• 基本信息
    导师姓名： 韩泽广 学科代码： 071000
    性别： 男 学科名称： 生物学
    培养单位： 附属瑞金医院 三级学科
    导师类型： 博士生导师 专业领域名称：
    联系方式： 专业领域代码：
    邮编： 邮箱地址： hanzg@chgc.sh.cn
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    中国生物化学与分子生物学会蛋白质组学专业委员会委员
    The Open Systems Biology Journal (Editorial Advisory Board)
    BMC Bioinformatics杂志Associate Editors（副主编）
    World Journal of Gastroenterology编委
    THE OPEN PARASITOLOGY JOURNAL(Editorial Advisory Board)
    ISRN Tropical Medicine杂志编委
    《科学通报》特约编辑
    The scientific world journal杂志（Genetics）编委
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    2016ZX10002018-009病毒性肝炎相关肝癌转移复发的预测诊断与精准防治研究国家科技重大专项“艾滋病和病毒性肝炎等重大传染病防治” 2016-01~2020-12 378万元  子课题负责人
    2016ZX10002022-004肝癌分子分型相关基因突变检测与DLK1丰度检测试剂盒研制及临床应用研究国家科技重大专项“艾滋病和病毒性肝炎等重大传染病防治” 2016-01~2020-12 600万元  子课题负责人
    81472621染色质重塑调节因子ARID1A缺失在肝癌发生发展过程中的作用及其机制研究国家自然科学基金 2015-01~2018-12 85万元  课题负责人
    14140902500基于IRTKS基因剔除的脂肪肝和糖尿病小鼠模型的建立上海市科委 2014-07~2016-09 25万元  课题负责人
    81272271LZP介导的肝脏脂质代谢在肿瘤发生发展的作用及其分子机制研究国家自然科学基金 2013-01~2016-12 70万元  课题负责人
    2013ZX10002010-006基于肝癌组织外显子组突变检测的分子分型与DLK1丰度检测试剂盒研制卫生部重大专项 2013-01~2015-12 196.03万元  子课题负责人
    2012ZX10002012-008肝癌转移相关分子标志物和治疗靶标筛选和验证卫生部重大专项 2012-01~2015-12 331.77万元  子课题负责人
    81071722SCARA5在肝癌发生和转移过程中的作用及分子机制研究国家自然科学基金 2011-01~2014-12 32万元  课题负责人
    2010CB529200基于系统生物医学基础的白血病临床转化研究（首席科学家）973计划项目 2010-01~2014-12 3000万元  主要责任人
    2008ZX10002-020病毒性相关肝癌发生发展的分子网络调控机制与干预位点研究国家“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项课题 2008-10~2010-12 820.25万元  子课题负责人
    2008ZX10002-021病毒性肝炎相关肝癌转移复发的分子标志预测与干预新策略研究国家“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项课题 2008-10~2010-12 270.355万元  子课题负责人
    20072901200肝癌表观遗传学异常与转录组改变和临床特性的关联研究国际科技合作与交流专项 2008-01~2010-12 100万元  主要责任人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Hu T, Yang H,  PDZRN4 acts as a suppressor of cell proliferation in human liver cancer cell lines.  Cell Biochem Funct.  2015  33(7):443-9 
    Xia PY , Wang S, Xiong Z, Ye BQ, Huang LY,, Fan ZS  IRTKS negatively regulates antiviral immunity through PCBP2 sumoylation-mediated MAVS degradation  Nat Commun.   2015  doi: 10.1038/ncomms9132 
    Fang JZ, Li C, Liu XY, Hu TT, Fan ZS,  Hepatocyte-Specific Arid1a Deficiency Initiates Mouse Steatohepatitis and Hepatocellular Carcinoma.  PLoS One.  2015  10(11):e0143042. doi: 10.1371/journal.pone.0143042. 
    Zhang ZZ, Huang J, Wang YP, Cai B,  NOXIN as a cofactor of DNA polymerase-primase complex could promote hepatocellular carcinoma.   Int J Cancer.   2015  137(4):765-75 
    Wang Q, Zhai YY, Dai JH, Li KY, Deng Q,  SAMD9L Inactivation Promotes Cell Proliferation via Facilitating G1-S Transition in Hepatitis B Virus-associated Hepatocellular Carcinoma.  Int J Biol Sci.  2014  10(8):807-816  
    Deng Q, Li KY, Chen H, Dai JH, Zhai YY, Wang Q, Li N, Wang YP,  RNA interference against cancer/testis genes identifies DUSP21 as a potential therapeutic target in human hepatocellular carcinoma  Hepatology  2014  59(2):518-530 
      Mutational landscape of hepatoblastoma goes beyond Wnt-β-catenin pathway.   Hepatology  2014  60(5):1476-8. 
    Huang LY, Wang YP, Wei BF, Yang J, Wang JQ, Wu BH, Zhang ZZ, Hou YY, Sun WM, Hu RM, Ning G,  Deficiency of IRTKS as an adaptor of insulin receptor leads to insulin resistance.  Cell Res.  2013  23(11):1310-1321 
    Cheng N, Li Y,  Argonaute2 promotes tumor metastasis by way of up-regulating focal adhesion kinase expression in hepatocellular carcinoma.   Hepatology  2013  57(5):1906-1918 
    Wang YP, Huang LY, Sun WM, Zhang ZZ, Fang JZ, Wei BF, Wu BH,  Insulin receptor tyrosine kinase substrate activates EGFR/ERK signalling pathway and promotes cell proliferation of hepatocellular carcinoma.   Cancer Lett.   2013  337(1):96-106 
    Liu RF, Xu X, Huang J, Fei QL, Chen F, Li YD,  Down-regulation of miR-517a and miR-517c promotes proliferation of hepatocellular carcinoma cells via targeting Pyk2  Cancer Lett.  2013  329(2):164-173 
    Zhou B, Li Y, Deng Q, Wang H, Wang Y, Cai B,  SRPK1 contributes to malignancy of hepatocellular carcinoma through a possible mechanism involving PI3K/Akt  Mol Cell Biochem  2013  379(1-2):191-199 
    Li Y, Zhou B, Dai J, Liu R,  Aberrant upregulation of LRRC1 contributes to human hepatocellular carcinoma  Mol Biol Rep.   2013  40(7):4543-4551 
    Tao HC, Wang HX, Dai M, Gu CY, Wang Q,, Cai B.  Targeting SHCBP1 Inhibits Cell Proliferation in Human Hepatocellular Carcinoma Cells.  Asian Pac J Cancer Prev.   2013  14(10):5645-5650 
    Huang J, Deng Q, Wang Q, Li KY, Dai JH, Li N, Zhu ZD, Zhou B, Liu XY, Liu RF, Fei QL, Chen H, Cai B, Zhou B, Xiao HS, Qin LX,  Exome sequencing of hepatitis B virus-associated hepatocellular carcinoma.  Nature Genetics  2012  44(10):1117-1121 
    Wang H, Li Y, Wang Y,, Cai B.   C9orf100, a new member of the Dbl-family guanine nucleotide exchange factors, promotes cell proliferation and migration in hepatocellular carcinoma.  Mol Med Report.  2012  5(5):1169-74 
    Xu X, Liu RF, Zhang X, Huang LY, Chen F, Fei QL,  DLK1 as a potential target against cancer stem/progenitor cells of hepatocellular carcinoma.  Mol Cancer Ther.  2012  11(3):629-38 
    Wei YJ, Hu QQ, Gu CY, Wang YP,, Cai B.   Up-regulation of NICE-3 as a Novel EDC Gene Could Contribute to Human Hepatocellular Carcinoma.  Asian Pac J Cancer Prev.  2012  13(9):4363-8. 
    Wang H, Wu K, Sun Y, Li Y, Wu M, Qiao Q, Wei Y,, Cai B.   STC2 is upregulated in hepatocellular carcinoma and promotes cell proliferation and migration in vitro.   BMB Rep.  2012  45(11):629-34 
      Functional Genomic Studies: Insights into the Pathogenesis of Liver Cancer.  Annu Rev Genomics Hum Genet  2012  13:171-205 
    Yan B, Zhang ZZ, Huang LY, Shen HL,  OIT3 deficiency impairs uric acid reabsorption in renal tubule  FEBS Lett.  2012  586(6):760-5 
    Fu Y, Huang J, Wang KS, Zhang X,  RNA interference targeting CITRON can significantly inhibit the proliferation of hepatocellular carcinoma cells.   Mol Biol Rep  2011  38(2):693-702 
    Stefanska B, Huang J, Bhattacharyya B, Suderman M, Hallett M,, Szyf M.  Definition of the landscape of promoter DNA hypomethylation in liver cancer.  Cancer Res.  2011  71(17):5891-903 
    Xu X, Liu RF, Wan BB, Xing WM, Huang J,  Expression of a novel gene FAM43B repressing cell proliferation is regulated by DNA methylation in hepatocellular carcinoma cell lines.  Mol Cell Biochem  2011  354(1-2):11-20 
    Wang KS, Chen G, Shen HL, Li TT, Chen F, Wang QW, Wang ZQ,, Zhang X.   Insulin receptor tyrosine kinase substrate enhances low levels of MDM2-mediated p53 ubiquitination.   PLoS One  2011  6(8):e23571. 
    Deng Q, Wang Q, Zong WY, Zheng DL, Wen YX, Wang KS, Teng XM, Zhang X, Huang J,  E2F8 Contributes to Human Hepatocellular Carcinoma via Regulating Cell Proliferation.  Cancer Res  2010  70(2):782-791 
      Systems biomedical analysis of Schistosoma japonicum.   Frontiers of Medicine in China  2010  4(2):157-165 
    Huang J, Zheng DL, Qin FS, Cheng N, Chen H, Wan BB, Wang YP, Xiao HS,  Genetic and epigenetic silencing of SCARA5 may contribute to hepatocellular carcinoma by activating FAK signaling  J Clin Invest.  2010  120(1):223-241 
      Epigenetic analysis in the search for tumor suppressor genes.  Epigenomics  2010  2(4):489-493 
    Liu F, Cui SJ, Hu W, Feng Z, Wang ZQ,  Excretory/secretory proteome of the adult developmental stage of human blood fluke, Schistosoma japonicum  Mol Cell Proteomics.  2009  8(6):1236-1251 
    Huang J, Pei Hao, Hui Chen, Wei Hu, Qing Yan, Feng Liu,  Genome-wide identification of Schistosoma japonicum microRNAs using a deep sequencing approach  PLoS One  2009  4(12): e8206 
    Huang J, Lin Y, Li L, Qing D, Teng XM, Zhang YL, Hu X, Hu Y, Yang P,  ARHI, as a novel suppressor of cell growth and downregulated in human hepatocellular carcinoma, could contribute to hepatocarcinogenesis.  Mol Carcinog.  2009  48(2):130-140 
    Zheng DL, Zhang L, Cheng N, Xu X, Deng Q, Teng XM, Wang KS, Zhang X, Huang J,  Epigenetic modification induced by hepatitis B virus X protein via interaction with de novo DNA methyltransferase DNMT3A.  J Hepatol  2009  50(2):377-387 
    Wang ZQ, Xing WM, Fan HH, Wang KS, Zhang HK, Wang QW, Qi J, Yang HM, Yang J, Ren YN, Cui SJ, Zhang X, Liu F, Lin DH, Wang WH, Hoffmann MK,  The novel lipopolysaccharide-binding protein CRISPLD2 is a critical serum protein to regulate endotoxin function.  J Immunol  2009  183(10):6646-6656 
    , Brindley PJ, Wang SY, Chen Z.  Schistosoma genomics: new perspectives on schistosome biology and host-parasite interaction  Annu Rev Genomics Hum Genet  2009  10:211-240 
    Ma Y, Qi X, Du J, Song S, Feng D, Qi J, Zhu Z, Zhang X, Xiao H,, Hao X  Identification of candidate genes for human pituitary development by EST analysis  BMC Genomics.  2009  10:109 
    The Schistosoma japonicum Genome Sequencing and Functional Analysis Consortium.  The Schistosoma japonicum genome reveals features of host-parasite interplay  Nature  2009  460：345-351