Zeguang Han*  Deficiency of IRTKS as an adaptor of insulin receptor leads to insulin resistance  Cell Res  2013  23:1310-1321 
    , Ruixin Liu#, Feng Wang#, Jie Hong, Xiaoying Li, Maopei Chen, Yingying Ke, Xianfeng Zhang, Qinyun Ma, Rui Wang, Juan Shi, Bin Cui, Weiqiong Gu, Yifei Zhang, Zhiguo Zhang, Weiqing Wang, Xuefeng Xia, Mingyao Liu and Guang Ning*  Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch.  Nat Cell Biol  2013  15:1455-1463 
    , Xiaoying Li, Yingying Ke, Yan Lu, Feng Wang, Nengguang Fan, Haiyan Sun, Huijie Zhang, Ruixin Liu, Jun Yang, Lei Ye, Mingyao Liu, and Guang Ning*   GPR48 Increases Mineralocorticoid Receptor Gene Expression  J Am Soc Nephrol  2012  23:281-293 
    Xiaoying Li, Yan Lu, Haiyan Sun,, Jun Yang, Huijie Zhang, Nengguang Fan, Jia Xu, Jingjing Jiang, Ruya Liu, Dali Li, Mingyao Liu, Guang Ning*  G protein-coupled receptor 48 upregulates estrogen receptor alpha expression via cAMP/PKA signaling in the male reproductive tract  Development  2010  137:151-157