基本信息

导师姓名：	黄雷	学科代码：	100100
性别：	女	学科名称：	基础医学
培养单位：	基础医学院	三级学科
导师类型：	博士生导师	专业领域名称：
联系方式：	上海交通大学医学院组织胚胎学与遗传发育系上海市重庆南路280号5号楼505 室 200025 电话：021-63846590-776576	专业领域代码：
邮编：	200025	邮箱地址：	leihuang@shsmu.edu.cn

研究方向 (点击浏览详细信息)


肿瘤干细胞及靶向治疗

社会任职


上海病理生理学会理事
黄浦区人大代表
上海交通大学医学院“中青年知识分子联谊会”副会长
美国人类遗传学会会员、中国遗传学会会员、中国细胞生物学学会会员

科研项目

项目编号	项目名称	课题来源	起止年月	批准经费	承担职责
82073111	黏蛋白1泛素化修饰的动态调控机制及其肿瘤治疗意义研究	国家自然科学基金面上项目	2021-01~2024-12	55万元	课题负责人
81874197	黏蛋白1调控肿瘤干细胞分裂模式的机制及临床意义研究	国家自然科学基金面上项目	2019-01~2022-12	57万元	课题负责人
2015CB910403	代谢应激过程中蛋白质修饰相关的生物标志物和潜在靶点的发现	国家重大研究计划项目	2015-01~2019-12	60万元	课题参与人
81472461	MUC1在产后乳腺退化中的作用及其与TNBC发病的关系研究	国家自然科学基金面上项目	2015-01~2018-12	72万元	课题负责人
81272262	MUC1在肺癌早期发生和转移中的作用和机制研究	国家自然科学基金面上项目	2013-01~2016-12	80万元	课题负责人
2012CB967000	肿瘤干细胞的动态演进及干预研究	国家重大研究计划项目	2012-01~2016-12	92万元	课题参与人
11140902600	乳腺癌小鼠模型的建立及肿瘤发生机制研究	上海市科委实验动物研究项目	2011-12~2013-09	20万元	课题负责人
81071666	MDMX基因定点诱变小鼠模型的建立及其生物学功能研究	国家自然科学基金面上项目	2011-01~2013-12	35万元	课题负责人
NCET-08-0349	MUC1在肺癌治疗中的作用及其机制研究	教育部“新世纪优秀人才支持计划	2009-01~2011-12	50万元	课题负责人
30871363	MUC1在乳腺癌治疗中的作用及其机制研究	国家自然科学基金面上项目	2009-01~2011-12	35万元	课题负责人
07pj14065	MUC1在肺癌发病和治疗中的作用及其机制研究	上海市科委“浦江人才计划”	2007-09~2009-09	20万元	课题负责人
30671169	MUC1过度表达小鼠模型的建立及其致瘤机制研究	国家自然科学基金面上项目	2007-01~2009-12	30万元	课题负责人

学术论文

作者	论文标题	期刊名	出版年	卷期页码
Morimoto Y, Fushimi A, Yamashita N, Hagiwara M, Bhattacharya A, Cheng J, Frost TC, Ahmad R, Daimon T, Huang L, Hata T, Takahashi H, Yamamoto M, Suzuki Y, DeCaprio JA, Kufe D*.	Addiction of Merkel cell carcinoma to MUC1-C identifies a potential new target for treatment	Oncogene	2022	41(27):3511-3523
Li Q, Chu Y, Li S, Yu L, Deng H, Liao C, Liao X, Yang C, Qi M, Cheng J, Chen G, Huang L （通讯作者）	The oncoprotein MUC1 facilitates breast cancer progression by promoting Pink1-dependent mitophagy via ATAD3A destabilization.	Cell Death & Disease.	2022	13(10): 899-915
Pang Z#,Dong X#,Deng H#,Wang C,Liao X,Liao C,Liao Y,Tian W,Cheng Jinke,Chen G,Yi H,Huang L （通讯作者）	MUC1 triggers lineage plasticity of Her2 positive mammary tumors	Oncogene	2022	41(22):3064-3078
Liao C, Yu L, Pang Z, Deng H, Liao X, Li S, Cheng J, Qi M, Chen G,Huang L* （通讯作者）	WWP1 targeting MUC1 for ubiquitin-mediated lysosomal degradation to suppress carcinogenesis	Signal Transduction and Targeted Therapy	2021	6(1):297-300
Guan Y,Wang Y,Li B,Shen K,Li Q,Ni Y,Huang L. （通讯作者）	Mitophagy in carcinogenesis, drug resistance and anticancer therapeutics.	Cancer Cell International.	2021	21(350):1-9
Wu AY, Gu LY, Cang W, Cheng MX, Wang WJ, Di W, Huang L* （通讯作者）, Qiu LH*.	Fn14 overcomes cisplatin resistance of high-grade serous ovarian cancer by promoting Mdm2-mediated p53-R248Q ubiquitination and degradation.	J Exp Clin Cancer Res.	2019	38 (1):176.
Lv Y, Cang W, Li Q, Liao X, Zhan M, Deng H, Li S, Jin W, Pang Z, Qiu X, Zhao K, Chen G, Qiu L, Huang L （通讯作者）	Erlotinib overcomes paclitaxel-resistant cancer stem cells by blocking the EGFR-CREB/GRβ-IL-6 axis in MUC1-positive cervical cancer	Oncogenesis	2019	8(12):70
Wang Y, Liao X, Ye Q, Huang L （通讯作者）	Clinic implication of MUC1 O-glycosylation and C1GALT1 in esophagus squamous cell carcinoma.	Sci China Life Sci.	2018	61(11):1389-1395.
Gamze Kuser-Abali, Lu Gong, Jiawei Yan, Qingqing Liu, Weiqi Zeng, Amanda Williamson, Chuan Bian Lim, Mary Ellen Molloy, John B. Little, Lei Huang, Zhi-Min Yuan.	An EZH2-mediated epigenetic mechanism behind p53-dependent tissue sensitivity to DNA damage.	Proc Natl Acad Sci U S A.	2018	115(13):3452-3457.
Yuan Li, Zhi Pang, Xinran Dong, Xiaodong Liao, Huayun Deng, Chunhua Liao, Yahui Liao, Guoqiang Chen, Lei Huang. （通讯作者）	MUC1 induces M2 type macrophage influx during postpartum mammary gland involution and triggers breast cancer.	Oncotarget.	2018	9 (3): 3446-3458
Hu Y, Li D, Wu A, Qiu X, Di W, Huang L* （通讯作者）, Qiu L*.	TWEAK-stimulated macrophages inhibit metastasis of epithelial ovarian cancer via exosomal shuttling of microRNA.	Cancer Lett.	2017	393:60-67.
Fu RJ, He W, Wang XB, Li L, Zhao HB, Liu XY, Pang Z, Chen GQ, Huang L* （通讯作者）, Zhao KW*.	DNMT1-mediated hypermethylation of Krüppel-like factor 5 regulates the progression of clear cell renal cell carcinoma.	Cell Death & Disease	2017	8(7):e2952.
Jin W, Liao X, Lv Y, Pang Z, Wang Y, Li Q, Liao Y, Ye Q, Chen G, Zhao K, Huang L. （通讯作者）	MUC1 induces acquired chemoresistance by upregulating ABCB1 in EGFR-dependent manner.	Cell Death & Disease	2017	8(8):e2980
Zhao XY, Li L, Wang XB, Fu RJ, Lv YP, Jin W, Meng C, Chen GQ, Huang L* （通讯作者）, Zhao KW*.	Inhibition of Snail Family Transcriptional Repressor 2 (SNAI2) Enhances Multidrug Resistance of Hepatocellular Carcinoma Cells.	PLoS ONE.	2016	11(10):e0164752.
Wang Y, Shang W, Lei X, Shen S, Zhang H, Wang Z, Huang L, Yu Z, Ong H, Yin X, Yang W, Zhang C.	Opposing functions of PLAG1 in pleomorphic adenoma: a microarray analysis of PLAG1 transgenic mice	Biotechnol Lett	2013	35(9):1377-85
Wang F, Wang PX, Wu XL, Dang SY, Chen Y, Ni YY, Gao LH, Lu SY, Kuang Y, Huang L, Fei J, Wang ZG, Pang XF.	Deficiency of Adiponectin Protects against Ovariectomy-Induced Osteoporosis in Mice.	PLoS One	2013	8(7):e68497.
Xu WY, Gu MM, Sun LH, Guo WT, Zhu HB, Ma JF, Yuan WT, Kuang Y, Ji BJ, Wu XL, Chen Y, Zhang HX, Sun FT, Huang W, Huang L, Chen SD, Wang ZG.	A nonsense mutation in DHTKD1 causes Charcot-Marie-Tooth disease type 2 in a large Chinese pedigree.	Am J Hum Genet	2012	91(6):1088-94.
Li Y, Yi H, Yao Y, Liao X, Xie Y, Yang J, Yan Z, Wang L, Lu S, Kuang Y, Gu M, Fei J, Wang Z, Huang L （通讯作者）	The Cytoplasmic Domain of MUC1 Induces Hyperplasia in the Mammary Gland and Correlates with Nuclear Accumulation of β-catenin.	PLoS ONE	2011	6(4):e19102
Shen S, Yang W, Wang Z, Lei X, Xu L, Wang Y, Wang L, Huang L, Yu Z, Zhang X Li J, Chen Y, Zhao X, Yin X, Zhang C.	. Tumor-Initiating Cells Are Enriched in CD44(hi) Population in Murine Salivary Gland Tumor.	PLoS ONE.	2011	6(8)
Ye Q, Yan Z, Liao X, Li Y, Yang J, Sun J, Kawano T, Wang X, Cao Z,Wang Z, Huang L （通讯作者）	MUC1 induces metastasis in esophageal squamous cell carcinoma by upregulating matrix metalloproteinase 13	Lab Invest	2011	91(5):778-87
Huang L （通讯作者）, Yan Z, Liao X, Li Y, Yang J, Wang ZG, Zuo Y, Kawai H, Shadfan M, Ganapathy S, Yuan ZM.	The MDM2/MDMX complex is required for control of p53 activity in vivo.	Proc Natl Acad Sci U S A.	2011	108(29):12001-6
Shen S, Yang W, Wang Z, Lei X, Xu L, Wang Y, Wang L, Huang L, Yu Z, Zhang X Li J, Chen Y, Zhao X, Yin X, Zhang C.	. Tumor-Initiating Cells Are Enriched in CD44(hi) Population in Murine Salivary Gland Tumor.	PLoS ONE.	2011	6(8)
Huang L, Liao X., Beckett M., Li Y., Khanna K. K., Wang Z., Kharbanda S., Weichselbaum R. and Kufe D.	MUC1 Oncoprotein Interacts Directly With ATM and Promotes the DNA Damage Response to Ionizing Radiation.	Genes & Cancer.	2010	1(3):239-250
Macdermed DM, Khodarev NN, Pitroda SP, Edwards DC, Pelizzari CA, Huang L, Kufe DW, Weichselbaum RR.	MUC1-associated proliferation signature predicts outcomes in lung adenocarcinoma patients.	BMC Med Genomics.	2010	3(1):16.1-12
Khodarev NN, Pitroda SP, Beckett MA, Macdermed DM, Huang L, Kufe DW, Weichselbaum RR.	MUC1-Induced Transcriptional Programs Associated with Tumorigenesis Predict Outcome in Breast and Lung.	Cancer Res.	2009	69(7):2833-7
Wu XL, Gu MM, Huang L, Liu XS, Zhang HX, Ding XY, Xu JQ, Cui B, Wang L, Lu SY, Chen XY, Zhang HG, Huang W, Yuan WT, Yang JM, Gu Q, Fei J, Chen Z, Yuan ZM, Wang ZG.	Multiple synostoses syndrome is due to a missense mutation in exon 2 of FGF9 gene.	Am J Hum Genet.	2009	85(1):53-63.
Leng Y, Cao C, Ren J, Huang L, Chen D, Kufe D.	Nuclear import of the MUC1-C oncoprotein is mediated by nucleoporin Nup62.	J Biol Chem.	2007	282(27):19321-30
Ren J, Raina D, Chen W, Li G, Huang L, Kufe D.	MUC1 oncoprotein functions in activation of fibroblast growth factor receptor signaling.	Mol Cancer Res.	2006	4(11):873-83.
Huang L, Chen D., Liu D, Yin L, Kharbanda S, Kufe D.	MUC1 Oncoprotein Blocks Glycogen Synthasa Kinase 3β-Mediated Phosphorylation and Degradation of β-catenin.	Cancer Research.	2005	65(22) :10413-10422
Ren J, Agata N, Chen D, Li Y, Yu WH, Huang L, Raina D, Chen W, Kharbanda S, Kufe D.	Human MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agents.	Cancer Cell.	2004	5(2):163-75.
Yin L, Huang L, Kufe D.	MUC1 oncoprotein activates the FOXO3a transcription factor in a survival response to oxidative stress.	J Biol Chem.	2004	279(44):45721-7
Huang L, Ren J, Chen D, Li Y, Kharbanda S, Kufe D.	MUC1 Cytoplasmic Domain Coactivates Wnt Target Gene Transcription and Confers Transformation.	Cancer Biol Ther.	2003	2(6):702-706.