• 基本信息
    导师姓名： 洪登礼 学科代码： 100100
    性别： 男 学科名称： 基础医学
    培养单位： 基础医学院 三级学科
    导师类型： 博士生导师 专业领域名称：
    联系方式： Tel:021-53520912 Fax:021-64154900 专业领域代码：
    邮编： 200025 邮箱地址： dlhong@sjtu.edu.cn
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    Blood、Oncotarget等杂志审稿人
    Annals of Hematology & Oncology杂志编辑
    ASH、ISSCR、ISEH等国际协会会员
    国家自然科学基金委员会项目二审评委专家
    首届上海肿瘤干细胞国际研讨会执行主席
    上海脐带血库专家委员会委员
    中国血液生理学专业委员会造血微环境学组副组长
    中国生物物理学会衰老生物学分会理事
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    81920108005白血病干细胞克隆性表观遗传结构在骨髓微环境中的塑造和演化国家自然科学基金国际(地区)合作与交流项目 2020-01~2024-12 248万元  课题负责人
    31872842发育过程中FEV调控造血干细胞自我更新的机制和转换国家自然科学基金面上项目 2019-01~2022-12 60万元  课题负责人
    81721004应激与肿瘤国家自然科学基金创新研究群体项目 2018-01~2023-12 1050万元  课题参与人
    81730007急性白血病骨髓微环境在治疗过程中的微生态演国家自然科学基金重点项目 2018-01~2022-12 293万元  课题负责人
    91442106白血病骨髓免疫豁免微环境的组成和形成机制国家自然科学基金重大研究计划/培育项目 2015-01~2017-12 100万元  课题负责人
    2012CB967000肿瘤干细胞的动态演进及干预研究科技部重大科学研究计划 2012-01~2016-08 392万元  子课题负责人
    81120108006BCR-ABL相关急性淋巴细胞白血病干细胞克隆性演化的遗传变异多样性国家自然科学基金国际(地区)合作与交流项目 2012-01~2016-12 280万元  课题负责人
    10PJ1406500干细胞在相关白血病起始和发展中的缓慢克隆性演化上海市浦江人才计划 2010-07~2012-06 25万元  课题负责人
    1172091前白血病干细胞生物学特性研究上海市白玉兰科技人才基金 2010-06~2011-05 3万元  课题负责人
    90919055TEL-AML1启动的干细胞克隆性演化的表观遗传调控机制国家自然科学基金重大计划培育项目 2010-01~2012-12 60万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Dong X, Mu LL, Liu XL, Zhu H, Yang SC, Lai X, Liu HJ, Feng HY, Lu Q, Zhou BB, Chen HZ, Chen GQ, Lovell JF,, and Fang C  Biomimetic, Hypoxia-Responsive Nanoparticles Overcome Residual Chemoresistant Leukemic Cells with Co-targeting of Therapy-Induced Bone Marrow Niches  Advanced Functional Material  2020  2000309 
    Chen YL, Tang C, Zhang MY, Huang WL, Ding LX, Li BS, Shen SH, Liu SL, Li H, Zhu ZQ, Chen HW, Tang ZH, Chen J,, Chen HZ, Duan CW, Zhou BS  Blocking ATM-dependent NF-κB pathway overcomes niche protection and improves chemotherapy response in acute lymphoblastic leukemia  Leukemia  2019  33(10): 2365-2378 
    Tang C, Li MH, Chen YL, Sun HY, Liu SL, Zheng WW, Zhang MY, Li H, Fu W, Zhang WJ, Liang AB, Tang ZH,, Zhou BS, Duan CW  Chemotherapy-induced niche perturbs hematopoietic reconstitution in B-cell acute lymphoblastic leukemia  J Exp Clin Cancer Res  2018  37(1):204 
    Li Z, Li SP, Li RY, Zhu H, Liu X, Guo XL, Mu LL, Cai JJ, Bai F, Chen GQ,  Leukaemic alterations of IKZF1 prime stemness and malignancy programs in human lymphocytes  Cell Death Dis  2018  9(5):526 
    Liu TH, Tang YJ, Huang Y, Wang L, Guo XL, Mi JQ, Liu LG, Zhu H, Zhang Y, Chen L, Liu X, Zhang LH, Ye QJ, Li BS, Tang JY, Ford A, Enver T, Liu F, Chen GQ,  Expression of the fetal hematopoiesis regulator FEV indicates leukemias of prenatal origin  Leukemia  2017  (5):1079-1086 
    Mu LL, Ke F, Guo XL, Cai JJ,  Neoplasms in the bone marrow niches: disturbance of the microecosystem  Int J Hematol  2017  105(5):558-565 
    Wang J, Yin MZ, Zhao KW, Ke F, Jin WJ, Guo XL, Liu TH, Liu XY, Gu H, Yu XM, Li Z, Mu LL,, Chen J, Chen GQ  APC/C is essential for hematopoiesis and impaired in aplastic anemia  Oncotarget  2017  8(38):63360-63369 
    Guo XL, Chu L, Ke F, Mu LL, Li Z, Cai JJ, Li HF,  Recipient bone marrow assimilates the myeloid/lymphoid reconstitution of distinct fetal hematopoietic stem cells  Oncotarget  2017  8 (65):108981-108988 
    Boto C, Quartin E, Cai YJ, Martín-Lorenzo A, Cenador MBG, Pinto S, Gupta R, Enver T, Sánchez-García I,, Pires das Neves R, Ferreira L  Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation  Nat Commun  2017  8:15204 
    Liu S,Liu HY,Qin R,Shu Y,Liu ZD,Zhang PH,Duan CW,,Yu J,Zou L  The cellular senescence of leukemia-initiating cells from acute lymphoblastic leukemia is postponed by β-Arrestin1 binding with P300-Sp1 to regulate hTERT transcription  Cell Death Dis  2017  8(4):e2756 
    Fan D, Li Z, Zhou X, Li Z, Duan C, Liu T, Zhang F, Huang Y, Zhang Y, Gao F, Guo Y, Gupta R, Chen G, Enver T, Tang J,, D  Stem Cell Programs are Retained in Human Leukaemic Lymphoblasts  Oncogene  2015  34(16):2083-93 
    Liang Y, Hu J, Li J, Liu Y, Yu J, Zhuang X, Mu L, Kong X,, Yang Q, Hu G  Epigenetic Activation of TWIST1 by MTDH Promotes Cancer Stem-like Cell Traits in Breast Cancer  Cancer Research  2015  75(17):3672-80 
    Duan Caiwen,Shi Jun,Chen Jing,Wang Bo,Yu Yehua,Qin Xia,Zhou Xiangcheng,Li Zuoqing,Zhang Fang,Yin Minzhi, Tao Ying,Mi Jianqing,Li Linheng,Tariq Enver,Chen Guo Qiang,  Leukaemia Propagating Cells Rebuild an Evolving Niche in Response to Therapy  Cancer Cell  2014  25(6):778-793 
    Kong Y, Chang YJ, Liu YR, Wang YZ, Jiang Q, Jiang H, Qin YZ, Hu Y, Lai YY, Duan CW,, Huang XJ  CD34(+)CD38(-)CD58(-) cells are leukemia-propagating cells in Philadelphia chromosome-positive acute lymphoblastic leukemia  Leukemia  2014  28(12):2398-401 
    He M, Wang QY, Yin QQ, Tang J, Lu Y, Zhou CX, Duan CW,, Tanaka T, Chen GQ, Zhao Q  HIF-1α downregulates miR-17/20a directly targeting p21 and STAT3: a role in myeloid leukemic cell differentiation  Cell Death Differentiation  2013  20(3):408-18 
    Wang Lu,Liu Tianhui,Xu Linjie, Gao Ya,Wei Yonglong, Duan Caiwen,Chen Guo-Qiang,Lin Shuo,Patient Roger,Zhang Bo,,Liu Feng   Fev regulates hematopoietic stem cell development via ERK signaling  Blood  2013  122(3):367-375 
    Tipping A, J Pina C, Castor A,, Rodrigues NP, Lazzari L, May GE, Jacobsen SE, Enver T  High GATA-2 expression inhibits human haematopoietic stem and progenitor cell function via effects on cell cycle  Blood  2009  113(12):2661-72 
    Ford AM, Palmi C, BuenoC,, Cardus P, Knight D, Cazzaniga G, Enver T, Greaves M  The TEL-AML1 leukaemia fusion gene dysregulates the TGF-beta pathway in early B lineage progenitor cells  J Clin Invest  2009  119(4):826-36 
    , Gupta R, Ancliff P, Atzberger, A, Brown J, Soneji S, Green J, Colman S, Piacibello W, Brckle V, Tsuzuki S, Greaves M, Enver T  Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukaemia  Science  2008  319：336 
    Pina C, May G, Soneji S,, Enver, T  MLLT3 regulates early human erythroid and megakaryocytic cell fate  Cell Stem Cell  2008  2, 264-73 
    Gupta R,, Iborra F, Sarno S, Enver T.   NOV (CCN3) functions as a regulator of human hematopoietic stem or progenitor cells  Science  2007  316：590-3 
    Chan A,, Atzberger A, Kollnberger S, Filer AD, Buckley CD, McMichael A, Enver T, Bowness P.   Human NK cells differentiate into CD56dim cells: role of contact with peripheral fibroblasts.   J Immunol.  2007  179, 89-94. 
    Tsuzuki S,, Gupta R, Mastsuo K, Seto M, Enver T   Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1  PLoS Med  2007  4 e172 
    Enver T, Tsuzuki S, Brown J,, Gupta R, Ford T, Egucchi MI, Egucchi M, Greaves M  Developmental impact of leukemic fusion genes on stem cell fate  Ann N Y Acad Sci  2005  1044, 16-23 
    Leone F, Perissinotto E, Cavalloni G, Fonsato V, Bruno S, Surrenti N,, Capaldi A, Geuna M, Piacibello W, Aglietta M  Expression of the c-ErbB-2/HER2 proto-oncogene in normal hematopoietic cells  J Leukoc Biol  2003  74, 593-601