- 基本信息
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导师姓名：
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沈蕾
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学科代码：
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100100
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性别：
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女
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学科名称：
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基础医学
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培养单位：
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基础医学院
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三级学科
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导师类型：
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博士生导师
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专业领域名称：
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联系方式：
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上海市重庆南路280号5号楼1202室
电话分机： 776365
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专业领域代码：
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邮编：
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200025
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邮箱地址：
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lshen@shsmu.edu.cn
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- 研究方向 (点击浏览详细信息)
- 社会任职
- 科研项目
| 31570921 | PLZF对3型天然淋巴细胞(ILC3)发育和功能的调控作用及机制研究 | 国家自然科学基金 |
2016-01~2019-12
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60万元
| 课题参与人 |
| 81571533 | SUMO特异性蛋白酶1(SENP1)对脂肪组织巨噬细胞的调控作 用以及与2型糖尿病发生的关系 | 国家自然科学基金面上项目 |
2016-01~2019-12
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58万元
| 课题负责人 |
| 81373210 | B淋巴细胞调节肥胖诱导胰岛素抵抗的作用机制 | 国家自然科学基金面上项目 |
2014-01~2017-12
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70万元
| 课题负责人 |
| 12345678 | 获得性免疫系统在胰岛素抵抗和2型糖尿病中的作用及机制 | 国家高层次人才计划 |
2014-01~2017-12
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200万元
| 课题负责人 |
- 学术论文
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Wang H,, Sun X, Liu F, Feng W, Jiang C, Chu X, Ye X, Jiang C, Wang Y, Zhang P, Zang M, Zhu D, Bi Y.
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Adipose group 1 innate lymphoid cells promote adipose tissue fibrosis and diabetes in obesity.
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Nat Commun.
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2019
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10(1):3254
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Cai T, Qiu J, Ji Y, Li W, Ding Z, Suo C, Chang J, Wang J, He R, Qian Y, Guo X, Zhou L, Sheng H,, Qiu J.
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IL-17-producing ST2+ group 2 Innate Lymphoid Cells play a pathogenic role in lung inflammation
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J Allergy Clin Immunol.
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2019
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143(1):229-244
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Yu T, Zuo Y, Cai R, Huang X, Wu S, Zhang C, Chin YE, Li D, Zhang Z, Xia N, Wang Q, Shen H, Yao X, Zhang ZY, Xue S,, Cheng J.
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SENP1 regulates IFN-g-STAT1 signaling through STAT3-SOCS3 negative feedback loop
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J Mol Cell Biol
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2017
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9(2):144-153
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McLaughlin T, Ackerman SE,, Engleman E.
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Role of innate and adaptive immunity in obesity-associated metabolic disease.
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J Clin Invest
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2017
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127(1): 5-13
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, Zhang H, Caimol M, Benike CJ, Chakravarty EF, Strober S, Engleman EG.
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Invariant natural killer T cells in lupus patients promote IgG and IgG autoantibody production.
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Eur J Immunol
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2015
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45(2): 612-623
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, Chng MH, Alonso MN, Yuan R, Winer DA, Engleman EG.
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B-1a Lymphocytes Attenuate Insulin Resistance.
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Diabetes.
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2015
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64(2):593-603
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Winer DA, Winer S, Chng MH,, Engleman EG.
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B Lymphocytes in obesity-related adipose tissue inflammation and insulin resistance.
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Cell Mol Life Sci.
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2014
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71(6):1033-43
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McLaughlin T, Liu LF, Lamendola C,, Morton J, Rivas H, Winer D, Tolentino L, Choi O, Zhang H, Hui Yen Chng M, Engleman E.
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T-cell profile in adipose tissue is associated with insulin resistance and systemic inflammation in humans.
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Arterioscler Thromb Vasc Biol.
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2014
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34(12):2637-43
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Winer D, Winer S,, Wadia P, Yantha J, Paltser G, Tsui H, Wu P, Davidson M, Alonso M, Leong H, Glassford A, Caimol M, Tedder T, McLaughlin T, Miklos D, Dosch HM, Engleman EG.
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B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies
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Nature Medicine
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2011
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17(5):610-617
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Zhang B, Lo C,, Sood R, Jones C, Cusmano-Ozog K, Park-Snyder S, Wong W, Jeng M, Cowan T, Engleman EG, Zehnder J.
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The role of vanin-1 and oxidative stress-related pathways in distinguishing acute and chronic pediatric ITP
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Blood
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2011
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117(17):4569-4579
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Song XT, Evel-Kabler K,, Rollins L, Huang XF, Chen SY.
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Nature Medicine
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2008
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14(3):258-265
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, Evel-Kabler K, Strube R, Chen SY.
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Silencing of SOCS1 enhances antigen presentation by dendritic cells and antigen-specific anti-tumor immunity.
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Nature Biotechnology
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2004
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22(12):1546-53
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