• 基本信息
    导师姓名： 贾浩 学科代码： 100100
    性别： 男 学科名称： 基础医学
    培养单位： 基础医学院 三级学科
    导师类型： 硕士生导师 专业领域名称：
    联系方式： 上海市黄浦区重庆南路280号 上海交通大学基础医学院生化与分子细胞学系 专业领域代码：
    邮编： 200025 邮箱地址： fonney@sjtu.edu.cn
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    上海口腔医学会口腔黏膜病专委会委员，上海市东方英才（青年）、上海市青年科技启明星，上海交通大学青年岗位能手，上海交通大学医学院“上药杏林育才奖”、“九龙医学优秀青年人才奖”
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    20220501开发病原微生物的快速检测系统教育部重点实验室开放课题 2022-09~2024-09 30万元  课题负责人
    2020501人畜共患病的机制研究教育部重点实验室开放课题 2020-09~2022-09 30万元  课题负责人
    31970679AJUBA通过磷酸化STAT5促进间充质干细胞向成骨分化命运决定的机制研究国家自然基金面上项目 2020-01~2023-12 52万元  课题负责人
    19QA1405000上海市青年“科技启明星"上海市科委 2019-04~2022-04 40万元  课题负责人
    2017034上海人才发展基金上海市人力资源保障局 2018-01~2020-12 20万元  课题负责人
    201717上海交通大学新进教师启动计划上海交通大学 2018-01~2020-12 20万元  课题负责人
    31601114AJUBA调控IFIT2介导的细胞凋亡及其在结直肠癌发展中的作用与机制研究国家自然基金青年基金 2017-01~2019-12 20万元  课题负责人
    31671415LIM蛋白Ajuba促进脂肪细胞分化的机制研究国家自然基金面上项目 2017-01~2020-12 62万元  课题参与人
    2015M57036AJUBA介导的结直肠癌发展中的作用与机制研究中国博士后科学基金面上资助一等资助 2015-06~2016-12 8万元  课题负责人
    81130039Atm 介导的Smad1 磷酸化在DNA损伤应激反应及肿瘤发生中的作用国家自然基金(重点项目) 2012-01~2017-12 280万元  课题参与人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Xia K, Chen X, Wang W, Liu Q, Zhao M, Ma J,  Roles of mechanosensitive ion channels in immune cells  Heliyon   2023  Dec 4;10(1):e23318 
    Zou X, Ma L, Zhang Y, Zhang Q, Xu C, Zhang D, Chu Y, Zhang J, Li M, Zhang H, Wang J, Peng C, Wei G, Wu Y, Hou Z,  GATA zinc finger protein p66β promotes breast cancer cell migration by acting as a co-activator of Snail  Cell Death Dis  2023  Jun 28;14(6):382 
    Yang X, Zhou T, Ji T,, Liu W(*).  Comment on circulatory miRNAs as therapeutic molecules for oral potentially malignant disorder and oral squamous cell carcinoma.  Oral Oncology  2022  May 6;130:105901.  
    Han Yan,Qi Li,Mengying Li,Xiuqun Zou,Ningning Bai,Zichao Yu,Jie Zhang, Dan Zhang,Qun Zhang,Jiamin Wang,,Yingjie Wu(*),Zhaoyuan Hou(*)  Ajuba functions as a co-activator of C/EBPβ to induce expression of PPARγ and C/EBPα during adipogenesis  Mol Cell Endocrinol  2022  Jan 1;539:111485. 
    Linjun Shi(#),Yuquan Yang,Mengying Li,Chenxi Li,Zengtong Zhou,Guoyao Tang,Lan Wu1,Yilin Yao,Xuemin Shen,Zhaoyuan Hou,  LncRNA IFITM4P is activated through LPS/TLR4 and promotes immune escape by up-regulating PD-L1 via dual mechanism during oral carcinogenesis  MOLECULAR THERAPY  2022  Apr 6;30(4):1564-1577. 
    Jinrui Xu,Yuquan Yang,Zhaoyuan Hou,,Yujiong Wang(*)  TRPV2-spike protein interaction mediates the entry of SARS-CoV-2 into macrophages in febrile conditions  Theranostics   2021  11(15):7379-7390 
    张纯希,李想,周钰翔,刘禛,杨于权,  骨骼微环境中谁决定间充质干细胞的分化命运  中国组织工程研究   2021  25(25):4045-4052. 
    , Ao Zhang(#), Yuquan Yang, Yaqi Cui, Jianrong Xu, Hewei Jiang, Shengce Tao, Dawei Zhang, Heping Zeng, Zhaoyuan Hou, Jijun Feng(*)   A graphene oxide coated tapered microfiber acting as a super-sensor for rapid detection of SARS-CoV-2  Lab on a Chip  2021  May 7 
    ,Yuquan Yang(#),Mengying Li(#),Yimin Chu,Huan Song,Jie Zhang,Dan Zhang, Qun Zhang,Ying Xu,Jiamin Wang,Hong Xu,Xiuqun Zou,Haixia Peng,Zhaoyuan Hou(*)  Snail enhances arginine synthesis by inhibiting ubiquitination-mediated degradation of ASS1  EMBO Reports  2021  2021 Aug 4;22(8):e51780 
    崔雅琦,白玉冰,许怡晨,谭心辰,李梦莹,  脂肪来源的间充质干细胞及外囊泡促成骨分化的研究进展  上海交通大学学报 (医学版)   2020  2020, 40(12): 
    Cai J, Li M, Wang X, Li L, Li Q, Hou Z,, Liu S(*).  USP37 Promotes Lung Cancer Cell Migration by Stabilizing Snail Protein via Deubiquitination.  Front Genet.  2020  Jan 10;10:1324.  
    , Peng H, Hou Z(*) .  Ajuba: An emerging signal transducer in oncogenesis.  Pharmacol Res   2020  Jan;151:104546.  
    Zhang B, Song L, Cai J, Li L, Xu H, Li M, Wang J, Shi M, Chen H,, Hou Z.  The LIM protein Ajuba/SP1 complex forms a feed forward loop to induce SP1 target genes and promote pancreatic cancer cell proliferation.  J Exp Clin Cancer Res.   2019  2019 May 17;38(1):205.  
    Xu B, Li Q, Chen N, Zhu C, Meng Q, Ayyanathan K, Qian W,, Wang J, Ni P, Hou Z.  The LIM protein Ajuba recruits DBC1 and CBP/p300 to acetylate ERα and enhances ERα target gene expression in breast cancer cells.  Nucleic Acids Res  2019  18;47(5):2322-2335.  
    Huan Song,Weiyi Wang,Bo Shen,,Zhaoyuan Hou,Ping Chen,Yunwei Sun(*).  Pretreatment with probiotic Bifico ameliorates colitis-associated cancer in mice: Transcriptome and gut flora profiling.  Cancer science  2018  109(3):666-677. 
    , Song L, Cong Q, Wang J , Xu H,Chu, Y.; Li, Q.; Zhang, Y.; Zou, X.; Zhang, C.; Chin, Y. E.; Zhang, X.; Li, Z.; Zhu, K.; Wang, B.(*); Peng, H.(*); Hou, Z.(*)  The LIM protein AJUBA promotes colorectal cancer cell survival through suppression of JAK1/STAT1/IFIT2 network  ONCOGENE  2017  2017.5.11, 36(19): 2655~2666. 
    Cong Qian(#),, Li Ping, Qiu Shoutao, Yeh James, Wang Yibin; Zhang, Zhen-Lin; Ao, Junping; Li, Baojie(*); Liu, Huijuan(*)  p38 alpha MAPK regulates proliferation and differentiation of osteoclast progenitors and bone remodeling in an aging- dependent manner  Scientific Reports  2017  2017.4.10, 7  
    Yang D(#), Hou T(#), Li L,Chu Y, Zhou F, Xu Y, Hou X, Song H,Zhu K,Hou Z,Peng H(*),  Smad1 promotes colorectal cancer cell migration through Ajuba transactivation.   Oncotarget  2017  2017.12.30, 30(8): 110415~110425  
    Qian Cong(#),, Soma Biswas, Ping Li; Shoutao Qiu; Qi Deng; Xizhi Guo; Gang Ma; Jenny Fang Ling Chau; Yibin Wang; Zhen-Lin Zhang; Xinquan Jiang; Huijuan Liu(*); Baojie Li(*)  p38a MAPK Regulates Lineage Commitment and OPG Synthesis of BoneMarrow Stromal Cells to Prevent Bone Loss under Physiological andPathological Conditions  Stem Cell Reports  2016  2016, 6(1-13): 1~13  
    Zhou Tielin(#), Li Jing, Zhao Peiquan, Liu Huijuan,Jia Deyong,,He Lin,Cang Yong, Boast, Sharon; Chen, Yi-Han; Thibault, Helene; Scherrer-Crosbie, Marielle; Goff, Stephen P(*); Li, Baojie(*)  Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy.  PNAS  2015  2015.12.22, 112(51): 15666~15671  
    , Cong Q,Chua J F L,Liu H, Xia X,Zhang X, Lin J, Habib S L, Ao J, Zuo Q,Fu C, Li B(*) .   p57Kip2 is an unrecognized DNA damage response effector molecule that functions in tumor suppression and chemoresistance.  ONCOGENE  2015  2015.9.8, 2015: 3568~3581 
    Ruan Xinsen(#), Zuo Qiao(#),, Chau Jenny; Lin, Jinlin; Ao, Junping; Xia, Xuechun; Liu, Huijuan; Habib, Samy L; Fu, Chuangang(*); Li, Baojie(*)   P53 deficiency-induced Smad1 upregulation suppresses tumorigenesis and causes chemoresistance in colorectal cancers  J Mol Cell Biol  2015  2015.4, 7(2): 105~118  
    Chau Jenny Fung Ling(#),Jia Deyong(#), Wang Zhongfeng(#),Liu Zhi, Hu Yuanyu, Zhang Xin,,Lai Keng Po, Leong, Wai Fook; Au, Bi Jin; Mishina, Yuji; Chen, Ye-Guang; Biondi, Christine; Robertson, Elizabeth; Xie, Dong; Liu, Huijuan; He, Lin; Wang, Xueying; Yu, Qiang; Li, Baojie(*)  A crucial role for bone morphogenetic protein-Smad1 signalling in the DNA damage response.  Nature Communications  2012  2012, 3: 836~836