- 基本信息
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导师姓名：
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郭澄
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学科代码：
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1002Z2
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性别：
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男
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学科名称：
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临床中西医结合
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培养单位：
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附属第六人民医院
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三级学科
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导师类型：
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博士生导师
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专业领域名称：
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联系方式：
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上海市宜山路600号，附属第六人民医院药剂科 邮箱：gboss@126.com
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专业领域代码：
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邮编：
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200233
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邮箱地址：
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gboss@ 126.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
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中国医院协会临床药事管理专业委员会委员
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《中国临床药学杂志》等6家杂志编委
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中国药学会医院药学专委会委员
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上海市康复医学研究会临床药学专业委员会主任委员
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上海市医院协会药事管理专委会副主任委员
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上海市药学会医院药学专委会副主任委员
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《中国药房》杂志副主编
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- 科研项目
| 2016ZB0302-01 | 上海市卫生计生系统重要薄弱学科建设 | 上海市卫生与计划生育委员会 |
2017-01~2019-12
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26万元
| 课题负责人 |
| 16DZ1911109 | 注射用苯磺顺阿曲库胺（库泰）在骨科手术中的应用性研究 | 上海市科学技术委员会 |
2016-09~2019-09
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20万元
| 课题负责人 |
| AB83110002016007 | 上海市临床药学重点专科建设基金 | 上海市卫计委 |
2016-08~2018-08
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100万元
| 课题负责人 |
| 20154Y0191 | CerK 调节脊髓星形胶质细胞炎性因子表达及其在炎性疼痛中的作用 | 上海市卫计委 |
2016-01~2018-12
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2万元
| 课题参与人 |
| 81503125 | 基于核糖体蛋白S5的木犀草素抗肝纤维化新靶点及机制研究 | 国家自然科学基金青年项目 |
2016-01~2018-12
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17.9万元
| 课题参与人 |
| 81503155 | β2-AR激动剂福莫特罗调控BCKDC改善恶病质骨骼肌萎缩的作用机制研究 | 国家自然科学基金青年项目 |
2016-01~2018-12
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17.9万元
| 课题参与人 |
| YG2014MS21 | 天然Nur77激动剂金丝桃苷及其结构类似物抑制血管平滑肌细胞增生作用机制研究 | 上海交大“科技创新专项资金”
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2015-01~2017-12
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15万元
| 课题参与人 |
| YG2014QN08 | 基于一种S1P/S1PR1新型通路治疗骨癌痛的研究 | 上海交大“科技创新专项资金” |
2015-01~2017-12
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8万元
| 课题参与人 |
| ZY3-RCPY-3-1036 | 中医药（中药临床药学）专门人才计划 | 上海市卫生局 |
2014-09~2016-08
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10万元
| 课题参与人 |
| 14ZR1432200 | 金丝桃苷调控Nur77表达抑制血管平滑肌细胞增殖机制研究 | 上海市科委 |
2014-07~2017-06
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10万元
| 课题参与人 |
| 81202599 | 多奈哌齐立体选择性代谢和转运机制及相关候选基因研究 | 国家自然科学基金 |
2013-01~2015-12
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23万元
| 课题参与人 |
| 2013BAI06B04Y023026 | 紫杉醇、卡培他滨的综合评价研究 | 国家科技部科技支撑计划子课题 |
2013-01~2015-12
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54万元
| 子课题负责人 |
| 81072687 | ERK5/MAPK信号通路在肝纤维化中的作用及木犀草素抗肝纤维化作用机制的研究 | 国家自然科学基金 |
2011-01~2013-12
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32万元
| 课题负责人 |
| 2010Y008A | 中药威灵仙微乳制剂的临床前研究
| 上海市卫生局 |
2011-01~2012-12
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3万元
| 课题负责人 |
| 10dz1920806 | 美哒灵、优哒灵临床用药评价及药物经济学研究
| 上海市科委 |
2010-08~2013-12
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10万元
| 课题负责人 |
- 学术论文
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Yang Quan-Jun, Huo Yan, Han Yong-Long, Wan Li-Li, Li Jie, Huang Jin-Lu, Lu Jin, Chen Peng-Guo, Gan Run,
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Selumetinib attenuate skeletal muscle wasting in murine cachexia model through ERK inhibition and AKT activation.
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Molecular cancer therapeutics
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2017
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16(2), 334-343.
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Quan-Jun Y1, Jian-Ping Z1, Jian-Hua Z2, Yong-Long H1, Bo X1, Jing-Xian Z1, Bona D3, Yuan Z2,
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Distinct Metabolic Profile of Inhaled Budesonide and Salbutamol in Asthmatic Children during Acute Exacerbation.
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Basic Clin Pharmacol Toxicol.
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2017
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120(3):303-311
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QuanJun Y1, GenJin Y2, LiLi W1, YongLong H1, Yan H1, Jie L1, JinLu H1, Jin L1, Run G1,
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Protective Effects of Dexrazoxane against Doxorubicin-Induced Cardiotoxicity: A Metabolomic Study
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Plos One
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2017
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12(1):e0169567
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Jin Lu, Jianliang Fu, Yuan Zhong, Pengguo Chen, Quanjun Yang, Yuwu Zhao, Lili Wan,
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The roles of apolipoprotein E3 and CYP2D6 (rs1065852) gene polymorphisms in the predictability of responses to individualized therapy with donepezil in Han Chinese patients with Alzheimer's disease
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Neuroscience Letters
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2016
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614（43–48）
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Jin-lu Huang, Yan Huo, Li-li Wan, Quan-jun Yang, Jie Li,
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CerK might contribute to inflammatory pain. Comments on Yu WL, Sun Y (2015). CerK inhibition might be a good potential therapeutic target for diseases. Br J Pharmacol 172: 2165.
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British Journal of Pharmacology
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2016
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173:1248-1249
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Zhi-yong Zhou, Li-li Wan, Quan-jun Yang, Yong-long Han, Dan Li, Jin Lu,
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Nilotinib reverses ABCB1/P-glycoprotein-mediated multidrug resistance but increases cardiotoxicity of doxorubicin in a MDR xenograft model
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Toxicology Letters
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2016
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DOI: 10.1016/j.toxlet.2016.07.710
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Pengguo Chen, Jie Li, Yan Huo, Jin Lu, Lili Wan, Quanjun Yang, Jinlu Huang, Run Gan & Cheng Guo
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Adenovirus-mediated expression of orphan nuclear receptor NR4A2 targeting hepatic stellate cell attenuates liver fibrosis in rats
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Sci Rep.
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2016
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6:33593.
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Li J,Li X,Xu W,Wang S,Hu Z,Zhang Q,Deng X,Wang J,Zhang J,
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Antifibrotic effects of luteolin on hepatic stellate cells and liver fibrosis by targeting AKT/mTOR/p70S6K and TGFβ/Smad signalling pathways.
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Liver Int
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2015
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35(4):1222-33
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Liu LY,Han YL,Zhu JH,Yu Q,Yang QJ,Lu J,
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A sensitive and high-throughput LC-MS/MS method for inhibition assay of seven major cytochrome P450s in human liver microsomes using an in vitro cocktail of probe substrates.
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Biomed Chromatogr.
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2015
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29(3):437-44
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Pengguo Chen, Jie Li, Yan Huo, Jin Lu, Lili Wan, Bin Li, Run Gan,
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Orphan nuclear receptor NR4A2 inhibits hepatic stellate cell proliferation through MAPK pathway in liver fibrosis
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PeerJ
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2015
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3: e1518
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Yang Quan-Jun, Bian Jun,Wan Li-Li,Han Yong-Long,Li Bin,Yu Qi, Li Yan,, and Yang Gen-Jin*
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NMR-based metabolomics reveals distinct pathways mediated by curcumin in cachexia mice bearing CT26 tumor
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RSC Adv.
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2015
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5, 11766-11775
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Bin Li,Run Gan, Quanjun Yang, Jinlu Huang, Pengguo Chen, Lili Wan,
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Chinese Herbal Medicines as an Adjunctive Therapy for Unresectable Pancreatic Cancer: A Systematic Review and Meta-Analysis
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EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
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2015
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2015：1-15
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Jin Lu, Lili Wan, Yuan Zhong, Qi Yu, Yonglong Han, Pengguo Chen, Beiyun Wang, Wei Li, Ya Miao,
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Stereoselective metabolism of donepezil and steady-state plasma concentrations of S-donepezil based on CYP2D6 polymorphisms in the therapeutic responses of Han Chinese patients with Alzheimer's disease
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Journal of Pharmacological Sciences
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2015
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2015, 129(3): 188–195
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Yang QuanJun,Yang GenJin,Wan LiLi,Huo Yan,Han YongLong, Lu Jin, Li Jie, Huang JinLu,
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Integrated Analysis of Serum and Intact Muscle Metabonomics Identify Metabolic Profiles of Cancer Cachexia in a Dynamic Mouse Model
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RSC ADVANCES
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2015
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5：92438 - 92448
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Li B, Wan L, Li Y, Yu Q, Chen P, Gan R, Yang Q, Han Y,
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Baicalin, a component of Scutellaria baicalensis, alleviates anorexia and inhibits skeletal muscle atrophy in experimental cancer cachexia.
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Tumour Biol.
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2014
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35(12):12415-25
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Huo Y, Yi B, Chen M, Wang N, Chen P,, Sun J*.
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Induction of Nur77 by Hyperoside Inhibits Vascular Smooth Muscle Cell Proliferation and Neointimal Formation.
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Biochem Pharmacol.
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2014
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15;92(4):590-8
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Han YL, Li D, Yang QJ, Zhou ZY, Liu LY, Li B, Lu J,
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In vitro inhibitory effects of scutellarin on six human/rat cytochrome P450 enzymes and P-glycoprotein.
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Molecules.
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2014
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19(5):5748-60.
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Wan Lili, Sun Yehong, Yu Qi, Huo Yan, Zhu Jinhui, Li Yan,
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In vitro permeability analysis, pharmacokinetic and brain distribution study in mice of imperatorin, isoimperatorin and cnidilin in Radix Angelicae Dahuricae
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Fitoerapia
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2013
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85:144-153
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Yang Quanjun#, Yang Genjin#, Wan Lili, Li Bin, Lu Jin, Yu Qi, Li Yan, Han Yonglong,, Zhang Junping*
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Serum metabolic profiles reveal the effect of formoterol on cachexia in tumor-bearing mice
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Molecular BioSystems
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2013
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9（12）, 3015-3025
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Wan Lili,, Zhou Zhiyong, Yu Qi, Li Yan, Li Dan, Zheng Xueli, Zhong Yuan
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Steady-State Plasma Concentration of Donepezil Enantiomers and Its Stereoselective Metabolism and Transport In Vitro
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chirality
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2013
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25:498-505
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Yang Quanjun#, Wan Lili#, Zhou Zhiyong, Li Yan, Yu Qi, Liu Liya, Li bin,
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Parthenolide from Parthenium integrifolium reduces tumor burden and alleviate cachexia symptoms in the murine CT-26 model of colorectal carcinoma
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Phytomedicine
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2013
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20（11）:992–998
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Zhiyong Zhou, Lili Wan, Yonglong Han, Xiangle Meng, Quanjun Yang, Yan Li, Qi Yu, Zan Shen,
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ABCB1-overexpressing MG63/DOX cell xenograft model: Maintain the MDR phenotype in vivo
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Pharmaceutical Biology
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2013
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51（8）：968-973
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Zhi-yong Zhou, Li-li Wan, Quan-jun Yang, Yong-long Han, Yan Li, Qi Yu ,, Xiao Li*
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Evaluation of the Pharmacokinetics and Cardiotoxicity of Doxorubicin in Rat Receiving Nilotinib
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Toxicology and Applied Pharmacology
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2013
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272:238-244
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