- 基本信息
|
导师姓名：
|
陈赛娟
|
学科代码：
|
100201
|
|
|
性别：
|
女
|
学科名称：
|
内科学
|
|
培养单位：
|
附属瑞金医院
|
三级学科
|
血液病
|
|
导师类型：
|
博士生导师
|
专业领域名称：
|
内科学 专业学位
|
|
联系方式：
|
|
专业领域代码：
|
105101
|
|
邮编：
|
|
邮箱地址：
|
sjchen@stn.sh.cn
|
- 研究方向 (点击浏览详细信息)
- 社会任职
| |
|
中国科学技术协会第七届全国委员会副主席
|
|
中国病理生理学会实验血液学第7届专业委员会主任委员
|
|
上海市医学会副会长
|
|
上海市科协主席
|
|
中国青少年科技辅导员协会理事长
|
|
中华医学会副会长
|
- 科研项目
| 19MC1910700 | 上海市血液系统疾病临床医学研究中心 | 上海市科委 |
2020-01~2022-12
|
1500万元
| 课题负责人 |
| 2019CXJQ01 | 重大疾病的干细胞治疗研发与临床转化体系建立 | 上海卫健委（创新集群项目） |
2019-01~2023-12
|
1600万元
| 课题负责人 |
| / | 上海市临床重点专科建设项目-血液科 | 上海市卫健委 |
2019-01~2023-12
|
1597.6万元
| 课题负责人 |
| 81861148030 | 儿童和青少年高危急性淋巴细胞白血病发病机制和靶向治疗的研究 | 国家自然基金（国际合作） |
2018-10~2021-09
|
160万元
| 课题负责人 |
| 2017ZZ01002 | 上海市血液疾病临床医学中心 | 上海市卫健委 |
2017-07~2020-06
|
974.34万元
| 课题负责人 |
| B17029 | 转化医学学科创新引智基地 | 教育部引智计划
|
2017-01~2021-12
|
450万元
| 课题负责人 |
- 学术论文
|
Fu YK, Tan Y, Wu B, Dai YT, Xu XG, Pan MM, Chen ZW, Qiao N, Wu J, Jiang L, Lu J, Chen B, Avigail Rein , Shai Izraeli, Sun XJ, Huang JY, Huang QH, Chen Z,
|
Gata2-L359V impairs primitive and definitive hematopoiesis and blocks cell differentiation in murine chronic myelogenous leukemia model.
|
Cell Death Dis.
|
2021
|
Jun 2;12(6):568.
|
|
9. Lin XJ, Qiao N, Shen Y, Fang H, Xue Q, Cui BW, Chen L, Zhu HM, Zhang SJ, Chen Y, Jiang L, Wang SY, Li JM, Wang BS, Chen B, Chen Z,
|
Integration of Genomic and Transcriptomic Markers Improves the Prognosis Prediction of Acute Promyelocytic Leukemia.
|
Clin Cancer Res.
|
2021
|
10.1158
|
|
8. Chen L, Zhu HM, Li Y, Liu QF, Hu Y, Zhou JF, Jin J, Hu JD, Liu T, Wu DP, Chen JP, Lai YR, Wang JX, Li J, Li JY, Du X, Wang X, Yang MZ, Yan JS, Ouyang GF, Liu L, Hou M, Huang XJ, Yan XJ, Xu D, Li WM, Li DJ, Lou YJ, Wu ZJ, Niu T, Wang Y, Li XY, You JH, Zhao HJ, Chen Y, Shen Y, Chen QS, Chen Y, Li J, Wang BS, Zhao WL, Mi JQ, Wang KK, Hu J, Chen Z,, Li JM.
|
Arsenic trioxide replacing or reducing chemotherapy in consolidation therapy for acute promyelocytic leukemia (APL2012 trial).
|
Proc Natl Acad Sci U S A
|
2021
|
118(6):e2020382118
|
|
Chen S, Wu JL, Liang Y, Tang YG, Song HX, Wu LL, Xing YF, Yan N, Li YT, Wang ZY, Xiao SJ, Lu X,, Lu M.
|
Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site.
|
Cancer Cell
|
2021
|
39(2):225-239
|
|
Zhang XN, Tan Y, Ling Y, Lu G, Liu F, Yi ZG, Jia XG, Wu M, Shi BS, Xu SB, Chen J, Wang W, Chen B, Jiang L, Yu ST, Lu J, Wang JZ, Xu MZ, Yuan ZH, Zhang Q, Zhang XX, Zhao GP, Wang SY,, Lu HZ.
|
Viral and Host Factors Related to the Clinical Outcome of COVID-19.
|
Nature
|
2020
|
583(7816):437-440.
|
|
Wang DW, Zhang GW, Gu JJ, Shao XH, Dai YT, Li JF, Pan XH, Yao SX, Xu AN, Jin Y, Huang JY, Shi QZ, Zhu J, Xi XD, Chen Z,
|
In vivo generated hematopoietic stem cells from genome edited induced pluripotent stem cells are functional in platelet-targeted gene therapy of murine hemophilia A.
|
Haematologica.
|
2020
|
105(4):175-179.
|
|
Wu SF, Xia L, Shi XD, Dai YJ, Zhang WN, Zhao JM, Zhang W, Weng XQ, Lu J, Le HY, Tao SC, Zhu J, Chen Z, Wang YY,
|
RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation.
|
Proc Natl Acad Sci U S A.
|
2020
|
117(25):14395-14404.
|
|
Xiong J, Cui BW, Wang N, Dai YT, Zhang H, Wang CF, Zhong HJ, Cheng S, Ou-Yang BS, Hu Y, Zhang X, Xu B, Qian WB, Tao R, Yan F, Hu JD, Hou M, Ma XJ, Wang X, Liu YH, Zhu ZM, Huang XB, Liu L, Wu CY, Huang L, Shen YF, Huang RB, Xu JY, Wang C, Wu DP, Yu L, Li JF, Xu PP, Wang L, Huang JY,, Zhao WL.
|
Genomic and Transcriptomic Characterization of Natural Killer T Cell Lymphoma.
|
Cancer Cell
|
2020
|
37:403-419.
|
|
Jiang L, Li XP, Dai YT, Chen B, Weng XQ, Xiong SM, Zhang M, Huang JY, Chen Z,
|
Multidimensional study of the heterogeneity of leukemia cells in t(8;21) acute myelogenous leukemia identifies the subtype with poor outcome.
|
Proc Natl Acad Sci U S A
|
2020
|
117(33):20117-20126
|
|
Zhou Y, Wei CJ, Xiong SM, Dong LL, Chen Z,, Cheng L.
|
Trajectory of chemical cocktail-induced neutrophil reprogramming.
|
J Hematol Oncol.
|
2020
|
13(1):171
|
|
Zhou Y, Zhu XL, Dai YT, Xiong SM, Wei CJ, Yu P, Tang YW, Wu L, Li JF, Liu D, Wang YL, Chen Z,, Huang JY, Cheng L.
|
Chemical Cocktail Induces Hematopoietic Reprogramming and Expands Hematopoietic Stem/Progenitor Cells.
|
Advanced Science
|
2019
|
7(1):1901785
|
|
Chen XJ, Zhang WN, Chen B, Xi WD, Lu Y, Huang JY, Wang YY, Long J, Wu SF, Zhang YX, Wang S, Li SX, Yin T, Lu M, Xi XD, Li JM, Wang KK, Chen Z,
|
Homoharringtonine deregulates MYC transcriptional expression by directly binding NF-κB repressing factor.
|
Proc Natl Acad Sci U S A
|
2019
|
116:2220-2225.
|
|
Xu J, Chen LJ, Yang SS, Sun Y, Wu W, Liu YF, Xu J, Zhuang Y, Zhang W, Weng XQ, Wu J, Wang Y, Wang J, Yan H, Xu WB, Jiang H, Du J, Ding XY, Li B, Li JM, Fu WJ, Zhu J, Zhu L, Chen Z, Fan XF, Hou J, Li JY, Mi JQ,
|
Exploratory trial of a biepitopic CAR T-targeting B cell maturation antigen in relapsed/refractory multiple myeloma.
|
Proc Natl Acad Sci U S A.
|
2019
|
116:9543-9551.
|
|
Zhang YL, Sun JW, Xie YY, Zhou Y, Liu P, Song JC, Xu CH, Wang L, Liu D, Xu AN, Chen Z,, Sun XJ, Huang QH.
|
Setd2 deficiency impairs hematopoietic stem cell self-renewal and causes malignant transformation.
|
Cell Res.
|
2018
|
2018;28:476-490.
|
|
Zhang W, Zhao C, Zhao JM, Zhu YM, Weng XQ, Chen QS, Sun HP, Mi JQ, Li JM, Zhu J, Chen Z, Pandolfi PP,, Yan XJ, Xu J.
|
Inactivation of PBX3 and HOXA9 by down-regulating H3K79 methylation represses NPM1-mutated leukemic cell survival.
|
Theranostics
|
2018
|
8:4359-4371.
|
|
Mao JH, Ma L, Shen Y, Zhu KK, Zhang R, Xi WD, Ruan Z, Luo C, Chen Z, Xi XD,
|
Arsenic circumvents the gefitinib resistance by binding to P62 and mediating autophagic degradation of EGFR in non-small cell lung cancer.
|
Cell Death Dis.
|
2018
|
9:963.
|
|
Dong X, Zhang WN, Wu HY, Huang JY, Zhang M, Wang PR, Zhang H, Chen Z,, Meng GY.
|
Structural basis of DUX4/IGH-driven transactivation.
|
Leukemia.
|
2018
|
32:1466-1476.
|
|
Tan YT, Ye L, Xie F, Beyer AI, Muench MO, Wang J, Chen Z, Liu H,, Kan YW.
|
Respecifying human iPSC-derived blood cells into highly engraftable hematopoietic stem and progenitor cells with a single factor.
|
Proc Natl Acad Sci U S A.
|
2018
|
115:2180-2185.
|
|
Li JF, Dai YT, Lilljebj?rn H, Shen SH, Cui BW, Bai L, Liu YF, Qian MX, Kubota Y, Kiyoi H, Matsumura I, Miyazaki Y, Olsson L, Tan AM, Ariffin H, Chen J, Takita J, Yasuda T, Mano H, Johansson B, Yang JJ, Yeoh AE, Hayakawa F, Chen Z, Pui CH, Fioretos T,, Huang JY.
|
Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases.
|
Proc Natl Acad Sci U S A.
|
2018
|
2018;115:11711-11720.
|
|
Chen B, Jiang L, Zhong ML, Li JF, Li BS, Peng LJ, Dai YT, Cui BW, Yan TQ, Zhang WN, Weng XQ, Xie YY, Lu J, Ren RB, Chen SN, Hu JD, Wu DP, Chen Z, Tang JY, Huang JY, Mi JQ,
|
Identification of fusion genes and characterization of transcriptome features in T-cell acute lymphoblastic leukemia.
|
Proc Natl Acad Sci U S A.
|
2018
|
115:373-378.
|
|
Dai YJ, Wang YY, Huang JY, Xia L, Shi XD, Xu J, Lu J, Su XB, Yang Y, Zhang WN, Wang PP, Wu SF, Huang T, Mi JQ, Han ZG, Chen Z,
|
Conditional knock-in of Dnmt3a R878H initiates acute myeloid leukemia with mTOR pathway involvement.
|
PNAS
|
2017
|
114:5237-5242
|
|