基本信息

导师姓名：	刘旭	学科代码：	100201
性别：	男	学科名称：	内科学
培养单位：	附属胸科医院	三级学科	心血管病
导师类型：	博士生导师	专业领域名称：	内科学专业学位
联系方式：		专业领域代码：	105101
邮编：		邮箱地址：	xkliuxu@126.com

研究方向 (点击浏览详细信息)



心脏起搏与心脏电生理的临床与基础研究

社会任职


中国生物医学工程学会青年委员，上海市医学会心血管分会青年委员，上海市生物工程学会起搏与电生理学分会主委。中华心律失常杂志第四届编委会委员，中国心脏起博与心电生理杂志常委、编委。中国介入心脏病杂志编委，国际心血管病杂志编委，上海市优秀学科带头人。
上海医学领军人才，第12届徐汇区人大代表
中国医师协会心律分会常委，中华医学会心学管病分会心律失常学组委员，中国心电监护学会副主委

科研项目

项目编号	项目名称	课题来源	起止年月	批准经费	承担职责
2018YFC1312500	心房颤动风险评估方案及干预策略的优化研究	重大慢性非传染性疾病防控研究定向项目重点专项	2018-08~2020-12	196万元	子课题负责人
81670305	成纤维细胞MR致心房纤维化的机制及在房颤发生中的作用	2016国家自然科学基金面上项目	2017-01~2020-12	52万元	课题负责人
/	心肌袖发育关键基因PITX2c突变导致房颤的机制研究	2015年上海市医学领军人才（第四批）	2015-11~2020-10	45万元	课题负责人
SHDC12014119	持续性心房颤动的内外科杂交治疗	上海市市级医院新兴前沿技术联合攻关项目	2014-10~2017-09	80万元	课题负责人
81370301	心肌袖发育关键基因PITX2c突变导致房颤的机制研究	2013国家自然科学基金面上项目	2014-01~2017-12	70万元	课题负责人
12411951800	持续性心房颤动导管消融终点优化策略的研究	2012年度上海市“科技创新行动计划”医学与农业领域项目（医学重点项目）	2012-10~2015-09	40万元	课题负责人
2011BAI11B12	心房颤动的发生机制及干预方法学研究	国家科技支撑计划	2012-01~2015-12	30万元	课题参与人
11xd1404400	慢性持续性房颤导管消融策略的临床研究	上海市优秀学术带头人计划	2011-06~2013-05	40万元	课题负责人
30871083	M3-mAchR在心房颤动复杂碎裂心房电位形成中的作用及机制	2008国家自然科学基金面上项目	2009-01~2011-12	32万元	课题负责人
08411960900	复杂碎裂心房电位在慢性持续性心房颤动中的应用研究	上海市科委生药处面上项目	2008-11~2011-10	10万元	课题负责人
200802157	经导管射频消融治疗心房颤动的多中心临床研究	卫生部卫生行业科研专项项目	2008-01~2010-01	10万元	主要责任人
06XJ21115	肺静脉前庭电学隔离对房颤发生的实验研究	上海交通大学科研基金	2007-01~2009-09	5万元	课题负责人
2006AA02Z4E4	心脏三维标测设备及心房颤动标测消融系列导管的研发	国家863计划生物和医药技术领域2006年度专项课题	2006-01~2009-12	50万元	子课题负责人
	恶性室性心律失常及心脏性猝死干预研究	国家“十一五”科技攻关项目	2006-01~2008-12	30万元	子课题负责人

学术论文

作者	论文标题	期刊名	出版年	卷期页码
Lin RJ,Zeng C, Xu K,Wu SH,Qin M,Liu X （通讯作者）	Dispersion-guided ablation in conjunction with circumferential pulmonary vein isolation is superior to stepwise ablation approach for persistent atrial fibrillation	Int J Cardiol	2019	278:97-103
Qin M,Lin RJ,Wu SH,Liu X （通讯作者）	Extra pulmonary vein driver mapping and ablation in paroxysmal atrial fibrillation by electrogram dispersion analysis	J Cardiovasc Electrophysiol	2019	30(2):164-170
Xu K, Wang Y, Wu S, Zhou L, Zhao L, Jiang W, Zhang X, Liu X （通讯作者）	The role of superior vena cava in catheter ablation of long-standing persistent atrial fibrillation.	Europace	2017	19(10):1670-1675.
Chen XQ, Zhang DL, Zhang MJ, Guo M, Zhan YY, Liu F, Jiang WF, Zhou L, Zhao L, Wang QX, Liu X. （通讯作者）	TRIF promotes angiotensin II-induced cross-talk between fibroblasts and macrophages in atrial fibrosis.	Biochem Biophys Res Commun.	2015	464(1):100-5
Zhao L, Xu K, Jiang W, Zhou L, Wang Y, Zhang X, Wu S, Liu X. （通讯作者）	Long-term outcomes of catheter ablation of atrial fibrillation in dilated cardiomyopathy.	Int J Cardiol.	2015	190:227-32.
Chen XQ, Liu X （通讯作者）, Wang QX, Zhang MJ, Guo M, Liu F, Jiang WF, Zhou L.	Pioglitazone inhibits angiotensin II-induced atrial fibroblasts proliferation via NF-κB/TGF-β1/TRIF/TRAF6 pathway.	Exp Cell Res	2015	330(1):43-55.
Zhang D, Liu X （通讯作者）, Chen X, Gu J, Li F, Zhang W, Zheng Y	Role of the MAPKs/TGF-β1/TRAF6 signaling pathway in atrial fibrosis of patients with chronic atrial fibrillation and rheumatic mitral valve disease	Cardiology	2014	129(4):216-23
Zhao L, Jiang W, Zhou L, Gu J, Wang Y, Liu Y, Zhang X, Wu S, Liu X. （通讯作者）	The role of valvular regurgitation in catheter ablation outcomes of patients with long-standing persistent atrial fibrillation	Europace	2014	16(6):848-54
Zhao L, Wu S, Jiang W, Zhou L, Gu J, Wang Y, Liu Y, Zhang X, Liu X. （通讯作者）	Differential clinical characteristics and prognosis of patients with longstanding persistent atrial fibrillation presenting with recurrent atrial tachycardia versus recurrent atrial fibrillation after first ablation.	J Cardiovasc Electrophysiol.	2014	25(3):259-65
Zhang XD, Gu J, Jiang WF, Zhao L, Zhou L, Wang YL, Liu YG, Liu X （通讯作者）	Optimal rhythm-control strategy for recurrent atrial tachycardia after catheter ablation of persistent atrial fibrillation: a randomized clinical trial.	Eur Heart J	2014	35(20):1327-34
Gu J, Hu W, Liu X. （通讯作者）	Pioglitazone improves potassium channel remodeling induced by angiotensin II in atrial myocytes.	Med Sci Monit Basic Res.	2014	20:153-60
Zhao L, Jiang W, Zhou L, Gu J, Wang Y, Liu Y, Zhang X, Wu S, Liu X. （通讯作者）	Why atrial fibrillation recurs in patients who obtained current ablation endpoints with longstanding persistent atrial fibrillation	J Interv Card Electrophysiol	2013	37(3):283-90
Wang YL, Liu X （通讯作者）, Tan HW, Zhou L, Jiang WF, Gu J, Liu YG	Evaluation of linear lesions in the left and right atrium in ablation of long-standing atrial fibrillation	Pacing Clin Electrophysiol	2013	36(10):1202-10.
Gu J, Liu X （通讯作者）, Jiang WF, Li F, Zhao L, Zhou L, Wang YL, Liu YG, Zhang XD, Wu SH, Xu K, Zhang DL, Gu JN.	Comparison of catheter ablation and surgical ablation in patients with long-standing persistent atrial fibrillation and rheumatic heart disease: a four-year follow-up study	Int J Cardiol.	2013	168(6):5372-7
Zhang XD, Tan HW, Gu J, Jiang WF, Zhao L, Wang YL, Liu YG, Zhou L, Gu JN, Liu X. （通讯作者）	Efficacy and safety of catheter ablation for long-standing persistent atrial fibrillation in women.	Pacing Clin Electrophysiol	2013	36(10):1236-44
Xu K, Liu X. （通讯作者）	Atrial fibrillation in China.	Chin Med J (Engl)	2013	126(22):4366-70
Gu J, Liu X （通讯作者）, Tan H, Zhou L, Jiang W, Wang Y, Liu Y, Gu J.	Impact of chronic obstructive pulmonary disease on procedural outcomes and quality of life in patients with atrial fibrillation undergoing catheter ablation.	J Cardiovasc Electrophysiol.	2013	24(2):148-54.
Zhang XD, Gu J, Jiang WF, Zhao L, Wang YL, Liu YG, Zhou L, Gu JN, Wu SH, Xu K, Liu X （通讯作者）	The impact of age on the efficacy and safety of catheter ablation for long-standing persistent atrial fibrillation.	Int J Cardiol.	2013	168(3):2693-8.
Wu SH, Jiang WF, Gu J, Zhao L, Wang YL, Liu YG, Zhou L, Gu JN, Xu K, Liu X. （通讯作者）	Benefits and risks of additional ablation of complex fractionated atrial electrograms for patients with atrial fibrillation: a systematic review and meta-analysis	Int J Cardiol.	2013	169(1):35-43.
Gu J, Liu X （通讯作者）, Wang QX, Guo M, Liu F, Song ZP, Zhang DD.	Beneficial effects of pioglitazone on atrial structural and electrical remodeling in vitro cellular models	J Mol Cell Cardiol.	2013	65:1-8
Tan HW, Wang XH, Shi HF, Zhou L, Gu JN, Liu X. （通讯作者）	Catheter ablation of atrial fibrillation in a patient with Left atrial wall thickness: anatomic aspects relevant to catheter ablation of atrial fibrillation.	Chin Med J (Engl).	2012	125(1):12-5.
Gu J, Liu X （通讯作者）, Tan H, Zhou L, Jiang W, Wang Y, Liu Y, Gu J.	Impact of Chronic Obstructive Pulmonary Disease on Procedural Outcomes and Quality of Life in Patients with Atrial Fibrillation Undergoing Catheter Ablation	J Cardiovasc Electrophysiol	2012
Gu J, Liu X （通讯作者）, Wang QX, Tan HW, Guo M, Jiang WF, Zhou L.	Angiotensin II increases CTGF expression via MAPKs/TGF-β1/TRAF6 pathway in atrial fibroblasts	Exp Cell Res	2012	318(16):2105-15
Gu J, Liu X （通讯作者）, Tan H, Zhou L, Gu J, Jiang W, Wang Y, Liu Y.	Extensive antiarrhythmic drugs after catheter ablation of persistent atrial fibrillation	Acta Cardiol	2012	67(4):407-14
Zhang XL, Wu LQ, Liu X （通讯作者）, Yang YQ, Tan HW, Wang XH, Zhou L, Jiang WF, Li Z.	Association of angiotensin-converting enzyme gene I/D and CYP11B2 gene -344T/C polymorphisms with lone atrial fibrillation and its recurrence after catheter ablation.	Exp Ther Med.	2012	4(4):741-747
Wang X, Liu X （通讯作者）, Shi H, Tan H, Jiang W, Wang Y, Yang G, Zhou L.	Early recurrences after paroxysmal atrial fibrillation ablation: when is the proper timing for reablation?	Pacing Clin Electrophysiol.	2011	34(6):709-16.
Tan HW, Wang XH, Shi HF, Sun YM, Zhou L, Gu JN, Han B, Jiang WF, Yang GS, Liu X. （通讯作者）	Congestive heart failure after extensive catheter ablation for atrial fibrillation: prevalence, characterization, and outcome	J Cardiovasc Electrophysiol	2011	22(6):632-7
Gu J, Liu X （通讯作者）, Wang X, Shi H, Tan H, Zhou L, Gu J, Jiang W, Wang Y.	Beneficial effect of pioglitazone on the outcome of catheter ablation in patients with paroxysmal atrial fibrillation and type 2 diabetes mellitus	Europace.	2011	13(9):1256-61
Yang YQ, Wang MY, Zhang XL, Tan HW, Shi HF, Jiang WF, Wang XH, Fang WY, Liu X. （通讯作者）	GATA4 loss-of-function mutations in familial atrial fibrillation.	Clin Chim Acta	2011	412(19-20):1825-30
Liu X （通讯作者）, Tan HW, Wang XH, Shi HF, Li YZ, Li F, Zhou L, Gu JN.	Efficacy of catheter ablation and surgical CryoMaze procedure in patients with long-lasting persistent atrial fibrillation and rheumatic heart disease: a randomized trial.	Eur Heart J.	2010	31(21):2633-41
Yang YQ, Zhang XL, Wang XH, Tan HW, Shi HF, Fang WY, Liu X. （通讯作者）	Familial aggregation of lone atrial fibrillation in the Chinese population	Intern Med.	2010	49(22):2385-91.
Tan HW, Liu X, Bi XP, Xing SS, Li L, Gong HP, et al.	IL-18 overexpression promotes vascular inflammation and remodeling in a rat model of metabolic syndrome	Atherosclerosis	2010	208:350-357.
Yang YQ, Zhang XL, Wang XH, Tan HW, Shi HF, Jiang WF, Fang WY, Liu X. （通讯作者）	Connexin40 nonsense mutation in familial atrial fibrillation	Int J Mol Med.	2010	26(4):605-10.
Yang YQ, Zhang XL, Wang XH, Tan HW, Wang XH, Shi HF （通讯作者）, Han B, Tan HW, Jiang WF, Liu X.	Catheter ablation of atrial fibrillation in a patient with dextrocardia: what is the challenge?	Chin Med J (Engl).	2010	123(17):2478-9.
Wang X, Liu X （通讯作者）, Shi H, Gu J, Sun Y, Zhou L, Hu W	Heart rhythm disorders and pacemakers: Pulmonary vein isolation combined with substrate modification for persistent atrial fibrillation treatment in patients with valvular heart diseases.	Heart	2009	95:1773-1783
Liu X （通讯作者）, Shi HF, Tan HW, Wang XH, Zhou L, Gu JN	Decreased connexin 43 and increased fibrosis in atrial regions susceptible to complex fractionated atrial electrograms	Cardiology	2009	114:22-29.
Tan HW, Wang XH, Shi HF, Yang GS, Zhou L, Gu JN, Jiang WF, Liu X （通讯作者）	Efficacy, safety and outcome of catheter ablation for atrial fibrillation in octogenarians.	Int J Cardiol	2009
Wang XH, Liu X （通讯作者）, Sun YM, Shi HF, Zhou L, Gu JN.	Pulmonary vein isolation combined with superior vena cava isolation for atrial fibrillation ablation: a prospective randomized study.	Europace	2008	10:600-605.
Wang XH, Shi HF, Sun YM, Gu JN, Zhou L, Liu X （通讯作者）	Circumferential pulmonary vein isolation: the role of key target sites	Europace	2008	10:197-204.
Wang XH, Liu X （通讯作者）, Sun YM, Gu JN, Shi HF, Zhou L, Hu W.	Early identification and treatment of PV re-connections: role of observation time and impact on clinical results of atrial fibrillation ablation	Europace	2007	9:481-486.