• 基本信息
    导师姓名： 钟久昌 学科代码： 100201
    性别： 男 学科名称： 内科学
    培养单位： 附属瑞金医院 三级学科 心血管病
    导师类型： 博士生导师 专业领域名称：
    联系方式： 上海市黄浦区瑞金二路197号上海交通大学医学院附属瑞金医院高血压研究所32号楼302室；Tel:021-64370045 ext 611111 专业领域代码：
    邮编： 200025 邮箱地址： jiuchangzhong@aliyun.com
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    国家心血管病中心高血压专家委员会常务委员
    中国高血压联盟理事
    中华医学会心血管病学分会高血压病学组和基础研究学组全国委员
    中国中药协会微循环用药委员会副主任委员
    国家自然科学基金重点项目和国家重大研究计划项目评审专家
    中国药理学会表观遗传学专业委员会常务委员
    国际心脏协会中国分会委员/《欧洲心脏病学杂志》中文版编委
    中国病理生理学会心血管专业委员会委员/中国病理生理协会生物活性小分子专委会委员
    Am J Physiol Heart Circ Physiol、Br. J Pharmacol、Hypertension、CEPP、Life Sciences、Biochimie、World J Cardiol、Lipid and Cardiovasc Res评审专家或编委
    《中华高血压杂志》、《中国分子心脏病学杂志》、《中华心脏与心律电子杂志》、《上海医学》、《药学进展》等期刊编委
    教育部国家学位中心评审专家库成员、教育部长江学者青年长江学者评审专家、上海市优秀博士学位论文奖、上海市科技进步奖评审专家库成员
    中俄医学研究中心代谢疾病研究所学术委员会常务委员
    《Front Cardiovasc Med》期刊副主编
    中国医师协会心血管内科分会高血压专业委员会委员/ 中国医促会血管疾病高血压分会常务委员
    上海交通大学SMC晨星青年学者（A类）；加拿大AHFMR青年学者；香港荣华学者
    上海市浦江人才
    美国心脏协会高血压研究委员会/ 国际心脏协会中国转化医学委员会委员
    中国医师协会高血压专业血管风险评估工作委员会委员
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    91849111Apelin-APJ信号与心脏衰老研究国家基金委重大研究计划资助项目 2019-01~2021-12 62万元  课题负责人
    81770253国家自然科学基金面上项目：miRNA-122介导血管外膜APLN-AMPK自噬信号调控在高血压血管重构损伤的作用研究国家自然科学基金面上项目 2018-01~2021-12 68万元  课题负责人
    20152509上海市教委人才项目/上海交通大学医学院高峰学科项目：高血压心血管重构机制及其潜在治疗靶点的研究上海市教委人才项目/上海交通大学医学院高峰学科项目 2015-01~2019-12 100万元  课题负责人
    91339108 国家重大研究计划资助项目：ACE2/Apelin信号对高血压血管外膜炎症、氧化应激及重构的调控作用与机制 国家重大研究计划资助项目 2014-01~2016-12 85万元  课题负责人
    2014CB542300国家重点基础研究发展计划（骨干）：循环miRNA生物学功能及临床应用国家重点基础研究发展计划（国家973计划骨干） 2014-01~2018-12 453万元  课题参与人
    81370362国家自然科学基金面上项目：ACE2基因对高血压Fractalkine/CX3CR1信号及其心肌损害的作用机制国家自然科学基金面上项目 2014-01~2017-12 70万元  课题负责人
    2013121ACE2基因在高血压心肌氧化应激中的保护效应研究上海交通大学SMC“晨星青年学者奖励计划”（A类） 2013-01~2016-12 15万元  课题负责人
    81170246国家自然科学基金面上项目：ACE2-Ang-(1-7)-Mas轴介导的抗高血压肾间质纤维化作用及其分子机制。国家自然科学基金 2012-01~2015-12 60万元  课题负责人
    201111ACE2在介导高血压心血管增殖中的调控作用及其分子机制上海交通大学医学院“新百人计划”项目 2011-10~2014-09 15万元  课题负责人
    11PJ1408300上海市科委项目：ACE2基因调控高血压肾纤维化的炎症机制研究。上海市科委项目（上海市浦江人才计划） 2011-09~2013-12 20万元  课题负责人
    30973522国家自然科学基金面上项目：Profilin-1介导高血压血管平滑肌细胞增殖及ACE2调控作用研究。国家自然科学基金资助项目 2010-01~2012-12 25万元  课题负责人
    T200907医学细胞与分子生物学技术(心血管研究)。浙江省高等学校创新团队 2009-01~2013-12 150万元  子课题负责人
    20080803加拿大国际合作项目：The regulatory roles of angiotensin converting enzyme 2 (ACE2) in myocardial ischemic injury。加拿大国际合作项目(加拿大AHFMR卫生与健康研究基金项目) 2008-10~2011-12 55万元  课题负责人
    30700328国家自然科学基金项目：血管紧张素转换酶2(ACE2)基因在高血压血管重塑中的调控作用及其机制。国家自然科学基金青年科学基金项目 2008-01~2010-12 17万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Meng L, Yuan W, Chi H, Han R, Zhang Y, Pan X, Meng J, Liu Y, Song J,, Liu X.  Genetic deletion of CMG2 exacerbates systemic-to-pulmonary shunt-induced pulmonary arterial hypertension  FASEB J.   2021  35(4):e21421 
    Ma Z, Zhao L, Martin S, Zhang YP, Dong Y,, Yang XC*.  Lower Plasma Elabela Levels in Hypertensive Patients with Heart Failure Predict the Occurrence of Major Adverse Cardiac Events: A Preliminary Study.  Front Cardiovasc Med.  2021  8(1):638468. 
    Liu Y, Song JW, Lin JY, Miao R,  Roles of MicroRNA-122 in Cardiovascular Fibrosis and Related Diseases  Cardiovasc Toxicol  2020  20(5):463-473. 
    Zheng ML, Liu XY, Han RJ, Yuan W, Sun K,, Yang XC*.   Circulating exosomal long non-coding RNAs in patients with acute myocardial infarction.  J Cell Mol Med  2020  24(16):9388-9396 
    Ma Z, Song JJ, Martin S, Yang XC*,  The Elabela-APJ axis: a promising therapeutic target for heart failure.   Heart Fail Rev  2020  20:1-10. doi: 10.1007/s10741-020-09957-5.  
    Song JJ, Ma Z, Wang J, Chen LX,  Gender Differences in Hypertension.   J Cardiovasc Transl Res.   2020  13(1):47-54. 
    3. Miao R, Dong X, Gong J, Wang Y, Guo X, Li Y, Li J, Yang S, Kuang T, Wan J, Liu M, Zhai Z,, Yang Y*  Possible immune regulation mechanisms for the progression of chronic thromboembolic pulmonary hypertension  Thromb Res  2020  198:122-131. 
    DU SL, Yang XC,, Wang LF*, Fan YF*.  Plasma levels of Elabela are associated with coronary angiographic severity in patients with acute coronary syndrome.  J Geriatr Cardiol.   2020  17(11):674-679. 
    Gheblawi M#, Wang K#, Viveiros A, Nguyen Q,, Turner AJ, Raizada MK, Grant MB, Oudit GY*.  Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2.   Circ Res.   2020  126(10):1456-1474. 
    Li X, Liu Y, Song J,  Increased plasma ACE2 concentration does not mean increased risk of SARS-CoV-2 infection and increased fatality rate of COVID-19.   Acta Pharm Sin B.   2020  10(10):2010-2014. 
    Li S, Gao Y, Liu Y, Li J, Yang X, Hu R, Liu J, Zhang Y, Zuo K, Li K, Yin X, Chen M,, Yang X*.  Myofibroblast-Derived Exosomes Contribute to Development of a Susceptible Substrate for Atrial Fibrillation.  Cardiology  2020  145(5):324-332. 
    Song JJ, Yang M, Liu Y, Song JW, Wang J, Chi HJ, Liu XY, Zuo K, Yang XC,  MicroRNA-122 aggravates angiotensin II-mediated apoptosis and autophagy imbalance in rat aortic adventitial fibroblasts via the modulation of SIRT6-elabela-ACE2 signaling  Eur J Pharmacol  2020  883:173374 
    Bao M, Li P, Li Q, Chen H, Zhong Y, Li S, Jin L, Wang W, Chen Z,, Geng B, Fan Y, Yang X, Cai J*.   Genetic screening for monogenic hypertension in hypertensive individuals in a clinical setting.   J Med Genet.  2020  57(8):571-580. 
    Miao R, Gong J, Zhang C, Wang Y, Guo X, Li J, Yang S, Kuang T,, Feng H*.   Hsa_circ_0046159 is involved in the development of chronic thromboembolic pulmonary hypertension.  J Thromb Thrombolysis.  2020  49(3):386-394. 
    Gheblawi M, Wang K, Viveiros A, Nguyen Q,, Turner AJ, Raizada MK, Grant MB, Oudit GY.  Response by Gheblawi et al to Letter Regarding Article, "Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2".  Circ Res.   2020  127(2):e46-e47. 
    Liu XM, Du SL, Miao R, Wang LF*,  Targeting the forkhead box protein P1 pathway as a novel therapeutic approach for cardiovascular diseases.   Heart Fail Rev.   2020  21:1-8doi: 10.1007/s10741-020-09992-2. 
    Zuo K, Li J, Li K, Hu C, Gao Y, Chen M, Hu R, Liu Y, Chi H, Wang H, Qin Y, Liu X, Li S, Cai J,, Yang X*.  Disordered gut microbiota and alterations in metabolic patterns are associated with atrial fibrillation.Gigascience. 2019  Gigascience  2019  8(6). pii: giz058. 
    Tang M, Huang Z, Luo X, Liu M, Wang L, Qi Z, Huang S,, Chen JX, Li L, Wu D, Chen L.   Ferritinophagy activation and sideroflexin1-dependent mitochondria iron overload is involved in apelin-13-induced cardiomyocytes hypertrophy.   Free Radic Biol Med.  2019  134:445-457. doi: 10.1016/j.freeradbiomed.2019.01.052.  
    Wang J,Wei L, Yang X,  Roles of Growth Differentiation Factor 15 in Atherosclerosis and Coronary Artery Disease  Journal of American Heart Association  2019  8（1）：012826-012838 
    Wang J,Wei L, Yang X,  Roles of Growth Differentiation Factor 15 in Atherosclerosis and Coronary Artery Disease  Journal of American Heart Association  2019  8（1）012826 
    He L, Zhou Q, Huang Z, Xu J, Zhou H, Lv D, Lu L, Huang S, Tang M,, Chen JX, Luo X, Li L, Chen L.   PINK1/Parkin-mediated mitophagy promotes apelin-13-induced vascular smooth muscle cell proliferation by AMPKα and exacerbates atherosclerotic lesions.  J Cell Physiol  2019  234(6):8668-8682. 
    Chi H, Feng H, Shang X, Jiao J, Sun L, Jiang W, Meng X, Fan Y, Lin X,, Yang X*.   Circulating connective tissue growth factor is associated with diastolic dysfunction in patients with diastolic heart failure.  Cardiology  2019  143(3-4):77-84. 
    Zhou X, Li J, Guo J, Geng B, Ji W, Zhao Q, Li J, Liu X, Liu J, Guo Z, Cai W, Ma Y, Ren D, Miao J, Chen S, Zhang Z, Chen J,, Liu W, Zou M, Li Y, Cai J  Gut-dependent microbial translocation induces inflammation and cardiovascular events after ST-elevation myocardial infarction  Microbiome  2018  6(1):66-78 
    Wang J, Zhang DP, Liu HB,, Yang XC*  Should atrial fibrillation patients with hypertension as an additional risk factor of the CHA2DS2-VASc score receive oral anticoagulation?.  J Geriatr Cardiol  2018  15（3）:229-234 
    Zhang ZZ, Wang W, Jin HY, Chen X, Cheng YW, Xu YL, Song B, Penninger JM, Oudit GY,  Apelin is a negative regulator of angiotensin II-mediated adverse myocardial remodeling and dysfunction. Hypertension 2017  Hypertension  2017  70(6):1165-1175 
    , Zhang ZZ, Wang W, McKinnie SMK, Vederas JC, Oudit GY.  Targeting the Apelin pathway as a novel therapeutic approach for cardiovascular diseases. Biochim Biophys Acta-Mol Bas Dis 2017  Biochim Biophys Acta-Mol Bas Dis  2017  1863(8):1942-1950 
    Chen YY, Zhang P, Zhou XM, Liu D,, Zhang CJ, Jin LJ, Yu HM.  Relationship between genetic variants of ACE2 gene and circulating levels of ACE2 and its metabolites  J Clin Pharm Ther.  2017  Epub ahead of print 
    Shi J, Bei Y, Kong X, Liu X, Lei Z, Xu T, Wang H, Xuan Q, Chen P, Xu J, Che L, Liu H,, Sluijter JP, Li X, Rosenzweig A, Xiao J.  miR-17-3p Contributes to Exercise-Induced Cardiac Growth and Protects against Myocardial Ischemia-Reperfusion Injury.Theranostics. 2017  Theranostics  2017  7(3):664-676. 
    Tao L, Bei Y, Chen P, Lei Z, Fu S, Zhang H, Xu J, Che L, Chen X, Sluijter JP, Das S, Cretoiu D, Xu B,, Xiao J, Li X.  Crucial Role of miR-433 in Regulating Cardiac Fibrosis. Theranostics. 2016  Theranostics  2016  6(12):2068-2083. 
    Wang H, Bei Y, Huang P, Zhou Q, Shi J, Sun Q,, Li X, Kong X, Xiao J.Mol Ther Nucleic Acids. 2016  Inhibition of miR-155 Protects Against LPS-induced Cardiac Dysfunction and Apoptosis in Mice.Mol Ther Nucleic Acids. 2016   Mol Ther Nucleic Acids  2016  5(10):e374 
    Chen LJ, Xu YL, Song B, Yu HM, Oudit GY, Xu R, Zhang ZZ, Jin HY, Chang Q, Zhu DL,  Angiotensin-converting enzyme 2 ameliorates renal fibrosis by blocking the activation of mTOR/ERK signaling in apolipoprotein e-deficient mice. Peptides 2016  Peptides  2016  79(1):49-57 
    Xu R, Zhang ZZ, Chen LJ, Yu HM, Guo SJ, Xu YL, Oudit GY, Zhang Y, Chang Q, Song B, Chen DR, Zhu DL,  Ascending aortic adventitial remodeling and fibrosis are ameliorated with Apelin-13 in rats after TAC via suppression of the miRNA-122 and LGR4-β-catenin signaling. Peptides 2016  Peptides  2016  86(1):85-94 
    Chen YY, Liu D, Zhang P,, Zhang CJ, Wu SL, Zhang YQ, Liu GZ, He M, Jin LJ, Yu HM.  Impact of ACE2 gene polymorphism on antihypertensive efficacy of ACE inhibitors. J Hum Hypertens. 2016   J Hum Hypertens  2016  30(12):766-771. 
    Liu D, Chen Y, Zhang P,, Jin L, Zhang C, Lin S, Wu S, Yu H.  Association between circulating levels of ACE2-Ang-(1-7)-MAS axis and ACE2 gene polymorphisms in hypertensive patients. Medicine (Baltimore). 2016   Medicine (Baltimore)  2016  95(24):e3876. 
    Patel VB,, Grant MB, Oudit GY  Role of the ACE2/Angiotensin 1-7 axis of the renin-angiotensin system in heart failure. Circulation Research 2016  Circulation Research  2016  118(8): 1313-1326 
    Jin HY, Chen LJ, Zhang ZZ, Xu YL, Song B, Xu R, Oudit GY, Gao PJ, Zhu DL,  Deletion of angiotensin-converting enzyme 2 exacerbates renal inflammation and injury in apolipoprotein E-deficient mice through modulation of the nephrin and TNF-alpha-TNFRSF1A signaling. J Transl Med, 2015  J Transl Med  2015  13(1):255-271 
    Chen LJ, Xu R, Yu HM, Chang Q,  The ACE2/Apelin Signaling, MicroRNAs, and Hypertension. Int J Hypertens, 2015  Int J Hypertens  2015  2015(8968):1-6 
    Patel VB,, Fan D, Basu R,... Kassiri Z, Oudit GY  Angiotensin converting enzyme 2 is a critical determinant of angiotensin II-induced loss of vascular smooth muscle cells and adverse vascular remodeling. Hypertension, 2014  Hypertension  2014  64(1):157-164 
    Li Y, Jiang H, Ruan C,, Gao P, Zhu D, Niu W, Guo S  Transient receptor potential melastatin 7 interacting with macrophages promotes vascular adventitial remodeling in the transverse aortic constriction rats. Hypertens Res, 2014  Hypertens Res  2014  37(1):35-42 
    Zhang ZZ, Chen LJ,  ACE2/Ang-(1-7) signaling and vascular remodeling. Sci China Life Sci, 2014  Sci China Life Sci.  2014  57(8):802-828 
    Zhang ZZ, Chen LJ, Song B, Xu YL, Chen DR, Zhu DL, Gao PJ, Oudit GY,  Apelin treatment enhances ACE2 expression and attenuates angiotensin ii-mediated aortic fibrosis in apolipoprotein E-deficient mice  J Am Coll Cardiol.   2014  64(16S):C6-7 
    Sun J, Yang W, Zhu Y, Liu X, Wei X, Wang B,, Fu Y*.  The Relationship Between Nocturnal Blood Pressure and Hemorrhagic Stroke in Chinese Hypertensive Patients. J Clin Hypertens (Greenwich), 2014  J Clin Hypertens (Greenwich)  2014  16(9):652-657 
    Chen J, Ren J, Wu J, Cai M, Liu W, Zou J, Li X, Li P, Nie H,, Xu C, Zhou T  Effects of rapamycin on DC-SIGN expression and biological functions in DC. Front Biosci (Landmark Ed), 2014  Front Biosci (Landmark Ed).  2014  19(1):557-565 
    Yu H, Lin S,, He M, Jin L, Zhang Y, Liu G.  A core promoter variant of angiotensinogen gene and interindividual variation in response to angiotensin-converting enzyme inhibitors. J Renin Angiotensin Aldosterone Syst, 2014  J Renin Angiotensin Aldosterone Syst  2014  15(4):540-546 
    Patel VB,Putko B, Wang Z,, Oudit GY  Manipulating angiotensin metabolism with angiotensin converting enzyme 2 (ACE2) in heart failure. Drug Discov Today, 2014  Drug Discov Today:Therapeutic Strategies  2014  9(4):141-148 
    Cai M, Wu J, Mao C, Ren J, Li P, Li X,, Xu C, Zhou T  A Lectin-EGF antibody promotes regulatory T cells and attenuates nephrotoxic nephritis via DC-SIGN on dendritic cells. J Transl Med, 2013  J Transl Med  2013  11(1):103-108 
    Song B, Zhang ZZ,, Yu XY, Oudit GY, Jin HY, Lu L, Xu YL, Kassiri Z, Shen WF, Gao PJ, Zhu DL  Loss of angiotensin-converting enzyme 2 exacerbates myocardial injury via activation of the CTGF-Fractalkine signaling pathway. Circulation Journal, 2013  Circulation Journal  2013  77(12):2997-3006 
    Song B, Jin HY, Yu X, ...,  Angiotensin-converting enzyme 2 attenuates oxidative stress and VSMC proliferation via the JAK2/STAT3/SOCS3 and profilin-1/MAPK signaling pathways. Regul Pept, 2013  Regul Pept   2013  185(1):44-51 
    Zhang ZZ, Shang QH, Jin HY, Song B, Oudit GY, Lu L, Zhou T, Xu YL, Gao PJ, Zhu DL, Penninger JM,  Cardiac Protective Effects of Irbesartan via the PPAR-gamma Signaling Pathway in Angiotensin-Converting Enzyme 2-Deficient Mice. J Transl Med, 2013  J Transl Med  2013  11(1):229-239 
    Jin HY, Song B, Oudit GY, Davidge ST, Yu HM, Jiang YY, Gao PJ, Zhu DL, Ning G, Kassiri Z, Penninger JM,  ACE2 Deficiency Enhances Angiotensin II-Mediated Aortic Profilin-1 Expression, Inflammation and Peroxynitrite Production. PLoS ONE, 2012  PLoS ONE  2012  7(6):-3850 
    Patel VB, Bodiga S, Basu R, Das SK, Wang W, Wang Z, Lo J, Grant MB,, Kassiri Z, Oudit GY  Loss of angiotensin-converting enzyme-2 exacerbates diabetic cardiovascular complications and leads to systolic and vascular dysfunction: a critical role of the angiotensin II/AT1 receptor axis. Circulation Research, 2012  Circulation Research  2012  110(10):1322-1335 
    Patel VB, Bodiga S, Fan D, Das SK, Wang Z, Wang W, Basu R,, Kassiri Z, Oudit GY   Cardioprotective Effects Mediated by Angiotensin II Type 1 Receptor Blockade and Enhancing Angiotensin 1-7 in Experimental Heart Failure in Angiotensin-Converting Enzyme 2-Null Mice. Hypertension, 2012  Hypertension  2012  59(6):1195-1203 
    , Ye JY, Jin HY, et al.  Telmisartan attenuates aortic hypertrophy in hypertensive rats by the modulation of ACE2 and profilin-1 expression. Regul Pept, 2011  Regul Pept  2011  166 (1-3):90-97 
    , Guo D, Chen CB, et al.  Prevention of angiotensin II-mediated renal oxidative stress, inflammation and fibrosis by angiotensin converting enzyme 2. Hypertension, 2011  Hypertension  2011  57(2):314-322 
    Bodiga S,, Wang W, Basu R, Lo J, Liu GC, Guo D, Holland SM, Scholey JW, Penninger JM, Kassiri Z, Oudit GY  Enhanced susceptibility to biomechanical stress in ACE2 null mice is prevented by loss of the p47phox NADPH oxidase subunit. Cardiovascular Research, 2011  Cardiovascular Research  2011  91(1):151-161 
    Long XE, Gong ZH, Pan L, Zhong ZW, Le YP, Liu Q, Guo JM,  Suppression of CDK2 expression by siRNA induces cell cycle arrest and cell proliferation inhibition in human cancer cells. BMB Rep, 2010  BMB Rep  2010  43(4):291-296 
    Oudit GY, Liu GC,, Basu R, Chow FL, Zhou J, Loibner H, Janzek E, Schuster M, Penninger JM, Herzenberg AM, Kassiri Z, Scholey JW  Human recombinant ACE2 reduces the progression of diabetic nephropathy. Diabetes, 2010  Diabetes  2010  59(2):529-538 
    , Basu R, Guo D, Chow FL, Byrns S, Shuster M, Loibner H, Wang X, Penninger JM, Kassiri Z, Oudit GY  Angiotensin converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis and cardiac dysfunction. Circulation, 2010  Circulation  2010  122(7):717-728 
    Oudit GY, Liu GC,, Schuster M, Penninger JM, Herzenberg AM, Kassiri Z, Scholey JW   Recombinant human angiotensin converting enzyme 2 normalizes blood pressure and reduces the progression of diabetic nephropathy. Circulation, 2009  Circulation  2009  120(10):S1076 
    Xiao B, Guo J, Miao Y, Jiang Z, Huan R, Zhang Y, Li D,  Detection of miR-106a in gastric carcinoma and its clinical significance. Clinica Chimica Acta, 2009  Clinica Chimica Acta  2009  400(1-2):97-102 
    Kassiri Z,, Guo D, Basu R, Wang XH, Scholey J, Penning JM, Oudit GY   Loss of angiotensin converting enzyme 2 leads to maladaptive left ventricular remodeling in response to myocardial infarction. Circulation:Heart Failure, 2009  Circulation:Heart Failure  2009  2(5):446-455 
    Yu HM, Lin SG, Jin L, Yu Y,, Zhang Y, Liu G  Adenine/ cytosine1166 polymorphism of the angiotensin II type 1 receptor gene and the antihypertensive response to angiotensin-converting enzyme inhibitors. Journal of Hypertension, 2009  Journal of Hypertension  2009  27(11):2278-2282 
    , Yu XY*, Lin QX, Li XH, Huang XZ, Xiao DZ, Lin SG   Enhanced angiotensin converting enzyme 2 regulates the insulin/Akt signalling pathway by blockade of macrophage migration inhibitory factor expression. British Journal of Pharmacology, 2008  British Journal of Pharmacology  2008  153(1):66-74 
    , Yu XY*, Huang Y, Yung LM, Lau CW, Lin SG  Apelin modulates aortic vascular tone via endothelial nitric oxide synthase phosphorylation pathway in diabetic mice. Cardiovascular Research, 2007  Cardiovascular Research  2007  74(3):388-395 
    , Huang Y, Yung LM, Lau CW, Leung FP, Wong T, Lin SG, Yu XY   The novel peptide apelin regulates intrarenal artery tone in diabetic mice. Regul Pept, 2007  Regul Pept  2007  144(1):-3 
    Yang YM, Huang DY, Liu GF,, Du K, Li YF, Song XH  Inhibitory effects of vitamin A on TCDD-induced CYP 1A1 enzyme activity and expression. Toxicol Sci, 2005  Toxicol Sci  2005  85(1):727-734 
    Yang YM, Huang DY, Liu GF,,Du K, Li YF, Song XH  Effects of 2,3,7,8-Tetra-chloro-dibenzo-p-dioxin on Vitamin A Metabolism in Mice. J Biochem Mol Toxicol, 2005  J Biochem Mol Toxicol  2005  19(1):1-9 
    , Huang DY*, Liu GF, Jin HY, Yang YM, Li YF, Song XH, Du K  Effects of all-trans retinoic acid on orphan receptor APJ signaling in spontaneously hypertensive rats. Cardiovascular Research, 2005  Cardiovascular Research  2005  65(3):743-750 
    , Huang DY, Yang YM, Li YF, Liu GF, Song XH, Du K  Upregulation of angiotensin-converting enzyme 2 by all-trans retinoic acid in spontaneously hypertensive rats. Hypertension, 2004  Hypertension  2004  44(6):907-912